LeishMANIAdb
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Putative GTP-binding protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative GTP-binding protein
Gene product:
GTP-binding elongation factor tu family protein - putative
Species:
Leishmania infantum
UniProt:
A4I9C0_LEIIN
TriTrypDb:
LINF_330037200
Length:
842

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, GTP-binding

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I9C0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9C0

Function

Biological processes
Term Name Level Count
GO:0006414 translational elongation 5 1
GO:0008152 metabolic process 1 1
GO:0009058 biosynthetic process 2 1
GO:0009059 macromolecule biosynthetic process 4 1
GO:0009987 cellular process 1 1
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:1901576 organic substance biosynthetic process 3 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0003924 GTPase activity 7 12
GO:0005488 binding 1 12
GO:0005525 GTP binding 5 12
GO:0016462 pyrophosphatase activity 5 12
GO:0016787 hydrolase activity 2 12
GO:0016817 hydrolase activity, acting on acid anhydrides 3 12
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 12
GO:0017076 purine nucleotide binding 4 12
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 12
GO:0019001 guanyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032561 guanyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12
GO:0003676 nucleic acid binding 3 8
GO:0003746 translation elongation factor activity 4 8
GO:0008135 translation factor activity, RNA binding 3 8
GO:0045182 translation regulator activity 1 8
GO:0090079 translation regulator activity, nucleic acid binding 2 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 546 550 PF00656 0.437
CLV_C14_Caspase3-7 83 87 PF00656 0.473
CLV_NRD_NRD_1 170 172 PF00675 0.400
CLV_NRD_NRD_1 246 248 PF00675 0.496
CLV_NRD_NRD_1 347 349 PF00675 0.521
CLV_NRD_NRD_1 572 574 PF00675 0.241
CLV_NRD_NRD_1 580 582 PF00675 0.231
CLV_NRD_NRD_1 623 625 PF00675 0.421
CLV_NRD_NRD_1 713 715 PF00675 0.385
CLV_NRD_NRD_1 827 829 PF00675 0.556
CLV_NRD_NRD_1 88 90 PF00675 0.580
CLV_PCSK_KEX2_1 153 155 PF00082 0.643
CLV_PCSK_KEX2_1 246 248 PF00082 0.496
CLV_PCSK_KEX2_1 346 348 PF00082 0.498
CLV_PCSK_KEX2_1 580 582 PF00082 0.252
CLV_PCSK_KEX2_1 709 711 PF00082 0.436
CLV_PCSK_KEX2_1 88 90 PF00082 0.579
CLV_PCSK_PC1ET2_1 153 155 PF00082 0.557
CLV_PCSK_PC1ET2_1 709 711 PF00082 0.450
CLV_PCSK_SKI1_1 117 121 PF00082 0.495
CLV_PCSK_SKI1_1 163 167 PF00082 0.505
CLV_PCSK_SKI1_1 484 488 PF00082 0.249
CLV_PCSK_SKI1_1 496 500 PF00082 0.241
CLV_PCSK_SKI1_1 565 569 PF00082 0.248
CLV_PCSK_SKI1_1 796 800 PF00082 0.306
CLV_Separin_Metazoa 770 774 PF03568 0.437
DEG_SCF_TRCP1_1 250 256 PF00400 0.335
DEG_SCF_TRCP1_1 366 371 PF00400 0.437
DEG_SPOP_SBC_1 329 333 PF00917 0.650
DOC_ANK_TNKS_1 802 809 PF00023 0.448
DOC_CKS1_1 472 477 PF01111 0.534
DOC_CYCLIN_yCln2_LP_2 537 543 PF00134 0.437
DOC_CYCLIN_yCln2_LP_2 835 841 PF00134 0.544
DOC_MAPK_gen_1 525 535 PF00069 0.437
DOC_MAPK_gen_1 580 587 PF00069 0.448
DOC_MAPK_gen_1 714 720 PF00069 0.450
DOC_MAPK_gen_1 800 809 PF00069 0.504
DOC_MAPK_MEF2A_6 528 537 PF00069 0.437
DOC_MAPK_NFAT4_5 528 536 PF00069 0.448
DOC_MAPK_RevD_3 609 625 PF00069 0.507
DOC_PP1_RVXF_1 794 800 PF00149 0.554
DOC_PP2B_LxvP_1 537 540 PF13499 0.460
DOC_PP2B_LxvP_1 567 570 PF13499 0.437
DOC_PP2B_LxvP_1 835 838 PF13499 0.533
DOC_USP7_MATH_1 113 117 PF00917 0.616
DOC_USP7_MATH_1 211 215 PF00917 0.677
DOC_USP7_MATH_1 248 252 PF00917 0.395
DOC_USP7_MATH_1 308 312 PF00917 0.641
DOC_USP7_MATH_1 328 332 PF00917 0.792
DOC_USP7_MATH_1 457 461 PF00917 0.524
DOC_USP7_MATH_1 462 466 PF00917 0.491
DOC_USP7_MATH_1 479 483 PF00917 0.469
DOC_USP7_MATH_1 550 554 PF00917 0.414
DOC_USP7_UBL2_3 826 830 PF12436 0.591
DOC_WW_Pin1_4 207 212 PF00397 0.648
DOC_WW_Pin1_4 220 225 PF00397 0.762
DOC_WW_Pin1_4 322 327 PF00397 0.788
DOC_WW_Pin1_4 330 335 PF00397 0.668
DOC_WW_Pin1_4 471 476 PF00397 0.547
DOC_WW_Pin1_4 548 553 PF00397 0.437
DOC_WW_Pin1_4 61 66 PF00397 0.675
LIG_14-3-3_CanoR_1 403 408 PF00244 0.469
LIG_14-3-3_CanoR_1 496 505 PF00244 0.448
LIG_14-3-3_CanoR_1 759 767 PF00244 0.437
LIG_Actin_WH2_2 484 501 PF00022 0.437
LIG_Actin_WH2_2 760 775 PF00022 0.437
LIG_APCC_ABBA_1 105 110 PF00400 0.372
LIG_BIR_II_1 1 5 PF00653 0.542
LIG_BIR_III_2 549 553 PF00653 0.523
LIG_BRCT_BRCA1_1 640 644 PF00533 0.389
LIG_EVH1_2 725 729 PF00568 0.339
LIG_FHA_1 154 160 PF00498 0.574
LIG_FHA_1 254 260 PF00498 0.451
LIG_FHA_1 333 339 PF00498 0.623
LIG_FHA_1 371 377 PF00498 0.438
LIG_FHA_1 402 408 PF00498 0.450
LIG_FHA_1 42 48 PF00498 0.546
LIG_FHA_1 498 504 PF00498 0.437
LIG_FHA_1 64 70 PF00498 0.546
LIG_FHA_1 640 646 PF00498 0.376
LIG_FHA_1 655 661 PF00498 0.363
LIG_FHA_1 664 670 PF00498 0.382
LIG_FHA_1 802 808 PF00498 0.437
LIG_FHA_1 809 815 PF00498 0.437
LIG_FHA_2 429 435 PF00498 0.556
LIG_FHA_2 472 478 PF00498 0.485
LIG_FHA_2 485 491 PF00498 0.392
LIG_FHA_2 544 550 PF00498 0.437
LIG_FHA_2 621 627 PF00498 0.440
LIG_GBD_Chelix_1 166 174 PF00786 0.437
LIG_GBD_Chelix_1 531 539 PF00786 0.339
LIG_LIR_Gen_1 511 519 PF02991 0.437
LIG_LIR_Nem_3 255 260 PF02991 0.380
LIG_LIR_Nem_3 511 515 PF02991 0.437
LIG_LIR_Nem_3 672 677 PF02991 0.395
LIG_LIR_Nem_3 728 732 PF02991 0.450
LIG_LIR_Nem_3 746 752 PF02991 0.562
LIG_MLH1_MIPbox_1 640 644 PF16413 0.389
LIG_PCNA_yPIPBox_3 92 104 PF02747 0.406
LIG_Rb_pABgroove_1 483 491 PF01858 0.437
LIG_SH2_CRK 423 427 PF00017 0.504
LIG_SH2_CRK 512 516 PF00017 0.440
LIG_SH2_CRK 594 598 PF00017 0.483
LIG_SH2_NCK_1 196 200 PF00017 0.586
LIG_SH2_NCK_1 489 493 PF00017 0.437
LIG_SH2_NCK_1 594 598 PF00017 0.483
LIG_SH2_SRC 196 199 PF00017 0.628
LIG_SH2_SRC 749 752 PF00017 0.437
LIG_SH2_STAP1 512 516 PF00017 0.437
LIG_SH2_STAP1 594 598 PF00017 0.396
LIG_SH2_STAT3 14 17 PF00017 0.367
LIG_SH2_STAT3 766 769 PF00017 0.462
LIG_SH2_STAT5 423 426 PF00017 0.404
LIG_SH2_STAT5 497 500 PF00017 0.437
LIG_SH2_STAT5 766 769 PF00017 0.462
LIG_SH3_3 321 327 PF00018 0.642
LIG_SH3_3 434 440 PF00018 0.539
LIG_SUMO_SIM_anti_2 141 147 PF11976 0.522
LIG_SUMO_SIM_anti_2 735 740 PF11976 0.437
LIG_SUMO_SIM_par_1 482 490 PF11976 0.449
LIG_SUMO_SIM_par_1 678 684 PF11976 0.478
LIG_TRAF2_1 80 83 PF00917 0.418
LIG_TRAF2_2 48 53 PF00917 0.515
LIG_TYR_ITIM 421 426 PF00017 0.417
LIG_TYR_ITIM 592 597 PF00017 0.339
LIG_UBA3_1 566 574 PF00899 0.312
MOD_CDK_SPK_2 471 476 PF00069 0.326
MOD_CK1_1 219 225 PF00069 0.697
MOD_CK1_1 332 338 PF00069 0.683
MOD_CK1_1 367 373 PF00069 0.298
MOD_CK1_1 374 380 PF00069 0.297
MOD_CK1_1 405 411 PF00069 0.296
MOD_CK1_1 455 461 PF00069 0.347
MOD_CK1_1 59 65 PF00069 0.651
MOD_CK1_1 604 610 PF00069 0.296
MOD_CK2_1 231 237 PF00069 0.651
MOD_CK2_1 403 409 PF00069 0.292
MOD_CK2_1 428 434 PF00069 0.384
MOD_CK2_1 471 477 PF00069 0.481
MOD_CK2_1 88 94 PF00069 0.610
MOD_Cter_Amidation 86 89 PF01082 0.640
MOD_GlcNHglycan 176 179 PF01048 0.552
MOD_GlcNHglycan 2 5 PF01048 0.593
MOD_GlcNHglycan 250 253 PF01048 0.423
MOD_GlcNHglycan 305 308 PF01048 0.580
MOD_GlcNHglycan 310 313 PF01048 0.600
MOD_GlcNHglycan 366 369 PF01048 0.309
MOD_GlcNHglycan 414 417 PF01048 0.428
MOD_GlcNHglycan 449 452 PF01048 0.390
MOD_GlcNHglycan 454 457 PF01048 0.376
MOD_GlcNHglycan 459 462 PF01048 0.315
MOD_GlcNHglycan 464 467 PF01048 0.235
MOD_GlcNHglycan 517 520 PF01048 0.314
MOD_GlcNHglycan 58 61 PF01048 0.672
MOD_GlcNHglycan 760 763 PF01048 0.322
MOD_GSK3_1 149 156 PF00069 0.399
MOD_GSK3_1 207 214 PF00069 0.700
MOD_GSK3_1 216 223 PF00069 0.640
MOD_GSK3_1 231 238 PF00069 0.580
MOD_GSK3_1 318 325 PF00069 0.718
MOD_GSK3_1 328 335 PF00069 0.718
MOD_GSK3_1 364 371 PF00069 0.324
MOD_GSK3_1 398 405 PF00069 0.277
MOD_GSK3_1 462 469 PF00069 0.367
MOD_GSK3_1 480 487 PF00069 0.291
MOD_GSK3_1 59 66 PF00069 0.624
MOD_GSK3_1 639 646 PF00069 0.414
MOD_GSK3_1 739 746 PF00069 0.391
MOD_GSK3_1 754 761 PF00069 0.303
MOD_GSK3_1 771 778 PF00069 0.290
MOD_N-GLC_1 199 204 PF02516 0.724
MOD_N-GLC_1 316 321 PF02516 0.681
MOD_N-GLC_1 421 426 PF02516 0.288
MOD_N-GLC_1 604 609 PF02516 0.289
MOD_N-GLC_1 663 668 PF02516 0.434
MOD_NEK2_1 166 171 PF00069 0.388
MOD_NEK2_1 174 179 PF00069 0.410
MOD_NEK2_1 498 503 PF00069 0.293
MOD_NEK2_1 601 606 PF00069 0.312
MOD_NEK2_1 643 648 PF00069 0.472
MOD_NEK2_1 73 78 PF00069 0.529
MOD_NEK2_1 739 744 PF00069 0.297
MOD_NEK2_2 466 471 PF00069 0.302
MOD_PIKK_1 63 69 PF00454 0.502
MOD_PIKK_1 654 660 PF00454 0.337
MOD_PK_1 403 409 PF00069 0.278
MOD_PK_1 709 715 PF00069 0.505
MOD_PKA_1 153 159 PF00069 0.531
MOD_PKA_1 709 715 PF00069 0.424
MOD_PKA_1 88 94 PF00069 0.570
MOD_PKA_2 153 159 PF00069 0.410
MOD_PKA_2 402 408 PF00069 0.295
MOD_PKA_2 480 486 PF00069 0.372
MOD_PKA_2 524 530 PF00069 0.302
MOD_PKA_2 709 715 PF00069 0.464
MOD_PKA_2 758 764 PF00069 0.274
MOD_PKA_2 87 93 PF00069 0.598
MOD_Plk_1 238 244 PF00069 0.527
MOD_Plk_1 421 427 PF00069 0.323
MOD_Plk_1 556 562 PF00069 0.368
MOD_Plk_1 583 589 PF00069 0.410
MOD_Plk_1 639 645 PF00069 0.364
MOD_Plk_1 663 669 PF00069 0.429
MOD_Plk_1 775 781 PF00069 0.294
MOD_Plk_4 155 161 PF00069 0.553
MOD_Plk_4 202 208 PF00069 0.627
MOD_Plk_4 253 259 PF00069 0.519
MOD_Plk_4 334 340 PF00069 0.619
MOD_Plk_4 371 377 PF00069 0.289
MOD_Plk_4 421 427 PF00069 0.358
MOD_Plk_4 484 490 PF00069 0.293
MOD_Plk_4 498 504 PF00069 0.254
MOD_Plk_4 639 645 PF00069 0.404
MOD_Plk_4 647 653 PF00069 0.344
MOD_Plk_4 663 669 PF00069 0.426
MOD_Plk_4 725 731 PF00069 0.324
MOD_ProDKin_1 207 213 PF00069 0.646
MOD_ProDKin_1 220 226 PF00069 0.763
MOD_ProDKin_1 322 328 PF00069 0.788
MOD_ProDKin_1 330 336 PF00069 0.652
MOD_ProDKin_1 471 477 PF00069 0.427
MOD_ProDKin_1 548 554 PF00069 0.274
MOD_ProDKin_1 61 67 PF00069 0.663
MOD_SUMO_for_1 35 38 PF00179 0.447
MOD_SUMO_for_1 705 708 PF00179 0.395
TRG_DiLeu_BaEn_1 255 260 PF01217 0.435
TRG_DiLeu_BaEn_1 793 798 PF01217 0.350
TRG_DiLeu_BaEn_1 816 821 PF01217 0.522
TRG_DiLeu_BaLyEn_6 95 100 PF01217 0.549
TRG_DiLeu_LyEn_5 793 798 PF01217 0.350
TRG_ENDOCYTIC_2 423 426 PF00928 0.368
TRG_ENDOCYTIC_2 512 515 PF00928 0.274
TRG_ENDOCYTIC_2 594 597 PF00928 0.339
TRG_ENDOCYTIC_2 749 752 PF00928 0.418
TRG_ER_diArg_1 245 247 PF00400 0.497
TRG_ER_diArg_1 345 348 PF00400 0.510
TRG_ER_diArg_1 579 581 PF00400 0.295
TRG_NLS_Bipartite_1 153 175 PF00514 0.434
TRG_NLS_MonoExtC_3 827 833 PF00514 0.511
TRG_NLS_MonoExtN_4 826 832 PF00514 0.589

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I4K5 Leptomonas seymouri 68% 100%
A0A0S4JM58 Bodo saltans 52% 100%
A0A1X0NRK6 Trypanosomatidae 47% 97%
A0A3R7MHD3 Trypanosoma rangeli 50% 100%
A0A3S7X775 Leishmania donovani 100% 100%
A4HLZ0 Leishmania braziliensis 84% 100%
C9ZJA2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 53% 100%
E9B4B9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 99%
Q4Q3Q6 Leishmania major 93% 100%
V5BF52 Trypanosoma cruzi 50% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS