PPM-type phosphatase domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I9D6_LEIIN

TriTrypDb:

LINF_330039200

Length:

657

Annotations

Annotations by Jardim et al.

Structural Proteins, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I9D6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9D6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	367	371	PF00656	0.505
CLV_NRD_NRD_1	262	264	PF00675	0.624
CLV_NRD_NRD_1	409	411	PF00675	0.447
CLV_NRD_NRD_1	579	581	PF00675	0.432
CLV_NRD_NRD_1	8	10	PF00675	0.529
CLV_PCSK_KEX2_1	192	194	PF00082	0.590
CLV_PCSK_KEX2_1	233	235	PF00082	0.656
CLV_PCSK_KEX2_1	262	264	PF00082	0.713
CLV_PCSK_KEX2_1	596	598	PF00082	0.485
CLV_PCSK_KEX2_1	8	10	PF00082	0.681
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.590
CLV_PCSK_PC1ET2_1	233	235	PF00082	0.653
CLV_PCSK_PC1ET2_1	596	598	PF00082	0.553
CLV_PCSK_SKI1_1	406	410	PF00082	0.382
CLV_PCSK_SKI1_1	490	494	PF00082	0.501
CLV_PCSK_SKI1_1	506	510	PF00082	0.260
CLV_PCSK_SKI1_1	583	587	PF00082	0.437
CLV_PCSK_SKI1_1	636	640	PF00082	0.616
CLV_Separin_Metazoa	605	609	PF03568	0.460
DOC_AGCK_PIF_1	598	603	PF00069	0.514
DOC_ANK_TNKS_1	549	556	PF00023	0.483
DOC_CDC14_PxL_1	1	9	PF14671	0.504
DOC_MAPK_gen_1	262	269	PF00069	0.625
DOC_MAPK_gen_1	415	425	PF00069	0.492
DOC_MAPK_gen_1	490	500	PF00069	0.520
DOC_MAPK_MEF2A_6	418	427	PF00069	0.484
DOC_MAPK_MEF2A_6	493	502	PF00069	0.389
DOC_USP7_MATH_1	147	151	PF00917	0.599
DOC_USP7_MATH_1	157	161	PF00917	0.579
DOC_USP7_MATH_1	180	184	PF00917	0.673
DOC_USP7_MATH_1	274	278	PF00917	0.695
DOC_USP7_MATH_1	295	299	PF00917	0.753
DOC_USP7_MATH_1	44	48	PF00917	0.528
DOC_USP7_MATH_1	448	452	PF00917	0.494
DOC_USP7_MATH_1	616	620	PF00917	0.489
DOC_USP7_MATH_1	78	82	PF00917	0.677
DOC_USP7_MATH_1	98	102	PF00917	0.659
DOC_USP7_UBL2_3	264	268	PF12436	0.678
DOC_USP7_UBL2_3	309	313	PF12436	0.589
DOC_USP7_UBL2_3	347	351	PF12436	0.561
DOC_USP7_UBL2_3	506	510	PF12436	0.375
DOC_WW_Pin1_4	18	23	PF00397	0.751
DOC_WW_Pin1_4	457	462	PF00397	0.418
DOC_WW_Pin1_4	541	546	PF00397	0.535
DOC_WW_Pin1_4	641	646	PF00397	0.484
LIG_14-3-3_CanoR_1	193	203	PF00244	0.646
LIG_14-3-3_CanoR_1	262	269	PF00244	0.620
LIG_14-3-3_CanoR_1	36	41	PF00244	0.641
LIG_Actin_WH2_2	422	439	PF00022	0.480
LIG_BIR_II_1	1	5	PF00653	0.536
LIG_CaM_IQ_9	398	413	PF13499	0.515
LIG_Clathr_ClatBox_1	323	327	PF01394	0.341
LIG_Clathr_ClatBox_1	467	471	PF01394	0.503
LIG_EH1_1	317	325	PF00400	0.376
LIG_eIF4E_1	318	324	PF01652	0.373
LIG_FHA_1	167	173	PF00498	0.626
LIG_FHA_1	210	216	PF00498	0.669
