Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I991_LEIIN

TriTrypDb:

LINF_330030900

Length:

388

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I991

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I991

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.632
CLV_C14_Caspase3-7	137	141	PF00656	0.516
CLV_C14_Caspase3-7	200	204	PF00656	0.733
CLV_C14_Caspase3-7	327	331	PF00656	0.574
CLV_C14_Caspase3-7	65	69	PF00656	0.772
CLV_NRD_NRD_1	129	131	PF00675	0.722
CLV_NRD_NRD_1	30	32	PF00675	0.675
CLV_PCSK_KEX2_1	129	131	PF00082	0.722
CLV_PCSK_KEX2_1	30	32	PF00082	0.675
CLV_PCSK_SKI1_1	282	286	PF00082	0.579
DEG_APCC_DBOX_1	281	289	PF00400	0.569
DOC_AGCK_PIF_1	305	310	PF00069	0.592
DOC_ANK_TNKS_1	70	77	PF00023	0.718
DOC_CKS1_1	165	170	PF01111	0.556
DOC_USP7_MATH_1	315	319	PF00917	0.687
DOC_USP7_MATH_1	348	352	PF00917	0.731
DOC_USP7_MATH_1	37	41	PF00917	0.745
DOC_USP7_MATH_1	43	47	PF00917	0.736
DOC_USP7_MATH_1	50	54	PF00917	0.613
DOC_WW_Pin1_4	146	151	PF00397	0.801
DOC_WW_Pin1_4	161	166	PF00397	0.566
LIG_14-3-3_CanoR_1	14	19	PF00244	0.523
LIG_14-3-3_CanoR_1	31	37	PF00244	0.538
LIG_14-3-3_CanoR_1	77	82	PF00244	0.744
LIG_APCC_ABBAyCdc20_2	301	307	PF00400	0.606
LIG_BIR_III_4	247	251	PF00653	0.636
LIG_BIR_III_4	330	334	PF00653	0.539
LIG_BRCT_BRCA1_1	140	144	PF00533	0.722
LIG_FHA_1	111	117	PF00498	0.596
LIG_FHA_1	348	354	PF00498	0.675
LIG_FHA_1	76	82	PF00498	0.710
LIG_FHA_2	151	157	PF00498	0.674
LIG_FHA_2	195	201	PF00498	0.730
LIG_FHA_2	287	293	PF00498	0.542
LIG_LIR_Gen_1	139	150	PF02991	0.634
LIG_LIR_Gen_1	307	316	PF02991	0.623
LIG_LIR_Gen_1	95	105	PF02991	0.582
LIG_LIR_Nem_3	139	145	PF02991	0.635
LIG_LIR_Nem_3	307	311	PF02991	0.639
LIG_LIR_Nem_3	95	101	PF02991	0.574
LIG_NRBOX	177	183	PF00104	0.640
LIG_REV1ctd_RIR_1	308	317	PF16727	0.664
LIG_SH2_CRK	142	146	PF00017	0.573
LIG_SH2_STAP1	142	146	PF00017	0.573
LIG_SH2_STAT5	142	145	PF00017	0.624
LIG_SH2_STAT5	308	311	PF00017	0.681
LIG_SH3_3	162	168	PF00018	0.580
LIG_TRAF2_1	197	200	PF00917	0.728
LIG_TRAF2_1	93	96	PF00917	0.687
MOD_CK1_1	164	170	PF00069	0.752
MOD_CK1_1	26	32	PF00069	0.631
MOD_CK1_1	268	274	PF00069	0.693
MOD_CK1_1	4	10	PF00069	0.699
MOD_CK1_1	52	58	PF00069	0.751
MOD_CK2_1	194	200	PF00069	0.724
MOD_CK2_1	268	274	PF00069	0.693
MOD_CK2_1	286	292	PF00069	0.440
MOD_CK2_1	315	321	PF00069	0.665
MOD_CK2_1	348	354	PF00069	0.668
MOD_CK2_1	43	49	PF00069	0.782
MOD_CK2_1	90	96	PF00069	0.694
MOD_Cter_Amidation	127	130	PF01082	0.595
MOD_GlcNHglycan	107	111	PF01048	0.690
MOD_GlcNHglycan	146	149	PF01048	0.727
MOD_GlcNHglycan	169	172	PF01048	0.600
MOD_GlcNHglycan	31	34	PF01048	0.701
MOD_GlcNHglycan	317	320	PF01048	0.597
MOD_GlcNHglycan	327	330	PF01048	0.548
MOD_GlcNHglycan	335	338	PF01048	0.676
MOD_GlcNHglycan	350	353	PF01048	0.520
MOD_GlcNHglycan	374	377	PF01048	0.670
MOD_GlcNHglycan	45	48	PF01048	0.545
MOD_GlcNHglycan	64	67	PF01048	0.585
MOD_GlcNHglycan	87	90	PF01048	0.697
MOD_GSK3_1	106	113	PF00069	0.592
MOD_GSK3_1	134	141	PF00069	0.621
MOD_GSK3_1	146	153	PF00069	0.752
MOD_GSK3_1	190	197	PF00069	0.747
MOD_GSK3_1	315	322	PF00069	0.650
MOD_N-GLC_1	190	195	PF02516	0.690
MOD_N-GLC_1	219	224	PF02516	0.684
MOD_N-GLC_1	286	291	PF02516	0.553
MOD_N-GLC_1	85	90	PF02516	0.743
MOD_NEK2_1	1	6	PF00069	0.757
MOD_NEK2_1	144	149	PF00069	0.734
MOD_NEK2_1	155	160	PF00069	0.619
MOD_NEK2_1	372	377	PF00069	0.705
MOD_NEK2_1	85	90	PF00069	0.607
MOD_NEK2_2	306	311	PF00069	0.618
MOD_PIKK_1	184	190	PF00454	0.569
MOD_PK_1	255	261	PF00069	0.703
MOD_PKA_2	26	32	PF00069	0.638
MOD_PKA_2	76	82	PF00069	0.745
MOD_Plk_1	150	156	PF00069	0.603
MOD_Plk_1	265	271	PF00069	0.723
MOD_Plk_1	306	312	PF00069	0.677
MOD_Plk_2-3	265	271	PF00069	0.723
MOD_Plk_2-3	364	370	PF00069	0.716
MOD_Plk_4	140	146	PF00069	0.688
MOD_Plk_4	268	274	PF00069	0.693
MOD_Plk_4	306	312	PF00069	0.679
MOD_ProDKin_1	146	152	PF00069	0.801
MOD_ProDKin_1	161	167	PF00069	0.561
MOD_SUMO_rev_2	114	122	PF00179	0.624
MOD_SUMO_rev_2	247	256	PF00179	0.710
TRG_ENDOCYTIC_2	142	145	PF00928	0.574
TRG_ENDOCYTIC_2	308	311	PF00928	0.634

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7U9	Leishmania donovani	100%	100%
A4HLT2	Leishmania braziliensis	57%	100%
E9B458	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q3W7	Leishmania major	83%	100%