LeishMANIAdb
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Transcription elongation factor-like protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Transcription elongation factor-like protein
Gene product:
transcription elongation factor-like protein
Species:
Leishmania infantum
UniProt:
A4I9C2_LEIIN
TriTrypDb:
LINF_330037400
Length:
473

Annotations

Annotations by Jardim et al.

Transcription, Transcription elongation factor-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 12
GO:0043226 organelle 2 12
GO:0043227 membrane-bounded organelle 3 12
GO:0043229 intracellular organelle 3 12
GO:0043231 intracellular membrane-bounded organelle 4 12
GO:0110165 cellular anatomical entity 1 12
GO:0005654 nucleoplasm 2 1

Phosphorylation

Amastigote: 260, 268
Promastigote/Amastigote: 269

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I9C2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9C2

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006351 DNA-templated transcription 7 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009058 biosynthetic process 2 12
GO:0009059 macromolecule biosynthetic process 4 12
GO:0009987 cellular process 1 12
GO:0016070 RNA metabolic process 5 12
GO:0018130 heterocycle biosynthetic process 4 12
GO:0019438 aromatic compound biosynthetic process 4 12
GO:0032774 RNA biosynthetic process 5 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0034654 nucleobase-containing compound biosynthetic process 4 12
GO:0043170 macromolecule metabolic process 3 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044249 cellular biosynthetic process 3 12
GO:0044271 cellular nitrogen compound biosynthetic process 4 12
GO:0046483 heterocycle metabolic process 3 12
GO:0071704 organic substance metabolic process 2 12
GO:0090304 nucleic acid metabolic process 4 12
GO:0097659 nucleic acid-templated transcription 6 12
GO:1901360 organic cyclic compound metabolic process 3 12
GO:1901362 organic cyclic compound biosynthetic process 4 12
GO:1901576 organic substance biosynthetic process 3 12
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 12
GO:0003746 translation elongation factor activity 4 12
GO:0005488 binding 1 12
GO:0008135 translation factor activity, RNA binding 3 12
GO:0008270 zinc ion binding 6 12
GO:0043167 ion binding 2 12
GO:0043169 cation binding 3 12
GO:0045182 translation regulator activity 1 12
GO:0046872 metal ion binding 4 12
GO:0046914 transition metal ion binding 5 12
GO:0090079 translation regulator activity, nucleic acid binding 2 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 420 424 PF00656 0.395
CLV_C14_Caspase3-7 58 62 PF00656 0.403
CLV_NRD_NRD_1 319 321 PF00675 0.502
CLV_NRD_NRD_1 349 351 PF00675 0.415
CLV_PCSK_KEX2_1 132 134 PF00082 0.500
CLV_PCSK_KEX2_1 273 275 PF00082 0.595
CLV_PCSK_KEX2_1 440 442 PF00082 0.303
CLV_PCSK_PC1ET2_1 132 134 PF00082 0.471
CLV_PCSK_PC1ET2_1 273 275 PF00082 0.595
