LeishMANIAdb
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Putative enoyl-CoA hydratase/Enoyl-CoA isomerase/3-hydroxyacyl-CoA dehydrogenase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative enoyl-CoA hydratase/Enoyl-CoA isomerase/3-hydroxyacyl-CoA dehydrogenase
Gene product:
enoyl-CoA hydratase/Enoyl-CoA isomerase/3- hydroxyacyl-CoA dehydrogenase - putative
Species:
Leishmania infantum
UniProt:
A4I9A0_LEIIN
TriTrypDb:
LINF_330035300 *
Length:
660

Annotations

Annotations by Jardim et al.

Fatty acid metabolism, enoyl-CoA hydratase/Enoyl-CoA isomerase/3-hydroxyacyl-CoA dehydrogenase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005777 peroxisome 6 1
GO:0020015 glycosome 7 1
GO:0042579 microbody 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I9A0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9A0

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 11
GO:0006629 lipid metabolic process 3 11
GO:0006631 fatty acid metabolic process 4 11
GO:0008152 metabolic process 1 11
GO:0009987 cellular process 1 11
GO:0019752 carboxylic acid metabolic process 5 11
GO:0032787 monocarboxylic acid metabolic process 6 11
GO:0043436 oxoacid metabolic process 4 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0044255 cellular lipid metabolic process 3 11
GO:0044281 small molecule metabolic process 2 11
GO:0071704 organic substance metabolic process 2 11
GO:0006635 fatty acid beta-oxidation 6 9
GO:0009056 catabolic process 2 9
GO:0009062 fatty acid catabolic process 5 9
GO:0016042 lipid catabolic process 4 9
GO:0016054 organic acid catabolic process 4 9
GO:0019395 fatty acid oxidation 5 9
GO:0030258 lipid modification 4 9
GO:0034440 lipid oxidation 5 9
GO:0044242 cellular lipid catabolic process 4 9
GO:0044248 cellular catabolic process 3 9
GO:0044282 small molecule catabolic process 3 9
GO:0046395 carboxylic acid catabolic process 5 9
GO:0072329 monocarboxylic acid catabolic process 6 9
GO:1901575 organic substance catabolic process 3 9
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity 5 7
GO:0004300 enoyl-CoA hydratase activity 5 6
GO:0005488 binding 1 11
GO:0016491 oxidoreductase activity 2 11
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 3 11
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4 11
GO:0016829 lyase activity 2 6
GO:0016835 carbon-oxygen lyase activity 3 6
GO:0016836 hydro-lyase activity 4 6
GO:0016853 isomerase activity 2 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0051287 NAD binding 4 11
GO:0070403 NAD+ binding 4 11
GO:0097159 organic cyclic compound binding 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 46 50 PF00656 0.518
CLV_C14_Caspase3-7 487 491 PF00656 0.624
CLV_NRD_NRD_1 359 361 PF00675 0.332
CLV_NRD_NRD_1 36 38 PF00675 0.527
CLV_NRD_NRD_1 443 445 PF00675 0.455
CLV_NRD_NRD_1 5 7 PF00675 0.659
CLV_NRD_NRD_1 553 555 PF00675 0.416
CLV_NRD_NRD_1 557 559 PF00675 0.411
CLV_NRD_NRD_1 623 625 PF00675 0.279
CLV_NRD_NRD_1 89 91 PF00675 0.497
CLV_PCSK_KEX2_1 251 253 PF00082 0.368
CLV_PCSK_KEX2_1 35 37 PF00082 0.542
CLV_PCSK_KEX2_1 404 406 PF00082 0.604
CLV_PCSK_KEX2_1 551 553 PF00082 0.418
CLV_PCSK_KEX2_1 557 559 PF00082 0.400
CLV_PCSK_PC1ET2_1 251 253 PF00082 0.368
CLV_PCSK_PC1ET2_1 404 406 PF00082 0.604
CLV_PCSK_PC1ET2_1 551 553 PF00082 0.499
CLV_PCSK_PC7_1 32 38 PF00082 0.483
CLV_PCSK_PC7_1 553 559 PF00082 0.496
CLV_PCSK_SKI1_1 333 337 PF00082 0.330
CLV_PCSK_SKI1_1 367 371 PF00082 0.392
CLV_PCSK_SKI1_1 427 431 PF00082 0.453
CLV_PCSK_SKI1_1 452 456 PF00082 0.367
CLV_PCSK_SKI1_1 553 557 PF00082 0.453
CLV_PCSK_SKI1_1 568 572 PF00082 0.122
CLV_PCSK_SKI1_1 59 63 PF00082 0.428
CLV_PCSK_SKI1_1 651 655 PF00082 0.286
DEG_APCC_DBOX_1 135 143 PF00400 0.335
DEG_APCC_DBOX_1 332 340 PF00400 0.383
DEG_APCC_DBOX_1 524 532 PF00400 0.461
DEG_Nend_UBRbox_2 1 3 PF02207 0.458
DOC_CDC14_PxL_1 316 324 PF14671 0.328
DOC_CKS1_1 400 405 PF01111 0.459
DOC_CKS1_1 453 458 PF01111 0.481
DOC_CYCLIN_RxL_1 361 374 PF00134 0.383
DOC_CYCLIN_RxL_1 56 64 PF00134 0.564
DOC_CYCLIN_yClb3_PxF_3 424 430 PF00134 0.271
DOC_MAPK_FxFP_2 600 603 PF00069 0.328
DOC_MAPK_gen_1 523 531 PF00069 0.394
DOC_MAPK_HePTP_8 271 283 PF00069 0.307
DOC_MAPK_MEF2A_6 108 116 PF00069 0.499
DOC_MAPK_MEF2A_6 160 168 PF00069 0.318
DOC_MAPK_MEF2A_6 18 27 PF00069 0.576
DOC_MAPK_MEF2A_6 274 283 PF00069 0.307
DOC_MAPK_MEF2A_6 523 531 PF00069 0.491
DOC_MAPK_MEF2A_6 97 104 PF00069 0.531
DOC_PP1_RVXF_1 566 572 PF00149 0.270
DOC_PP2B_LxvP_1 66 69 PF13499 0.526
DOC_PP4_FxxP_1 283 286 PF00568 0.268
DOC_PP4_FxxP_1 430 433 PF00568 0.426
DOC_PP4_FxxP_1 600 603 PF00568 0.455
DOC_PP4_FxxP_1 638 641 PF00568 0.270
DOC_USP7_MATH_1 123 127 PF00917 0.583
DOC_USP7_MATH_1 257 261 PF00917 0.376
DOC_USP7_MATH_1 384 388 PF00917 0.406
DOC_USP7_MATH_1 393 397 PF00917 0.502
DOC_USP7_MATH_1 468 472 PF00917 0.505
DOC_USP7_MATH_1 516 520 PF00917 0.698
DOC_USP7_MATH_1 527 531 PF00917 0.398
DOC_USP7_MATH_1 632 636 PF00917 0.445
DOC_USP7_UBL2_3 621 625 PF12436 0.364
DOC_WW_Pin1_4 114 119 PF00397 0.632
DOC_WW_Pin1_4 287 292 PF00397 0.261
DOC_WW_Pin1_4 399 404 PF00397 0.503
DOC_WW_Pin1_4 452 457 PF00397 0.481
DOC_WW_Pin1_4 509 514 PF00397 0.692
LIG_14-3-3_CanoR_1 108 116 PF00244 0.562
LIG_14-3-3_CanoR_1 160 168 PF00244 0.255
LIG_14-3-3_CanoR_1 297 306 PF00244 0.304
LIG_14-3-3_CanoR_1 333 343 PF00244 0.339
LIG_14-3-3_CanoR_1 35 40 PF00244 0.690
LIG_14-3-3_CanoR_1 385 389 PF00244 0.382
LIG_14-3-3_CanoR_1 6 10 PF00244 0.653
LIG_14-3-3_CanoR_1 79 86 PF00244 0.501
LIG_14-3-3_CanoR_1 90 100 PF00244 0.564
LIG_Actin_WH2_2 147 162 PF00022 0.360
LIG_BRCT_BRCA1_1 29 33 PF00533 0.545
LIG_BRCT_BRCA1_1 634 638 PF00533 0.328
LIG_Clathr_ClatBox_1 369 373 PF01394 0.404
LIG_eIF4E_1 329 335 PF01652 0.279
