Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I9A8_LEIIN

TriTrypDb:

LINF_330036100

Length:

834

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I9A8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9A8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.515
CLV_C14_Caspase3-7	454	458	PF00656	0.537
CLV_C14_Caspase3-7	537	541	PF00656	0.515
CLV_C14_Caspase3-7	608	612	PF00656	0.604
CLV_NRD_NRD_1	233	235	PF00675	0.589
CLV_NRD_NRD_1	240	242	PF00675	0.620
CLV_NRD_NRD_1	282	284	PF00675	0.550
CLV_NRD_NRD_1	305	307	PF00675	0.650
CLV_NRD_NRD_1	430	432	PF00675	0.454
CLV_NRD_NRD_1	444	446	PF00675	0.538
CLV_NRD_NRD_1	487	489	PF00675	0.684
CLV_NRD_NRD_1	490	492	PF00675	0.685
CLV_NRD_NRD_1	50	52	PF00675	0.682
CLV_NRD_NRD_1	567	569	PF00675	0.509
CLV_NRD_NRD_1	629	631	PF00675	0.658
CLV_NRD_NRD_1	709	711	PF00675	0.753
CLV_NRD_NRD_1	724	726	PF00675	0.533
CLV_NRD_NRD_1	766	768	PF00675	0.612
CLV_NRD_NRD_1	769	771	PF00675	0.596
CLV_NRD_NRD_1	97	99	PF00675	0.570
CLV_PCSK_FUR_1	303	307	PF00082	0.562
CLV_PCSK_FUR_1	488	492	PF00082	0.653
CLV_PCSK_FUR_1	767	771	PF00082	0.668
CLV_PCSK_FUR_1	93	97	PF00082	0.596
CLV_PCSK_KEX2_1	233	235	PF00082	0.589
CLV_PCSK_KEX2_1	240	242	PF00082	0.620
CLV_PCSK_KEX2_1	282	284	PF00082	0.550
CLV_PCSK_KEX2_1	305	307	PF00082	0.650
CLV_PCSK_KEX2_1	430	432	PF00082	0.455
CLV_PCSK_KEX2_1	444	446	PF00082	0.536
CLV_PCSK_KEX2_1	487	489	PF00082	0.703
CLV_PCSK_KEX2_1	490	492	PF00082	0.708
CLV_PCSK_KEX2_1	50	52	PF00082	0.682
CLV_PCSK_KEX2_1	629	631	PF00082	0.658
CLV_PCSK_KEX2_1	709	711	PF00082	0.745
CLV_PCSK_KEX2_1	723	725	PF00082	0.581
CLV_PCSK_KEX2_1	769	771	PF00082	0.650
CLV_PCSK_KEX2_1	95	97	PF00082	0.653
CLV_PCSK_PC1ET2_1	769	771	PF00082	0.621
CLV_PCSK_PC7_1	236	242	PF00082	0.608
CLV_PCSK_PC7_1	765	771	PF00082	0.605
CLV_PCSK_PC7_1	93	99	PF00082	0.653
CLV_PCSK_SKI1_1	136	140	PF00082	0.571
CLV_PCSK_SKI1_1	146	150	PF00082	0.609
CLV_PCSK_SKI1_1	19	23	PF00082	0.545
CLV_PCSK_SKI1_1	346	350	PF00082	0.558
CLV_PCSK_SKI1_1	375	379	PF00082	0.614
CLV_PCSK_SKI1_1	391	395	PF00082	0.647
CLV_PCSK_SKI1_1	434	438	PF00082	0.453
DEG_APCC_DBOX_1	390	398	PF00400	0.609
DEG_SPOP_SBC_1	124	128	PF00917	0.542
DEG_SPOP_SBC_1	506	510	PF00917	0.646
DEG_SPOP_SBC_1	746	750	PF00917	0.585
DOC_ANK_TNKS_1	109	116	PF00023	0.583
DOC_CYCLIN_RxL_1	429	440	PF00134	0.461
DOC_CYCLIN_yCln2_LP_2	597	603	PF00134	0.600
DOC_MAPK_gen_1	131	139	PF00069	0.543
DOC_MAPK_gen_1	430	437	PF00069	0.434
DOC_MAPK_gen_1	487	497	PF00069	0.565
DOC_PIKK_1	731	739	PF02985	0.665
DOC_PP1_RVXF_1	17	23	PF00149	0.541
DOC_PP4_FxxP_1	659	662	PF00568	0.490
DOC_USP7_MATH_1	120	124	PF00917	0.633
DOC_USP7_MATH_1	151	155	PF00917	0.732
DOC_USP7_MATH_1	161	165	PF00917	0.775
DOC_USP7_MATH_1	254	258	PF00917	0.674
DOC_USP7_MATH_1	281	285	PF00917	0.726
DOC_USP7_MATH_1	451	455	PF00917	0.628
DOC_USP7_MATH_1	470	474	PF00917	0.651
DOC_USP7_MATH_1	506	510	PF00917	0.691
DOC_USP7_MATH_1	636	640	PF00917	0.572
DOC_USP7_MATH_1	649	653	PF00917	0.755
DOC_USP7_MATH_1	654	658	PF00917	0.588
DOC_USP7_MATH_1	668	672	PF00917	0.420
DOC_USP7_MATH_1	719	723	PF00917	0.679
DOC_USP7_MATH_1	747	751	PF00917	0.649
DOC_USP7_MATH_1	759	763	PF00917	0.532
DOC_USP7_MATH_1	776	780	PF00917	0.763
DOC_USP7_MATH_1	794	798	PF00917	0.519
DOC_USP7_UBL2_3	434	438	PF12436	0.529
DOC_WW_Pin1_4	157	162	PF00397	0.619
DOC_WW_Pin1_4	191	196	PF00397	0.708
DOC_WW_Pin1_4	277	282	PF00397	0.730
DOC_WW_Pin1_4	59	64	PF00397	0.634
DOC_WW_Pin1_4	592	597	PF00397	0.563
DOC_WW_Pin1_4	614	619	PF00397	0.716
DOC_WW_Pin1_4	658	663	PF00397	0.534
DOC_WW_Pin1_4	712	717	PF00397	0.623
DOC_WW_Pin1_4	9	14	PF00397	0.531
LIG_14-3-3_CanoR_1	146	151	PF00244	0.630
LIG_14-3-3_CanoR_1	155	161	PF00244	0.567
LIG_14-3-3_CanoR_1	197	206	PF00244	0.640
LIG_14-3-3_CanoR_1	240	250	PF00244	0.625
LIG_14-3-3_CanoR_1	282	287	PF00244	0.686
LIG_14-3-3_CanoR_1	341	345	PF00244	0.564
LIG_14-3-3_CanoR_1	346	356	PF00244	0.581
LIG_14-3-3_CanoR_1	37	47	PF00244	0.705
LIG_14-3-3_CanoR_1	405	411	PF00244	0.638
LIG_14-3-3_CanoR_1	709	716	PF00244	0.724
LIG_14-3-3_CanoR_1	775	781	PF00244	0.672
LIG_BIR_II_1	1	5	PF00653	0.557
LIG_BRCT_BRCA1_1	206	210	PF00533	0.567
LIG_BRCT_BRCA1_1	538	542	PF00533	0.550
LIG_BRCT_BRCA1_1	655	659	PF00533	0.553
LIG_CtBP_PxDLS_1	407	411	PF00389	0.597
LIG_CtBP_PxDLS_1	621	625	PF00389	0.622
LIG_deltaCOP1_diTrp_1	440	449	PF00928	0.518
LIG_EH1_1	819	827	PF00400	0.524
LIG_FHA_1	15	21	PF00498	0.548
LIG_FHA_1	320	326	PF00498	0.653
LIG_FHA_1	524	530	PF00498	0.658
LIG_FHA_1	615	621	PF00498	0.601
LIG_FHA_1	750	756	PF00498	0.560
LIG_FHA_2	274	280	PF00498	0.602
LIG_FHA_2	374	380	PF00498	0.604
LIG_FHA_2	512	518	PF00498	0.602
LIG_FHA_2	535	541	PF00498	0.516
LIG_FHA_2	676	682	PF00498	0.593
LIG_Integrin_RGD_1	630	632	PF01839	0.591
LIG_Integrin_RGD_1	772	774	PF01839	0.583
LIG_LIR_Apic_2	656	662	PF02991	0.517
LIG_LIR_Gen_1	2	8	PF02991	0.548
LIG_LIR_Gen_1	23	30	PF02991	0.573
LIG_LIR_Gen_1	678	688	PF02991	0.655
LIG_LIR_Nem_3	2	7	PF02991	0.550
LIG_LIR_Nem_3	23	27	PF02991	0.568
LIG_LIR_Nem_3	328	334	PF02991	0.540
LIG_LIR_Nem_3	355	359	PF02991	0.570
LIG_LIR_Nem_3	678	683	PF02991	0.647
LIG_LIR_Nem_3	828	834	PF02991	0.512
LIG_MLH1_MIPbox_1	655	659	PF16413	0.553
LIG_MYND_1	360	364	PF01753	0.559
LIG_MYND_1	618	622	PF01753	0.595
LIG_SH2_STAP1	4	8	PF00017	0.548
LIG_SH2_STAP1	735	739	PF00017	0.616
LIG_SH2_STAT3	45	48	PF00017	0.693
LIG_SH2_STAT5	125	128	PF00017	0.551
LIG_SH2_STAT5	332	335	PF00017	0.599
LIG_SH3_3	354	360	PF00018	0.565
LIG_SH3_3	615	621	PF00018	0.784
LIG_SH3_3	790	796	PF00018	0.593
LIG_SUMO_SIM_par_1	363	368	PF11976	0.616
LIG_TRAF2_1	412	415	PF00917	0.603
LIG_TRAF2_1	425	428	PF00917	0.383
LIG_TRAF2_1	573	576	PF00917	0.468
LIG_WRC_WIRS_1	655	660	PF05994	0.618
LIG_WRC_WIRS_1	817	822	PF05994	0.522
MOD_CDC14_SPxK_1	194	197	PF00782	0.572
MOD_CDK_SPK_2	277	282	PF00069	0.561
MOD_CDK_SPxK_1	191	197	PF00069	0.571
MOD_CDK_SPxK_1	277	283	PF00069	0.539
MOD_CK1_1	123	129	PF00069	0.670
MOD_CK1_1	154	160	PF00069	0.577
MOD_CK1_1	190	196	PF00069	0.685
MOD_CK1_1	285	291	PF00069	0.690
MOD_CK1_1	38	44	PF00069	0.634
MOD_CK1_1	482	488	PF00069	0.656
MOD_CK1_1	508	514	PF00069	0.629
MOD_CK1_1	523	529	PF00069	0.775
MOD_CK1_1	536	542	PF00069	0.534
MOD_CK1_1	559	565	PF00069	0.586
MOD_CK1_1	59	65	PF00069	0.584
MOD_CK1_1	599	605	PF00069	0.707
MOD_CK1_1	623	629	PF00069	0.669
MOD_CK1_1	695	701	PF00069	0.590
MOD_CK1_1	711	717	PF00069	0.651
MOD_CK1_1	749	755	PF00069	0.615
MOD_CK1_1	82	88	PF00069	0.609
MOD_CK1_1	89	95	PF00069	0.619
MOD_CK2_1	373	379	PF00069	0.618
MOD_CK2_1	527	533	PF00069	0.582
MOD_CK2_1	559	565	PF00069	0.541
MOD_CK2_1	675	681	PF00069	0.662
MOD_Cter_Amidation	231	234	PF01082	0.536
MOD_Cter_Amidation	485	488	PF01082	0.575
MOD_GlcNHglycan	104	107	PF01048	0.574
MOD_GlcNHglycan	122	125	PF01048	0.602
MOD_GlcNHglycan	162	166	PF01048	0.630
MOD_GlcNHglycan	169	172	PF01048	0.654
MOD_GlcNHglycan	179	183	PF01048	0.589
