LeishMANIAdb
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D-alanyl-glycyl endopeptidase-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
D-alanyl-glycyl endopeptidase-like protein
Gene product:
cysteine peptidase - Clan CA - family C51 - putative
Species:
Leishmania infantum
UniProt:
A4I9C4_LEIIN
TriTrypDb:
LINF_330037600 *
Length:
369

Annotations

Annotations by Jardim et al.

Proteases, D-alanyl-glycyl endopeptidase-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 22
NetGPI no yes: 0, no: 22
Cellular components
Term Name Level Count
GO:0016020 membrane 2 19
GO:0110165 cellular anatomical entity 1 19
GO:0005737 cytoplasm 2 1

Expansion

Sequence features

A4I9C4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9C4

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0016874 ligase activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 228 230 PF00675 0.439
CLV_NRD_NRD_1 340 342 PF00675 0.495
CLV_PCSK_KEX2_1 228 230 PF00082 0.439
CLV_PCSK_KEX2_1 340 342 PF00082 0.560
DEG_SCF_FBW7_1 161 168 PF00400 0.339
DEG_SCF_TRCP1_1 91 96 PF00400 0.545
DOC_PP1_RVXF_1 359 366 PF00149 0.191
DOC_PP1_SILK_1 112 117 PF00149 0.155
DOC_PP2B_LxvP_1 282 285 PF13499 0.322
DOC_PP4_FxxP_1 38 41 PF00568 0.564
DOC_USP7_MATH_1 12 16 PF00917 0.697
DOC_USP7_MATH_1 277 281 PF00917 0.281
DOC_USP7_MATH_1 42 46 PF00917 0.673
DOC_USP7_MATH_1 69 73 PF00917 0.753
DOC_USP7_MATH_2 42 48 PF00917 0.570
DOC_WW_Pin1_4 161 166 PF00397 0.345
DOC_WW_Pin1_4 233 238 PF00397 0.238
DOC_WW_Pin1_4 8 13 PF00397 0.720
LIG_APCC_ABBA_1 342 347 PF00400 0.187
LIG_APCC_ABBAyCdc20_2 341 347 PF00400 0.190
LIG_BIR_II_1 1 5 PF00653 0.564
LIG_BIR_III_3 1 5 PF00653 0.564
LIG_BRCT_BRCA1_1 211 215 PF00533 0.422
LIG_BRCT_BRCA1_1 6 10 PF00533 0.577
LIG_deltaCOP1_diTrp_1 250 256 PF00928 0.241
LIG_deltaCOP1_diTrp_1 323 331 PF00928 0.306
LIG_FHA_1 119 125 PF00498 0.377
LIG_FHA_1 203 209 PF00498 0.381
LIG_FHA_1 277 283 PF00498 0.307
LIG_FHA_1 348 354 PF00498 0.298
LIG_FHA_2 195 201 PF00498 0.394
LIG_FHA_2 352 358 PF00498 0.313
LIG_GBD_Chelix_1 119 127 PF00786 0.215
LIG_LIR_Gen_1 164 173 PF02991 0.191
LIG_LIR_Gen_1 190 201 PF02991 0.236
LIG_LIR_Gen_1 255 260 PF02991 0.322
LIG_LIR_Nem_3 164 169 PF02991 0.307
LIG_LIR_Nem_3 190 196 PF02991 0.316
LIG_LIR_Nem_3 255 259 PF02991 0.317
LIG_LIR_Nem_3 333 338 PF02991 0.356
LIG_NRBOX 118 124 PF00104 0.305
LIG_Pex14_1 252 256 PF04695 0.259
LIG_Pex14_1 331 335 PF04695 0.309
LIG_Pex14_2 173 177 PF04695 0.309
LIG_PTB_Apo_2 171 178 PF02174 0.237
LIG_PTB_Apo_2 250 257 PF02174 0.184
LIG_SH2_CRK 112 116 PF00017 0.396
LIG_SH2_CRK 136 140 PF00017 0.267
LIG_SH2_CRK 216 220 PF00017 0.251
LIG_SH2_GRB2like 179 182 PF00017 0.309
LIG_SH2_GRB2like 193 196 PF00017 0.295
LIG_SH2_GRB2like 335 338 PF00017 0.310
LIG_SH2_PTP2 193 196 PF00017 0.388
LIG_SH2_STAP1 226 230 PF00017 0.223
LIG_SH2_STAP1 338 342 PF00017 0.292
LIG_SH2_STAT3 230 233 PF00017 0.331
LIG_SH2_STAT3 293 296 PF00017 0.203
LIG_SH2_STAT5 186 189 PF00017 0.371
LIG_SH2_STAT5 193 196 PF00017 0.375
LIG_SH2_STAT5 210 213 PF00017 0.368
LIG_SH2_STAT5 216 219 PF00017 0.296
LIG_SH2_STAT5 241 244 PF00017 0.322
LIG_SH2_STAT5 320 323 PF00017 0.303
LIG_SH3_3 155 161 PF00018 0.453
LIG_SUMO_SIM_anti_2 121 126 PF11976 0.303
LIG_SUMO_SIM_par_1 350 357 PF11976 0.231
LIG_TYR_ITIM 110 115 PF00017 0.412
LIG_TYR_ITIM 191 196 PF00017 0.402
LIG_TYR_ITIM 344 349 PF00017 0.326