LIG_FHA_1 132 138 PF00498 0.569
LIG_FHA_1 330 336 PF00498 0.274
LIG_FHA_1 364 370 PF00498 0.383
LIG_FHA_1 509 515 PF00498 0.693
LIG_FHA_2 453 459 PF00498 0.457
LIG_FHA_2 485 491 PF00498 0.663
LIG_FHA_2 53 59 PF00498 0.612
LIG_HP1_1 527 531 PF01393 0.450
LIG_LIR_Apic_2 419 425 PF02991 0.430
LIG_LIR_Apic_2 635 641 PF02991 0.271
LIG_LIR_Gen_1 563 574 PF02991 0.397
LIG_LIR_Gen_1 654 659 PF02991 0.393
LIG_LIR_Nem_3 317 322 PF02991 0.402
LIG_LIR_Nem_3 337 343 PF02991 0.342
LIG_LIR_Nem_3 448 454 PF02991 0.388
LIG_LIR_Nem_3 524 529 PF02991 0.293
LIG_LIR_Nem_3 541 547 PF02991 0.458
LIG_LIR_Nem_3 563 569 PF02991 0.419
LIG_LYPXL_SIV_4 53 61 PF13949 0.521
LIG_LYPXL_yS_3 319 322 PF13949 0.328
LIG_LYPXL_yS_3 526 529 PF13949 0.379
LIG_PCNA_TLS_4 180 187 PF02747 0.328
LIG_Pex14_2 655 659 PF04695 0.342
LIG_SH2_CRK 451 455 PF00017 0.398
LIG_SH2_NCK_1 54 58 PF00017 0.571
LIG_SH2_SRC 612 615 PF00017 0.315
LIG_SH2_STAP1 540 544 PF00017 0.463
LIG_SH2_STAP1 612 616 PF00017 0.252
LIG_SH2_STAT5 186 189 PF00017 0.461
LIG_SH2_STAT5 329 332 PF00017 0.364
LIG_SH2_STAT5 453 456 PF00017 0.476
LIG_SH2_STAT5 54 57 PF00017 0.478
LIG_SH3_3 10 16 PF00018 0.498
LIG_SH3_3 113 119 PF00018 0.647
LIG_SH3_3 214 220 PF00018 0.393
LIG_SH3_3 397 403 PF00018 0.639
LIG_SH3_3 407 413 PF00018 0.681
LIG_SH3_3 422 428 PF00018 0.363
LIG_SUMO_SIM_anti_2 152 158 PF11976 0.284
LIG_SUMO_SIM_anti_2 162 168 PF11976 0.255
LIG_SUMO_SIM_par_1 165 170 PF11976 0.283
LIG_SUMO_SIM_par_1 320 325 PF11976 0.429
LIG_SUMO_SIM_par_1 527 533 PF11976 0.468
LIG_TRAF2_1 455 458 PF00917 0.428
LIG_TYR_ITIM 542 547 PF00017 0.342
LIG_UBA3_1 242 251 PF00899 0.383
LIG_UBA3_1 312 318 PF00899 0.381
MOD_CDK_SPK_2 399 404 PF00069 0.464
MOD_CDK_SPxK_1 399 405 PF00069 0.461
MOD_CK1_1 121 127 PF00069 0.706
MOD_CK1_1 38 44 PF00069 0.702
MOD_CK1_1 396 402 PF00069 0.603
MOD_CK1_1 411 417 PF00069 0.518
MOD_CK1_1 519 525 PF00069 0.639
MOD_CK1_1 530 536 PF00069 0.372
MOD_CK1_1 81 87 PF00069 0.523
MOD_CK2_1 159 165 PF00069 0.311
MOD_CK2_1 186 192 PF00069 0.328
MOD_CK2_1 411 417 PF00069 0.574
MOD_CK2_1 452 458 PF00069 0.440
MOD_CK2_1 52 58 PF00069 0.628
MOD_Cter_Amidation 442 445 PF01082 0.365
MOD_GlcNHglycan 109 112 PF01048 0.629
MOD_GlcNHglycan 120 123 PF01048 0.585
MOD_GlcNHglycan 260 263 PF01048 0.311
MOD_GlcNHglycan 395 398 PF01048 0.566
MOD_GlcNHglycan 413 416 PF01048 0.557
MOD_GlcNHglycan 476 479 PF01048 0.562
MOD_GlcNHglycan 490 494 PF01048 0.623
MOD_GlcNHglycan 518 521 PF01048 0.571
MOD_GSK3_1 114 121 PF00069 0.620
MOD_GSK3_1 123 130 PF00069 0.626
MOD_GSK3_1 146 153 PF00069 0.391
MOD_GSK3_1 251 258 PF00069 0.444
MOD_GSK3_1 35 42 PF00069 0.588
MOD_GSK3_1 395 402 PF00069 0.554
MOD_GSK3_1 468 475 PF00069 0.508
MOD_GSK3_1 515 522 PF00069 0.658
MOD_GSK3_1 543 550 PF00069 0.474
MOD_GSK3_1 78 85 PF00069 0.568
MOD_N-GLC_1 287 292 PF02516 0.383
MOD_N-GLC_1 538 543 PF02516 0.442
MOD_NEK2_1 150 155 PF00069 0.322
MOD_NEK2_1 208 213 PF00069 0.252
MOD_NEK2_1 25 30 PF00069 0.339
MOD_NEK2_1 322 327 PF00069 0.453
MOD_NEK2_1 334 339 PF00069 0.395
MOD_NEK2_1 363 368 PF00069 0.436
MOD_NEK2_1 416 421 PF00069 0.587
MOD_NEK2_1 5 10 PF00069 0.557
MOD_NEK2_1 507 512 PF00069 0.536
MOD_NEK2_1 61 66 PF00069 0.481
MOD_NEK2_1 78 83 PF00069 0.374
MOD_PIKK_1 269 275 PF00454 0.364
MOD_PIKK_1 68 74 PF00454 0.582
MOD_PIKK_1 78 84 PF00454 0.589
MOD_PIKK_1 91 97 PF00454 0.447
MOD_PK_1 35 41 PF00069 0.495
MOD_PKA_1 251 257 PF00069 0.328
MOD_PKA_1 35 41 PF00069 0.495
MOD_PKA_1 553 559 PF00069 0.450
MOD_PKA_2 107 113 PF00069 0.520
MOD_PKA_2 159 165 PF00069 0.255
MOD_PKA_2 194 200 PF00069 0.269
MOD_PKA_2 208 214 PF00069 0.237
MOD_PKA_2 251 257 PF00069 0.405
MOD_PKA_2 35 41 PF00069 0.675
MOD_PKA_2 384 390 PF00069 0.406
MOD_PKA_2 393 399 PF00069 0.525
MOD_PKA_2 443 449 PF00069 0.434
MOD_PKA_2 5 11 PF00069 0.618
MOD_PKA_2 553 559 PF00069 0.528
MOD_PKA_2 78 84 PF00069 0.475
MOD_Plk_1 457 463 PF00069 0.456
MOD_Plk_1 538 544 PF00069 0.335
MOD_Plk_2-3 127 133 PF00069 0.538
MOD_Plk_2-3 543 549 PF00069 0.409
MOD_Plk_4 251 257 PF00069 0.282
MOD_Plk_4 354 360 PF00069 0.219
MOD_Plk_4 384 390 PF00069 0.328
MOD_Plk_4 468 474 PF00069 0.497
MOD_Plk_4 501 507 PF00069 0.708
MOD_Plk_4 530 536 PF00069 0.510
MOD_Plk_4 654 660 PF00069 0.438
MOD_ProDKin_1 114 120 PF00069 0.632
MOD_ProDKin_1 287 293 PF00069 0.261
MOD_ProDKin_1 399 405 PF00069 0.500
MOD_ProDKin_1 452 458 PF00069 0.482
MOD_ProDKin_1 509 515 PF00069 0.691
MOD_SUMO_rev_2 85 93 PF00179 0.684
TRG_DiLeu_BaEn_1 63 68 PF01217 0.512
TRG_DiLeu_BaLyEn_6 330 335 PF01217 0.330
TRG_ENDOCYTIC_2 17 20 PF00928 0.658
TRG_ENDOCYTIC_2 319 322 PF00928 0.448
TRG_ENDOCYTIC_2 343 346 PF00928 0.266
TRG_ENDOCYTIC_2 451 454 PF00928 0.397
TRG_ENDOCYTIC_2 526 529 PF00928 0.379
TRG_ENDOCYTIC_2 544 547 PF00928 0.471
TRG_ER_diArg_1 187 190 PF00400 0.330
TRG_ER_diArg_1 207 210 PF00400 0.122
TRG_ER_diArg_1 35 37 PF00400 0.501
TRG_ER_diArg_1 463 466 PF00400 0.561
TRG_ER_diArg_1 552 554 PF00400 0.446
TRG_ER_diArg_1 557 559 PF00400 0.417
TRG_NLS_MonoCore_2 550 555 PF00514 0.436
TRG_Pf-PMV_PEXEL_1 367 371 PF00026 0.383
TRG_Pf-PMV_PEXEL_1 59 63 PF00026 0.556
TRG_Pf-PMV_PEXEL_1 631 636 PF00026 0.330

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HVX9 Leptomonas seymouri 56% 71%
A0A1X0NSP5 Trypanosomatidae 30% 83%
A0A3R7KS65 Trypanosoma rangeli 31% 83%
A0A3S7X716 Leishmania donovani 99% 71%
A4HLX1 Leishmania braziliensis 77% 100%
C9ZJC6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 82%
E9B4A0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
P76083 Escherichia coli (strain K12) 27% 100%
Q4Q3S6 Leishmania major 92% 100%
V5B7W6 Trypanosoma cruzi 24% 81%
V5BN63 Trypanosoma cruzi 30% 78%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS