LeishMANIAdb
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Secreted protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Secreted protein
Gene product:
Protein of unknown function (DUF2946), putative
Species:
Leishmania infantum
UniProt:
A4I9D7_LEIIN
TriTrypDb:
Length:
110

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 3
NetGPI no yes: 0, no: 3
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I9D7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9D7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 66 68 PF00675 0.683
CLV_NRD_NRD_1 99 101 PF00675 0.546
CLV_PCSK_KEX2_1 99 101 PF00082 0.546
CLV_PCSK_SKI1_1 32 36 PF00082 0.594
CLV_PCSK_SKI1_1 44 48 PF00082 0.511
CLV_PCSK_SKI1_1 95 99 PF00082 0.625
DOC_MAPK_MEF2A_6 72 80 PF00069 0.503
DOC_USP7_UBL2_3 68 72 PF12436 0.702
DOC_WW_Pin1_4 14 19 PF00397 0.615
DOC_WW_Pin1_4 44 49 PF00397 0.641
LIG_14-3-3_CanoR_1 22 28 PF00244 0.537
LIG_FHA_2 88 94 PF00498 0.581
LIG_LIR_Gen_1 98 108 PF02991 0.516
LIG_LIR_Nem_3 98 104 PF02991 0.521
LIG_SH2_CRK 101 105 PF00017 0.542
LIG_SH2_GRB2like 101 104 PF00017 0.541
LIG_SH2_SRC 101 104 PF00017 0.541
LIG_SH3_3 2 8 PF00018 0.592
LIG_SUMO_SIM_par_1 51 56 PF11976 0.647
MOD_CDK_SPK_2 46 51 PF00069 0.595
MOD_CDK_SPxxK_3 44 51 PF00069 0.597
MOD_CK1_1 82 88 PF00069 0.561
MOD_CK2_1 87 93 PF00069 0.551
MOD_GlcNHglycan 55 58 PF01048 0.604
MOD_GSK3_1 78 85 PF00069 0.509
MOD_NEK2_1 23 28 PF00069 0.642
MOD_NEK2_1 53 58 PF00069 0.509
MOD_OFUCOSY 79 86 PF10250 0.513
MOD_PKA_1 67 73 PF00069 0.695
MOD_Plk_1 70 76 PF00069 0.684
MOD_Plk_2-3 87 93 PF00069 0.583
MOD_Plk_4 55 61 PF00069 0.643
MOD_ProDKin_1 14 20 PF00069 0.614
MOD_ProDKin_1 44 50 PF00069 0.644
MOD_SUMO_rev_2 87 97 PF00179 0.575
TRG_DiLeu_BaLyEn_6 30 35 PF01217 0.613
TRG_DiLeu_BaLyEn_6 48 53 PF01217 0.591
TRG_ENDOCYTIC_2 101 104 PF00928 0.541
TRG_ER_diArg_1 99 101 PF00400 0.541

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7X794 Leishmania donovani 97% 98%
E9AEH5 Leishmania major 85% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS