Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I961_LEIIN

TriTrypDb:

LINF_330028700

Length:

646

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I961

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I961

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	326	330	PF00656	0.764
CLV_NRD_NRD_1	114	116	PF00675	0.636
CLV_NRD_NRD_1	159	161	PF00675	0.633
CLV_NRD_NRD_1	234	236	PF00675	0.718
CLV_NRD_NRD_1	335	337	PF00675	0.724
CLV_NRD_NRD_1	416	418	PF00675	0.606
CLV_PCSK_KEX2_1	234	236	PF00082	0.714
CLV_PCSK_KEX2_1	335	337	PF00082	0.749
CLV_PCSK_KEX2_1	570	572	PF00082	0.784
CLV_PCSK_KEX2_1	577	579	PF00082	0.674
CLV_PCSK_KEX2_1	636	638	PF00082	0.614
CLV_PCSK_PC1ET2_1	570	572	PF00082	0.784
CLV_PCSK_PC1ET2_1	577	579	PF00082	0.674
CLV_PCSK_PC1ET2_1	636	638	PF00082	0.625
CLV_PCSK_SKI1_1	628	632	PF00082	0.627
CLV_PCSK_SKI1_1	633	637	PF00082	0.589
DEG_Nend_Nbox_1	1	3	PF02207	0.660
DEG_SPOP_SBC_1	248	252	PF00917	0.591
DEG_SPOP_SBC_1	293	297	PF00917	0.759
DEG_SPOP_SBC_1	301	305	PF00917	0.663
DOC_CDC14_PxL_1	521	529	PF14671	0.552
DOC_CYCLIN_RxL_1	444	454	PF00134	0.505
DOC_MAPK_gen_1	633	643	PF00069	0.736
DOC_PP2B_LxvP_1	265	268	PF13499	0.703
DOC_USP7_MATH_1	140	144	PF00917	0.728
DOC_USP7_MATH_1	249	253	PF00917	0.695
DOC_USP7_MATH_1	271	275	PF00917	0.635
DOC_USP7_MATH_1	293	297	PF00917	0.661
DOC_USP7_MATH_1	317	321	PF00917	0.750
DOC_USP7_MATH_1	38	42	PF00917	0.558
DOC_USP7_MATH_1	413	417	PF00917	0.825
DOC_USP7_MATH_1	424	428	PF00917	0.635
DOC_USP7_MATH_1	430	434	PF00917	0.532
DOC_USP7_MATH_1	492	496	PF00917	0.744
DOC_USP7_MATH_1	501	505	PF00917	0.659
DOC_USP7_MATH_1	533	537	PF00917	0.716
DOC_USP7_MATH_1	543	547	PF00917	0.599
DOC_USP7_MATH_1	95	99	PF00917	0.527
DOC_USP7_UBL2_3	577	581	PF12436	0.799
DOC_WW_Pin1_4	235	240	PF00397	0.839
DOC_WW_Pin1_4	242	247	PF00397	0.714
DOC_WW_Pin1_4	28	33	PF00397	0.743
DOC_WW_Pin1_4	284	289	PF00397	0.741
DOC_WW_Pin1_4	641	646	PF00397	0.681
LIG_14-3-3_CanoR_1	195	200	PF00244	0.505
LIG_14-3-3_CanoR_1	205	213	PF00244	0.709
LIG_14-3-3_CanoR_1	24	34	PF00244	0.536
LIG_14-3-3_CanoR_1	335	341	PF00244	0.764
LIG_14-3-3_CanoR_1	384	393	PF00244	0.815
LIG_14-3-3_CanoR_1	40	50	PF00244	0.490
LIG_14-3-3_CanoR_1	605	614	PF00244	0.748
LIG_Actin_WH2_2	67	84	PF00022	0.336
LIG_BRCT_BRCA1_1	167	171	PF00533	0.708
LIG_BRCT_BRCA1_1	52	56	PF00533	0.362
LIG_Clathr_ClatBox_1	359	363	PF01394	0.644
LIG_eIF4E_1	471	477	PF01652	0.523
LIG_FHA_1	29	35	PF00498	0.600
LIG_FHA_1	305	311	PF00498	0.791
LIG_FHA_1	323	329	PF00498	0.537
LIG_FHA_1	459	465	PF00498	0.481
LIG_FHA_1	550	556	PF00498	0.708
LIG_FHA_2	207	213	PF00498	0.753
LIG_FHA_2	218	224	PF00498	0.548
LIG_FHA_2	478	484	PF00498	0.530
LIG_Integrin_RGD_1	155	157	PF01839	0.816
LIG_LIR_Apic_2	168	172	PF02991	0.688
LIG_LIR_Apic_2	520	525	PF02991	0.664
LIG_LIR_Gen_1	349	356	PF02991	0.738
LIG_LIR_Gen_1	517	526	PF02991	0.544
LIG_LIR_Gen_1	53	64	PF02991	0.322
LIG_LIR_Nem_3	104	108	PF02991	0.412
LIG_LIR_Nem_3	344	350	PF02991	0.788
LIG_LIR_Nem_3	517	521	PF02991	0.546
LIG_LIR_Nem_3	53	59	PF02991	0.321
LIG_PCNA_yPIPBox_3	444	453	PF02747	0.607
LIG_Pex14_2	518	522	PF04695	0.632
LIG_SH2_STAP1	197	201	PF00017	0.574
LIG_SH2_STAP1	50	54	PF00017	0.565
LIG_SH2_STAT3	186	189	PF00017	0.672
LIG_SH2_STAT5	105	108	PF00017	0.426
LIG_SH2_STAT5	197	200	PF00017	0.558
LIG_SH2_STAT5	340	343	PF00017	0.825
LIG_SH2_STAT5	471	474	PF00017	0.514
LIG_SH2_STAT5	80	83	PF00017	0.491
LIG_SH3_3	134	140	PF00018	0.727
LIG_SH3_3	142	148	PF00018	0.633
LIG_SH3_3	261	267	PF00018	0.739
LIG_SH3_3	552	558	PF00018	0.750
LIG_SUMO_SIM_par_1	436	442	PF11976	0.705
LIG_SUMO_SIM_par_1	448	454	PF11976	0.427
LIG_SUMO_SIM_par_1	619	626	PF11976	0.733
LIG_TRAF2_1	480	483	PF00917	0.669
LIG_TYR_ITIM	109	114	PF00017	0.525
LIG_UBA3_1	631	636	PF00899	0.711
LIG_WRC_WIRS_1	213	218	PF05994	0.766
LIG_WRC_WIRS_1	485	490	PF05994	0.616
MOD_CK1_1	287	293	PF00069	0.709
MOD_CK1_1	295	301	PF00069	0.620
MOD_CK1_1	302	308	PF00069	0.605
MOD_CK1_1	309	315	PF00069	0.635
MOD_CK1_1	36	42	PF00069	0.540
MOD_CK1_1	387	393	PF00069	0.824
MOD_CK1_1	403	409	PF00069	0.647
MOD_CK1_1	416	422	PF00069	0.730
MOD_CK1_1	487	493	PF00069	0.688
MOD_CK1_1	505	511	PF00069	0.552
MOD_CK1_1	6	12	PF00069	0.518
MOD_CK1_1	90	96	PF00069	0.648
MOD_CK2_1	15	21	PF00069	0.637
MOD_CK2_1	206	212	PF00069	0.753
MOD_CK2_1	217	223	PF00069	0.542
MOD_CK2_1	408	414	PF00069	0.800
MOD_CK2_1	460	466	PF00069	0.481
MOD_CK2_1	477	483	PF00069	0.402
MOD_CK2_1	514	520	PF00069	0.708
MOD_Cter_Amidation	232	235	PF01082	0.759
MOD_GlcNHglycan	251	254	PF01048	0.736
MOD_GlcNHglycan	273	276	PF01048	0.793
MOD_GlcNHglycan	279	282	PF01048	0.857
MOD_GlcNHglycan	299	302	PF01048	0.477
MOD_GlcNHglycan	319	322	PF01048	0.783
MOD_GlcNHglycan	325	328	PF01048	0.735
MOD_GlcNHglycan	36	39	PF01048	0.560
MOD_GlcNHglycan	410	413	PF01048	0.755
MOD_GlcNHglycan	426	429	PF01048	0.534
MOD_GlcNHglycan	495	498	PF01048	0.738
MOD_GlcNHglycan	504	507	PF01048	0.630
MOD_GlcNHglycan	535	538	PF01048	0.734
MOD_GlcNHglycan	545	548	PF01048	0.695
MOD_GlcNHglycan	552	555	PF01048	0.670
MOD_GlcNHglycan	59	62	PF01048	0.308
MOD_GlcNHglycan	610	613	PF01048	0.781
MOD_GlcNHglycan	82	85	PF01048	0.622
MOD_GlcNHglycan	97	100	PF01048	0.451
MOD_GSK3_1	24	31	PF00069	0.532
MOD_GSK3_1	247	254	PF00069	0.729
MOD_GSK3_1	267	274	PF00069	0.488
MOD_GSK3_1	287	294	PF00069	0.683
MOD_GSK3_1	295	302	PF00069	0.642
MOD_GSK3_1	304	311	PF00069	0.625
MOD_GSK3_1	32	39	PF00069	0.525
MOD_GSK3_1	369	376	PF00069	0.770
MOD_GSK3_1	387	394	PF00069	0.582
MOD_GSK3_1	399	406	PF00069	0.809
MOD_GSK3_1	416	423	PF00069	0.541
MOD_GSK3_1	46	53	PF00069	0.581
MOD_GSK3_1	484	491	PF00069	0.692
MOD_GSK3_1	501	508	PF00069	0.558
MOD_GSK3_1	510	517	PF00069	0.696
MOD_GSK3_1	533	540	PF00069	0.735
MOD_GSK3_1	543	550	PF00069	0.667
MOD_GSK3_1	586	593	PF00069	0.777
MOD_GSK3_1	637	644	PF00069	0.753
MOD_N-GLC_1	477	482	PF02516	0.585
MOD_N-GLC_1	637	642	PF02516	0.531
MOD_NEK2_1	227	232	PF00069	0.747
MOD_NEK2_1	291	296	PF00069	0.692
MOD_NEK2_1	306	311	PF00069	0.733
MOD_NEK2_1	43	48	PF00069	0.634
MOD_NEK2_1	458	463	PF00069	0.489
MOD_NEK2_1	467	472	PF00069	0.494
MOD_NEK2_1	488	493	PF00069	0.657
MOD_NEK2_1	510	515	PF00069	0.674
MOD_NEK2_1	54	59	PF00069	0.302
MOD_NEK2_2	75	80	PF00069	0.487
MOD_PIKK_1	369	375	PF00454	0.711
MOD_PIKK_1	400	406	PF00454	0.833
MOD_PIKK_1	43	49	PF00454	0.516
MOD_PIKK_1	458	464	PF00454	0.484
MOD_PK_1	637	643	PF00069	0.751
MOD_PKA_2	123	129	PF00069	0.557
MOD_PKA_2	25	31	PF00069	0.516
MOD_PKA_2	322	328	PF00069	0.822
MOD_PKA_2	39	45	PF00069	0.517
MOD_PKA_2	416	422	PF00069	0.607
MOD_PKB_1	24	32	PF00069	0.516
MOD_Plk_1	50	56	PF00069	0.596
MOD_Plk_1	62	68	PF00069	0.306
MOD_Plk_1	637	643	PF00069	0.751
MOD_Plk_2-3	451	457	PF00069	0.586
MOD_Plk_4	140	146	PF00069	0.599
MOD_Plk_4	165	171	PF00069	0.783
MOD_Plk_4	251	257	PF00069	0.682
MOD_Plk_4	287	293	PF00069	0.631
MOD_Plk_4	460	466	PF00069	0.459
MOD_Plk_4	467	473	PF00069	0.430
MOD_Plk_4	484	490	PF00069	0.440
MOD_Plk_4	637	643	PF00069	0.697
MOD_Plk_4	75	81	PF00069	0.482
MOD_ProDKin_1	235	241	PF00069	0.839
MOD_ProDKin_1	242	248	PF00069	0.713
MOD_ProDKin_1	28	34	PF00069	0.744
MOD_ProDKin_1	284	290	PF00069	0.740
TRG_DiLeu_BaEn_2	356	362	PF01217	0.545
TRG_DiLeu_BaLyEn_6	445	450	PF01217	0.501
TRG_DiLeu_BaLyEn_6	522	527	PF01217	0.683
TRG_DiLeu_BaLyEn_6	617	622	PF01217	0.688
TRG_ENDOCYTIC_2	111	114	PF00928	0.506
TRG_ENDOCYTIC_2	347	350	PF00928	0.782
TRG_ER_diArg_1	234	237	PF00400	0.717
TRG_ER_diArg_1	335	338	PF00400	0.754
TRG_NES_CRM1_1	357	370	PF08389	0.666

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2A9	Leptomonas seymouri	36%	100%
A0A3Q8IEY7	Leishmania donovani	98%	100%
A4HLR1	Leishmania braziliensis	68%	99%
E9B437	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q3Y8	Leishmania major	89%	99%