CLV_PCSK_PC1ET2_1 440 442 PF00082 0.303
CLV_PCSK_PC7_1 128 134 PF00082 0.511
CLV_PCSK_SKI1_1 186 190 PF00082 0.372
CLV_PCSK_SKI1_1 351 355 PF00082 0.438
CLV_PCSK_SKI1_1 362 366 PF00082 0.340
CLV_PCSK_SKI1_1 459 463 PF00082 0.225
CLV_PCSK_SKI1_1 74 78 PF00082 0.372
DEG_APCC_DBOX_1 185 193 PF00400 0.288
DEG_SCF_SKP2-CKS1_1 383 390 PF00560 0.468
DEG_SPOP_SBC_1 334 338 PF00917 0.394
DOC_MAPK_gen_1 359 369 PF00069 0.430
DOC_MAPK_MEF2A_6 362 369 PF00069 0.456
DOC_MAPK_NFAT4_5 362 370 PF00069 0.371
DOC_PP2B_LxvP_1 254 257 PF13499 0.658
DOC_USP7_MATH_1 112 116 PF00917 0.424
DOC_USP7_MATH_1 117 121 PF00917 0.623
DOC_USP7_MATH_1 149 153 PF00917 0.600
DOC_USP7_MATH_1 210 214 PF00917 0.319
DOC_USP7_MATH_1 245 249 PF00917 0.541
DOC_USP7_MATH_1 265 269 PF00917 0.582
DOC_USP7_MATH_1 280 284 PF00917 0.575
DOC_USP7_MATH_1 286 290 PF00917 0.523
DOC_USP7_MATH_1 97 101 PF00917 0.470
DOC_WW_Pin1_4 266 271 PF00397 0.548
DOC_WW_Pin1_4 282 287 PF00397 0.576
DOC_WW_Pin1_4 289 294 PF00397 0.603
DOC_WW_Pin1_4 31 36 PF00397 0.532
DOC_WW_Pin1_4 330 335 PF00397 0.359
DOC_WW_Pin1_4 384 389 PF00397 0.418
LIG_14-3-3_CanoR_1 228 234 PF00244 0.336
LIG_14-3-3_CanoR_1 23 30 PF00244 0.344
LIG_14-3-3_CanoR_1 320 324 PF00244 0.363
LIG_14-3-3_CanoR_1 441 446 PF00244 0.272
LIG_APCC_ABBA_1 10 15 PF00400 0.425
LIG_APCC_ABBAyCdc20_2 9 15 PF00400 0.423
LIG_BIR_II_1 1 5 PF00653 0.422
LIG_FHA_1 456 462 PF00498 0.210
LIG_FHA_2 198 204 PF00498 0.467
LIG_FHA_2 320 326 PF00498 0.506
LIG_FHA_2 336 342 PF00498 0.325
LIG_FHA_2 355 361 PF00498 0.408
LIG_FHA_2 399 405 PF00498 0.388
LIG_FHA_2 442 448 PF00498 0.332
LIG_FHA_2 460 466 PF00498 0.076
LIG_FHA_2 50 56 PF00498 0.462
LIG_FHA_2 68 74 PF00498 0.241
LIG_LIR_Gen_1 156 166 PF02991 0.406
LIG_LIR_Gen_1 322 331 PF02991 0.362
LIG_LIR_Gen_1 8 17 PF02991 0.320
LIG_LIR_Nem_3 156 161 PF02991 0.549
LIG_LIR_Nem_3 322 327 PF02991 0.364
LIG_LIR_Nem_3 8 14 PF02991 0.300
LIG_MYND_1 218 222 PF01753 0.446
LIG_PCNA_PIPBox_1 426 435 PF02747 0.314
LIG_SH2_CRK 324 328 PF00017 0.360
LIG_SH2_GRB2like 324 327 PF00017 0.359
LIG_SH2_NCK_1 324 328 PF00017 0.360
LIG_SH2_SRC 13 16 PF00017 0.478
LIG_SH2_SRC 324 327 PF00017 0.505
LIG_SH2_SRC 4 7 PF00017 0.441
LIG_SH2_STAP1 324 328 PF00017 0.506
LIG_SH2_STAP1 340 344 PF00017 0.368
LIG_SH2_STAT3 391 394 PF00017 0.466
LIG_SH2_STAT3 446 449 PF00017 0.248
LIG_SH2_STAT5 13 16 PF00017 0.480
LIG_SH2_STAT5 198 201 PF00017 0.460
LIG_SH2_STAT5 391 394 PF00017 0.466
LIG_SH2_STAT5 4 7 PF00017 0.439
LIG_SH2_STAT5 460 463 PF00017 0.296
LIG_SH3_2 279 284 PF14604 0.449
LIG_SH3_3 219 225 PF00018 0.463
LIG_SH3_3 264 270 PF00018 0.636
LIG_SH3_3 276 282 PF00018 0.673
LIG_SH3_3 44 50 PF00018 0.382
LIG_TRAF2_1 26 29 PF00917 0.437
LIG_TRAF2_1 406 409 PF00917 0.458
LIG_TYR_ITSM 320 327 PF00017 0.388
LIG_UBA3_1 426 434 PF00899 0.322
LIG_WRC_WIRS_1 230 235 PF05994 0.442
MOD_CDK_SPK_2 384 389 PF00069 0.466
MOD_CDK_SPxK_1 384 390 PF00069 0.468
MOD_CDK_SPxxK_3 266 273 PF00069 0.676
MOD_CK1_1 171 177 PF00069 0.292
MOD_CK1_1 213 219 PF00069 0.509
MOD_CK1_1 289 295 PF00069 0.548
MOD_CK1_1 333 339 PF00069 0.465
MOD_CK2_1 197 203 PF00069 0.459
MOD_CK2_1 23 29 PF00069 0.341
MOD_CK2_1 398 404 PF00069 0.405
MOD_CK2_1 441 447 PF00069 0.214
MOD_CK2_1 449 455 PF00069 0.190
MOD_CK2_1 49 55 PF00069 0.379
MOD_CK2_1 67 73 PF00069 0.242
MOD_Cter_Amidation 438 441 PF01082 0.293
MOD_GlcNHglycan 114 117 PF01048 0.406
MOD_GlcNHglycan 119 122 PF01048 0.542
MOD_GlcNHglycan 153 156 PF01048 0.621
MOD_GlcNHglycan 174 177 PF01048 0.405
MOD_GlcNHglycan 259 262 PF01048 0.531
MOD_GlcNHglycan 293 296 PF01048 0.536
MOD_GlcNHglycan 311 314 PF01048 0.656
MOD_GlcNHglycan 382 385 PF01048 0.361
MOD_GlcNHglycan 451 454 PF01048 0.236
MOD_GlcNHglycan 99 102 PF01048 0.535
MOD_GSK3_1 149 156 PF00069 0.597
MOD_GSK3_1 167 174 PF00069 0.458
MOD_GSK3_1 282 289 PF00069 0.535
MOD_GSK3_1 315 322 PF00069 0.568
MOD_GSK3_1 330 337 PF00069 0.296
MOD_GSK3_1 380 387 PF00069 0.322
MOD_GSK3_1 455 462 PF00069 0.243
MOD_N-GLC_1 427 432 PF02516 0.367
MOD_N-GLC_2 64 66 PF02516 0.352
MOD_NEK2_1 202 207 PF00069 0.301
MOD_NEK2_1 287 292 PF00069 0.636
MOD_NEK2_1 335 340 PF00069 0.571
MOD_NEK2_1 427 432 PF00069 0.409
MOD_NEK2_1 67 72 PF00069 0.349
MOD_NEK2_1 82 87 PF00069 0.317
MOD_PIKK_1 213 219 PF00454 0.517
MOD_PIKK_1 315 321 PF00454 0.452
MOD_PKA_2 319 325 PF00069 0.372
MOD_Plk_1 180 186 PF00069 0.397
MOD_Plk_1 340 346 PF00069 0.403
MOD_Plk_1 372 378 PF00069 0.357
MOD_Plk_1 427 433 PF00069 0.352
MOD_Plk_1 82 88 PF00069 0.428
MOD_Plk_4 210 216 PF00069 0.335
MOD_Plk_4 319 325 PF00069 0.472
MOD_Plk_4 340 346 PF00069 0.485
MOD_Plk_4 372 378 PF00069 0.472
MOD_Plk_4 428 434 PF00069 0.300
MOD_Plk_4 441 447 PF00069 0.217
MOD_Plk_4 49 55 PF00069 0.448
MOD_ProDKin_1 266 272 PF00069 0.548
MOD_ProDKin_1 282 288 PF00069 0.576
MOD_ProDKin_1 289 295 PF00069 0.603
MOD_ProDKin_1 31 37 PF00069 0.527
MOD_ProDKin_1 330 336 PF00069 0.359
MOD_ProDKin_1 384 390 PF00069 0.420
MOD_SUMO_rev_2 201 207 PF00179 0.450
TRG_DiLeu_BaEn_1 361 366 PF01217 0.375
TRG_DiLeu_BaEn_3 371 377 PF01217 0.364
TRG_ENDOCYTIC_2 158 161 PF00928 0.558
TRG_ENDOCYTIC_2 324 327 PF00928 0.359
TRG_ENDOCYTIC_2 328 331 PF00928 0.322
TRG_ENDOCYTIC_2 44 47 PF00928 0.391
TRG_ER_diArg_1 367 370 PF00400 0.361
TRG_Pf-PMV_PEXEL_1 23 27 PF00026 0.438
TRG_Pf-PMV_PEXEL_1 236 241 PF00026 0.421
TRG_Pf-PMV_PEXEL_1 350 355 PF00026 0.497

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZC4 Leptomonas seymouri 62% 98%
A0A0S4JM53 Bodo saltans 25% 91%
A0A0S4JM77 Bodo saltans 29% 100%
A0A1X0NRX7 Trypanosomatidae 38% 99%
A0A3Q8IGU5 Leishmania donovani 100% 100%
A0A3R7KDK8 Trypanosoma rangeli 38% 100%
A4HLZ2 Leishmania braziliensis 82% 100%
C9ZJ99 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
E9B4C1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
O75764 Homo sapiens 22% 100%
Q4Q3Q4 Leishmania major 93% 100%
V5BJM3 Trypanosoma cruzi 37% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS