LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Mitochondrial guide RNA binding complex subunit 2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Mitochondrial guide RNA binding complex subunit 2
Gene product:
MRB1-associated protein
Species:
Leishmania infantum
UniProt:
A4I9B3_LEIIN
TriTrypDb:
LINF_330036600
Length:
502

Annotations

Annotations by Jardim et al.

RNA Processing, guide RNA associated 1

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 22
NetGPI no yes: 0, no: 22
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 3
GO:0005739 mitochondrion 5 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2

Expansion

Sequence features

A4I9B3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9B3

Function

Biological processes
Term Name Level Count
GO:0000959 mitochondrial RNA metabolic process 6 2
GO:0000963 mitochondrial RNA processing 6 2
GO:0006139 nucleobase-containing compound metabolic process 3 2
GO:0006396 RNA processing 6 2
GO:0006725 cellular aromatic compound metabolic process 3 2
GO:0006807 nitrogen compound metabolic process 2 2
GO:0008152 metabolic process 1 2
GO:0009451 RNA modification 5 1
GO:0009987 cellular process 1 2
GO:0010467 gene expression 4 2
GO:0016070 RNA metabolic process 5 2
GO:0016071 mRNA metabolic process 6 1
GO:0016556 mRNA modification 6 1
GO:0034641 cellular nitrogen compound metabolic process 3 2
GO:0043170 macromolecule metabolic process 3 2
GO:0043412 macromolecule modification 4 1
GO:0044237 cellular metabolic process 2 2
GO:0044238 primary metabolic process 2 2
GO:0046483 heterocycle metabolic process 3 2
GO:0071704 organic substance metabolic process 2 2
GO:0090304 nucleic acid metabolic process 4 2
GO:0140053 mitochondrial gene expression 5 2
GO:1901360 organic cyclic compound metabolic process 3 2
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 2
GO:0003723 RNA binding 4 2
GO:0003729 mRNA binding 5 2
GO:0005488 binding 1 2
GO:0097159 organic cyclic compound binding 2 2
GO:1901363 heterocyclic compound binding 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 329 333 PF00656 0.507
CLV_C14_Caspase3-7 390 394 PF00656 0.485
CLV_NRD_NRD_1 160 162 PF00675 0.590
CLV_NRD_NRD_1 17 19 PF00675 0.701
CLV_NRD_NRD_1 232 234 PF00675 0.484
CLV_NRD_NRD_1 325 327 PF00675 0.437
CLV_NRD_NRD_1 414 416 PF00675 0.343
CLV_NRD_NRD_1 433 435 PF00675 0.458
CLV_PCSK_KEX2_1 160 162 PF00082 0.574
CLV_PCSK_KEX2_1 17 19 PF00082 0.697
CLV_PCSK_KEX2_1 232 234 PF00082 0.484
CLV_PCSK_KEX2_1 325 327 PF00082 0.452
CLV_PCSK_KEX2_1 376 378 PF00082 0.360
CLV_PCSK_KEX2_1 433 435 PF00082 0.387
CLV_PCSK_PC1ET2_1 376 378 PF00082 0.410
CLV_PCSK_SKI1_1 257 261 PF00082 0.461
DOC_MAPK_gen_1 160 168 PF00069 0.548
DOC_MAPK_gen_1 266 274 PF00069 0.468
DOC_MAPK_gen_1 433 439 PF00069 0.407
DOC_MAPK_MEF2A_6 358 366 PF00069 0.372
DOC_MAPK_MEF2A_6 420 429 PF00069 0.418
DOC_PP1_RVXF_1 231 238 PF00149 0.424
DOC_PP1_RVXF_1 255 261 PF00149 0.478
