Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I9C9_LEIIN

TriTrypDb:

LINF_330038200

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I9C9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9C9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	274	278	PF00656	0.739
CLV_C14_Caspase3-7	401	405	PF00656	0.696
CLV_NRD_NRD_1	110	112	PF00675	0.715
CLV_NRD_NRD_1	136	138	PF00675	0.682
CLV_NRD_NRD_1	227	229	PF00675	0.654
CLV_NRD_NRD_1	25	27	PF00675	0.559
CLV_NRD_NRD_1	317	319	PF00675	0.738
CLV_NRD_NRD_1	383	385	PF00675	0.612
CLV_NRD_NRD_1	386	388	PF00675	0.654
CLV_NRD_NRD_1	389	391	PF00675	0.684
CLV_PCSK_FUR_1	384	388	PF00082	0.686
CLV_PCSK_KEX2_1	136	138	PF00082	0.644
CLV_PCSK_KEX2_1	187	189	PF00082	0.622
CLV_PCSK_KEX2_1	194	196	PF00082	0.649
CLV_PCSK_KEX2_1	229	231	PF00082	0.690
CLV_PCSK_KEX2_1	317	319	PF00082	0.722
CLV_PCSK_KEX2_1	334	336	PF00082	0.370
CLV_PCSK_KEX2_1	382	384	PF00082	0.602
CLV_PCSK_KEX2_1	386	388	PF00082	0.646
CLV_PCSK_KEX2_1	389	391	PF00082	0.675
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.667
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.646
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.672
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.567
CLV_PCSK_PC7_1	382	388	PF00082	0.630
CLV_PCSK_SKI1_1	261	265	PF00082	0.633
CLV_PCSK_SKI1_1	298	302	PF00082	0.460
CLV_Separin_Metazoa	179	183	PF03568	0.591
CLV_Separin_Metazoa	262	266	PF03568	0.646
DOC_ANK_TNKS_1	388	395	PF00023	0.654
DOC_PP1_RVXF_1	332	339	PF00149	0.553
DOC_PP4_FxxP_1	385	388	PF00568	0.696
DOC_USP7_MATH_1	120	124	PF00917	0.668
DOC_USP7_MATH_1	193	197	PF00917	0.694
DOC_USP7_MATH_1	2	6	PF00917	0.780
DOC_USP7_MATH_1	200	204	PF00917	0.656
DOC_USP7_MATH_1	220	224	PF00917	0.547
DOC_USP7_MATH_1	316	320	PF00917	0.711
DOC_USP7_MATH_1	355	359	PF00917	0.660
DOC_USP7_MATH_1	64	68	PF00917	0.697
DOC_USP7_MATH_1	9	13	PF00917	0.674
DOC_USP7_UBL2_3	186	190	PF12436	0.640
DOC_WW_Pin1_4	11	16	PF00397	0.780
DOC_WW_Pin1_4	122	127	PF00397	0.725
DOC_WW_Pin1_4	91	96	PF00397	0.760
LIG_14-3-3_CanoR_1	317	323	PF00244	0.681
LIG_BIR_II_1	1	5	PF00653	0.626
LIG_BIR_III_3	1	5	PF00653	0.782
LIG_BIR_III_4	146	150	PF00653	0.657
LIG_FHA_1	302	308	PF00498	0.668
LIG_FHA_1	79	85	PF00498	0.738
LIG_FHA_1	86	92	PF00498	0.602
LIG_FHA_2	242	248	PF00498	0.651
LIG_FHA_2	255	261	PF00498	0.617
LIG_LIR_Gen_1	67	77	PF02991	0.640
LIG_LIR_Nem_3	158	164	PF02991	0.572
LIG_LIR_Nem_3	57	62	PF02991	0.580
LIG_LIR_Nem_3	67	72	PF02991	0.573
LIG_LIR_Nem_3	94	99	PF02991	0.681
LIG_LYPXL_yS_3	59	62	PF13949	0.637
LIG_PCNA_PIPBox_1	326	335	PF02747	0.571
LIG_PCNA_yPIPBox_3	167	181	PF02747	0.598
LIG_PCNA_yPIPBox_3	326	337	PF02747	0.583
LIG_RPA_C_Fungi	132	144	PF08784	0.666
LIG_SH2_CRK	69	73	PF00017	0.602
LIG_SH2_NCK_1	104	108	PF00017	0.706
LIG_SH2_NCK_1	253	257	PF00017	0.663
LIG_SH2_NCK_1	37	41	PF00017	0.681
LIG_SH2_SRC	104	107	PF00017	0.706
