Uncharacterized protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I9C1_LEIIN

TriTrypDb:

LINF_330037300

Length:

151

Annotations

LeishMANIAdb annotations

Probably not embedded into the membranes.

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I9C1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9C1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	56	60	PF00656	0.573
CLV_NRD_NRD_1	126	128	PF00675	0.531
CLV_PCSK_KEX2_1	10	12	PF00082	0.337
CLV_PCSK_KEX2_1	126	128	PF00082	0.531
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.337
CLV_PCSK_SKI1_1	109	113	PF00082	0.263
DOC_PP1_RVXF_1	77	84	PF00149	0.497
DOC_USP7_MATH_1	55	59	PF00917	0.491
DOC_WW_Pin1_4	131	136	PF00397	0.353
LIG_14-3-3_CanoR_1	109	118	PF00244	0.371
LIG_14-3-3_CanoR_1	11	20	PF00244	0.608
LIG_14-3-3_CanoR_1	126	130	PF00244	0.318
LIG_BIR_II_1	1	5	PF00653	0.612
LIG_FHA_2	54	60	PF00498	0.546
LIG_LIR_Nem_3	112	118	PF02991	0.368
LIG_LIR_Nem_3	128	133	PF02991	0.316
LIG_LIR_Nem_3	77	81	PF02991	0.529
LIG_LYPXL_S_1	129	133	PF13949	0.537
LIG_LYPXL_yS_3	130	133	PF13949	0.341
LIG_PCNA_yPIPBox_3	97	105	PF02747	0.571
LIG_PTB_Phospho_1	145	151	PF10480	0.361
LIG_SH2_CRK	78	82	PF00017	0.495
LIG_SH2_STAT5	89	92	PF00017	0.486
LIG_SH3_3	126	132	PF00018	0.402
LIG_SH3_3	17	23	PF00018	0.571
MOD_CK1_1	134	140	PF00069	0.423
MOD_Cter_Amidation	124	127	PF01082	0.425
MOD_GlcNHglycan	13	16	PF01048	0.396
MOD_GlcNHglycan	34	37	PF01048	0.288
MOD_GlcNHglycan	91	94	PF01048	0.311
MOD_GSK3_1	55	62	PF00069	0.575
MOD_N-GLC_1	97	102	PF02516	0.225
MOD_NEK2_2	125	130	PF00069	0.301
MOD_PIKK_1	109	115	PF00454	0.391
MOD_PK_1	97	103	PF00069	0.420
MOD_PKA_1	10	16	PF00069	0.563
MOD_PKA_2	10	16	PF00069	0.628
MOD_PKA_2	125	131	PF00069	0.304
MOD_Plk_1	97	103	PF00069	0.557
MOD_ProDKin_1	131	137	PF00069	0.347
TRG_DiLeu_BaEn_1	71	76	PF01217	0.529
TRG_ENDOCYTIC_2	130	133	PF00928	0.417
TRG_ENDOCYTIC_2	78	81	PF00928	0.495
TRG_ER_diArg_1	65	68	PF00400	0.587
TRG_Pf-PMV_PEXEL_1	67	71	PF00026	0.320

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTD3	Leptomonas seymouri	34%	94%
A0A0N1PDI5	Leptomonas seymouri	66%	100%
A0A0S4JQI6	Bodo saltans	42%	100%
A0A1X0NJU2	Trypanosomatidae	27%	100%
A0A1X0NR99	Trypanosomatidae	48%	100%
A0A3S7WP26	Leishmania donovani	32%	90%
A0A3S7X736	Leishmania donovani	100%	100%
A0A422N2T1	Trypanosoma rangeli	30%	100%
A0A422NKR0	Trypanosoma rangeli	48%	100%
A4H495	Leishmania braziliensis	34%	100%
A4HLZ1	Leishmania braziliensis	87%	100%
C9ZJA0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
C9ZUD9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AKF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B4C0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q3Q5	Leishmania major	90%	100%
V5BJW3	Trypanosoma cruzi	24%	100%
V5DB75	Trypanosoma cruzi	50%	100%