LIG_FHA_1	26	32	PF00498	0.517
LIG_FHA_1	351	357	PF00498	0.488
LIG_FHA_1	399	405	PF00498	0.479
LIG_FHA_2	206	212	PF00498	0.617
LIG_FHA_2	280	286	PF00498	0.734
LIG_FHA_2	328	334	PF00498	0.527
LIG_FHA_2	475	481	PF00498	0.465
LIG_FHA_2	509	515	PF00498	0.494
LIG_FHA_2	600	606	PF00498	0.459
LIG_FHA_2	615	621	PF00498	0.577
LIG_FHA_2	641	647	PF00498	0.445
LIG_LIR_Gen_1	451	457	PF02991	0.404
LIG_LIR_Nem_3	197	203	PF02991	0.716
LIG_LIR_Nem_3	600	606	PF02991	0.516
LIG_PCNA_yPIPBox_3	311	324	PF02747	0.421
LIG_REV1ctd_RIR_1	500	510	PF16727	0.355
LIG_SH2_STAP1	452	456	PF00017	0.438
LIG_SH2_STAT5	601	604	PF00017	0.585
LIG_SH3_3	334	340	PF00018	0.402
LIG_SH3_3	459	465	PF00018	0.382
LIG_SH3_3	7	13	PF00018	0.660
LIG_SUMO_SIM_anti_2	322	327	PF11976	0.383
LIG_SUMO_SIM_par_1	322	327	PF11976	0.339
LIG_SUMO_SIM_par_1	333	339	PF11976	0.380
LIG_TRAF2_1	513	516	PF00917	0.510
LIG_UBA3_1	467	473	PF00899	0.450
LIG_WRC_WIRS_1	219	224	PF05994	0.707
LIG_WRC_WIRS_1	482	487	PF05994	0.421
LIG_WW_3	588	592	PF00397	0.445
MOD_CDC14_SPxK_1	544	547	PF00782	0.508
MOD_CDK_SPxK_1	541	547	PF00069	0.528
MOD_CK1_1	194	200	PF00069	0.709
MOD_CK1_1	205	211	PF00069	0.723
MOD_CK1_1	254	260	PF00069	0.653
MOD_CK1_1	277	283	PF00069	0.680
MOD_CK1_1	361	367	PF00069	0.482
MOD_CK1_1	541	547	PF00069	0.428
MOD_CK2_1	279	285	PF00069	0.669
MOD_CK2_1	474	480	PF00069	0.389
MOD_CK2_1	508	514	PF00069	0.422
MOD_CK2_1	599	605	PF00069	0.456
MOD_CK2_1	614	620	PF00069	0.501
MOD_CK2_1	640	646	PF00069	0.521
MOD_Cter_Amidation	231	234	PF01082	0.673
MOD_Cter_Amidation	348	351	PF01082	0.576
MOD_GlcNHglycan	193	196	PF01048	0.773
MOD_GlcNHglycan	197	200	PF01048	0.600
MOD_GlcNHglycan	230	233	PF01048	0.629
MOD_GlcNHglycan	271	274	PF01048	0.610
MOD_GlcNHglycan	363	366	PF01048	0.551
MOD_GlcNHglycan	386	389	PF01048	0.387
MOD_GlcNHglycan	539	543	PF01048	0.423
MOD_GlcNHglycan	560	563	PF01048	0.389
MOD_GlcNHglycan	591	594	PF01048	0.455
MOD_GlcNHglycan	614	617	PF01048	0.522
MOD_GlcNHglycan	69	72	PF01048	0.577
MOD_GlcNHglycan	96	99	PF01048	0.694
MOD_GSK3_1	18	25	PF00069	0.725
MOD_GSK3_1	191	198	PF00069	0.689
MOD_GSK3_1	205	212	PF00069	0.629
MOD_GSK3_1	248	255	PF00069	0.712
MOD_GSK3_1	26	33	PF00069	0.505
MOD_GSK3_1	274	281	PF00069	0.701
MOD_GSK3_1	286	293	PF00069	0.593
MOD_GSK3_1	368	375	PF00069	0.400
MOD_GSK3_1	476	483	PF00069	0.460
MOD_GSK3_1	504	511	PF00069	0.476
MOD_GSK3_1	612	619	PF00069	0.506
MOD_GSK3_1	641	648	PF00069	0.547
MOD_GSK3_1	67	74	PF00069	0.641
MOD_GSK3_1	94	101	PF00069	0.623
MOD_N-GLC_1	180	185	PF02516	0.678
MOD_N-GLC_1	252	257	PF02516	0.713
MOD_N-GLC_1	277	282	PF02516	0.716
MOD_NEK2_1	109	114	PF00069	0.639
MOD_NEK2_1	140	145	PF00069	0.581
MOD_NEK2_1	269	274	PF00069	0.709
MOD_NEK2_1	360	365	PF00069	0.465
MOD_NEK2_1	427	432	PF00069	0.363
MOD_NEK2_1	67	72	PF00069	0.596
MOD_NEK2_2	147	152	PF00069	0.659
MOD_NEK2_2	157	162	PF00069	0.627
MOD_NEK2_2	51	56	PF00069	0.521
MOD_PIKK_1	186	192	PF00454	0.725
MOD_PIKK_1	26	32	PF00454	0.522
MOD_PIKK_1	398	404	PF00454	0.477
MOD_PK_1	36	42	PF00069	0.498
MOD_PKA_1	262	268	PF00069	0.659
MOD_PKA_1	350	356	PF00069	0.486
MOD_PKA_2	262	268	PF00069	0.668
MOD_Plk_1	180	186	PF00069	0.708
MOD_Plk_1	205	211	PF00069	0.751
MOD_Plk_1	252	258	PF00069	0.681
MOD_Plk_1	427	433	PF00069	0.355
MOD_Plk_1	599	605	PF00069	0.518
MOD_Plk_2-3	333	339	PF00069	0.399
MOD_Plk_4	118	124	PF00069	0.615
MOD_Plk_4	126	132	PF00069	0.636
MOD_Plk_4	135	141	PF00069	0.552
MOD_Plk_4	147	153	PF00069	0.645
MOD_Plk_4	157	163	PF00069	0.598
MOD_Plk_4	30	36	PF00069	0.542
MOD_Plk_4	319	325	PF00069	0.355
MOD_Plk_4	339	345	PF00069	0.512
MOD_Plk_4	368	374	PF00069	0.357
MOD_Plk_4	429	435	PF00069	0.445
MOD_ProDKin_1	18	24	PF00069	0.751
MOD_ProDKin_1	457	463	PF00069	0.416
MOD_ProDKin_1	541	547	PF00069	0.538
MOD_ProDKin_1	641	647	PF00069	0.491
MOD_SUMO_rev_2	265	269	PF00179	0.689
MOD_SUMO_rev_2	284	289	PF00179	0.721
MOD_SUMO_rev_2	574	582	PF00179	0.446
MOD_SUMO_rev_2	614	623	PF00179	0.531
MOD_SUMO_rev_2	632	641	PF00179	0.377
TRG_DiLeu_BaEn_4	514	520	PF01217	0.538
TRG_ENDOCYTIC_2	110	113	PF00928	0.525
TRG_ENDOCYTIC_2	200	203	PF00928	0.719
TRG_ENDOCYTIC_2	45	48	PF00928	0.631
TRG_ENDOCYTIC_2	452	455	PF00928	0.397
TRG_ENDOCYTIC_2	603	606	PF00928	0.513
TRG_ENDOCYTIC_2	72	75	PF00928	0.690
TRG_ENDOCYTIC_2	79	82	PF00928	0.610
TRG_ENDOCYTIC_2	86	89	PF00928	0.514
TRG_ENDOCYTIC_2	99	102	PF00928	0.702
TRG_ER_diArg_1	261	263	PF00400	0.699
TRG_ER_diArg_1	7	9	PF00400	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF45	Leptomonas seymouri	64%	76%
A0A1X0NRD1	Trypanosomatidae	42%	80%
A0A1X0NST4	Trypanosomatidae	30%	80%
A0A3Q8II25	Leishmania donovani	33%	99%
A0A3S7X791	Leishmania donovani	99%	100%
A4HM05	Leishmania braziliensis	78%	98%
A4I9D8	Leishmania infantum	32%	100%
C9ZJQ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	86%
E9B4D6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
E9B4D7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	98%
Q4Q3P1	Leishmania major	95%	100%
V5B7N5	Trypanosoma cruzi	26%	100%
V5D844	Trypanosoma cruzi	38%	100%