LIG_UBA3_1 110 116 PF00899 0.432
MOD_CDK_SPK_2 8 13 PF00069 0.577
MOD_CK1_1 11 17 PF00069 0.680
MOD_CK1_1 152 158 PF00069 0.448
MOD_CK1_1 18 24 PF00069 0.733
MOD_CK1_1 185 191 PF00069 0.282
MOD_CK1_1 261 267 PF00069 0.305
MOD_CK1_1 351 357 PF00069 0.216
MOD_CK1_1 89 95 PF00069 0.600
MOD_CK2_1 194 200 PF00069 0.320
MOD_CK2_1 58 64 PF00069 0.695
MOD_GlcNHglycan 151 154 PF01048 0.649
MOD_GlcNHglycan 233 236 PF01048 0.510
MOD_GlcNHglycan 33 36 PF01048 0.522
MOD_GlcNHglycan 332 335 PF01048 0.469
MOD_GlcNHglycan 44 47 PF01048 0.548
MOD_GlcNHglycan 71 74 PF01048 0.505
MOD_GlcNHglycan 88 91 PF01048 0.533
MOD_GlcNHglycan 95 98 PF01048 0.519
MOD_GSK3_1 14 21 PF00069 0.758
MOD_GSK3_1 145 152 PF00069 0.475
MOD_GSK3_1 161 168 PF00069 0.312
MOD_GSK3_1 182 189 PF00069 0.329
MOD_GSK3_1 202 209 PF00069 0.323
MOD_GSK3_1 307 314 PF00069 0.337
MOD_GSK3_1 347 354 PF00069 0.345
MOD_GSK3_1 4 11 PF00069 0.712
MOD_GSK3_1 58 65 PF00069 0.673
MOD_GSK3_1 89 96 PF00069 0.635
MOD_N-GLC_1 143 148 PF02516 0.618
MOD_N-GLC_1 182 187 PF02516 0.487
MOD_N-GLC_1 194 199 PF02516 0.545
MOD_N-GLC_1 202 207 PF02516 0.581
MOD_N-GLC_1 252 257 PF02516 0.512
MOD_N-GLC_1 261 266 PF02516 0.477
MOD_N-GLC_1 336 341 PF02516 0.505
MOD_N-GLC_1 69 74 PF02516 0.569
MOD_N-GLC_1 86 91 PF02516 0.424
MOD_NEK2_1 134 139 PF00069 0.463
MOD_NEK2_1 177 182 PF00069 0.304
MOD_NEK2_1 260 265 PF00069 0.183
MOD_NEK2_1 348 353 PF00069 0.304
MOD_NEK2_1 6 11 PF00069 0.576
MOD_PIKK_1 20 26 PF00454 0.632
MOD_PKA_2 31 37 PF00069 0.701
MOD_PKA_2 62 68 PF00069 0.718
MOD_Plk_1 15 21 PF00069 0.674
MOD_Plk_1 182 188 PF00069 0.300
MOD_Plk_1 194 200 PF00069 0.237
MOD_Plk_1 252 258 PF00069 0.325
MOD_Plk_1 261 267 PF00069 0.330
MOD_Plk_1 77 83 PF00069 0.709
MOD_Plk_4 118 124 PF00069 0.394
MOD_Plk_4 165 171 PF00069 0.233
MOD_Plk_4 182 188 PF00069 0.402
MOD_Plk_4 194 200 PF00069 0.341
MOD_Plk_4 206 212 PF00069 0.302
MOD_Plk_4 252 258 PF00069 0.331
MOD_ProDKin_1 161 167 PF00069 0.344
MOD_ProDKin_1 233 239 PF00069 0.238
MOD_ProDKin_1 8 14 PF00069 0.720
TRG_DiLeu_BaLyEn_6 106 111 PF01217 0.605
TRG_DiLeu_BaLyEn_6 255 260 PF01217 0.253
TRG_ENDOCYTIC_2 112 115 PF00928 0.341
TRG_ENDOCYTIC_2 136 139 PF00928 0.316
TRG_ENDOCYTIC_2 193 196 PF00928 0.357
TRG_ENDOCYTIC_2 216 219 PF00928 0.285
TRG_ENDOCYTIC_2 302 305 PF00928 0.308
TRG_ENDOCYTIC_2 345 348 PF00928 0.305
TRG_ER_diArg_1 228 230 PF00400 0.239
TRG_ER_diArg_1 340 342 PF00400 0.349

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I309 Leptomonas seymouri 29% 100%
A0A0N1I7J8 Leptomonas seymouri 59% 93%
A0A0N1PB04 Leptomonas seymouri 36% 100%
A0A1X0NR98 Trypanosomatidae 47% 100%
A0A1X0NY88 Trypanosomatidae 23% 100%
A0A1X0NYK9 Trypanosomatidae 24% 100%
A0A3R7LYQ4 Trypanosoma rangeli 41% 100%
A0A3S5IRC8 Trypanosoma rangeli 40% 100%
A0A3S7WZA9 Leishmania donovani 26% 100%
A0A422NKH5 Trypanosoma rangeli 31% 100%
A4HEJ1 Leishmania braziliensis 27% 100%
A4HLZ4 Leishmania braziliensis 60% 100%
A4I1M7 Leishmania infantum 26% 100%
C9ZJ94 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
C9ZJ95 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
E9AXR1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9B4C6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 96%
Q4Q9R0 Leishmania major 26% 100%
V5BF57 Trypanosoma cruzi 29% 100%
V5DB66 Trypanosoma cruzi 42% 100%
V5DIU8 Trypanosoma cruzi 27% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS