LeishMANIAdb
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Putative mitochondrial processing peptidase alpha subunit

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative mitochondrial processing peptidase alpha subunit
Gene product:
metallo-peptidase - Clan ME - Family M16
Species:
Leishmania infantum
UniProt:
A4I9A1_LEIIN
TriTrypDb:
LINF_330035400
Length:
483

Annotations

Annotations by Jardim et al.

Proteases, mitochondrial processing peptidase alpha subunit

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005739 mitochondrion 5 1
GO:0017087 mitochondrial processing peptidase complex 3 1
GO:0032991 protein-containing complex 1 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0098798 mitochondrial protein-containing complex 2 1
GO:0110165 cellular anatomical entity 1 1
GO:1902494 catalytic complex 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I9A1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9A1

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0006839 mitochondrial transport 4 1
GO:0006886 intracellular protein transport 4 1
GO:0008104 protein localization 4 1
GO:0009987 cellular process 1 1
GO:0015031 protein transport 4 1
GO:0030150 protein import into mitochondrial matrix 4 1
GO:0033036 macromolecule localization 2 1
GO:0033365 protein localization to organelle 5 1
GO:0044743 protein transmembrane import into intracellular organelle 4 1
GO:0045184 establishment of protein localization 3 1
GO:0046907 intracellular transport 3 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0055085 transmembrane transport 2 1
GO:0065002 intracellular protein transmembrane transport 4 1
GO:0070585 protein localization to mitochondrion 6 1
GO:0070727 cellular macromolecule localization 3 1
GO:0071702 organic substance transport 4 1
GO:0071705 nitrogen compound transport 4 1
GO:0071806 protein transmembrane transport 3 1
GO:0072594 establishment of protein localization to organelle 4 1
GO:0072655 establishment of protein localization to mitochondrion 5 1
GO:1990542 mitochondrial transmembrane transport 3 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 11
GO:0043167 ion binding 2 11
GO:0043169 cation binding 3 11
GO:0046872 metal ion binding 4 11
GO:0003824 catalytic activity 1 2
GO:0004175 endopeptidase activity 4 2
GO:0004222 metalloendopeptidase activity 5 2
GO:0008233 peptidase activity 3 2
GO:0008237 metallopeptidase activity 4 2
GO:0016787 hydrolase activity 2 2
GO:0140096 catalytic activity, acting on a protein 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 193 195 PF00675 0.385
CLV_PCSK_KEX2_1 193 195 PF00082 0.385
CLV_PCSK_SKI1_1 149 153 PF00082 0.419
CLV_PCSK_SKI1_1 200 204 PF00082 0.267
CLV_PCSK_SKI1_1 30 34 PF00082 0.313
CLV_PCSK_SKI1_1 325 329 PF00082 0.267
DEG_Nend_Nbox_1 1 3 PF02207 0.516
DEG_SCF_FBW7_1 420 425 PF00400 0.464
DOC_CKS1_1 195 200 PF01111 0.334
DOC_CYCLIN_yCln2_LP_2 169 175 PF00134 0.386
DOC_MAPK_MEF2A_6 275 284 PF00069 0.340
DOC_MAPK_MEF2A_6 378 386 PF00069 0.301
DOC_MAPK_MEF2A_6 98 107 PF00069 0.340
DOC_PP1_RVXF_1 219 225 PF00149 0.289
DOC_PP2B_LxvP_1 105 108 PF13499 0.331
DOC_USP7_MATH_1 69 73 PF00917 0.380
DOC_USP7_MATH_2 357 363 PF00917 0.198
DOC_USP7_UBL2_3 271 275 PF12436 0.267
DOC_WW_Pin1_4 171 176 PF00397 0.526
DOC_WW_Pin1_4 194 199 PF00397 0.334
DOC_WW_Pin1_4 377 382 PF00397 0.263
DOC_WW_Pin1_4 418 423 PF00397 0.464
DOC_WW_Pin1_4 478 483 PF00397 0.595
LIG_14-3-3_CanoR_1 143 147 PF00244 0.515
LIG_14-3-3_CanoR_1 193 198 PF00244 0.398
LIG_14-3-3_CanoR_1 75 81 PF00244 0.510
LIG_Actin_WH2_2 463 480 PF00022 0.418
LIG_APCC_ABBA_1 451 456 PF00400 0.314
LIG_BRCT_BRCA1_1 152 156 PF00533 0.380
LIG_eIF4E_1 344 350 PF01652 0.252
LIG_FHA_1 150 156 PF00498 0.454
LIG_FHA_1 24 30 PF00498 0.388
LIG_FHA_1 245 251 PF00498 0.427
LIG_FHA_1 294 300 PF00498 0.340
LIG_FHA_1 448 454 PF00498 0.314
LIG_FHA_1 76 82 PF00498 0.501
LIG_FHA_2 125 131 PF00498 0.387
LIG_FHA_2 194 200 PF00498 0.267
LIG_FHA_2 262 268 PF00498 0.361
LIG_FHA_2 31 37 PF00498 0.341
LIG_FHA_2 419 425 PF00498 0.346
LIG_LIR_Gen_1 153 162 PF02991 0.370
LIG_LIR_Gen_1 186 195 PF02991 0.254
LIG_LIR_Gen_1 296 304 PF02991 0.379
LIG_LIR_Gen_1 408 418 PF02991 0.327
LIG_LIR_Gen_1 462 470 PF02991 0.447
LIG_LIR_Gen_1 473 482 PF02991 0.549
LIG_LIR_Nem_3 153 159 PF02991 0.369
LIG_LIR_Nem_3 186 191 PF02991 0.254
LIG_LIR_Nem_3 293 297 PF02991 0.264
LIG_LIR_Nem_3 321 327 PF02991 0.267
LIG_LIR_Nem_3 408 414 PF02991 0.314
LIG_LIR_Nem_3 450 454 PF02991 0.308
LIG_LIR_Nem_3 462 466 PF02991 0.356
LIG_LIR_Nem_3 473 477 PF02991 0.378
LIG_PDZ_Class_1 478 483 PF00595 0.556
LIG_SH2_CRK 463 467 PF00017 0.443
LIG_SH2_CRK 474 478 PF00017 0.499
LIG_SH2_NCK_1 195 199 PF00017 0.310
LIG_SH2_STAT5 195 198 PF00017 0.298
LIG_SH2_STAT5 253 256 PF00017 0.277
LIG_SH2_STAT5 259 262 PF00017 0.282
LIG_SH2_STAT5 294 297 PF00017 0.343
LIG_SH2_STAT5 418 421 PF00017 0.484
LIG_SH3_3 169 175 PF00018 0.386
LIG_SH3_3 442 448 PF00018 0.332
LIG_SUMO_SIM_anti_2 102 107 PF11976 0.351
LIG_SUMO_SIM_anti_2 114 120 PF11976 0.329
LIG_SUMO_SIM_anti_2 392 400 PF11976 0.364
LIG_SUMO_SIM_par_1 392 400 PF11976 0.365
LIG_TRAF2_1 421 424 PF00917 0.469
LIG_UBA3_1 154 161 PF00899 0.438
LIG_UBA3_1 45 52 PF00899 0.315
LIG_WRC_WIRS_1 294 299 PF05994 0.373
MOD_CDK_SPxK_1 194 200 PF00069 0.334
MOD_CK1_1 145 151 PF00069 0.510
MOD_CK1_1 23 29 PF00069 0.324
MOD_CK1_1 231 237 PF00069 0.397
MOD_CK1_1 309 315 PF00069 0.267
MOD_CK1_1 473 479 PF00069 0.485
MOD_CK2_1 171 177 PF00069 0.503
MOD_CK2_1 193 199 PF00069 0.263
MOD_CK2_1 232 238 PF00069 0.427
MOD_CK2_1 261 267 PF00069 0.361
MOD_CK2_1 418 424 PF00069 0.352
MOD_GlcNHglycan 164 167 PF01048 0.474
MOD_GlcNHglycan 235 238 PF01048 0.395
MOD_GlcNHglycan 311 314 PF01048 0.254
MOD_GlcNHglycan 354 357 PF01048 0.267
MOD_GlcNHglycan 428 431 PF01048 0.418
MOD_GlcNHglycan 439 443 PF01048 0.362
MOD_GSK3_1 137 144 PF00069 0.448
MOD_GSK3_1 145 152 PF00069 0.357
MOD_GSK3_1 16 23 PF00069 0.364
MOD_GSK3_1 194 201 PF00069 0.385
MOD_GSK3_1 224 231 PF00069 0.340
MOD_GSK3_1 232 239 PF00069 0.355
MOD_GSK3_1 261 268 PF00069 0.361
MOD_GSK3_1 295 302 PF00069 0.267
MOD_GSK3_1 305 312 PF00069 0.256
MOD_GSK3_1 338 345 PF00069 0.267
MOD_GSK3_1 373 380 PF00069 0.377
MOD_GSK3_1 418 425 PF00069 0.350
MOD_GSK3_1 426 433 PF00069 0.366
MOD_GSK3_1 473 480 PF00069 0.523
MOD_GSK3_1 75 82 PF00069 0.432
MOD_N-GLC_1 261 266 PF02516 0.327
MOD_N-GLC_1 275 280 PF02516 0.244
MOD_N-GLC_1 416 421 PF02516 0.427
MOD_N-GLC_1 477 482 PF02516 0.571
MOD_NEK2_1 141 146 PF00069 0.520
MOD_NEK2_1 2 7 PF00069 0.612
MOD_NEK2_1 20 25 PF00069 0.398
MOD_NEK2_1 203 208 PF00069 0.271
MOD_NEK2_1 232 237 PF00069 0.348
MOD_NEK2_1 295 300 PF00069 0.412
MOD_NEK2_1 352 357 PF00069 0.253
MOD_NEK2_1 470 475 PF00069 0.408
MOD_NEK2_1 477 482 PF00069 0.498
MOD_PIKK_1 373 379 PF00454 0.354
MOD_PIKK_1 390 396 PF00454 0.230
MOD_PIKK_1 79 85 PF00454 0.401
MOD_PKA_1 193 199 PF00069 0.412
MOD_PKA_2 142 148 PF00069 0.521
MOD_PKA_2 16 22 PF00069 0.378
MOD_PKA_2 193 199 PF00069 0.408
MOD_PKA_2 23 29 PF00069 0.320
MOD_PKA_2 74 80 PF00069 0.492
MOD_Plk_1 149 155 PF00069 0.377
MOD_Plk_1 198 204 PF00069 0.313
MOD_Plk_1 275 281 PF00069 0.269
MOD_Plk_1 416 422 PF00069 0.432
MOD_Plk_2-3 181 187 PF00069 0.310
MOD_Plk_4 142 148 PF00069 0.509
MOD_Plk_4 150 156 PF00069 0.420
MOD_Plk_4 228 234 PF00069 0.320
MOD_Plk_4 299 305 PF00069 0.260
MOD_Plk_4 99 105 PF00069 0.329
MOD_ProDKin_1 171 177 PF00069 0.531
MOD_ProDKin_1 194 200 PF00069 0.334
MOD_ProDKin_1 377 383 PF00069 0.263
MOD_ProDKin_1 418 424 PF00069 0.464
MOD_SUMO_for_1 51 54 PF00179 0.385
TRG_DiLeu_BaEn_1 462 467 PF01217 0.382
TRG_ENDOCYTIC_2 294 297 PF00928 0.265
TRG_ENDOCYTIC_2 463 466 PF00928 0.399
TRG_ENDOCYTIC_2 474 477 PF00928 0.310
TRG_ER_diArg_1 193 195 PF00400 0.385
TRG_NES_CRM1_1 114 128 PF08389 0.375

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDS4 Leptomonas seymouri 78% 100%
A0A1X0NSX1 Trypanosomatidae 66% 100%
A0A3Q8IMP0 Leishmania donovani 100% 100%
A0A422N4E4 Trypanosoma rangeli 63% 100%
A4HLX2 Leishmania braziliensis 90% 100%
C9ZJC5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 62% 100%
E9B4A1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
O04308 Arabidopsis thaliana 25% 97%
O32965 Mycobacterium leprae (strain TN) 22% 100%
O75439 Homo sapiens 23% 99%
O86835 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) 21% 100%
O94745 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 96%
P10507 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 20% 100%
P11914 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 29% 100%
P20069 Rattus norvegicus 27% 92%
P22695 Homo sapiens 23% 100%
P29677 Solanum tuberosum 27% 96%
P31800 Bos taurus 21% 100%
P31930 Homo sapiens 20% 100%
P43264 Euglena gracilis 23% 98%
P97997 Blastocladiella emersonii 27% 100%
Q03346 Rattus norvegicus 23% 99%
Q04805 Bacillus subtilis (strain 168) 22% 100%
Q0P5M8 Bos taurus 27% 92%
Q10713 Homo sapiens 27% 92%
Q23295 Caenorhabditis elegans 22% 100%
Q3SZ71 Bos taurus 23% 99%
Q42290 Arabidopsis thaliana 21% 91%
Q4Q3S5 Leishmania major 96% 100%
Q4W6B5 Dictyostelium discoideum 21% 100%
Q54F93 Dictyostelium discoideum 24% 100%
Q5R513 Pongo abelii 27% 92%
Q5REK3 Pongo abelii 23% 99%
Q95XN2 Caenorhabditis elegans 25% 94%
Q9CXT8 Mus musculus 23% 99%
Q9DB77 Mus musculus 22% 100%
Q9DC61 Mus musculus 26% 92%
Q9P7X1 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 21% 100%
Q9Y8B5 Lentinula edodes 20% 100%
Q9ZU25 Arabidopsis thaliana 25% 96%
V5BIM6 Trypanosoma cruzi 64% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS