LeishMANIAdb
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TMF_TATA_bd domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
TMF_TATA_bd domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I9A7_LEIIN
TriTrypDb:
LINF_330036000
Length:
1228

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0005794 Golgi apparatus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I9A7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9A7

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 4 1
GO:0006996 organelle organization 4 1
GO:0007030 Golgi organization 5 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0016192 vesicle-mediated transport 4 1
GO:0046907 intracellular transport 3 1
GO:0048193 Golgi vesicle transport 5 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0071840 cellular component organization or biogenesis 2 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0019899 enzyme binding 3 1
GO:0031267 small GTPase binding 5 1
GO:0051020 GTPase binding 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 1170 1174 PF00656 0.673
CLV_C14_Caspase3-7 333 337 PF00656 0.613
CLV_C14_Caspase3-7 35 39 PF00656 0.685
CLV_C14_Caspase3-7 893 897 PF00656 0.552
CLV_MEL_PAP_1 367 373 PF00089 0.566
CLV_NRD_NRD_1 1012 1014 PF00675 0.662
CLV_NRD_NRD_1 1044 1046 PF00675 0.663
CLV_NRD_NRD_1 1050 1052 PF00675 0.648
CLV_NRD_NRD_1 1088 1090 PF00675 0.674
CLV_NRD_NRD_1 1136 1138 PF00675 0.750
CLV_NRD_NRD_1 1225 1227 PF00675 0.623
CLV_NRD_NRD_1 25 27 PF00675 0.595
CLV_NRD_NRD_1 456 458 PF00675 0.610
CLV_NRD_NRD_1 524 526 PF00675 0.500
CLV_NRD_NRD_1 551 553 PF00675 0.697
CLV_NRD_NRD_1 785 787 PF00675 0.690
CLV_NRD_NRD_1 857 859 PF00675 0.519
CLV_NRD_NRD_1 92 94 PF00675 0.734
CLV_PCSK_KEX2_1 1012 1014 PF00082 0.665
CLV_PCSK_KEX2_1 1071 1073 PF00082 0.726
CLV_PCSK_KEX2_1 1136 1138 PF00082 0.750
CLV_PCSK_KEX2_1 1225 1227 PF00082 0.623
CLV_PCSK_KEX2_1 25 27 PF00082 0.595
CLV_PCSK_KEX2_1 456 458 PF00082 0.546
CLV_PCSK_KEX2_1 631 633 PF00082 0.510
CLV_PCSK_KEX2_1 662 664 PF00082 0.584
CLV_PCSK_KEX2_1 707 709 PF00082 0.556
CLV_PCSK_KEX2_1 785 787 PF00082 0.690
CLV_PCSK_KEX2_1 857 859 PF00082 0.538
CLV_PCSK_KEX2_1 92 94 PF00082 0.734
CLV_PCSK_KEX2_1 986 988 PF00082 0.541
CLV_PCSK_PC1ET2_1 1071 1073 PF00082 0.665
CLV_PCSK_PC1ET2_1 631 633 PF00082 0.510
CLV_PCSK_PC1ET2_1 662 664 PF00082 0.564
CLV_PCSK_PC1ET2_1 707 709 PF00082 0.556
CLV_PCSK_PC1ET2_1 986 988 PF00082 0.541
CLV_PCSK_PC7_1 1132 1138 PF00082 0.768
CLV_PCSK_SKI1_1 1051 1055 PF00082 0.726
CLV_PCSK_SKI1_1 1137 1141 PF00082 0.754
CLV_PCSK_SKI1_1 347 351 PF00082 0.590
CLV_PCSK_SKI1_1 361 365 PF00082 0.472
CLV_PCSK_SKI1_1 586 590 PF00082 0.616
CLV_PCSK_SKI1_1 594 598 PF00082 0.499
CLV_PCSK_SKI1_1 626 630 PF00082 0.597
CLV_PCSK_SKI1_1 632 636 PF00082 0.523
CLV_PCSK_SKI1_1 889 893 PF00082 0.559
DEG_Nend_Nbox_1 1 3 PF02207 0.651
DEG_SCF_FBW7_1 405 412 PF00400 0.741
DEG_SPOP_SBC_1 1189 1193 PF00917 0.698
DEG_SPOP_SBC_1 212 216 PF00917 0.656
DEG_SPOP_SBC_1 539 543 PF00917 0.504
DOC_CKS1_1 127 132 PF01111 0.590
DOC_CKS1_1 264 269 PF01111 0.730
DOC_CKS1_1 87 92 PF01111 0.604
DOC_CYCLIN_RxL_1 623 633 PF00134 0.536
DOC_MAPK_DCC_7 816 824 PF00069 0.563
DOC_MAPK_gen_1 56 63 PF00069 0.698
DOC_MAPK_gen_1 876 883 PF00069 0.595
DOC_MAPK_MEF2A_6 751 759 PF00069 0.569
DOC_MAPK_MEF2A_6 816 824 PF00069 0.563
DOC_PP1_RVXF_1 1156 1163 PF00149 0.566
DOC_PP2B_LxvP_1 230 233 PF13499 0.685
DOC_PP2B_LxvP_1 255 258 PF13499 0.706
DOC_PP4_FxxP_1 1207 1210 PF00568 0.789
DOC_PP4_FxxP_1 244 247 PF00568 0.611
DOC_USP7_MATH_1 109 113 PF00917 0.706
DOC_USP7_MATH_1 1176 1180 PF00917 0.763
DOC_USP7_MATH_1 1183 1187 PF00917 0.702
DOC_USP7_MATH_1 119 123 PF00917 0.621
DOC_USP7_MATH_1 1201 1205 PF00917 0.560
DOC_USP7_MATH_1 128 132 PF00917 0.573
DOC_USP7_MATH_1 199 203 PF00917 0.671
DOC_USP7_MATH_1 220 224 PF00917 0.759
DOC_USP7_MATH_1 247 251 PF00917 0.697
DOC_USP7_MATH_1 275 279 PF00917 0.486
DOC_USP7_MATH_1 330 334 PF00917 0.538
DOC_USP7_MATH_1 555 559 PF00917 0.744
DOC_USP7_MATH_1 562 566 PF00917 0.599
DOC_USP7_MATH_1 729 733 PF00917 0.665
DOC_USP7_UBL2_3 1052 1056 PF12436 0.672
DOC_WW_Pin1_4 1206 1211 PF00397 0.658
DOC_WW_Pin1_4 126 131 PF00397 0.698
DOC_WW_Pin1_4 133 138 PF00397 0.700
DOC_WW_Pin1_4 15 20 PF00397 0.696
DOC_WW_Pin1_4 171 176 PF00397 0.674
DOC_WW_Pin1_4 214 219 PF00397 0.752
DOC_WW_Pin1_4 233 238 PF00397 0.545
DOC_WW_Pin1_4 243 248 PF00397 0.611
DOC_WW_Pin1_4 263 268 PF00397 0.791
DOC_WW_Pin1_4 405 410 PF00397 0.870
DOC_WW_Pin1_4 86 91 PF00397 0.600
LIG_14-3-3_CanoR_1 1072 1081 PF00244 0.615
LIG_14-3-3_CanoR_1 120 125 PF00244 0.652
LIG_14-3-3_CanoR_1 213 218 PF00244 0.765
LIG_14-3-3_CanoR_1 361 371 PF00244 0.470
LIG_14-3-3_CanoR_1 382 386 PF00244 0.595
LIG_14-3-3_CanoR_1 423 431 PF00244 0.610
LIG_14-3-3_CanoR_1 456 460 PF00244 0.548
LIG_14-3-3_CanoR_1 594 603 PF00244 0.545
LIG_14-3-3_CanoR_1 764 768 PF00244 0.651
LIG_14-3-3_CanoR_1 92 101 PF00244 0.698
LIG_14-3-3_CterR_2 1225 1228 PF00244 0.737
LIG_Actin_WH2_2 367 384 PF00022 0.563
LIG_BRCT_BRCA1_1 1203 1207 PF00533 0.797
LIG_deltaCOP1_diTrp_1 4 12 PF00928 0.604
LIG_deltaCOP1_diTrp_1 417 422 PF00928 0.558
LIG_FAT_LD_1 755 763 PF03623 0.575
LIG_FHA_1 1185 1191 PF00498 0.682
LIG_FHA_1 201 207 PF00498 0.555
LIG_FHA_1 4 10 PF00498 0.602
LIG_FHA_1 409 415 PF00498 0.621
LIG_FHA_1 42 48 PF00498 0.618
LIG_FHA_1 437 443 PF00498 0.575
LIG_FHA_1 444 450 PF00498 0.476
LIG_FHA_1 752 758 PF00498 0.516
LIG_FHA_1 828 834 PF00498 0.583
LIG_FHA_2 172 178 PF00498 0.745
LIG_FHA_2 363 369 PF00498 0.564
LIG_FHA_2 653 659 PF00498 0.539
LIG_FHA_2 677 683 PF00498 0.578
LIG_FHA_2 723 729 PF00498 0.581
LIG_FHA_2 789 795 PF00498 0.644
LIG_FHA_2 933 939 PF00498 0.615
LIG_FHA_2 951 957 PF00498 0.672
LIG_HCF-1_HBM_1 611 614 PF13415 0.616
LIG_LIR_Apic_2 1204 1210 PF02991 0.797
LIG_LIR_Apic_2 243 247 PF02991 0.611
LIG_LIR_Gen_1 1157 1164 PF02991 0.631
LIG_LIR_Gen_1 129 140 PF02991 0.671
LIG_LIR_Gen_1 869 877 PF02991 0.470
LIG_LIR_Nem_3 1109 1115 PF02991 0.653
LIG_LIR_Nem_3 1157 1162 PF02991 0.631
LIG_LIR_Nem_3 129 135 PF02991 0.671
LIG_LIR_Nem_3 368 374 PF02991 0.453
LIG_LIR_Nem_3 869 874 PF02991 0.583
LIG_NRBOX 1098 1104 PF00104 0.555
LIG_NRBOX 823 829 PF00104 0.608
LIG_PCNA_yPIPBox_3 901 913 PF02747 0.533
LIG_Pex14_1 849 853 PF04695 0.610
LIG_RPA_C_Fungi 115 127 PF08784 0.656
LIG_SH2_NCK_1 118 122 PF00017 0.755
LIG_SH2_NCK_1 614 618 PF00017 0.549
LIG_SH2_PTP2 1112 1115 PF00017 0.610
LIG_SH2_STAP1 317 321 PF00017 0.549
LIG_SH2_STAT5 1112 1115 PF00017 0.610
LIG_SH3_2 137 142 PF14604 0.542
LIG_SH3_3 1116 1122 PF00018 0.790
LIG_SH3_3 124 130 PF00018 0.688
LIG_SH3_3 134 140 PF00018 0.610
LIG_SH3_3 261 267 PF00018 0.737
LIG_SUMO_SIM_anti_2 737 742 PF11976 0.541
LIG_SUMO_SIM_anti_2 754 760 PF11976 0.393
LIG_SUMO_SIM_par_1 901 907 PF11976 0.543
LIG_TRAF2_1 1108 1111 PF00917 0.627
LIG_TRAF2_1 158 161 PF00917 0.599
LIG_TRAF2_1 485 488 PF00917 0.504
LIG_TRAF2_1 567 570 PF00917 0.592
LIG_TRAF2_1 645 648 PF00917 0.570
LIG_TRAF2_1 946 949 PF00917 0.611
LIG_TRAF2_1 960 963 PF00917 0.592
LIG_WRC_WIRS_1 9 14 PF05994 0.553
MOD_CDC14_SPxK_1 246 249 PF00782 0.594
MOD_CDK_SPxK_1 243 249 PF00069 0.597
MOD_CDK_SPxK_1 86 92 PF00069 0.601
MOD_CDK_SPxxK_3 135 142 PF00069 0.542
MOD_CDK_SPxxK_3 86 93 PF00069 0.604
MOD_CK1_1 1065 1071 PF00069 0.686
MOD_CK1_1 1167 1173 PF00069 0.731
MOD_CK1_1 1188 1194 PF00069 0.766
MOD_CK1_1 1206 1212 PF00069 0.582
MOD_CK1_1 122 128 PF00069 0.748
MOD_CK1_1 131 137 PF00069 0.657
MOD_CK1_1 188 194 PF00069 0.800
MOD_CK1_1 200 206 PF00069 0.670
MOD_CK1_1 235 241 PF00069 0.706
MOD_CK1_1 243 249 PF00069 0.648
MOD_CK1_1 403 409 PF00069 0.787
MOD_CK1_1 558 564 PF00069 0.686
MOD_CK1_1 732 738 PF00069 0.531
MOD_CK1_1 942 948 PF00069 0.443
MOD_CK1_1 96 102 PF00069 0.615
MOD_CK1_1 968 974 PF00069 0.462
MOD_CK2_1 171 177 PF00069 0.734
MOD_CK2_1 362 368 PF00069 0.563
MOD_CK2_1 630 636 PF00069 0.568
MOD_CK2_1 652 658 PF00069 0.569
MOD_CK2_1 676 682 PF00069 0.576
MOD_CK2_1 722 728 PF00069 0.583
MOD_CK2_1 788 794 PF00069 0.641
MOD_CK2_1 8 14 PF00069 0.552
MOD_CK2_1 82 88 PF00069 0.646
MOD_CK2_1 932 938 PF00069 0.619
MOD_CK2_1 943 949 PF00069 0.484
MOD_CK2_1 994 1000 PF00069 0.609
MOD_CMANNOS 2 5 PF00535 0.545
MOD_GlcNHglycan 1099 1102 PF01048 0.614
MOD_GlcNHglycan 1144 1147 PF01048 0.815
MOD_GlcNHglycan 1168 1172 PF01048 0.732
MOD_GlcNHglycan 1187 1190 PF01048 0.532
MOD_GlcNHglycan 1192 1195 PF01048 0.634
MOD_GlcNHglycan 124 127 PF01048 0.758
MOD_GlcNHglycan 191 194 PF01048 0.741
MOD_GlcNHglycan 199 202 PF01048 0.753
MOD_GlcNHglycan 230 233 PF01048 0.716
MOD_GlcNHglycan 237 240 PF01048 0.609
MOD_GlcNHglycan 249 252 PF01048 0.593
MOD_GlcNHglycan 332 335 PF01048 0.645
MOD_GlcNHglycan 402 405 PF01048 0.766
MOD_GlcNHglycan 479 483 PF01048 0.576
MOD_GlcNHglycan 511 515 PF01048 0.504
MOD_GlcNHglycan 553 556 PF01048 0.755
MOD_GlcNHglycan 557 560 PF01048 0.737
MOD_GlcNHglycan 564 567 PF01048 0.587
MOD_GlcNHglycan 686 689 PF01048 0.538
MOD_GlcNHglycan 73 76 PF01048 0.739
MOD_GlcNHglycan 794 798 PF01048 0.720
MOD_GlcNHglycan 82 85 PF01048 0.702
MOD_GlcNHglycan 896 899 PF01048 0.545
MOD_GSK3_1 1181 1188 PF00069 0.804
MOD_GSK3_1 122 129 PF00069 0.691
MOD_GSK3_1 131 138 PF00069 0.707
MOD_GSK3_1 171 178 PF00069 0.729
MOD_GSK3_1 185 192 PF00069 0.637
MOD_GSK3_1 228 235 PF00069 0.723
MOD_GSK3_1 243 250 PF00069 0.528
MOD_GSK3_1 324 331 PF00069 0.550
MOD_GSK3_1 393 400 PF00069 0.623
MOD_GSK3_1 4 11 PF00069 0.538
MOD_GSK3_1 405 412 PF00069 0.664
MOD_GSK3_1 540 547 PF00069 0.683
MOD_GSK3_1 551 558 PF00069 0.618
MOD_GSK3_1 594 601 PF00069 0.431
MOD_GSK3_1 676 683 PF00069 0.464
MOD_GSK3_1 730 737 PF00069 0.514
MOD_GSK3_1 82 89 PF00069 0.668
MOD_GSK3_1 823 830 PF00069 0.642
MOD_GSK3_1 890 897 PF00069 0.555
MOD_GSK3_1 939 946 PF00069 0.502
MOD_GSK3_1 965 972 PF00069 0.480
MOD_N-GLC_1 1176 1181 PF02516 0.732
MOD_N-GLC_1 472 477 PF02516 0.473
MOD_N-GLC_1 859 864 PF02516 0.602
MOD_NEK2_1 1054 1059 PF00069 0.707
MOD_NEK2_1 1190 1195 PF00069 0.646
MOD_NEK2_1 189 194 PF00069 0.610
MOD_NEK2_1 381 386 PF00069 0.643
MOD_NEK2_1 965 970 PF00069 0.676
MOD_PIKK_1 1072 1078 PF00454 0.649
MOD_PIKK_1 1106 1112 PF00454 0.641
MOD_PIKK_1 1127 1133 PF00454 0.718
MOD_PIKK_1 1196 1202 PF00454 0.783
MOD_PIKK_1 156 162 PF00454 0.673
MOD_PIKK_1 220 226 PF00454 0.709
MOD_PIKK_1 266 272 PF00454 0.748
MOD_PIKK_1 275 281 PF00454 0.607
MOD_PIKK_1 437 443 PF00454 0.623
MOD_PIKK_1 598 604 PF00454 0.433
MOD_PIKK_1 652 658 PF00454 0.483
MOD_PIKK_1 680 686 PF00454 0.479
MOD_PIKK_1 739 745 PF00454 0.517
MOD_PIKK_1 93 99 PF00454 0.664
MOD_PIKK_1 994 1000 PF00454 0.609
MOD_PK_1 120 126 PF00069 0.652
MOD_PK_1 730 736 PF00069 0.455
MOD_PKA_1 25 31 PF00069 0.597
MOD_PKA_2 119 125 PF00069 0.662
MOD_PKA_2 212 218 PF00069 0.759
MOD_PKA_2 24 30 PF00069 0.626
MOD_PKA_2 381 387 PF00069 0.571
MOD_PKA_2 422 428 PF00069 0.533
MOD_PKA_2 455 461 PF00069 0.552
MOD_PKA_2 551 557 PF00069 0.693
MOD_PKA_2 64 70 PF00069 0.708
MOD_PKA_2 722 728 PF00069 0.574
MOD_PKA_2 763 769 PF00069 0.651
MOD_Plk_1 1038 1044 PF00069 0.617
MOD_Plk_1 1065 1071 PF00069 0.657
MOD_Plk_1 180 186 PF00069 0.734
MOD_Plk_1 275 281 PF00069 0.517
MOD_Plk_1 310 316 PF00069 0.468
MOD_Plk_1 510 516 PF00069 0.373
MOD_Plk_1 730 736 PF00069 0.531
MOD_Plk_1 849 855 PF00069 0.609
MOD_Plk_1 859 865 PF00069 0.467
MOD_Plk_1 879 885 PF00069 0.328
MOD_Plk_2-3 630 636 PF00069 0.431
MOD_Plk_2-3 879 885 PF00069 0.599
MOD_Plk_2-3 950 956 PF00069 0.610
MOD_Plk_2-3 991 997 PF00069 0.612
MOD_Plk_4 128 134 PF00069 0.700
MOD_Plk_4 766 772 PF00069 0.650
MOD_Plk_4 834 840 PF00069 0.600
MOD_ProDKin_1 1206 1212 PF00069 0.657
MOD_ProDKin_1 126 132 PF00069 0.701
MOD_ProDKin_1 133 139 PF00069 0.699
MOD_ProDKin_1 15 21 PF00069 0.704
MOD_ProDKin_1 171 177 PF00069 0.676
MOD_ProDKin_1 214 220 PF00069 0.749
MOD_ProDKin_1 233 239 PF00069 0.544
MOD_ProDKin_1 243 249 PF00069 0.613
MOD_ProDKin_1 263 269 PF00069 0.791
MOD_ProDKin_1 405 411 PF00069 0.870
MOD_ProDKin_1 86 92 PF00069 0.601
MOD_SUMO_for_1 357 360 PF00179 0.505
MOD_SUMO_for_1 502 505 PF00179 0.550
MOD_SUMO_for_1 744 747 PF00179 0.541
MOD_SUMO_for_1 883 886 PF00179 0.604
MOD_SUMO_for_1 960 963 PF00179 0.614
MOD_SUMO_rev_2 458 463 PF00179 0.555
MOD_SUMO_rev_2 726 732 PF00179 0.635
MOD_SUMO_rev_2 747 752 PF00179 0.537
TRG_DiLeu_BaEn_1 1111 1116 PF01217 0.672
TRG_DiLeu_BaEn_1 973 978 PF01217 0.537
TRG_DiLeu_BaEn_4 426 432 PF01217 0.563
TRG_DiLeu_BaEn_4 570 576 PF01217 0.597
TRG_DiLeu_BaEn_4 949 955 PF01217 0.611
TRG_DiLeu_BaLyEn_6 817 822 PF01217 0.676
TRG_ENDOCYTIC_2 1112 1115 PF00928 0.610
TRG_ER_diArg_1 1012 1015 PF00400 0.667
TRG_ER_diArg_1 455 457 PF00400 0.609
TRG_ER_diArg_1 572 575 PF00400 0.664
TRG_ER_diArg_1 721 724 PF00400 0.577
TRG_ER_diArg_1 785 787 PF00400 0.611
TRG_ER_diArg_1 857 859 PF00400 0.519
TRG_ER_diArg_1 92 94 PF00400 0.734
TRG_NES_CRM1_1 747 760 PF08389 0.594
TRG_Pf-PMV_PEXEL_1 1006 1010 PF00026 0.558
TRG_Pf-PMV_PEXEL_1 1012 1016 PF00026 0.515
TRG_Pf-PMV_PEXEL_1 1045 1049 PF00026 0.598
TRG_Pf-PMV_PEXEL_1 594 598 PF00026 0.607
TRG_Pf-PMV_PEXEL_1 626 630 PF00026 0.533
TRG_Pf-PMV_PEXEL_1 707 711 PF00026 0.558
TRG_Pf-PMV_PEXEL_1 92 97 PF00026 0.730

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IGT3 Leishmania donovani 99% 100%
A4HLX8 Leishmania braziliensis 55% 96%
E9B4A7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%
Q4Q3R9 Leishmania major 85% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS