CCHC-type domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I9A6_LEIIN

TriTrypDb:

LINF_330035900

Length:

914

Annotations

Annotations by Jardim et al.

Nucleic acid binding, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I9A6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9A6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0005488	binding	1	7
GO:0008270	zinc ion binding	6	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	357	361	PF00656	0.622
CLV_C14_Caspase3-7	640	644	PF00656	0.664
CLV_C14_Caspase3-7	65	69	PF00656	0.521
CLV_C14_Caspase3-7	909	913	PF00656	0.594
CLV_NRD_NRD_1	125	127	PF00675	0.649
CLV_NRD_NRD_1	307	309	PF00675	0.462
CLV_NRD_NRD_1	471	473	PF00675	0.538
CLV_NRD_NRD_1	521	523	PF00675	0.619
CLV_NRD_NRD_1	665	667	PF00675	0.485
CLV_NRD_NRD_1	723	725	PF00675	0.578
CLV_NRD_NRD_1	730	732	PF00675	0.572
CLV_NRD_NRD_1	760	762	PF00675	0.619
CLV_NRD_NRD_1	833	835	PF00675	0.542
CLV_NRD_NRD_1	842	844	PF00675	0.439
CLV_NRD_NRD_1	855	857	PF00675	0.565
CLV_NRD_NRD_1	896	898	PF00675	0.668
CLV_NRD_NRD_1	900	902	PF00675	0.689
CLV_PCSK_FUR_1	897	901	PF00082	0.605
CLV_PCSK_KEX2_1	124	126	PF00082	0.640
CLV_PCSK_KEX2_1	307	309	PF00082	0.418
CLV_PCSK_KEX2_1	471	473	PF00082	0.511
CLV_PCSK_KEX2_1	521	523	PF00082	0.619
CLV_PCSK_KEX2_1	665	667	PF00082	0.486
CLV_PCSK_KEX2_1	730	732	PF00082	0.609
CLV_PCSK_KEX2_1	760	762	PF00082	0.619
CLV_PCSK_KEX2_1	833	835	PF00082	0.499
CLV_PCSK_KEX2_1	842	844	PF00082	0.422
CLV_PCSK_KEX2_1	896	898	PF00082	0.680
CLV_PCSK_KEX2_1	899	901	PF00082	0.686
CLV_PCSK_PC7_1	896	902	PF00082	0.613
CLV_PCSK_SKI1_1	221	225	PF00082	0.460
CLV_PCSK_SKI1_1	290	294	PF00082	0.478
CLV_PCSK_SKI1_1	379	383	PF00082	0.583
CLV_PCSK_SKI1_1	567	571	PF00082	0.541
CLV_PCSK_SKI1_1	876	880	PF00082	0.633
DEG_APCC_DBOX_1	284	292	PF00400	0.488
DEG_APCC_DBOX_1	56	64	PF00400	0.610
DEG_Nend_Nbox_1	1	3	PF02207	0.487
DEG_SPOP_SBC_1	276	280	PF00917	0.486
DEG_SPOP_SBC_1	770	774	PF00917	0.619
DOC_ANK_TNKS_1	201	208	PF00023	0.475
DOC_ANK_TNKS_1	521	528	PF00023	0.629
DOC_CDC14_PxL_1	388	396	PF14671	0.605
DOC_CYCLIN_RxL_1	285	297	PF00134	0.480
DOC_CYCLIN_yCln2_LP_2	382	388	PF00134	0.588
DOC_MAPK_gen_1	132	140	PF00069	0.539
DOC_MAPK_gen_1	800	808	PF00069	0.479
DOC_MAPK_gen_1	896	906	PF00069	0.625
DOC_MAPK_MEF2A_6	800	808	PF00069	0.479
DOC_MAPK_MEF2A_6	94	103	PF00069	0.487
DOC_PP2B_LxvP_1	103	106	PF13499	0.525
DOC_PP2B_LxvP_1	410	413	PF13499	0.556
DOC_PP2B_LxvP_1	614	617	PF13499	0.675
DOC_PP4_FxxP_1	329	332	PF00568	0.622
DOC_PP4_FxxP_1	64	67	PF00568	0.562
DOC_USP7_MATH_1	276	280	PF00917	0.633
DOC_USP7_MATH_1	330	334	PF00917	0.636
DOC_USP7_MATH_1	369	373	PF00917	0.616
DOC_USP7_MATH_1	406	410	PF00917	0.643
DOC_USP7_MATH_1	526	530	PF00917	0.806
DOC_USP7_MATH_1	541	545	PF00917	0.546
DOC_USP7_MATH_1	684	688	PF00917	0.647
DOC_USP7_MATH_1	718	722	PF00917	0.583
DOC_USP7_MATH_1	752	756	PF00917	0.549
DOC_USP7_MATH_1	779	783	PF00917	0.599
DOC_USP7_MATH_1	820	824	PF00917	0.478
DOC_WW_Pin1_4	143	148	PF00397	0.589
DOC_WW_Pin1_4	254	259	PF00397	0.596
DOC_WW_Pin1_4	477	482	PF00397	0.452
DOC_WW_Pin1_4	512	517	PF00397	0.530
DOC_WW_Pin1_4	537	542	PF00397	0.575
DOC_WW_Pin1_4	624	629	PF00397	0.572
DOC_WW_Pin1_4	68	73	PF00397	0.666
DOC_WW_Pin1_4	766	771	PF00397	0.615
DOC_WW_Pin1_4	775	780	PF00397	0.567
DOC_WW_Pin1_4	856	861	PF00397	0.595
LIG_14-3-3_CanoR_1	124	129	PF00244	0.781
LIG_14-3-3_CanoR_1	132	137	PF00244	0.487
LIG_14-3-3_CanoR_1	141	146	PF00244	0.384
LIG_14-3-3_CanoR_1	219	228	PF00244	0.449
LIG_14-3-3_CanoR_1	290	299	PF00244	0.454
LIG_14-3-3_CanoR_1	375	382	PF00244	0.625
LIG_14-3-3_CanoR_1	472	482	PF00244	0.542
LIG_14-3-3_CanoR_1	59	64	PF00244	0.549
LIG_14-3-3_CanoR_1	7	13	PF00244	0.616
LIG_14-3-3_CanoR_1	741	750	PF00244	0.544
LIG_14-3-3_CanoR_1	821	828	PF00244	0.514
LIG_14-3-3_CanoR_1	876	885	PF00244	0.626
LIG_14-3-3_CanoR_1	899	905	PF00244	0.614
LIG_14-3-3_CanoR_1	98	104	PF00244	0.481
LIG_Actin_WH2_2	165	181	PF00022	0.537
LIG_Actin_WH2_2	205	223	PF00022	0.450
LIG_Actin_WH2_2	284	302	PF00022	0.533
LIG_Actin_WH2_2	563	581	PF00022	0.567
LIG_BRCT_BRCA1_1	136	140	PF00533	0.418
LIG_BRCT_BRCA1_1	258	262	PF00533	0.558
LIG_BRCT_BRCA1_1	691	695	PF00533	0.656
LIG_BRCT_BRCA1_1	75	79	PF00533	0.651
LIG_CSL_BTD_1	860	863	PF09270	0.577
LIG_FHA_1	376	382	PF00498	0.774
LIG_FHA_1	792	798	PF00498	0.496
LIG_FHA_1	900	906	PF00498	0.565
LIG_FHA_2	158	164	PF00498	0.494
LIG_FHA_2	222	228	PF00498	0.508
LIG_FHA_2	318	324	PF00498	0.527
LIG_FHA_2	526	532	PF00498	0.634
LIG_FHA_2	555	561	PF00498	0.621
LIG_FHA_2	646	652	PF00498	0.496
LIG_LIR_Apic_2	62	67	PF02991	0.604
LIG_LIR_Nem_3	137	143	PF02991	0.442
LIG_LIR_Nem_3	859	864	PF02991	0.598
LIG_MYND_1	91	95	PF01753	0.496
LIG_PCNA_yPIPBox_3	27	40	PF02747	0.460
LIG_RPA_C_Fungi	707	719	PF08784	0.602
LIG_SH2_NCK_1	482	486	PF00017	0.429
LIG_SH2_STAP1	310	314	PF00017	0.431
LIG_SH2_STAP1	440	444	PF00017	0.502
LIG_SH2_STAP1	482	486	PF00017	0.442
LIG_SH2_STAT3	348	351	PF00017	0.521
LIG_SH2_STAT5	184	187	PF00017	0.559
LIG_SH2_STAT5	376	379	PF00017	0.576
LIG_SH2_STAT5	39	42	PF00017	0.524
LIG_SH2_STAT5	582	585	PF00017	0.479
LIG_SH2_STAT5	737	740	PF00017	0.470
LIG_SH2_STAT5	798	801	PF00017	0.539
LIG_SH3_1	857	863	PF00018	0.571
LIG_SH3_3	117	123	PF00018	0.652
LIG_SH3_3	125	131	PF00018	0.591
LIG_SH3_3	226	232	PF00018	0.440
LIG_SH3_3	255	261	PF00018	0.552
LIG_SH3_3	324	330	PF00018	0.599
LIG_SH3_3	475	481	PF00018	0.549
LIG_SH3_3	508	514	PF00018	0.579
LIG_SH3_3	622	628	PF00018	0.643
LIG_SH3_3	694	700	PF00018	0.593
LIG_SH3_3	832	838	PF00018	0.475
LIG_SH3_3	857	863	PF00018	0.571
LIG_SUMO_SIM_anti_2	433	439	PF11976	0.450
LIG_SUMO_SIM_anti_2	599	607	PF11976	0.560
LIG_SUMO_SIM_par_1	141	146	PF11976	0.488
LIG_SUMO_SIM_par_1	311	317	PF11976	0.465
LIG_SUMO_SIM_par_1	433	439	PF11976	0.450
LIG_TRAF2_1	193	196	PF00917	0.406
LIG_TRAF2_1	224	227	PF00917	0.443
LIG_TRAF2_1	485	488	PF00917	0.657
LIG_TRAF2_1	848	851	PF00917	0.488
LIG_UBA3_1	786	790	PF00899	0.366
MOD_CDC14_SPxK_1	778	781	PF00782	0.546
MOD_CDK_SPK_2	143	148	PF00069	0.589
MOD_CDK_SPxK_1	775	781	PF00069	0.557
MOD_CK1_1	254	260	PF00069	0.602
MOD_CK1_1	278	284	PF00069	0.671
MOD_CK1_1	294	300	PF00069	0.402
MOD_CK1_1	436	442	PF00069	0.599
MOD_CK1_1	461	467	PF00069	0.635
MOD_CK1_1	515	521	PF00069	0.569
MOD_CK1_1	540	546	PF00069	0.629
MOD_CK1_1	62	68	PF00069	0.601
MOD_CK1_1	627	633	PF00069	0.789
MOD_CK1_1	689	695	PF00069	0.608
MOD_CK1_1	769	775	PF00069	0.627
MOD_CK2_1	162	168	PF00069	0.494
MOD_CK2_1	221	227	PF00069	0.445
MOD_CK2_1	317	323	PF00069	0.665
MOD_CK2_1	448	454	PF00069	0.665
MOD_CK2_1	525	531	PF00069	0.632
MOD_CK2_1	554	560	PF00069	0.639
MOD_CK2_1	752	758	PF00069	0.598
MOD_Cter_Amidation	897	900	PF01082	0.584
MOD_GlcNHglycan	221	224	PF01048	0.448
MOD_GlcNHglycan	280	283	PF01048	0.751
MOD_GlcNHglycan	402	405	PF01048	0.574
MOD_GlcNHglycan	410	413	PF01048	0.651
MOD_GlcNHglycan	450	453	PF01048	0.528
MOD_GlcNHglycan	460	463	PF01048	0.581
MOD_GlcNHglycan	49	52	PF01048	0.590
MOD_GlcNHglycan	631	634	PF01048	0.579
MOD_GlcNHglycan	64	67	PF01048	0.502
MOD_GlcNHglycan	648	651	PF01048	0.396
MOD_GlcNHglycan	683	687	PF01048	0.646
MOD_GlcNHglycan	691	694	PF01048	0.573
MOD_GlcNHglycan	75	78	PF01048	0.566
MOD_GlcNHglycan	781	784	PF01048	0.704
MOD_GlcNHglycan	822	825	PF01048	0.598
MOD_GSK3_1	157	164	PF00069	0.570
MOD_GSK3_1	252	259	PF00069	0.541
MOD_GSK3_1	272	279	PF00069	0.612
MOD_GSK3_1	291	298	PF00069	0.320
MOD_GSK3_1	370	377	PF00069	0.721
MOD_GSK3_1	473	480	PF00069	0.616
MOD_GSK3_1	490	497	PF00069	0.556
MOD_GSK3_1	537	544	PF00069	0.649
MOD_GSK3_1	55	62	PF00069	0.580
MOD_GSK3_1	620	627	PF00069	0.710
MOD_GSK3_1	637	644	PF00069	0.612
MOD_GSK3_1	682	689	PF00069	0.589
MOD_GSK3_1	742	749	PF00069	0.534
MOD_GSK3_1	766	773	PF00069	0.634
MOD_GSK3_1	775	782	PF00069	0.766
MOD_GSK3_1	906	913	PF00069	0.601
MOD_LATS_1	122	128	PF00433	0.605
MOD_N-GLC_1	779	784	PF02516	0.512
MOD_NEK2_1	291	296	PF00069	0.378
MOD_NEK2_1	314	319	PF00069	0.589
MOD_NEK2_1	370	375	PF00069	0.626
MOD_NEK2_1	438	443	PF00069	0.626
MOD_NEK2_1	46	51	PF00069	0.596
MOD_NEK2_1	637	642	PF00069	0.580
MOD_NEK2_1	688	693	PF00069	0.773
MOD_NEK2_1	85	90	PF00069	0.699
MOD_NEK2_2	885	890	PF00069	0.571
MOD_PIKK_1	426	432	PF00454	0.635
MOD_PIKK_1	438	444	PF00454	0.593
MOD_PIKK_1	85	91	PF00454	0.606
MOD_PIKK_1	851	857	PF00454	0.669
MOD_PIKK_1	862	868	PF00454	0.583
MOD_PK_1	124	130	PF00069	0.777
MOD_PK_1	900	906	PF00069	0.607
MOD_PKA_1	124	130	PF00069	0.699
MOD_PKA_1	899	905	PF00069	0.605
MOD_PKA_2	124	130	PF00069	0.696
MOD_PKA_2	374	380	PF00069	0.646
MOD_PKA_2	448	454	PF00069	0.583
MOD_PKA_2	455	461	PF00069	0.549
MOD_PKA_2	531	537	PF00069	0.674
MOD_PKA_2	554	560	PF00069	0.576
MOD_PKA_2	820	826	PF00069	0.573
MOD_PKA_2	885	891	PF00069	0.781
MOD_PKA_2	899	905	PF00069	0.574
MOD_PKB_1	219	227	PF00069	0.467
MOD_PKB_1	352	360	PF00069	0.557
MOD_PKB_1	57	65	PF00069	0.586
MOD_PKB_1	897	905	PF00069	0.640
MOD_Plk_1	424	430	PF00069	0.514
MOD_Plk_1	610	616	PF00069	0.576
MOD_Plk_4	433	439	PF00069	0.450
MOD_Plk_4	515	521	PF00069	0.585
MOD_Plk_4	554	560	PF00069	0.599
MOD_Plk_4	59	65	PF00069	0.588
MOD_Plk_4	637	643	PF00069	0.579
MOD_Plk_4	900	906	PF00069	0.618
MOD_ProDKin_1	143	149	PF00069	0.597
MOD_ProDKin_1	254	260	PF00069	0.596
MOD_ProDKin_1	477	483	PF00069	0.445
MOD_ProDKin_1	512	518	PF00069	0.524
MOD_ProDKin_1	537	543	PF00069	0.574
MOD_ProDKin_1	624	630	PF00069	0.571
MOD_ProDKin_1	68	74	PF00069	0.668
MOD_ProDKin_1	766	772	PF00069	0.619
MOD_ProDKin_1	775	781	PF00069	0.565
MOD_ProDKin_1	856	862	PF00069	0.595
TRG_DiLeu_BaEn_1	239	244	PF01217	0.504
TRG_DiLeu_BaEn_4	226	232	PF01217	0.440
TRG_DiLeu_BaEn_4	573	579	PF01217	0.494
TRG_DiLeu_BaLyEn_6	138	143	PF01217	0.405
TRG_DiLeu_BaLyEn_6	287	292	PF01217	0.434
TRG_DiLeu_BaLyEn_6	389	394	PF01217	0.540
TRG_DiLeu_BaLyEn_6	697	702	PF01217	0.655
TRG_ENDOCYTIC_2	310	313	PF00928	0.451
TRG_ER_diArg_1	123	126	PF00400	0.642
TRG_ER_diArg_1	307	309	PF00400	0.462
TRG_ER_diArg_1	40	43	PF00400	0.482
TRG_ER_diArg_1	471	473	PF00400	0.494
TRG_ER_diArg_1	520	522	PF00400	0.672
TRG_ER_diArg_1	57	60	PF00400	0.557
TRG_ER_diArg_1	664	666	PF00400	0.509
TRG_ER_diArg_1	730	732	PF00400	0.619
TRG_ER_diArg_1	832	834	PF00400	0.522
TRG_ER_diArg_1	841	843	PF00400	0.427
TRG_ER_diArg_1	895	897	PF00400	0.669
TRG_ER_diArg_1	899	901	PF00400	0.682
TRG_NES_CRM1_1	242	252	PF08389	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P548	Leptomonas seymouri	44%	80%
A0A3S7X755	Leishmania donovani	100%	78%
A4HLX7	Leishmania braziliensis	70%	100%
E9B4A6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q3S0	Leishmania major	88%	100%