MOD_GlcNHglycan	211	214	PF01048	0.721
MOD_GlcNHglycan	227	230	PF01048	0.495
MOD_GlcNHglycan	256	259	PF01048	0.688
MOD_GlcNHglycan	454	457	PF01048	0.638
MOD_GlcNHglycan	481	484	PF01048	0.647
MOD_GlcNHglycan	550	553	PF01048	0.467
MOD_GlcNHglycan	58	61	PF01048	0.688
MOD_GlcNHglycan	608	611	PF01048	0.796
MOD_GlcNHglycan	63	66	PF01048	0.733
MOD_GlcNHglycan	634	637	PF01048	0.573
MOD_GlcNHglycan	645	648	PF01048	0.611
MOD_GlcNHglycan	651	654	PF01048	0.593
MOD_GlcNHglycan	670	673	PF01048	0.445
MOD_GlcNHglycan	711	714	PF01048	0.753
MOD_GlcNHglycan	749	752	PF01048	0.599
MOD_GlcNHglycan	761	764	PF01048	0.637
MOD_GSK3_1	109	116	PF00069	0.802
MOD_GSK3_1	120	127	PF00069	0.573
MOD_GSK3_1	151	158	PF00069	0.628
MOD_GSK3_1	163	170	PF00069	0.670
MOD_GSK3_1	185	192	PF00069	0.667
MOD_GSK3_1	205	212	PF00069	0.714
MOD_GSK3_1	236	243	PF00069	0.598
MOD_GSK3_1	273	280	PF00069	0.678
MOD_GSK3_1	281	288	PF00069	0.798
MOD_GSK3_1	289	296	PF00069	0.631
MOD_GSK3_1	340	347	PF00069	0.606
MOD_GSK3_1	35	42	PF00069	0.583
MOD_GSK3_1	406	413	PF00069	0.700
MOD_GSK3_1	452	459	PF00069	0.599
MOD_GSK3_1	505	512	PF00069	0.619
MOD_GSK3_1	520	527	PF00069	0.575
MOD_GSK3_1	592	599	PF00069	0.649
MOD_GSK3_1	632	639	PF00069	0.541
MOD_GSK3_1	649	656	PF00069	0.674
MOD_GSK3_1	668	675	PF00069	0.412
MOD_GSK3_1	690	697	PF00069	0.696
MOD_GSK3_1	708	715	PF00069	0.529
MOD_GSK3_1	74	81	PF00069	0.621
MOD_GSK3_1	745	752	PF00069	0.599
MOD_GSK3_1	82	89	PF00069	0.712
MOD_N-GLC_1	38	43	PF02516	0.698
MOD_N-GLC_1	690	695	PF02516	0.688
MOD_N-GLC_2	224	226	PF02516	0.567
MOD_N-GLC_2	235	237	PF02516	0.580
MOD_NEK2_1	102	107	PF00069	0.560
MOD_NEK2_1	172	177	PF00069	0.612
MOD_NEK2_1	196	201	PF00069	0.717
MOD_NEK2_1	209	214	PF00069	0.516
MOD_NEK2_1	462	467	PF00069	0.589
MOD_NEK2_1	553	558	PF00069	0.404
MOD_NEK2_1	816	821	PF00069	0.490
MOD_NEK2_1	83	88	PF00069	0.617
MOD_NEK2_2	163	168	PF00069	0.535
MOD_NEK2_2	636	641	PF00069	0.552
MOD_NEK2_2	654	659	PF00069	0.520
MOD_PIKK_1	400	406	PF00454	0.558
MOD_PIKK_1	410	416	PF00454	0.479
MOD_PIKK_1	589	595	PF00454	0.553
MOD_PK_1	282	288	PF00069	0.623
MOD_PK_1	587	593	PF00069	0.470
MOD_PKA_1	240	246	PF00069	0.611
MOD_PKA_1	282	288	PF00069	0.551
MOD_PKA_1	709	715	PF00069	0.699
MOD_PKA_2	109	115	PF00069	0.710
MOD_PKA_2	154	160	PF00069	0.610
MOD_PKA_2	196	202	PF00069	0.634
MOD_PKA_2	235	241	PF00069	0.691
MOD_PKA_2	281	287	PF00069	0.684
MOD_PKA_2	340	346	PF00069	0.550
MOD_PKA_2	506	512	PF00069	0.684
MOD_PKA_2	708	714	PF00069	0.736
MOD_PKA_2	776	782	PF00069	0.719
MOD_PKA_2	83	89	PF00069	0.616
MOD_PKB_1	234	242	PF00069	0.600
MOD_PKB_1	54	62	PF00069	0.692
MOD_PKB_1	723	731	PF00069	0.609
MOD_Plk_1	524	530	PF00069	0.600
MOD_Plk_4	109	115	PF00069	0.576
MOD_Plk_4	163	169	PF00069	0.619
MOD_Plk_4	205	211	PF00069	0.551
MOD_Plk_4	282	288	PF00069	0.575
MOD_Plk_4	327	333	PF00069	0.584
MOD_Plk_4	623	629	PF00069	0.537
MOD_Plk_4	654	660	PF00069	0.547
MOD_Plk_4	776	782	PF00069	0.669
MOD_Plk_4	816	822	PF00069	0.496
MOD_ProDKin_1	157	163	PF00069	0.617
MOD_ProDKin_1	191	197	PF00069	0.709
MOD_ProDKin_1	277	283	PF00069	0.733
MOD_ProDKin_1	59	65	PF00069	0.633
MOD_ProDKin_1	592	598	PF00069	0.564
MOD_ProDKin_1	614	620	PF00069	0.718
MOD_ProDKin_1	658	664	PF00069	0.531
MOD_ProDKin_1	712	718	PF00069	0.626
MOD_ProDKin_1	9	15	PF00069	0.530
MOD_SUMO_for_1	437	440	PF00179	0.537
MOD_SUMO_rev_2	395	403	PF00179	0.587
MOD_SUMO_rev_2	562	571	PF00179	0.550
MOD_SUMO_rev_2	732	742	PF00179	0.613
TRG_DiLeu_BaEn_4	78	84	PF01217	0.546
TRG_ENDOCYTIC_2	134	137	PF00928	0.550
TRG_ENDOCYTIC_2	331	334	PF00928	0.669
TRG_ENDOCYTIC_2	4	7	PF00928	0.551
TRG_ENDOCYTIC_2	432	435	PF00928	0.450
TRG_ER_diArg_1	130	133	PF00400	0.577
TRG_ER_diArg_1	233	236	PF00400	0.596
TRG_ER_diArg_1	281	283	PF00400	0.545
TRG_ER_diArg_1	303	306	PF00400	0.639
TRG_ER_diArg_1	430	432	PF00400	0.460
TRG_ER_diArg_1	443	445	PF00400	0.528
TRG_ER_diArg_1	487	490	PF00400	0.691
TRG_ER_diArg_1	497	500	PF00400	0.606
TRG_ER_diArg_1	628	630	PF00400	0.772
TRG_ER_diArg_1	723	725	PF00400	0.631
TRG_ER_diArg_1	93	96	PF00400	0.597
TRG_NES_CRM1_1	811	823	PF08389	0.704
TRG_NLS_MonoCore_2	766	771	PF00514	0.671
TRG_NLS_MonoExtC_3	766	771	PF00514	0.595
TRG_NLS_MonoExtN_4	765	772	PF00514	0.600
TRG_Pf-PMV_PEXEL_1	375	379	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	475	479	PF00026	0.655
TRG_Pf-PMV_PEXEL_1	545	550	PF00026	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I487	Leptomonas seymouri	37%	95%
A0A3Q8IKF4	Leishmania donovani	99%	100%
A4HLX9	Leishmania braziliensis	63%	99%
E9B4A8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q3R8	Leishmania major	86%	100%