DOC_SPAK_OSR1_1 350 354 PF12202 0.378
DOC_SPAK_OSR1_1 365 369 PF12202 0.364
DOC_USP7_MATH_1 100 104 PF00917 0.402
DOC_USP7_MATH_1 207 211 PF00917 0.506
DOC_USP7_MATH_1 291 295 PF00917 0.378
DOC_USP7_MATH_1 316 320 PF00917 0.420
DOC_USP7_MATH_1 498 502 PF00917 0.661
DOC_USP7_MATH_1 88 92 PF00917 0.582
DOC_WW_Pin1_4 23 28 PF00397 0.645
DOC_WW_Pin1_4 397 402 PF00397 0.426
DOC_WW_Pin1_4 432 437 PF00397 0.400
DOC_WW_Pin1_4 44 49 PF00397 0.631
LIG_14-3-3_CanoR_1 11 15 PF00244 0.722
LIG_14-3-3_CanoR_1 17 23 PF00244 0.710
LIG_14-3-3_CanoR_1 269 273 PF00244 0.454
LIG_14-3-3_CanoR_1 325 331 PF00244 0.547
LIG_14-3-3_CanoR_1 41 48 PF00244 0.671
LIG_Actin_WH2_2 159 174 PF00022 0.532
LIG_Actin_WH2_2 376 391 PF00022 0.516
LIG_BIR_II_1 1 5 PF00653 0.558
LIG_BRCT_BRCA1_1 90 94 PF00533 0.493
LIG_deltaCOP1_diTrp_1 150 157 PF00928 0.582
LIG_deltaCOP1_diTrp_1 236 243 PF00928 0.401
LIG_deltaCOP1_diTrp_1 58 64 PF00928 0.461
LIG_FHA_1 269 275 PF00498 0.581
LIG_FHA_1 31 37 PF00498 0.711
LIG_FHA_1 352 358 PF00498 0.450
LIG_FHA_1 383 389 PF00498 0.367
LIG_FHA_1 424 430 PF00498 0.370
LIG_FHA_1 433 439 PF00498 0.398
LIG_FHA_1 54 60 PF00498 0.559
LIG_FHA_1 72 78 PF00498 0.339
LIG_FHA_1 91 97 PF00498 0.634
LIG_FHA_2 131 137 PF00498 0.627
LIG_FHA_2 139 145 PF00498 0.616
LIG_FHA_2 197 203 PF00498 0.479
LIG_GBD_Chelix_1 304 312 PF00786 0.438
LIG_LIR_Gen_1 164 173 PF02991 0.539
LIG_LIR_Gen_1 450 461 PF02991 0.363
LIG_LIR_Gen_1 51 60 PF02991 0.414
LIG_LIR_Nem_3 164 168 PF02991 0.538
LIG_LIR_Nem_3 175 180 PF02991 0.546
LIG_LIR_Nem_3 450 456 PF02991 0.365
LIG_LIR_Nem_3 475 479 PF02991 0.435
LIG_LIR_Nem_3 51 55 PF02991 0.427
LIG_SH2_CRK 185 189 PF00017 0.422
LIG_SH2_CRK 261 265 PF00017 0.486
LIG_SH2_CRK 476 480 PF00017 0.472
LIG_SH2_SRC 282 285 PF00017 0.418
LIG_SH2_STAP1 451 455 PF00017 0.312
LIG_SH2_STAT3 79 82 PF00017 0.409
LIG_SH2_STAT5 216 219 PF00017 0.492
LIG_SH2_STAT5 287 290 PF00017 0.465
LIG_SH2_STAT5 356 359 PF00017 0.361
LIG_SH2_STAT5 382 385 PF00017 0.528
LIG_SH2_STAT5 408 411 PF00017 0.355
LIG_SH2_STAT5 80 83 PF00017 0.407
LIG_SH3_1 176 182 PF00018 0.518
LIG_SH3_3 176 182 PF00018 0.518
LIG_SH3_3 21 27 PF00018 0.665
LIG_SH3_3 395 401 PF00018 0.450
LIG_SH3_3 452 458 PF00018 0.364
LIG_SH3_3 92 98 PF00018 0.672
LIG_SUMO_SIM_anti_2 452 458 PF11976 0.487
LIG_SUMO_SIM_par_1 435 440 PF11976 0.441
LIG_TYR_ITIM 259 264 PF00017 0.458
LIG_TYR_ITIM 449 454 PF00017 0.375
MOD_CDK_SPxK_1 44 50 PF00069 0.461
MOD_CK1_1 190 196 PF00069 0.462
MOD_CK1_1 28 34 PF00069 0.660
MOD_CK1_1 394 400 PF00069 0.424
MOD_CK1_1 44 50 PF00069 0.556
MOD_CK1_1 53 59 PF00069 0.487
MOD_CK1_1 71 77 PF00069 0.388
MOD_CK2_1 138 144 PF00069 0.685
MOD_CK2_1 293 299 PF00069 0.404
MOD_CK2_1 70 76 PF00069 0.414
MOD_CMANNOS 61 64 PF00535 0.406
MOD_DYRK1A_RPxSP_1 23 27 PF00069 0.505
MOD_GlcNHglycan 1 4 PF01048 0.742
MOD_GlcNHglycan 113 116 PF01048 0.502
MOD_GlcNHglycan 191 195 PF01048 0.561
MOD_GlcNHglycan 293 296 PF01048 0.489
MOD_GlcNHglycan 30 33 PF01048 0.675
MOD_GlcNHglycan 44 47 PF01048 0.667
MOD_GlcNHglycan 469 472 PF01048 0.411
MOD_GSK3_1 126 133 PF00069 0.740
MOD_GSK3_1 28 35 PF00069 0.703
MOD_GSK3_1 316 323 PF00069 0.337
MOD_GSK3_1 387 394 PF00069 0.429
MOD_GSK3_1 490 497 PF00069 0.564
MOD_GSK3_1 71 78 PF00069 0.475
MOD_LATS_1 16 22 PF00433 0.553
MOD_NEK2_1 242 247 PF00069 0.403
MOD_NEK2_1 260 265 PF00069 0.570
MOD_NEK2_1 339 344 PF00069 0.404
MOD_NEK2_1 351 356 PF00069 0.344
MOD_NEK2_1 36 41 PF00069 0.741
MOD_NEK2_1 429 434 PF00069 0.361
MOD_NEK2_1 437 442 PF00069 0.463
MOD_NEK2_1 492 497 PF00069 0.511
MOD_NEK2_1 70 75 PF00069 0.364
MOD_NEK2_2 320 325 PF00069 0.321
MOD_PIKK_1 356 362 PF00454 0.356
MOD_PIKK_1 418 424 PF00454 0.516
MOD_PKA_1 101 107 PF00069 0.575
MOD_PKA_1 17 23 PF00069 0.716
MOD_PKA_1 325 331 PF00069 0.533
MOD_PKA_2 10 16 PF00069 0.775
MOD_PKA_2 17 23 PF00069 0.792
MOD_PKA_2 268 274 PF00069 0.588
MOD_PKA_2 324 330 PF00069 0.520
MOD_PKA_2 388 394 PF00069 0.498
MOD_Plk_1 138 144 PF00069 0.665
MOD_Plk_1 50 56 PF00069 0.477
MOD_Plk_1 75 81 PF00069 0.517
MOD_Plk_4 101 107 PF00069 0.453
MOD_Plk_4 32 38 PF00069 0.658
MOD_Plk_4 394 400 PF00069 0.424
MOD_Plk_4 75 81 PF00069 0.448
MOD_Plk_4 90 96 PF00069 0.664
MOD_ProDKin_1 23 29 PF00069 0.645
MOD_ProDKin_1 397 403 PF00069 0.419
MOD_ProDKin_1 432 438 PF00069 0.405
MOD_ProDKin_1 44 50 PF00069 0.620
TRG_DiLeu_BaLyEn_6 433 438 PF01217 0.407
TRG_ENDOCYTIC_2 165 168 PF00928 0.588
TRG_ENDOCYTIC_2 177 180 PF00928 0.398
TRG_ENDOCYTIC_2 185 188 PF00928 0.375
TRG_ENDOCYTIC_2 261 264 PF00928 0.462
TRG_ENDOCYTIC_2 287 290 PF00928 0.398
TRG_ENDOCYTIC_2 451 454 PF00928 0.346
TRG_ENDOCYTIC_2 476 479 PF00928 0.474
TRG_ER_diArg_1 231 233 PF00400 0.392
TRG_ER_diArg_1 324 326 PF00400 0.407
TRG_ER_diArg_1 368 371 PF00400 0.373
TRG_NES_CRM1_1 186 202 PF08389 0.490
TRG_NES_CRM1_1 299 314 PF08389 0.526
TRG_NLS_MonoExtC_3 374 380 PF00514 0.399
TRG_NLS_MonoExtN_4 373 379 PF00514 0.442

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IK37 Leptomonas seymouri 28% 100%
A0A0N1IKX3 Leptomonas seymouri 77% 92%
A0A0S4IN88 Bodo saltans 29% 94%
A0A0S4JQR1 Bodo saltans 55% 93%
A0A1X0NRA1 Trypanosomatidae 70% 98%
A0A1X0NTQ0 Trypanosomatidae 29% 100%
A0A3Q8II17 Leishmania donovani 100% 100%
A0A3S7WX47 Leishmania donovani 28% 100%
A0A422NDT8 Trypanosoma rangeli 29% 100%
A0A422NKD3 Trypanosoma rangeli 68% 100%
A4HCA9 Leishmania braziliensis 27% 100%
A4HLY4 Leishmania braziliensis 87% 100%
A4HZU2 Leishmania infantum 28% 100%
C9ZJB1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 67% 100%
C9ZRN1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
E9AVP7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9B4B3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4Q3R2 Leishmania major 95% 100%
Q4QBT2 Leishmania major 28% 100%
V5BAI0 Trypanosoma cruzi 67% 100%
V5BVS4 Trypanosoma cruzi 29% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS