Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I964_LEIIN

TriTrypDb:

LINF_330029000

Length:

797

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4I964

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I964

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	177	181	PF00656	0.673
CLV_C14_Caspase3-7	323	327	PF00656	0.671
CLV_C14_Caspase3-7	580	584	PF00656	0.559
CLV_NRD_NRD_1	215	217	PF00675	0.525
CLV_NRD_NRD_1	304	306	PF00675	0.628
CLV_NRD_NRD_1	308	310	PF00675	0.610
CLV_NRD_NRD_1	31	33	PF00675	0.486
CLV_NRD_NRD_1	404	406	PF00675	0.546
CLV_NRD_NRD_1	496	498	PF00675	0.849
CLV_NRD_NRD_1	553	555	PF00675	0.493
CLV_NRD_NRD_1	56	58	PF00675	0.424
CLV_NRD_NRD_1	593	595	PF00675	0.450
CLV_PCSK_FUR_1	305	309	PF00082	0.567
CLV_PCSK_KEX2_1	215	217	PF00082	0.539
CLV_PCSK_KEX2_1	304	306	PF00082	0.628
CLV_PCSK_KEX2_1	307	309	PF00082	0.621
CLV_PCSK_KEX2_1	31	33	PF00082	0.486
CLV_PCSK_KEX2_1	404	406	PF00082	0.546
CLV_PCSK_KEX2_1	496	498	PF00082	0.833
CLV_PCSK_KEX2_1	553	555	PF00082	0.471
CLV_PCSK_KEX2_1	56	58	PF00082	0.424
CLV_PCSK_KEX2_1	593	595	PF00082	0.450
CLV_PCSK_KEX2_1	687	689	PF00082	0.496
CLV_PCSK_PC1ET2_1	687	689	PF00082	0.476
CLV_PCSK_PC7_1	304	310	PF00082	0.553
CLV_PCSK_SKI1_1	215	219	PF00082	0.558
CLV_PCSK_SKI1_1	526	530	PF00082	0.566
CLV_PCSK_SKI1_1	648	652	PF00082	0.486
DEG_APCC_DBOX_1	552	560	PF00400	0.696
DEG_APCC_DBOX_1	647	655	PF00400	0.466
DEG_Nend_Nbox_1	1	3	PF02207	0.637
DEG_SPOP_SBC_1	107	111	PF00917	0.684
DEG_SPOP_SBC_1	325	329	PF00917	0.727
DOC_CKS1_1	142	147	PF01111	0.762
DOC_CKS1_1	2	7	PF01111	0.628
DOC_CKS1_1	734	739	PF01111	0.735
DOC_CYCLIN_RxL_1	41	53	PF00134	0.591
DOC_CYCLIN_RxL_1	520	530	PF00134	0.422
DOC_CYCLIN_yCln2_LP_2	2	8	PF00134	0.722
DOC_CYCLIN_yCln2_LP_2	372	378	PF00134	0.679
DOC_CYCLIN_yCln2_LP_2	761	764	PF00134	0.772
DOC_MAPK_gen_1	593	601	PF00069	0.625
DOC_MAPK_gen_1	645	654	PF00069	0.597
DOC_MAPK_MEF2A_6	648	656	PF00069	0.456
DOC_PP1_RVXF_1	471	478	PF00149	0.383
DOC_PP2B_LxvP_1	116	119	PF13499	0.776
DOC_PP2B_LxvP_1	372	375	PF13499	0.802
DOC_PP2B_LxvP_1	754	757	PF13499	0.769
DOC_PP2B_LxvP_1	761	764	PF13499	0.772
DOC_PP2B_LxvP_1	778	781	PF13499	0.624
DOC_PP4_FxxP_1	142	145	PF00568	0.789
DOC_USP7_MATH_1	107	111	PF00917	0.731
DOC_USP7_MATH_1	153	157	PF00917	0.709
DOC_USP7_MATH_1	184	188	PF00917	0.701
DOC_USP7_MATH_1	210	214	PF00917	0.748
DOC_USP7_MATH_1	238	242	PF00917	0.701
DOC_USP7_MATH_1	269	273	PF00917	0.794
DOC_USP7_MATH_1	345	349	PF00917	0.710
DOC_USP7_MATH_1	363	367	PF00917	0.675
DOC_USP7_MATH_1	441	445	PF00917	0.749
DOC_USP7_MATH_1	487	491	PF00917	0.556
DOC_USP7_MATH_1	498	502	PF00917	0.467
DOC_USP7_MATH_1	585	589	PF00917	0.618
DOC_USP7_MATH_1	606	610	PF00917	0.572
DOC_USP7_MATH_1	715	719	PF00917	0.660
DOC_USP7_MATH_1	770	774	PF00917	0.722
DOC_USP7_MATH_1	97	101	PF00917	0.776
DOC_USP7_UBL2_3	442	446	PF12436	0.693
DOC_WW_Pin1_4	1	6	PF00397	0.631
DOC_WW_Pin1_4	110	115	PF00397	0.768
DOC_WW_Pin1_4	141	146	PF00397	0.768
DOC_WW_Pin1_4	188	193	PF00397	0.810
DOC_WW_Pin1_4	202	207	PF00397	0.682
DOC_WW_Pin1_4	226	231	PF00397	0.726
DOC_WW_Pin1_4	272	277	PF00397	0.726
DOC_WW_Pin1_4	286	291	PF00397	0.668
DOC_WW_Pin1_4	307	312	PF00397	0.730
DOC_WW_Pin1_4	370	375	PF00397	0.846
DOC_WW_Pin1_4	485	490	PF00397	0.579
DOC_WW_Pin1_4	56	61	PF00397	0.651
DOC_WW_Pin1_4	64	69	PF00397	0.657
DOC_WW_Pin1_4	717	722	PF00397	0.731
DOC_WW_Pin1_4	730	735	PF00397	0.636
LIG_14-3-3_CanoR_1	163	171	PF00244	0.733
LIG_14-3-3_CanoR_1	215	224	PF00244	0.695
LIG_14-3-3_CanoR_1	3	9	PF00244	0.625
LIG_14-3-3_CanoR_1	31	39	PF00244	0.688
LIG_14-3-3_CanoR_1	404	411	PF00244	0.769
LIG_14-3-3_CanoR_1	421	430	PF00244	0.643
LIG_14-3-3_CanoR_1	454	462	PF00244	0.774
LIG_14-3-3_CanoR_1	465	475	PF00244	0.511
LIG_14-3-3_CanoR_1	482	489	PF00244	0.438
LIG_14-3-3_CanoR_1	497	503	PF00244	0.551
LIG_14-3-3_CanoR_1	50	58	PF00244	0.618
LIG_14-3-3_CanoR_1	526	535	PF00244	0.318
LIG_14-3-3_CanoR_1	627	633	PF00244	0.612
LIG_14-3-3_CanoR_1	717	721	PF00244	0.756
LIG_14-3-3_CanoR_1	746	752	PF00244	0.807
LIG_BRCT_BRCA1_1	165	169	PF00533	0.749
LIG_BRCT_BRCA1_1	360	364	PF00533	0.738
LIG_BRCT_BRCA1_1	458	462	PF00533	0.727
LIG_BRCT_BRCA1_1	569	573	PF00533	0.654
LIG_BRCT_BRCA1_1	616	620	PF00533	0.639
LIG_BRCT_BRCA1_1	642	646	PF00533	0.560
LIG_BRCT_BRCA1_1	719	723	PF00533	0.746
LIG_deltaCOP1_diTrp_1	567	573	PF00928	0.701
LIG_EH_1	354	358	PF12763	0.760
LIG_FHA_1	111	117	PF00498	0.751
LIG_FHA_1	163	169	PF00498	0.665
LIG_FHA_1	247	253	PF00498	0.822
LIG_FHA_1	371	377	PF00498	0.804
LIG_FHA_1	38	44	PF00498	0.694
LIG_FHA_1	414	420	PF00498	0.782
LIG_FHA_1	498	504	PF00498	0.461
LIG_FHA_1	577	583	PF00498	0.649
LIG_FHA_1	653	659	PF00498	0.316
LIG_FHA_1	672	678	PF00498	0.449
LIG_FHA_2	175	181	PF00498	0.754
LIG_LIR_Apic_2	474	480	PF02991	0.349
LIG_LIR_Gen_1	170	179	PF02991	0.733
LIG_LIR_Gen_1	354	365	PF02991	0.715
LIG_LIR_Gen_1	567	575	PF02991	0.660
LIG_LIR_Gen_1	630	640	PF02991	0.662
LIG_LIR_Gen_1	647	658	PF02991	0.453
LIG_LIR_Gen_1	679	689	PF02991	0.646
LIG_LIR_LC3C_4	775	780	PF02991	0.713
LIG_LIR_Nem_3	170	174	PF02991	0.761
LIG_LIR_Nem_3	354	360	PF02991	0.715
LIG_LIR_Nem_3	522	528	PF02991	0.496
LIG_LIR_Nem_3	530	535	PF02991	0.359
LIG_LIR_Nem_3	567	572	PF02991	0.677
LIG_LIR_Nem_3	630	635	PF02991	0.665
LIG_LIR_Nem_3	647	653	PF02991	0.453
LIG_LIR_Nem_3	679	685	PF02991	0.645
LIG_LIR_Nem_3	750	754	PF02991	0.760
LIG_MYND_1	114	118	PF01753	0.716
LIG_MYND_1	370	374	PF01753	0.750
LIG_PCNA_yPIPBox_3	41	49	PF02747	0.629
LIG_Pex14_1	569	573	PF04695	0.702
LIG_Pex14_2	542	546	PF04695	0.376
LIG_Pex14_2	646	650	PF04695	0.283
LIG_SH2_CRK	575	579	PF00017	0.643
LIG_SH2_CRK	682	686	PF00017	0.719
LIG_SH2_GRB2like	575	578	PF00017	0.645
LIG_SH2_NCK_1	245	249	PF00017	0.752
LIG_SH2_NCK_1	607	611	PF00017	0.655
LIG_SH2_SRC	245	248	PF00017	0.748
LIG_SH2_SRC	575	578	PF00017	0.669
LIG_SH2_SRC	640	643	PF00017	0.640
LIG_SH2_STAP1	39	43	PF00017	0.687
LIG_SH2_STAT5	225	228	PF00017	0.774
LIG_SH2_STAT5	281	284	PF00017	0.715
LIG_SH2_STAT5	39	42	PF00017	0.679
LIG_SH2_STAT5	518	521	PF00017	0.479
LIG_SH2_STAT5	533	536	PF00017	0.355
LIG_SH2_STAT5	544	547	PF00017	0.383
LIG_SH3_3	115	121	PF00018	0.789
LIG_SH3_3	130	136	PF00018	0.718
LIG_SH3_3	284	290	PF00018	0.723
LIG_SH3_3	405	411	PF00018	0.780
LIG_SH3_3	435	441	PF00018	0.811
LIG_SH3_3	506	512	PF00018	0.548
LIG_SH3_3	731	737	PF00018	0.695
LIG_SH3_3	776	782	PF00018	0.762
LIG_Sin3_3	248	255	PF02671	0.677
LIG_SUMO_SIM_anti_2	655	661	PF11976	0.316
LIG_SUMO_SIM_par_1	123	128	PF11976	0.754
LIG_SUMO_SIM_par_1	4	9	PF11976	0.622
LIG_SUMO_SIM_par_1	650	655	PF11976	0.418
LIG_TRAF2_1	434	437	PF00917	0.810
LIG_TYR_ITIM	680	685	PF00017	0.719
LIG_UBA3_1	514	520	PF00899	0.533
LIG_WRC_WIRS_1	168	173	PF05994	0.732
LIG_WRC_WIRS_1	629	634	PF05994	0.630
LIG_WRC_WIRS_1	748	753	PF05994	0.758
LIG_WW_1	222	225	PF00397	0.729
LIG_WW_2	133	136	PF00397	0.671
MOD_CDK_SPxxK_3	188	195	PF00069	0.766
MOD_CK1_1	110	116	PF00069	0.800
MOD_CK1_1	156	162	PF00069	0.803
MOD_CK1_1	170	176	PF00069	0.705
MOD_CK1_1	272	278	PF00069	0.758
MOD_CK1_1	280	286	PF00069	0.794
MOD_CK1_1	289	295	PF00069	0.684
MOD_CK1_1	298	304	PF00069	0.650
MOD_CK1_1	30	36	PF00069	0.663
MOD_CK1_1	310	316	PF00069	0.709
MOD_CK1_1	368	374	PF00069	0.750
MOD_CK1_1	399	405	PF00069	0.776
MOD_CK1_1	463	469	PF00069	0.604
MOD_CK1_1	501	507	PF00069	0.559
MOD_CK1_1	527	533	PF00069	0.366
MOD_CK1_1	561	567	PF00069	0.667
MOD_CK1_1	59	65	PF00069	0.684
MOD_CK1_1	630	636	PF00069	0.647
MOD_CK1_1	661	667	PF00069	0.399
MOD_CK1_1	671	677	PF00069	0.383
MOD_CK1_1	732	738	PF00069	0.758
MOD_CK1_1	93	99	PF00069	0.774
MOD_CK2_1	170	176	PF00069	0.803
MOD_CK2_1	421	427	PF00069	0.785
MOD_CK2_1	431	437	PF00069	0.741
MOD_CK2_1	441	447	PF00069	0.656
MOD_CK2_1	561	567	PF00069	0.667
MOD_CK2_1	683	689	PF00069	0.720
MOD_DYRK1A_RPxSP_1	717	721	PF00069	0.771
MOD_GlcNHglycan	130	133	PF01048	0.559
MOD_GlcNHglycan	212	215	PF01048	0.583
MOD_GlcNHglycan	218	221	PF01048	0.537
MOD_GlcNHglycan	351	354	PF01048	0.553
MOD_GlcNHglycan	405	408	PF01048	0.590
MOD_GlcNHglycan	423	426	PF01048	0.434
MOD_GlcNHglycan	458	461	PF01048	0.641
MOD_GlcNHglycan	465	468	PF01048	0.350
MOD_GlcNHglycan	503	506	PF01048	0.677
MOD_GlcNHglycan	529	532	PF01048	0.366
MOD_GlcNHglycan	579	582	PF01048	0.369
MOD_GlcNHglycan	595	598	PF01048	0.402
MOD_GlcNHglycan	608	611	PF01048	0.368
MOD_GlcNHglycan	757	760	PF01048	0.571
MOD_GlcNHglycan	774	777	PF01048	0.583
MOD_GlcNHglycan	8	11	PF01048	0.457
MOD_GlcNHglycan	91	95	PF01048	0.511
MOD_GlcNHglycan	99	102	PF01048	0.527
MOD_GSK3_1	106	113	PF00069	0.748
MOD_GSK3_1	123	130	PF00069	0.709
MOD_GSK3_1	163	170	PF00069	0.787
MOD_GSK3_1	184	191	PF00069	0.766
MOD_GSK3_1	225	232	PF00069	0.708
MOD_GSK3_1	27	34	PF00069	0.673
MOD_GSK3_1	345	352	PF00069	0.848
MOD_GSK3_1	359	366	PF00069	0.678
MOD_GSK3_1	392	399	PF00069	0.805
MOD_GSK3_1	4	11	PF00069	0.628
MOD_GSK3_1	409	416	PF00069	0.651
MOD_GSK3_1	442	449	PF00069	0.762
MOD_GSK3_1	456	463	PF00069	0.636
MOD_GSK3_1	481	488	PF00069	0.719
MOD_GSK3_1	497	504	PF00069	0.505
MOD_GSK3_1	520	527	PF00069	0.453
MOD_GSK3_1	56	63	PF00069	0.671
MOD_GSK3_1	593	600	PF00069	0.655
MOD_GSK3_1	602	609	PF00069	0.606
MOD_GSK3_1	630	637	PF00069	0.635
MOD_GSK3_1	640	647	PF00069	0.597
MOD_GSK3_1	654	661	PF00069	0.399
MOD_GSK3_1	709	716	PF00069	0.780
MOD_GSK3_1	729	736	PF00069	0.604
MOD_GSK3_1	93	100	PF00069	0.784
MOD_N-GLC_1	345	350	PF02516	0.615
MOD_N-GLC_1	576	581	PF02516	0.438
MOD_N-GLC_1	602	607	PF02516	0.459
MOD_N-GLC_1	614	619	PF02516	0.356
MOD_NEK2_1	127	132	PF00069	0.804
MOD_NEK2_1	364	369	PF00069	0.769
MOD_NEK2_1	413	418	PF00069	0.705
MOD_NEK2_1	43	48	PF00069	0.617
MOD_NEK2_1	471	476	PF00069	0.349
MOD_NEK2_1	503	508	PF00069	0.514
MOD_NEK2_1	524	529	PF00069	0.440
MOD_NEK2_1	6	11	PF00069	0.674
MOD_NEK2_1	628	633	PF00069	0.626
MOD_NEK2_1	654	659	PF00069	0.466
MOD_NEK2_1	694	699	PF00069	0.744
MOD_NEK2_1	772	777	PF00069	0.799
MOD_OFUCOSY	666	672	PF10250	0.383
MOD_PIKK_1	345	351	PF00454	0.744
MOD_PIKK_1	387	393	PF00454	0.768
MOD_PIKK_1	446	452	PF00454	0.805
MOD_PIKK_1	460	466	PF00454	0.653
MOD_PIKK_1	487	493	PF00454	0.558
MOD_PIKK_1	621	627	PF00454	0.678
MOD_PIKK_1	630	636	PF00454	0.588
MOD_PKA_1	215	221	PF00069	0.733
MOD_PKA_1	31	37	PF00069	0.643
MOD_PKA_1	496	502	PF00069	0.548
MOD_PKA_1	593	599	PF00069	0.623
MOD_PKA_2	153	159	PF00069	0.776
MOD_PKA_2	162	168	PF00069	0.704
MOD_PKA_2	215	221	PF00069	0.756
MOD_PKA_2	27	33	PF00069	0.689
MOD_PKA_2	379	385	PF00069	0.748
MOD_PKA_2	403	409	PF00069	0.756
MOD_PKA_2	481	487	PF00069	0.673
MOD_PKA_2	496	502	PF00069	0.552
MOD_PKA_2	593	599	PF00069	0.652
MOD_PKA_2	644	650	PF00069	0.590
MOD_PKA_2	716	722	PF00069	0.814
MOD_Plk_1	246	252	PF00069	0.759
MOD_Plk_1	325	331	PF00069	0.730
MOD_Plk_1	395	401	PF00069	0.764
MOD_Plk_1	602	608	PF00069	0.663
MOD_Plk_4	12	18	PF00069	0.625
MOD_Plk_4	277	283	PF00069	0.782
MOD_Plk_4	498	504	PF00069	0.526
MOD_Plk_4	520	526	PF00069	0.463
MOD_Plk_4	558	564	PF00069	0.753
MOD_Plk_4	654	660	PF00069	0.503
MOD_Plk_4	763	769	PF00069	0.725
MOD_ProDKin_1	1	7	PF00069	0.629
MOD_ProDKin_1	110	116	PF00069	0.770
MOD_ProDKin_1	141	147	PF00069	0.766
MOD_ProDKin_1	188	194	PF00069	0.810
MOD_ProDKin_1	202	208	PF00069	0.682
MOD_ProDKin_1	226	232	PF00069	0.725
MOD_ProDKin_1	272	278	PF00069	0.726
MOD_ProDKin_1	286	292	PF00069	0.669
MOD_ProDKin_1	307	313	PF00069	0.729
MOD_ProDKin_1	370	376	PF00069	0.849
MOD_ProDKin_1	485	491	PF00069	0.582
MOD_ProDKin_1	56	62	PF00069	0.654
MOD_ProDKin_1	64	70	PF00069	0.658
MOD_ProDKin_1	717	723	PF00069	0.732
MOD_ProDKin_1	730	736	PF00069	0.638
MOD_SUMO_for_1	194	197	PF00179	0.722
MOD_SUMO_for_1	519	522	PF00179	0.442
TRG_DiLeu_BaEn_3	689	695	PF01217	0.595
TRG_DiLeu_BaLyEn_6	372	377	PF01217	0.736
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.587
TRG_DiLeu_BaLyEn_6	624	629	PF01217	0.567
TRG_ENDOCYTIC_2	532	535	PF00928	0.480
TRG_ENDOCYTIC_2	575	578	PF00928	0.669
TRG_ENDOCYTIC_2	682	685	PF00928	0.721
TRG_ER_diArg_1	215	217	PF00400	0.740
TRG_ER_diArg_1	304	307	PF00400	0.831
TRG_ER_diArg_1	496	498	PF00400	0.504
TRG_ER_diArg_1	552	554	PF00400	0.659
TRG_ER_diArg_1	56	58	PF00400	0.624
TRG_NES_CRM1_1	555	567	PF08389	0.661

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7U8	Leishmania donovani	99%	100%
A4HLR4	Leishmania braziliensis	51%	100%
E9B440	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q3Y5	Leishmania major	83%	100%