WD_REPEATS_REGION domain-containing protein

Quick info Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain - G-beta repeat - putative

Species:

Leishmania infantum

UniProt:

A4I986_LEIIN

TriTrypDb:

LINF_330030400

Length:

873

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005840	ribosome	5	7
GO:0005875	microtubule associated complex	2	8
GO:0030286	dynein complex	3	8
GO:0032991	protein-containing complex	1	9
GO:0043226	organelle	2	7
GO:0043228	non-membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043232	intracellular non-membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7
GO:1902494	catalytic complex	2	8
GO:1990904	ribonucleoprotein complex	2	7

Phosphorylation

Amastigote: 171, 495
Promastigote: 503
Promastigote/Amastigote: 497

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I986

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I986

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	8
GO:0007018	microtubule-based movement	3	8
GO:0009987	cellular process	1	8

Molecular functions
Term	Name	Level	Count
GO:0003774	cytoskeletal motor activity	1	8
GO:0003777	microtubule motor activity	2	8
GO:0008569	minus-end-directed microtubule motor activity	3	8
GO:0140657	ATP-dependent activity	1	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	169	171	PF00675	0.505
CLV_NRD_NRD_1	200	202	PF00675	0.683
CLV_NRD_NRD_1	217	219	PF00675	0.491
CLV_NRD_NRD_1	744	746	PF00675	0.341
CLV_NRD_NRD_1	828	830	PF00675	0.377
CLV_PCSK_FUR_1	336	340	PF00082	0.443
CLV_PCSK_KEX2_1	169	171	PF00082	0.505
CLV_PCSK_KEX2_1	200	202	PF00082	0.683
CLV_PCSK_KEX2_1	217	219	PF00082	0.680
CLV_PCSK_KEX2_1	338	340	PF00082	0.331
CLV_PCSK_KEX2_1	372	374	PF00082	0.482
CLV_PCSK_KEX2_1	546	548	PF00082	0.631
CLV_PCSK_PC1ET2_1	338	340	PF00082	0.398
CLV_PCSK_PC1ET2_1	372	374	PF00082	0.323
CLV_PCSK_PC1ET2_1	546	548	PF00082	0.615
CLV_PCSK_PC7_1	165	171	PF00082	0.500
CLV_PCSK_SKI1_1	338	342	PF00082	0.430
CLV_PCSK_SKI1_1	42	46	PF00082	0.439
CLV_PCSK_SKI1_1	487	491	PF00082	0.375
CLV_PCSK_SKI1_1	519	523	PF00082	0.621
CLV_PCSK_SKI1_1	66	70	PF00082	0.367
CLV_Separin_Metazoa	309	313	PF03568	0.551
DEG_COP1_1	646	655	PF00400	0.485
DEG_MDM2_SWIB_1	866	873	PF02201	0.400
DEG_SCF_FBW7_1	511	516	PF00400	0.683
DOC_ANK_TNKS_1	311	318	PF00023	0.474
DOC_CKS1_1	97	102	PF01111	0.329
DOC_MAPK_DCC_7	670	679	PF00069	0.393
DOC_MAPK_gen_1	371	377	PF00069	0.512
DOC_MAPK_gen_1	519	527	PF00069	0.541
DOC_MAPK_gen_1	543	553	PF00069	0.590
DOC_MAPK_gen_1	745	752	PF00069	0.285
DOC_MAPK_MEF2A_6	66	74	PF00069	0.418
DOC_MAPK_MEF2A_6	745	752	PF00069	0.287
DOC_MAPK_MEF2A_6	98	105	PF00069	0.337
DOC_PP1_RVXF_1	371	378	PF00149	0.324
DOC_PP1_RVXF_1	40	47	PF00149	0.426
DOC_PP2B_LxvP_1	772	775	PF13499	0.449
DOC_SPAK_OSR1_1	582	586	PF12202	0.302
DOC_USP7_MATH_1	206	210	PF00917	0.688
DOC_USP7_MATH_1	251	255	PF00917	0.593
DOC_USP7_MATH_1	34	38	PF00917	0.401
DOC_USP7_MATH_1	399	403	PF00917	0.299
DOC_USP7_MATH_1	411	415	PF00917	0.323
DOC_USP7_MATH_1	445	449	PF00917	0.345
DOC_USP7_MATH_1	584	588	PF00917	0.267
DOC_USP7_MATH_1	655	659	PF00917	0.403
DOC_USP7_UBL2_3	334	338	PF12436	0.423
DOC_USP7_UBL2_3	519	523	PF12436	0.671
DOC_WW_Pin1_4	129	134	PF00397	0.492
DOC_WW_Pin1_4	188	193	PF00397	0.682
DOC_WW_Pin1_4	202	207	PF00397	0.696
DOC_WW_Pin1_4	208	213	PF00397	0.727
DOC_WW_Pin1_4	218	223	PF00397	0.729
DOC_WW_Pin1_4	265	270	PF00397	0.641
DOC_WW_Pin1_4	287	292	PF00397	0.625
DOC_WW_Pin1_4	321	326	PF00397	0.578
DOC_WW_Pin1_4	509	514	PF00397	0.619
DOC_WW_Pin1_4	59	64	PF00397	0.394
DOC_WW_Pin1_4	672	677	PF00397	0.304
DOC_WW_Pin1_4	859	864	PF00397	0.382
DOC_WW_Pin1_4	96	101	PF00397	0.454
LIG_14-3-3_CanoR_1	169	173	PF00244	0.509
LIG_14-3-3_CanoR_1	200	205	PF00244	0.786
LIG_14-3-3_CanoR_1	217	222	PF00244	0.554
LIG_14-3-3_CanoR_1	487	494	PF00244	0.445
LIG_14-3-3_CanoR_1	50	58	PF00244	0.503
LIG_14-3-3_CanoR_1	514	518	PF00244	0.606
LIG_14-3-3_CanoR_1	526	534	PF00244	0.480
LIG_14-3-3_CanoR_1	636	642	PF00244	0.473
LIG_14-3-3_CanoR_1	829	835	PF00244	0.346
LIG_14-3-3_CanoR_1	868	873	PF00244	0.295
LIG_Actin_WH2_2	252	267	PF00022	0.653
LIG_Actin_WH2_2	298	314	PF00022	0.517
LIG_AP2alpha_1	617	621	PF02296	0.351
LIG_BRCT_BRCA1_1	19	23	PF00533	0.447
LIG_BRCT_BRCA1_1	252	256	PF00533	0.592
LIG_Clathr_ClatBox_1	295	299	PF01394	0.532
LIG_FHA_1	256	262	PF00498	0.684
LIG_FHA_1	290	296	PF00498	0.569
LIG_FHA_1	352	358	PF00498	0.406
LIG_FHA_1	415	421	PF00498	0.335
LIG_FHA_1	46	52	PF00498	0.467
LIG_FHA_1	5	11	PF00498	0.430
LIG_FHA_1	714	720	PF00498	0.306
LIG_FHA_1	742	748	PF00498	0.373
LIG_FHA_1	777	783	PF00498	0.535
LIG_FHA_1	796	802	PF00498	0.333
LIG_FHA_2	10	16	PF00498	0.363
LIG_FHA_2	322	328	PF00498	0.473
LIG_FHA_2	623	629	PF00498	0.312
LIG_FHA_2	737	743	PF00498	0.409
LIG_FHA_2	804	810	PF00498	0.290
LIG_FHA_2	81	87	PF00498	0.570
LIG_GBD_Chelix_1	375	383	PF00786	0.437
LIG_Integrin_isoDGR_2	55	57	PF01839	0.342
LIG_Integrin_RGD_1	306	308	PF01839	0.632
LIG_LIR_Gen_1	253	264	PF02991	0.598
LIG_LIR_Gen_1	297	305	PF02991	0.518
LIG_LIR_Gen_1	345	353	PF02991	0.301
LIG_LIR_Gen_1	569	577	PF02991	0.288
LIG_LIR_Gen_1	864	873	PF02991	0.308
LIG_LIR_LC3C_4	855	859	PF02991	0.239
LIG_LIR_Nem_3	253	259	PF02991	0.596
LIG_LIR_Nem_3	345	351	PF02991	0.302
LIG_LIR_Nem_3	562	566	PF02991	0.298
LIG_LIR_Nem_3	569	574	PF02991	0.264
LIG_LIR_Nem_3	864	869	PF02991	0.298
LIG_MYND_1	226	230	PF01753	0.534
LIG_PDZ_Class_1	868	873	PF00595	0.267
LIG_Pex14_1	613	617	PF04695	0.318
LIG_Pex14_2	617	621	PF04695	0.410
LIG_Pex14_2	759	763	PF04695	0.238
LIG_Pex14_2	866	870	PF04695	0.416
LIG_SH2_CRK	348	352	PF00017	0.282
LIG_SH2_NCK_1	204	208	PF00017	0.547
LIG_SH2_NCK_1	8	12	PF00017	0.436
LIG_SH2_STAT5	204	207	PF00017	0.533
LIG_SH2_STAT5	348	351	PF00017	0.284
LIG_SH2_STAT5	593	596	PF00017	0.251
LIG_SH2_STAT5	622	625	PF00017	0.214
LIG_SH2_STAT5	664	667	PF00017	0.250
LIG_SH2_STAT5	668	671	PF00017	0.282
LIG_SH2_STAT5	804	807	PF00017	0.316
LIG_SH2_STAT5	824	827	PF00017	0.220
LIG_SH3_3	127	133	PF00018	0.545
LIG_SH3_3	152	158	PF00018	0.612
LIG_SH3_3	219	225	PF00018	0.589
LIG_SH3_3	447	453	PF00018	0.362
LIG_SH3_3	514	520	PF00018	0.761
LIG_SH3_3	539	545	PF00018	0.561
LIG_SH3_3	647	653	PF00018	0.420
LIG_SH3_3	696	702	PF00018	0.399
LIG_SH3_3	94	100	PF00018	0.417
LIG_SH3_4	519	526	PF00018	0.618
LIG_SUMO_SIM_anti_2	362	367	PF11976	0.281
LIG_SUMO_SIM_par_1	364	369	PF11976	0.373
LIG_SUMO_SIM_par_1	442	448	PF11976	0.402
LIG_SUMO_SIM_par_1	548	554	PF11976	0.582
LIG_SUMO_SIM_par_1	697	703	PF11976	0.490
LIG_SUMO_SIM_par_1	727	733	PF11976	0.320
LIG_SUMO_SIM_par_1	99	104	PF11976	0.434
LIG_TRAF2_1	137	140	PF00917	0.565
LIG_TRAF2_1	149	152	PF00917	0.698
LIG_TRAF2_1	577	580	PF00917	0.315
LIG_TRAF2_1	83	86	PF00917	0.546
LIG_UBA3_1	365	372	PF00899	0.452
LIG_WRC_WIRS_1	560	565	PF05994	0.430
MOD_CDK_SPK_2	509	514	PF00069	0.506
MOD_CDK_SPxxK_3	59	66	PF00069	0.383
MOD_CK1_1	120	126	PF00069	0.621
MOD_CK1_1	132	138	PF00069	0.473
MOD_CK1_1	188	194	PF00069	0.705
MOD_CK1_1	199	205	PF00069	0.761
MOD_CK1_1	236	242	PF00069	0.617
MOD_CK1_1	249	255	PF00069	0.486
MOD_CK1_1	414	420	PF00069	0.306
MOD_CK1_1	473	479	PF00069	0.528
MOD_CK1_1	49	55	PF00069	0.339
MOD_CK1_1	503	509	PF00069	0.631
MOD_CK1_1	564	570	PF00069	0.436
MOD_CK1_1	658	664	PF00069	0.369
MOD_CK1_1	700	706	PF00069	0.461
MOD_CK1_1	762	768	PF00069	0.290
MOD_CK2_1	125	131	PF00069	0.487
MOD_CK2_1	146	152	PF00069	0.650
MOD_CK2_1	573	579	PF00069	0.358
MOD_CK2_1	622	628	PF00069	0.318
MOD_CK2_1	80	86	PF00069	0.567
MOD_CK2_1	815	821	PF00069	0.262
MOD_CK2_1	9	15	PF00069	0.367
MOD_GlcNHglycan	134	137	PF01048	0.541
MOD_GlcNHglycan	187	190	PF01048	0.676
MOD_GlcNHglycan	208	211	PF01048	0.725
MOD_GlcNHglycan	401	404	PF01048	0.397
MOD_GlcNHglycan	437	441	PF01048	0.328
MOD_GlcNHglycan	502	505	PF01048	0.594
MOD_GlcNHglycan	51	54	PF01048	0.419
MOD_GlcNHglycan	527	530	PF01048	0.631
MOD_GlcNHglycan	552	556	PF01048	0.498
MOD_GlcNHglycan	563	566	PF01048	0.290
MOD_GlcNHglycan	575	578	PF01048	0.353
MOD_GlcNHglycan	631	634	PF01048	0.346
MOD_GlcNHglycan	713	716	PF01048	0.374
MOD_GSK3_1	101	108	PF00069	0.431
MOD_GSK3_1	113	120	PF00069	0.599
MOD_GSK3_1	125	132	PF00069	0.545
MOD_GSK3_1	164	171	PF00069	0.384
MOD_GSK3_1	188	195	PF00069	0.653
MOD_GSK3_1	19	26	PF00069	0.401
MOD_GSK3_1	196	203	PF00069	0.688
MOD_GSK3_1	213	220	PF00069	0.723
MOD_GSK3_1	233	240	PF00069	0.453
MOD_GSK3_1	242	249	PF00069	0.484
MOD_GSK3_1	251	258	PF00069	0.551
MOD_GSK3_1	317	324	PF00069	0.615
MOD_GSK3_1	45	52	PF00069	0.484
MOD_GSK3_1	469	476	PF00069	0.472
MOD_GSK3_1	503	510	PF00069	0.614
MOD_GSK3_1	594	601	PF00069	0.429
MOD_GSK3_1	651	658	PF00069	0.317
MOD_GSK3_1	759	766	PF00069	0.272
MOD_GSK3_1	85	92	PF00069	0.655
MOD_LATS_1	232	238	PF00433	0.678
MOD_N-GLC_1	17	22	PF02516	0.414
MOD_N-GLC_1	192	197	PF02516	0.716
MOD_N-GLC_1	234	239	PF02516	0.649
MOD_N-GLC_1	608	613	PF02516	0.411
MOD_NEK2_1	164	169	PF00069	0.414
MOD_NEK2_1	17	22	PF00069	0.388
MOD_NEK2_1	183	188	PF00069	0.475
MOD_NEK2_1	264	269	PF00069	0.634
MOD_NEK2_1	301	306	PF00069	0.614
MOD_NEK2_1	366	371	PF00069	0.478
MOD_NEK2_1	377	382	PF00069	0.496
MOD_NEK2_1	45	50	PF00069	0.389
MOD_NEK2_1	469	474	PF00069	0.450
MOD_NEK2_1	475	480	PF00069	0.518
MOD_NEK2_1	494	499	PF00069	0.487
MOD_NEK2_1	507	512	PF00069	0.638
MOD_NEK2_1	559	564	PF00069	0.387
MOD_NEK2_1	594	599	PF00069	0.273
MOD_NEK2_1	637	642	PF00069	0.537
MOD_NEK2_1	682	687	PF00069	0.330
MOD_NEK2_1	763	768	PF00069	0.299
MOD_NEK2_1	815	820	PF00069	0.345
MOD_NEK2_1	857	862	PF00069	0.353
MOD_NEK2_2	329	334	PF00069	0.487
MOD_NEK2_2	792	797	PF00069	0.389
MOD_PIKK_1	351	357	PF00454	0.406
MOD_PIKK_1	391	397	PF00454	0.241
MOD_PIKK_1	492	498	PF00454	0.584
MOD_PKA_1	200	206	PF00069	0.684
MOD_PKA_1	217	223	PF00069	0.672
MOD_PKA_2	164	170	PF00069	0.496
MOD_PKA_2	199	205	PF00069	0.700
MOD_PKA_2	216	222	PF00069	0.667
MOD_PKA_2	228	234	PF00069	0.578
MOD_PKA_2	49	55	PF00069	0.339
MOD_PKA_2	513	519	PF00069	0.678
MOD_PKA_2	525	531	PF00069	0.598
MOD_PKB_1	485	493	PF00069	0.415
MOD_Plk_1	17	23	PF00069	0.441
MOD_Plk_1	192	198	PF00069	0.525
MOD_Plk_1	329	335	PF00069	0.489
MOD_Plk_1	377	383	PF00069	0.444
MOD_Plk_1	608	614	PF00069	0.327
MOD_Plk_1	763	769	PF00069	0.328
MOD_Plk_1	85	91	PF00069	0.542
MOD_Plk_4	117	123	PF00069	0.544
MOD_Plk_4	470	476	PF00069	0.516
MOD_Plk_4	598	604	PF00069	0.274
MOD_Plk_4	608	614	PF00069	0.276
MOD_Plk_4	68	74	PF00069	0.498
MOD_Plk_4	682	688	PF00069	0.435
MOD_Plk_4	736	742	PF00069	0.393
MOD_Plk_4	763	769	PF00069	0.269
MOD_Plk_4	830	836	PF00069	0.435
MOD_ProDKin_1	129	135	PF00069	0.484
MOD_ProDKin_1	188	194	PF00069	0.683
MOD_ProDKin_1	202	208	PF00069	0.696
MOD_ProDKin_1	218	224	PF00069	0.728
MOD_ProDKin_1	265	271	PF00069	0.643
MOD_ProDKin_1	287	293	PF00069	0.625
MOD_ProDKin_1	321	327	PF00069	0.571
MOD_ProDKin_1	509	515	PF00069	0.617
MOD_ProDKin_1	59	65	PF00069	0.385
MOD_ProDKin_1	672	678	PF00069	0.297
MOD_ProDKin_1	859	865	PF00069	0.384
MOD_ProDKin_1	96	102	PF00069	0.447
MOD_SUMO_for_1	387	390	PF00179	0.394
MOD_SUMO_rev_2	61	68	PF00179	0.470
MOD_SUMO_rev_2	81	89	PF00179	0.442
TRG_DiLeu_BaLyEn_6	673	678	PF01217	0.273
TRG_ENDOCYTIC_2	348	351	PF00928	0.284
TRG_ER_diArg_1	168	170	PF00400	0.495
TRG_ER_diArg_1	383	386	PF00400	0.349
TRG_ER_diArg_1	485	488	PF00400	0.424
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	38	43	PF00026	0.426

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCL0	Leptomonas seymouri	71%	99%
A0A1X0P3P9	Trypanosomatidae	49%	100%
A0A3R7KEX8	Trypanosoma rangeli	51%	100%
A0A3S7X3V5	Leishmania donovani	27%	100%
A0A3S7X707	Leishmania donovani	100%	100%
A4HIS9	Leishmania braziliensis	28%	100%
A4HLS7	Leishmania braziliensis	85%	99%
A4I631	Leishmania infantum	27%	100%
D0A6A0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9B1B6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B453	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q6U8	Leishmania major	27%	100%
Q9GRN2	Leishmania major	95%	100%
V5DQD1	Trypanosoma cruzi	52%	100%