PWWP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PWWP domain/TFIIS helical bundle-like domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I9C3_LEIIN

TriTrypDb:

LINF_330037500

Length:

593

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4I9C3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9C3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006351	DNA-templated transcription	7	3
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0009058	biosynthetic process	2	3
GO:0009059	macromolecule biosynthetic process	4	3
GO:0009987	cellular process	1	3
GO:0016070	RNA metabolic process	5	3
GO:0018130	heterocycle biosynthetic process	4	3
GO:0019438	aromatic compound biosynthetic process	4	3
GO:0032774	RNA biosynthetic process	5	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0034654	nucleobase-containing compound biosynthetic process	4	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044249	cellular biosynthetic process	3	3
GO:0044271	cellular nitrogen compound biosynthetic process	4	3
GO:0046483	heterocycle metabolic process	3	3
GO:0071704	organic substance metabolic process	2	3
GO:0090304	nucleic acid metabolic process	4	3
GO:0097659	nucleic acid-templated transcription	6	3
GO:1901360	organic cyclic compound metabolic process	3	3
GO:1901362	organic cyclic compound biosynthetic process	4	3
GO:1901576	organic substance biosynthetic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0005488	binding	1	2
GO:0008270	zinc ion binding	6	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0046914	transition metal ion binding	5	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	394	398	PF00656	0.597
CLV_C14_Caspase3-7	515	519	PF00656	0.615
CLV_C14_Caspase3-7	61	65	PF00656	0.544
CLV_NRD_NRD_1	158	160	PF00675	0.534
CLV_NRD_NRD_1	161	163	PF00675	0.538
CLV_NRD_NRD_1	167	169	PF00675	0.592
CLV_NRD_NRD_1	170	172	PF00675	0.636
CLV_NRD_NRD_1	188	190	PF00675	0.642
CLV_NRD_NRD_1	191	193	PF00675	0.650
CLV_NRD_NRD_1	201	203	PF00675	0.590
CLV_NRD_NRD_1	234	236	PF00675	0.586
CLV_NRD_NRD_1	278	280	PF00675	0.507
CLV_NRD_NRD_1	285	287	PF00675	0.463
CLV_NRD_NRD_1	443	445	PF00675	0.498
CLV_NRD_NRD_1	468	470	PF00675	0.373
CLV_NRD_NRD_1	497	499	PF00675	0.588
CLV_PCSK_FUR_1	159	163	PF00082	0.586
CLV_PCSK_FUR_1	168	172	PF00082	0.496
CLV_PCSK_FUR_1	495	499	PF00082	0.524
CLV_PCSK_KEX2_1	161	163	PF00082	0.526
CLV_PCSK_KEX2_1	167	169	PF00082	0.509
CLV_PCSK_KEX2_1	170	172	PF00082	0.543
CLV_PCSK_KEX2_1	201	203	PF00082	0.647
CLV_PCSK_KEX2_1	234	236	PF00082	0.665
CLV_PCSK_KEX2_1	285	287	PF00082	0.474
CLV_PCSK_KEX2_1	443	445	PF00082	0.444
CLV_PCSK_KEX2_1	468	470	PF00082	0.373
CLV_PCSK_KEX2_1	497	499	PF00082	0.587
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.533
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.498
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.530
CLV_PCSK_PC7_1	168	174	PF00082	0.487
CLV_PCSK_PC7_1	493	499	PF00082	0.562
CLV_PCSK_SKI1_1	242	246	PF00082	0.565
CLV_PCSK_SKI1_1	326	330	PF00082	0.364
CLV_PCSK_SKI1_1	352	356	PF00082	0.315
CLV_PCSK_SKI1_1	468	472	PF00082	0.440
DEG_SCF_FBW7_1	113	120	PF00400	0.675
DOC_CKS1_1	114	119	PF01111	0.602
DOC_CKS1_1	353	358	PF01111	0.502
DOC_CYCLIN_RxL_1	465	473	PF00134	0.413
DOC_MAPK_DCC_7	352	361	PF00069	0.463
DOC_MAPK_gen_1	326	335	PF00069	0.540
DOC_MAPK_gen_1	495	504	PF00069	0.640
DOC_MAPK_MEF2A_6	326	335	PF00069	0.547
DOC_MAPK_MEF2A_6	352	361	PF00069	0.540
DOC_PP4_FxxP_1	353	356	PF00568	0.518
DOC_PP4_FxxP_1	506	509	PF00568	0.582
DOC_PP4_FxxP_1	540	543	PF00568	0.686
DOC_USP7_MATH_1	10	14	PF00917	0.465
DOC_USP7_MATH_1	100	104	PF00917	0.630
DOC_USP7_MATH_1	117	121	PF00917	0.715
DOC_USP7_MATH_1	214	218	PF00917	0.668
DOC_USP7_MATH_1	238	242	PF00917	0.618
DOC_USP7_MATH_1	346	350	PF00917	0.565
DOC_USP7_MATH_1	40	44	PF00917	0.506
DOC_USP7_MATH_1	51	55	PF00917	0.451
DOC_USP7_MATH_1	83	87	PF00917	0.495
DOC_USP7_UBL2_3	163	167	PF12436	0.515
DOC_WW_Pin1_4	113	118	PF00397	0.711
DOC_WW_Pin1_4	266	271	PF00397	0.624
DOC_WW_Pin1_4	352	357	PF00397	0.502
DOC_WW_Pin1_4	516	521	PF00397	0.599
DOC_WW_Pin1_4	525	530	PF00397	0.498
DOC_WW_Pin1_4	534	539	PF00397	0.533
LIG_14-3-3_CanoR_1	285	293	PF00244	0.416
LIG_14-3-3_CanoR_1	326	332	PF00244	0.409
LIG_14-3-3_CanoR_1	546	555	PF00244	0.546
LIG_14-3-3_CanoR_1	565	570	PF00244	0.526
LIG_Actin_WH2_2	314	331	PF00022	0.491
LIG_BIR_II_1	1	5	PF00653	0.674
LIG_BIR_III_2	105	109	PF00653	0.652
LIG_BRCT_BRCA1_1	536	540	PF00533	0.702
LIG_CSL_BTD_1	23	26	PF09270	0.448
LIG_FHA_1	295	301	PF00498	0.447
LIG_FHA_1	353	359	PF00498	0.516
LIG_FHA_1	483	489	PF00498	0.425
LIG_FHA_1	546	552	PF00498	0.555
LIG_FHA_1	585	591	PF00498	0.426
LIG_FHA_2	147	153	PF00498	0.487
LIG_FHA_2	189	195	PF00498	0.629
LIG_FHA_2	262	268	PF00498	0.662
LIG_FHA_2	3	9	PF00498	0.530
LIG_FHA_2	311	317	PF00498	0.432
LIG_FHA_2	392	398	PF00498	0.593
LIG_FHA_2	415	421	PF00498	0.435
LIG_LIR_Apic_2	505	509	PF02991	0.583
LIG_LIR_Apic_2	537	543	PF02991	0.642
LIG_LIR_Apic_2	549	555	PF02991	0.373
LIG_LIR_Gen_1	13	22	PF02991	0.545
LIG_LIR_Gen_1	136	146	PF02991	0.607
LIG_LIR_Nem_3	13	17	PF02991	0.545
LIG_LIR_Nem_3	136	142	PF02991	0.608
LIG_LIR_Nem_3	521	527	PF02991	0.756
LIG_NRBOX	466	472	PF00104	0.423
LIG_PALB2_WD40_1	365	373	PF16756	0.448
LIG_PTB_Apo_2	364	371	PF02174	0.516
LIG_SH2_CRK	278	282	PF00017	0.553
LIG_SH2_CRK	552	556	PF00017	0.446
LIG_SH2_STAP1	567	571	PF00017	0.545
LIG_SH2_STAT3	249	252	PF00017	0.582
LIG_SH2_STAT3	567	570	PF00017	0.592
LIG_SH2_STAT5	477	480	PF00017	0.557
LIG_SH3_3	20	26	PF00018	0.462
LIG_SH3_3	517	523	PF00018	0.595
LIG_SUMO_SIM_anti_2	43	49	PF11976	0.517
LIG_SUMO_SIM_par_1	450	455	PF11976	0.405
LIG_SUMO_SIM_par_1	488	494	PF11976	0.440
LIG_TRAF2_1	107	110	PF00917	0.637
LIG_TRAF2_1	417	420	PF00917	0.408
LIG_TRAF2_1	93	96	PF00917	0.473
LIG_TRFH_1	258	262	PF08558	0.593
LIG_UBA3_1	321	329	PF00899	0.348
MOD_CDK_SPK_2	266	271	PF00069	0.601
MOD_CDK_SPxxK_3	539	546	PF00069	0.640
MOD_CK1_1	2	8	PF00069	0.559
MOD_CK1_1	240	246	PF00069	0.574
MOD_CK1_1	266	272	PF00069	0.618
MOD_CK1_1	391	397	PF00069	0.559
MOD_CK1_1	414	420	PF00069	0.487
MOD_CK1_1	519	525	PF00069	0.637
MOD_CK1_1	534	540	PF00069	0.699
MOD_CK1_1	86	92	PF00069	0.495
MOD_CK2_1	146	152	PF00069	0.481
MOD_CK2_1	207	213	PF00069	0.697
MOD_CK2_1	250	256	PF00069	0.551
MOD_CK2_1	286	292	PF00069	0.490
MOD_CK2_1	414	420	PF00069	0.427
MOD_GlcNHglycan	117	120	PF01048	0.742
MOD_GlcNHglycan	131	134	PF01048	0.796
MOD_GlcNHglycan	176	179	PF01048	0.728
MOD_GlcNHglycan	19	22	PF01048	0.236
MOD_GlcNHglycan	204	207	PF01048	0.604
MOD_GlcNHglycan	209	212	PF01048	0.607
MOD_GlcNHglycan	217	220	PF01048	0.584
MOD_GlcNHglycan	242	245	PF01048	0.567
MOD_GlcNHglycan	282	285	PF01048	0.581
MOD_GlcNHglycan	308	311	PF01048	0.555
MOD_GlcNHglycan	381	384	PF01048	0.567
MOD_GlcNHglycan	454	457	PF01048	0.409
MOD_GlcNHglycan	5	8	PF01048	0.550
MOD_GlcNHglycan	51	54	PF01048	0.311
MOD_GlcNHglycan	61	64	PF01048	0.318
MOD_GSK3_1	113	120	PF00069	0.659
MOD_GSK3_1	236	243	PF00069	0.628
MOD_GSK3_1	280	287	PF00069	0.507
MOD_GSK3_1	288	295	PF00069	0.620
MOD_GSK3_1	302	309	PF00069	0.434
MOD_GSK3_1	327	334	PF00069	0.577
MOD_GSK3_1	49	56	PF00069	0.448
MOD_GSK3_1	508	515	PF00069	0.687
MOD_GSK3_1	532	539	PF00069	0.600
MOD_GSK3_1	546	553	PF00069	0.464
MOD_LATS_1	200	206	PF00433	0.550
MOD_N-GLC_1	173	178	PF02516	0.649
MOD_N-GLC_1	482	487	PF02516	0.398
MOD_NEK2_1	1	6	PF00069	0.581
MOD_NEK2_1	338	343	PF00069	0.508
MOD_NEK2_1	452	457	PF00069	0.474
MOD_NEK2_1	491	496	PF00069	0.495
MOD_NEK2_1	502	507	PF00069	0.658
MOD_OFUCOSY	390	395	PF10250	0.578
MOD_PIKK_1	294	300	PF00454	0.448
MOD_PIKK_1	374	380	PF00454	0.423
MOD_PIKK_1	508	514	PF00454	0.595
MOD_PK_1	565	571	PF00069	0.476
MOD_PKA_2	188	194	PF00069	0.722
MOD_PKA_2	250	256	PF00069	0.568
MOD_PKA_2	284	290	PF00069	0.435
MOD_PKA_2	388	394	PF00069	0.574
MOD_PKA_2	545	551	PF00069	0.542
MOD_PKB_1	171	179	PF00069	0.518
MOD_Plk_1	146	152	PF00069	0.501
MOD_Plk_1	331	337	PF00069	0.481
MOD_Plk_2-3	222	228	PF00069	0.603
MOD_Plk_2-3	388	394	PF00069	0.605
MOD_Plk_4	10	16	PF00069	0.292
MOD_Plk_4	346	352	PF00069	0.607
MOD_Plk_4	53	59	PF00069	0.596
MOD_ProDKin_1	113	119	PF00069	0.713
MOD_ProDKin_1	266	272	PF00069	0.622
MOD_ProDKin_1	352	358	PF00069	0.502
MOD_ProDKin_1	516	522	PF00069	0.598
MOD_ProDKin_1	525	531	PF00069	0.525
MOD_ProDKin_1	534	540	PF00069	0.583
MOD_SUMO_for_1	247	250	PF00179	0.587
TRG_DiLeu_BaEn_2	298	304	PF01217	0.443
TRG_DiLeu_BaLyEn_6	466	471	PF01217	0.427
TRG_DiLeu_BaLyEn_6	486	491	PF01217	0.294
TRG_ENDOCYTIC_2	278	281	PF00928	0.595
TRG_ENDOCYTIC_2	524	527	PF00928	0.609
TRG_ER_diArg_1	201	204	PF00400	0.652
TRG_ER_diArg_1	467	469	PF00400	0.394
TRG_ER_diArg_1	492	495	PF00400	0.492
TRG_ER_diArg_1	497	499	PF00400	0.569
TRG_NLS_Bipartite_1	159	175	PF00514	0.557
TRG_NLS_Bipartite_1	234	249	PF00514	0.564
TRG_NLS_MonoCore_2	158	163	PF00514	0.506
TRG_NLS_MonoCore_2	166	171	PF00514	0.503
TRG_NLS_MonoExtC_3	158	163	PF00514	0.559
TRG_NLS_MonoExtC_3	166	171	PF00514	0.503
TRG_NLS_MonoExtC_3	188	193	PF00514	0.651
TRG_NLS_MonoExtC_3	244	250	PF00514	0.611
TRG_NLS_MonoExtN_4	166	173	PF00514	0.622
TRG_NLS_MonoExtN_4	188	193	PF00514	0.669
TRG_NLS_MonoExtN_4	242	249	PF00514	0.536
TRG_Pf-PMV_PEXEL_1	468	473	PF00026	0.366

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5Y6	Leptomonas seymouri	53%	100%
A0A1X0NRB1	Trypanosomatidae	31%	100%
A0A3Q8IKG6	Leishmania donovani	100%	100%
A0A422NKE1	Trypanosoma rangeli	33%	100%
A4HLZ3	Leishmania braziliensis	78%	99%
E9B4C2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q3Q3	Leishmania major	91%	100%