Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I998_LEIIN

TriTrypDb:

LINF_330035100

Length:

579

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I998

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I998

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	405	409	PF00656	0.715
CLV_NRD_NRD_1	425	427	PF00675	0.724
CLV_NRD_NRD_1	49	51	PF00675	0.828
CLV_NRD_NRD_1	505	507	PF00675	0.694
CLV_NRD_NRD_1	61	63	PF00675	0.652
CLV_PCSK_KEX2_1	424	426	PF00082	0.732
CLV_PCSK_KEX2_1	49	51	PF00082	0.828
CLV_PCSK_KEX2_1	61	63	PF00082	0.652
CLV_PCSK_PC7_1	57	63	PF00082	0.678
CLV_PCSK_SKI1_1	101	105	PF00082	0.686
CLV_PCSK_SKI1_1	215	219	PF00082	0.658
CLV_PCSK_SKI1_1	355	359	PF00082	0.630
CLV_PCSK_SKI1_1	366	370	PF00082	0.435
CLV_PCSK_SKI1_1	434	438	PF00082	0.620
CLV_PCSK_SKI1_1	507	511	PF00082	0.695
CLV_PCSK_SKI1_1	540	544	PF00082	0.520
CLV_PCSK_SKI1_1	71	75	PF00082	0.542
CLV_PCSK_SKI1_1	80	84	PF00082	0.476
DEG_APCC_DBOX_1	452	460	PF00400	0.687
DEG_Nend_UBRbox_1	1	4	PF02207	0.621
DEG_SPOP_SBC_1	115	119	PF00917	0.673
DEG_SPOP_SBC_1	185	189	PF00917	0.608
DEG_SPOP_SBC_1	32	36	PF00917	0.614
DEG_SPOP_SBC_1	485	489	PF00917	0.703
DOC_CDC14_PxL_1	535	543	PF14671	0.488
DOC_MAPK_MEF2A_6	536	543	PF00069	0.533
DOC_PP1_RVXF_1	306	313	PF00149	0.667
DOC_PP2B_LxvP_1	28	31	PF13499	0.752
DOC_USP7_MATH_1	115	119	PF00917	0.696
DOC_USP7_MATH_1	185	189	PF00917	0.679
DOC_USP7_MATH_1	267	271	PF00917	0.722
DOC_USP7_MATH_1	276	280	PF00917	0.709
DOC_USP7_MATH_1	319	323	PF00917	0.507
DOC_USP7_MATH_1	360	364	PF00917	0.574
DOC_USP7_MATH_1	373	377	PF00917	0.447
DOC_USP7_MATH_1	419	423	PF00917	0.832
DOC_USP7_MATH_1	42	46	PF00917	0.608
DOC_USP7_MATH_1	485	489	PF00917	0.705
DOC_USP7_MATH_1	490	494	PF00917	0.657
DOC_WW_Pin1_4	188	193	PF00397	0.648
DOC_WW_Pin1_4	220	225	PF00397	0.642
DOC_WW_Pin1_4	284	289	PF00397	0.660
DOC_WW_Pin1_4	477	482	PF00397	0.684
LIG_14-3-3_CanoR_1	2	8	PF00244	0.597
LIG_14-3-3_CanoR_1	277	281	PF00244	0.699
LIG_14-3-3_CanoR_1	283	290	PF00244	0.657
LIG_14-3-3_CanoR_1	366	371	PF00244	0.619
LIG_14-3-3_CanoR_1	377	381	PF00244	0.572
LIG_14-3-3_CanoR_1	424	429	PF00244	0.713
LIG_14-3-3_CanoR_1	506	514	PF00244	0.815
LIG_14-3-3_CanoR_1	61	66	PF00244	0.770
LIG_14-3-3_CanoR_1	71	78	PF00244	0.488
LIG_BIR_III_4	204	208	PF00653	0.554
LIG_BIR_III_4	263	267	PF00653	0.617
LIG_BIR_III_4	395	399	PF00653	0.777
LIG_BRCT_BRCA1_1	255	259	PF00533	0.749
LIG_BRCT_BRCA1_1	3	7	PF00533	0.674
LIG_BRCT_BRCA1_1	343	347	PF00533	0.572
LIG_FHA_1	107	113	PF00498	0.719
LIG_FHA_1	148	154	PF00498	0.569
LIG_FHA_1	204	210	PF00498	0.477
LIG_FHA_1	33	39	PF00498	0.808
LIG_FHA_2	412	418	PF00498	0.694
LIG_FHA_2	42	48	PF00498	0.766
LIG_FHA_2	468	474	PF00498	0.541
LIG_FHA_2	478	484	PF00498	0.636
LIG_Integrin_RGD_1	131	133	PF01839	0.647
LIG_LIR_Gen_1	256	267	PF02991	0.688
LIG_LIR_Gen_1	344	352	PF02991	0.597
LIG_LIR_Gen_1	378	388	PF02991	0.637
LIG_LIR_Nem_3	256	262	PF02991	0.679
LIG_LIR_Nem_3	344	350	PF02991	0.586
LIG_LIR_Nem_3	378	383	PF02991	0.728
LIG_LIR_Nem_3	547	553	PF02991	0.530
LIG_LYPXL_yS_3	538	541	PF13949	0.496
LIG_RPA_C_Fungi	155	167	PF08784	0.591
LIG_SH2_STAP1	197	201	PF00017	0.460
LIG_SH2_STAP1	327	331	PF00017	0.607
LIG_SH2_STAP1	361	365	PF00017	0.629
LIG_SH2_STAT5	338	341	PF00017	0.483
LIG_SH2_STAT5	389	392	PF00017	0.565
LIG_SH2_STAT5	468	471	PF00017	0.538
LIG_SH3_1	222	228	PF00018	0.663
LIG_SH3_1	426	432	PF00018	0.727
LIG_SH3_2	429	434	PF14604	0.709
LIG_SH3_3	222	228	PF00018	0.745
LIG_SH3_3	426	432	PF00018	0.743
LIG_SH3_3	435	441	PF00018	0.652
LIG_SH3_3	52	58	PF00018	0.793
LIG_SH3_3	566	572	PF00018	0.594
LIG_SH3_3	573	579	PF00018	0.609
LIG_SH3_CIN85_PxpxPR_1	429	434	PF14604	0.709
LIG_SUMO_SIM_par_1	443	450	PF11976	0.657
LIG_TRAF2_1	103	106	PF00917	0.801
LIG_TRAF2_1	413	416	PF00917	0.690
LIG_TRFH_1	437	441	PF08558	0.542
LIG_TYR_ITIM	195	200	PF00017	0.500
LIG_UBA3_1	532	536	PF00899	0.468
LIG_WRC_WIRS_1	491	496	PF05994	0.626
LIG_WW_3	431	435	PF00397	0.694
MOD_CK1_1	113	119	PF00069	0.789
MOD_CK1_1	16	22	PF00069	0.707
MOD_CK1_1	175	181	PF00069	0.667
MOD_CK1_1	188	194	PF00069	0.501
MOD_CK1_1	203	209	PF00069	0.394
MOD_CK1_1	270	276	PF00069	0.698
MOD_CK1_1	311	317	PF00069	0.639
MOD_CK1_1	375	381	PF00069	0.741
MOD_CK1_1	461	467	PF00069	0.574
MOD_CK1_1	489	495	PF00069	0.776
MOD_CK1_1	60	66	PF00069	0.742
MOD_CK2_1	411	417	PF00069	0.705
MOD_CK2_1	467	473	PF00069	0.550
MOD_CK2_1	492	498	PF00069	0.711
MOD_Cter_Amidation	504	507	PF01082	0.737
MOD_GlcNHglycan	113	116	PF01048	0.703
MOD_GlcNHglycan	118	121	PF01048	0.673
MOD_GlcNHglycan	141	144	PF01048	0.513
MOD_GlcNHglycan	15	18	PF01048	0.709
MOD_GlcNHglycan	20	23	PF01048	0.733
MOD_GlcNHglycan	238	241	PF01048	0.716
MOD_GlcNHglycan	269	272	PF01048	0.657
MOD_GlcNHglycan	3	6	PF01048	0.586
MOD_GlcNHglycan	300	303	PF01048	0.708
MOD_GlcNHglycan	395	399	PF01048	0.614
MOD_GlcNHglycan	404	407	PF01048	0.628
MOD_GlcNHglycan	426	429	PF01048	0.663
MOD_GlcNHglycan	464	467	PF01048	0.555
MOD_GlcNHglycan	488	491	PF01048	0.612
MOD_GlcNHglycan	494	497	PF01048	0.701
MOD_GlcNHglycan	510	513	PF01048	0.775
MOD_GlcNHglycan	9	12	PF01048	0.653
MOD_GSK3_1	106	113	PF00069	0.691
MOD_GSK3_1	114	121	PF00069	0.676
MOD_GSK3_1	184	191	PF00069	0.677
MOD_GSK3_1	220	227	PF00069	0.717
MOD_GSK3_1	294	301	PF00069	0.706
MOD_GSK3_1	3	10	PF00069	0.629
MOD_GSK3_1	369	376	PF00069	0.531
MOD_GSK3_1	390	397	PF00069	0.597
MOD_GSK3_1	458	465	PF00069	0.606
MOD_GSK3_1	485	492	PF00069	0.682
MOD_GSK3_1	56	63	PF00069	0.758
MOD_GSK3_1	97	104	PF00069	0.788
MOD_N-GLC_1	175	180	PF02516	0.665
MOD_N-GLC_2	284	286	PF02516	0.622
MOD_N-GLC_2	546	548	PF02516	0.630
MOD_NEK2_1	1	6	PF00069	0.607
MOD_NEK2_1	137	142	PF00069	0.525
MOD_NEK2_1	146	151	PF00069	0.514
MOD_NEK2_1	33	38	PF00069	0.614
MOD_NEK2_1	458	463	PF00069	0.643
MOD_NEK2_1	508	513	PF00069	0.732
MOD_NEK2_1	7	12	PF00069	0.632
MOD_NEK2_2	419	424	PF00069	0.719
MOD_PIKK_1	101	107	PF00454	0.704
MOD_PIKK_1	451	457	PF00454	0.465
MOD_PKA_1	424	430	PF00069	0.708
MOD_PKA_1	61	67	PF00069	0.674
MOD_PKA_2	1	7	PF00069	0.605
MOD_PKA_2	137	143	PF00069	0.444
MOD_PKA_2	276	282	PF00069	0.699
MOD_PKA_2	376	382	PF00069	0.624
MOD_PKA_2	402	408	PF00069	0.631
MOD_PKA_2	424	430	PF00069	0.708
MOD_PKA_2	56	62	PF00069	0.714
MOD_Plk_1	147	153	PF00069	0.496
MOD_Plk_2-3	411	417	PF00069	0.691
MOD_Plk_4	190	196	PF00069	0.636
MOD_Plk_4	3	9	PF00069	0.621
MOD_ProDKin_1	188	194	PF00069	0.638
MOD_ProDKin_1	220	226	PF00069	0.645
MOD_ProDKin_1	284	290	PF00069	0.660
MOD_ProDKin_1	477	483	PF00069	0.689
TRG_ENDOCYTIC_2	197	200	PF00928	0.462
TRG_ENDOCYTIC_2	538	541	PF00928	0.564
TRG_ER_diArg_1	212	215	PF00400	0.463
TRG_ER_diArg_1	423	426	PF00400	0.730
TRG_ER_diArg_1	48	50	PF00400	0.820
TRG_ER_diArg_1	560	563	PF00400	0.714
TRG_ER_diArg_1	65	68	PF00400	0.553
TRG_Pf-PMV_PEXEL_1	323	328	PF00026	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBA9	Leptomonas seymouri	29%	98%
A0A3Q8IF25	Leishmania donovani	100%	100%
A4HLW9	Leishmania braziliensis	64%	100%
E9B498	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q3S8	Leishmania major	86%	100%