Non-specific serine/threonine protein kinase

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase - putative

Species:

Leishmania infantum

UniProt:

A4I967_LEIIN

TriTrypDb:

LINF_330025600

Length:

640

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Annotations by Jardim et al.

Metal Binding, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	yes	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 3

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Phosphorylation

Promastigote: 308, 311

Expansion

Sequence features

A4I967

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I967

Function

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Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0007165	signal transduction	2	1
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0035556	intracellular signal transduction	3	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004672	protein kinase activity	3	12
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0005488	binding	1	12
GO:0005509	calcium ion binding	5	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	238	242	PF00656	0.323
CLV_C14_Caspase3-7	365	369	PF00656	0.304
CLV_C14_Caspase3-7	445	449	PF00656	0.519
CLV_C14_Caspase3-7	468	472	PF00656	0.354
CLV_C14_Caspase3-7	561	565	PF00656	0.622
CLV_NRD_NRD_1	16	18	PF00675	0.749
CLV_NRD_NRD_1	244	246	PF00675	0.327
CLV_NRD_NRD_1	514	516	PF00675	0.373
CLV_NRD_NRD_1	617	619	PF00675	0.391
CLV_NRD_NRD_1	84	86	PF00675	0.290

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMD1	Leptomonas seymouri	82%	100%
A0A0S4IPB3	Bodo saltans	31%	95%
A0A0S4JIY0	Bodo saltans	53%	99%
A0A1X0NJJ7	Trypanosomatidae	29%	85%
A0A1X0P150	Trypanosomatidae	56%	100%
A0A2I0BVG8	Plasmodium falciparum (isolate NF54)	27%	100%
A0A3Q8IU22	Leishmania donovani	100%	100%
A0A3S5H5G0	Leishmania donovani	25%	100%
A0A3S5H5U5	Leishmania donovani	27%	100%
A0A3S5IQS7	Trypanosoma rangeli	30%	87%

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