LIG_SH2_STAT5	243	246	PF00017	0.652
LIG_SH2_STAT5	332	335	PF00017	0.506
LIG_SH3_3	112	118	PF00018	0.712
LIG_SH3_3	153	159	PF00018	0.580
LIG_SH3_3	39	45	PF00018	0.593
LIG_Sin3_3	140	147	PF02671	0.668
LIG_SUMO_SIM_par_1	297	306	PF11976	0.599
LIG_TRAF2_1	256	259	PF00917	0.613
LIG_TRAF2_1	290	293	PF00917	0.764
LIG_TRAF2_1	319	322	PF00917	0.708
LIG_ULM_U2AF65_1	334	339	PF00076	0.556
LIG_WW_3	14	18	PF00397	0.770
MOD_CDC14_SPxK_1	14	17	PF00782	0.773
MOD_CDK_SPxK_1	11	17	PF00069	0.777
MOD_CK1_1	11	17	PF00069	0.719
MOD_CK1_1	125	131	PF00069	0.718
MOD_CK1_1	254	260	PF00069	0.622
MOD_CK1_1	272	278	PF00069	0.738
MOD_CK1_1	291	297	PF00069	0.601
MOD_CK1_1	358	364	PF00069	0.566
MOD_CK2_1	241	247	PF00069	0.648
MOD_CK2_1	254	260	PF00069	0.568
MOD_CK2_1	316	322	PF00069	0.735
MOD_Cter_Amidation	226	229	PF01082	0.507
MOD_GlcNHglycan	11	14	PF01048	0.643
MOD_GlcNHglycan	122	125	PF01048	0.701
MOD_GlcNHglycan	2	5	PF01048	0.770
MOD_GlcNHglycan	247	250	PF01048	0.630
MOD_GlcNHglycan	253	256	PF01048	0.643
MOD_GlcNHglycan	273	277	PF01048	0.482
MOD_GlcNHglycan	312	315	PF01048	0.700
MOD_GlcNHglycan	357	360	PF01048	0.728
MOD_GSK3_1	125	132	PF00069	0.733
MOD_GSK3_1	241	248	PF00069	0.649
MOD_GSK3_1	338	345	PF00069	0.541
MOD_GSK3_1	44	51	PF00069	0.694
MOD_GSK3_1	7	14	PF00069	0.771
MOD_GSK3_1	80	87	PF00069	0.667
MOD_N-GLC_1	211	216	PF02516	0.758
MOD_NEK2_1	251	256	PF00069	0.636
MOD_NEK2_1	264	269	PF00069	0.660
MOD_NEK2_1	301	306	PF00069	0.521
MOD_NEK2_1	84	89	PF00069	0.758
MOD_NEK2_2	64	69	PF00069	0.699
MOD_PIKK_1	254	260	PF00454	0.616
MOD_PIKK_1	288	294	PF00454	0.766
MOD_PIKK_1	338	344	PF00454	0.557
MOD_PKA_1	194	200	PF00069	0.676
MOD_PKA_2	194	200	PF00069	0.723
MOD_PKA_2	264	270	PF00069	0.643
MOD_PKA_2	316	322	PF00069	0.735
MOD_Plk_1	220	226	PF00069	0.655
MOD_ProDKin_1	11	17	PF00069	0.777
MOD_ProDKin_1	122	128	PF00069	0.720
MOD_ProDKin_1	91	97	PF00069	0.760
MOD_SUMO_for_1	371	374	PF00179	0.597
MOD_SUMO_rev_2	254	263	PF00179	0.623
TRG_DiLeu_BaEn_4	259	265	PF01217	0.577
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.590
TRG_ENDOCYTIC_2	104	107	PF00928	0.706
TRG_ENDOCYTIC_2	243	246	PF00928	0.652
TRG_ENDOCYTIC_2	37	40	PF00928	0.673
TRG_ENDOCYTIC_2	59	62	PF00928	0.583
TRG_ENDOCYTIC_2	69	72	PF00928	0.582
TRG_ER_diArg_1	228	231	PF00400	0.681
TRG_ER_diArg_1	335	338	PF00400	0.494
TRG_ER_diArg_1	382	384	PF00400	0.609
TRG_ER_diArg_1	385	387	PF00400	0.651
TRG_ER_diArg_1	388	390	PF00400	0.682
TRG_NLS_Bipartite_1	317	338	PF00514	0.666
TRG_NLS_MonoExtC_3	185	190	PF00514	0.454
TRG_NLS_MonoExtC_3	227	233	PF00514	0.639

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2L6	Leptomonas seymouri	57%	100%
A0A3S7X784	Leishmania donovani	100%	100%
A4HLZ9	Leishmania braziliensis	79%	100%
E9B4C9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q3P7	Leishmania major	89%	100%
V5BJN0	Trypanosoma cruzi	27%	100%