Putative carboxypeptidase

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

carboxypeptidase - putative

Species:

Leishmania infantum

UniProt:

A4I993_LEIIN

TriTrypDb:

LINF_330034600

Length:

499

Annotations

Annotations by Jardim et al.

Proteases, carboxypeptidase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	yes	yes: 1
Forrest at al. (metacyclic)	yes	yes: 3
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 9

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 24
NetGPI	no	yes: 0, no: 24

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I993

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I993

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	25
GO:0006807	nitrogen compound metabolic process	2	25
GO:0008152	metabolic process	1	25
GO:0019538	protein metabolic process	3	25
GO:0043170	macromolecule metabolic process	3	25
GO:0044238	primary metabolic process	2	25
GO:0071704	organic substance metabolic process	2	25
GO:1901564	organonitrogen compound metabolic process	3	25
GO:0006518	peptide metabolic process	4	1
GO:0043603	amide metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	25
GO:0004180	carboxypeptidase activity	5	25
GO:0004181	metallocarboxypeptidase activity	6	25
GO:0008233	peptidase activity	3	25
GO:0008235	metalloexopeptidase activity	5	25
GO:0008237	metallopeptidase activity	4	25
GO:0008238	exopeptidase activity	4	25
GO:0016787	hydrolase activity	2	25
GO:0140096	catalytic activity, acting on a protein	2	25
GO:0016853	isomerase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	101	103	PF00675	0.316
CLV_NRD_NRD_1	117	119	PF00675	0.409
CLV_NRD_NRD_1	333	335	PF00675	0.395
CLV_NRD_NRD_1	433	435	PF00675	0.245
CLV_NRD_NRD_1	489	491	PF00675	0.235
CLV_NRD_NRD_1	86	88	PF00675	0.296
CLV_PCSK_KEX2_1	489	491	PF00082	0.304
CLV_PCSK_KEX2_1	86	88	PF00082	0.313
CLV_PCSK_SKI1_1	90	94	PF00082	0.293
DEG_APCC_DBOX_1	333	341	PF00400	0.228
DEG_APCC_DBOX_1	78	86	PF00400	0.272
DEG_Nend_UBRbox_2	1	3	PF02207	0.452
DOC_MAPK_gen_1	13	23	PF00069	0.277
DOC_USP7_MATH_1	146	150	PF00917	0.308
DOC_USP7_MATH_1	88	92	PF00917	0.463
DOC_USP7_UBL2_3	213	217	PF12436	0.208
DOC_USP7_UBL2_3	457	461	PF12436	0.290
DOC_WW_Pin1_4	148	153	PF00397	0.325
DOC_WW_Pin1_4	228	233	PF00397	0.233
DOC_WW_Pin1_4	305	310	PF00397	0.363
LIG_14-3-3_CanoR_1	105	114	PF00244	0.410
LIG_14-3-3_CanoR_1	244	250	PF00244	0.445
LIG_14-3-3_CanoR_1	334	338	PF00244	0.234
LIG_14-3-3_CanoR_1	87	96	PF00244	0.343
LIG_Actin_WH2_2	169	187	PF00022	0.242
LIG_BRCT_BRCA1_1	199	203	PF00533	0.228
LIG_eIF4E_1	469	475	PF01652	0.423
LIG_FHA_1	164	170	PF00498	0.379
LIG_FHA_1	245	251	PF00498	0.456
LIG_FHA_1	279	285	PF00498	0.259
LIG_FHA_1	306	312	PF00498	0.406
LIG_FHA_1	313	319	PF00498	0.368
LIG_FHA_1	416	422	PF00498	0.276
LIG_FHA_1	446	452	PF00498	0.296
LIG_FHA_1	469	475	PF00498	0.292
LIG_FHA_2	237	243	PF00498	0.367
LIG_FHA_2	54	60	PF00498	0.416
LIG_LIR_Gen_1	122	130	PF02991	0.439
LIG_LIR_Gen_1	151	160	PF02991	0.447
LIG_LIR_Gen_1	170	181	PF02991	0.297
LIG_LIR_Gen_1	214	221	PF02991	0.228
LIG_LIR_Gen_1	297	307	PF02991	0.296
LIG_LIR_Gen_1	8	17	PF02991	0.217
LIG_LIR_Nem_3	122	126	PF02991	0.284
LIG_LIR_Nem_3	151	156	PF02991	0.460
LIG_LIR_Nem_3	170	176	PF02991	0.294
LIG_LIR_Nem_3	18	23	PF02991	0.344
LIG_LIR_Nem_3	2	7	PF02991	0.282
LIG_LIR_Nem_3	214	218	PF02991	0.228
LIG_LIR_Nem_3	257	262	PF02991	0.406
LIG_LIR_Nem_3	297	302	PF02991	0.309
LIG_LIR_Nem_3	308	313	PF02991	0.322
LIG_LIR_Nem_3	388	392	PF02991	0.296
LIG_LIR_Nem_3	49	55	PF02991	0.298
LIG_LIR_Nem_3	8	14	PF02991	0.201
LIG_PCNA_yPIPBox_3	380	390	PF02747	0.299
LIG_PDZ_Class_2	494	499	PF00595	0.301
LIG_Pex14_2	199	203	PF04695	0.208
LIG_Pex14_2	215	219	PF04695	0.316
LIG_PTB_Apo_2	481	488	PF02174	0.304
LIG_PTB_Phospho_1	481	487	PF10480	0.304
LIG_SH2_CRK	173	177	PF00017	0.228
LIG_SH2_CRK	259	263	PF00017	0.228
LIG_SH2_GRB2like	173	176	PF00017	0.208
LIG_SH2_GRB2like	496	499	PF00017	0.280
LIG_SH2_PTP2	344	347	PF00017	0.316
LIG_SH2_SRC	160	163	PF00017	0.230
LIG_SH2_SRC	173	176	PF00017	0.330
LIG_SH2_SRC	496	499	PF00017	0.280
LIG_SH2_STAP1	153	157	PF00017	0.289
LIG_SH2_STAP1	425	429	PF00017	0.228
LIG_SH2_STAT3	425	428	PF00017	0.228
LIG_SH2_STAT5	143	146	PF00017	0.374
LIG_SH2_STAT5	249	252	PF00017	0.419
LIG_SH2_STAT5	313	316	PF00017	0.354
LIG_SH2_STAT5	344	347	PF00017	0.350
LIG_SH2_STAT5	389	392	PF00017	0.258
LIG_SH2_STAT5	415	418	PF00017	0.309
LIG_SH2_STAT5	487	490	PF00017	0.412
LIG_SH2_STAT5	496	499	PF00017	0.544
LIG_SH3_3	349	355	PF00018	0.289
LIG_SH3_5	309	313	PF00018	0.208
LIG_TRAF2_1	137	140	PF00917	0.286
LIG_UBA3_1	183	190	PF00899	0.259
LIG_UBA3_1	429	435	PF00899	0.423
MOD_CK1_1	192	198	PF00069	0.181
MOD_CK2_1	148	154	PF00069	0.261
MOD_CK2_1	36	42	PF00069	0.216
MOD_CK2_1	53	59	PF00069	0.401
MOD_Cter_Amidation	100	103	PF01082	0.228
MOD_GlcNHglycan	191	194	PF01048	0.294
MOD_GlcNHglycan	264	267	PF01048	0.254
MOD_GlcNHglycan	65	68	PF01048	0.368
MOD_GlcNHglycan	90	93	PF01048	0.414
MOD_GSK3_1	105	112	PF00069	0.337
MOD_GSK3_1	250	257	PF00069	0.450
MOD_GSK3_1	59	66	PF00069	0.417
MOD_NEK2_1	104	109	PF00069	0.419
MOD_NEK2_1	254	259	PF00069	0.300
MOD_NEK2_1	292	297	PF00069	0.336
MOD_NEK2_1	333	338	PF00069	0.401
MOD_NEK2_1	63	68	PF00069	0.430
MOD_PIKK_1	163	169	PF00454	0.228
MOD_PIKK_1	278	284	PF00454	0.220
MOD_PIKK_1	292	298	PF00454	0.363
MOD_PIKK_1	326	332	PF00454	0.312
MOD_PKA_2	104	110	PF00069	0.359
MOD_PKA_2	114	120	PF00069	0.334
MOD_PKA_2	243	249	PF00069	0.294
MOD_PKA_2	333	339	PF00069	0.209
MOD_PKA_2	476	482	PF00069	0.374
MOD_Plk_1	250	256	PF00069	0.335
MOD_Plk_2-3	59	65	PF00069	0.198
MOD_Plk_4	109	115	PF00069	0.364
MOD_Plk_4	139	145	PF00069	0.408
MOD_Plk_4	175	181	PF00069	0.310
MOD_Plk_4	192	198	PF00069	0.314
MOD_Plk_4	250	256	PF00069	0.302
MOD_Plk_4	294	300	PF00069	0.289
MOD_Plk_4	59	65	PF00069	0.311
MOD_Plk_4	6	12	PF00069	0.291
MOD_ProDKin_1	148	154	PF00069	0.325
MOD_ProDKin_1	228	234	PF00069	0.233
MOD_ProDKin_1	305	311	PF00069	0.363
MOD_SUMO_for_1	34	37	PF00179	0.228
MOD_SUMO_rev_2	365	373	PF00179	0.233
MOD_SUMO_rev_2	436	442	PF00179	0.228
TRG_DiLeu_BaEn_1	470	475	PF01217	0.279
TRG_DiLeu_BaEn_1	59	64	PF01217	0.228
TRG_DiLeu_BaEn_4	139	145	PF01217	0.374
TRG_DiLeu_LyEn_5	450	455	PF01217	0.183
TRG_ENDOCYTIC_2	153	156	PF00928	0.309
TRG_ENDOCYTIC_2	173	176	PF00928	0.325
TRG_ENDOCYTIC_2	259	262	PF00928	0.232
TRG_ENDOCYTIC_2	344	347	PF00928	0.332
TRG_ENDOCYTIC_2	389	392	PF00928	0.298
TRG_ENDOCYTIC_2	4	7	PF00928	0.333
TRG_ER_diArg_1	488	490	PF00400	0.304
TRG_ER_diArg_1	85	87	PF00400	0.286
TRG_NLS_Bipartite_1	86	106	PF00514	0.392
TRG_Pf-PMV_PEXEL_1	366	370	PF00026	0.289
TRG_Pf-PMV_PEXEL_1	61	65	PF00026	0.316

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IZ28	Bodo saltans	45%	100%
A0A1X0NY67	Trypanosomatidae	52%	99%
A0A1X0P441	Trypanosomatidae	57%	99%
A0A1X0P598	Trypanosomatidae	59%	99%
A0A3Q8IBW2	Leishmania donovani	52%	99%
A0A3Q8IJY8	Leishmania donovani	46%	100%
A0A3Q8IU74	Leishmania donovani	100%	100%
A0A3S7WSA3	Leishmania donovani	55%	99%
A0A422P042	Trypanosoma rangeli	57%	99%
A0A422P4R1	Trypanosoma rangeli	53%	99%
A4H716	Leishmania braziliensis	55%	100%
A4HLW4	Leishmania braziliensis	85%	100%
A4HVE5	Leishmania infantum	55%	100%
A4HVW0	Leishmania infantum	52%	100%
A4IC85	Leishmania infantum	46%	100%
D0A656	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	99%
E9AP43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
E9B493	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
P42663	Thermus aquaticus	35%	98%
P50848	Bacillus subtilis (strain 168)	34%	100%
Q4Q0D4	Leishmania major	51%	100%
Q4Q3T3	Leishmania major	97%	100%
Q4QFW7	Leishmania major	52%	100%
Q4QGE5	Leishmania major	55%	100%
Q5SLM3	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	33%	98%
Q8U3L0	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	32%	100%
V5DQA0	Trypanosoma cruzi	60%	99%