Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I958_LEIIN

TriTrypDb:

LINF_330028400

Length:

541

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I958

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I958

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.652
CLV_C14_Caspase3-7	273	277	PF00656	0.658
CLV_C14_Caspase3-7	432	436	PF00656	0.742
CLV_C14_Caspase3-7	93	97	PF00656	0.747
CLV_PCSK_KEX2_1	227	229	PF00082	0.684
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.684
CLV_PCSK_SKI1_1	129	133	PF00082	0.792
CLV_PCSK_SKI1_1	384	388	PF00082	0.582
CLV_PCSK_SKI1_1	458	462	PF00082	0.699
DEG_Nend_Nbox_1	1	3	PF02207	0.707
DEG_SCF_FBW7_1	362	368	PF00400	0.752
DEG_SPOP_SBC_1	155	159	PF00917	0.599
DEG_SPOP_SBC_1	270	274	PF00917	0.663
DEG_SPOP_SBC_1	365	369	PF00917	0.793
DEG_SPOP_SBC_1	430	434	PF00917	0.697
DOC_CKS1_1	348	353	PF01111	0.844
DOC_CKS1_1	362	367	PF01111	0.634
DOC_MAPK_DCC_7	129	137	PF00069	0.747
DOC_MAPK_FxFP_2	137	140	PF00069	0.804
DOC_MAPK_MEF2A_6	129	137	PF00069	0.747
DOC_PP1_RVXF_1	70	76	PF00149	0.738
DOC_PP2B_LxvP_1	521	524	PF13499	0.741
DOC_PP4_FxxP_1	137	140	PF00568	0.804
DOC_PP4_FxxP_1	153	156	PF00568	0.548
DOC_SPAK_OSR1_1	191	195	PF12202	0.619
DOC_USP7_MATH_1	109	113	PF00917	0.775
DOC_USP7_MATH_1	156	160	PF00917	0.736
DOC_USP7_MATH_1	21	25	PF00917	0.721
DOC_USP7_MATH_1	234	238	PF00917	0.774
DOC_USP7_MATH_1	251	255	PF00917	0.528
DOC_USP7_MATH_1	27	31	PF00917	0.690
DOC_USP7_MATH_1	270	274	PF00917	0.556
DOC_USP7_MATH_1	300	304	PF00917	0.751
DOC_USP7_MATH_1	318	322	PF00917	0.782
DOC_USP7_MATH_1	329	333	PF00917	0.712
DOC_USP7_MATH_1	334	338	PF00917	0.806
DOC_USP7_MATH_1	365	369	PF00917	0.736
DOC_USP7_MATH_1	430	434	PF00917	0.697
DOC_USP7_MATH_1	465	469	PF00917	0.659
DOC_USP7_MATH_1	524	528	PF00917	0.689
DOC_USP7_MATH_2	230	236	PF00917	0.822
DOC_WW_Pin1_4	170	175	PF00397	0.746
DOC_WW_Pin1_4	23	28	PF00397	0.637
DOC_WW_Pin1_4	283	288	PF00397	0.755
DOC_WW_Pin1_4	347	352	PF00397	0.809
DOC_WW_Pin1_4	361	366	PF00397	0.826
DOC_WW_Pin1_4	426	431	PF00397	0.747
DOC_WW_Pin1_4	488	493	PF00397	0.754
LIG_14-3-3_CanoR_1	266	270	PF00244	0.757
LIG_14-3-3_CanoR_1	288	296	PF00244	0.646
LIG_14-3-3_CanoR_1	335	339	PF00244	0.786
LIG_14-3-3_CanoR_1	458	464	PF00244	0.760
LIG_14-3-3_CanoR_1	525	533	PF00244	0.736
LIG_Actin_WH2_2	459	474	PF00022	0.521
LIG_BIR_III_2	313	317	PF00653	0.799
LIG_BIR_III_4	108	112	PF00653	0.642
LIG_BIR_III_4	96	100	PF00653	0.798
LIG_BRCT_BRCA1_1	78	82	PF00533	0.707
LIG_eIF4E_1	488	494	PF01652	0.752
LIG_FHA_1	266	272	PF00498	0.762
LIG_FHA_1	447	453	PF00498	0.684
LIG_FHA_1	465	471	PF00498	0.732
LIG_FHA_1	489	495	PF00498	0.748
LIG_FHA_2	410	416	PF00498	0.730
LIG_Integrin_RGD_1	100	102	PF01839	0.757
LIG_LIR_Apic_2	152	156	PF02991	0.670
LIG_LIR_Gen_1	76	82	PF02991	0.709
LIG_LIR_Nem_3	76	80	PF02991	0.706
LIG_MLH1_MIPbox_1	78	82	PF16413	0.707
LIG_NRBOX	255	261	PF00104	0.621
LIG_NRBOX	503	509	PF00104	0.737
LIG_Pex14_2	77	81	PF04695	0.707
LIG_Rb_LxCxE_1	407	425	PF01857	0.736
LIG_SH2_CRK	172	176	PF00017	0.860
LIG_SH2_NCK_1	172	176	PF00017	0.860
LIG_SH2_SRC	90	93	PF00017	0.761
LIG_SH2_STAT5	115	118	PF00017	0.798
LIG_SH3_3	176	182	PF00018	0.800
LIG_SH3_3	198	204	PF00018	0.764
LIG_SH3_3	207	213	PF00018	0.666
LIG_SH3_3	323	329	PF00018	0.800
LIG_SH3_3	345	351	PF00018	0.850
LIG_SH3_3	353	359	PF00018	0.721
LIG_SH3_3	367	373	PF00018	0.604
LIG_SH3_3	411	417	PF00018	0.627
LIG_SH3_3	491	497	PF00018	0.733
LIG_SH3_3	53	59	PF00018	0.631
LIG_SUMO_SIM_par_1	499	505	PF11976	0.643
LIG_TRAF2_1	417	420	PF00917	0.640
LIG_TRAF2_1	512	515	PF00917	0.584
LIG_TRAF2_1	6	9	PF00917	0.744
LIG_WRC_WIRS_1	423	428	PF05994	0.634
LIG_WRC_WIRS_1	77	82	PF05994	0.710
LIG_WW_3	324	328	PF00397	0.796
MOD_CDK_SPK_2	283	288	PF00069	0.653
MOD_CDK_SPK_2	352	357	PF00069	0.787
MOD_CDK_SPxK_1	366	372	PF00069	0.765
MOD_CK1_1	264	270	PF00069	0.856
MOD_CK1_1	272	278	PF00069	0.732
MOD_CK1_1	291	297	PF00069	0.547
MOD_CK1_1	31	37	PF00069	0.788
MOD_CK1_1	366	372	PF00069	0.757
MOD_CK1_1	425	431	PF00069	0.783
MOD_CK1_1	456	462	PF00069	0.765
MOD_CK2_1	272	278	PF00069	0.853
MOD_CK2_1	409	415	PF00069	0.791
MOD_GlcNHglycan	119	122	PF01048	0.709
MOD_GlcNHglycan	163	166	PF01048	0.814
MOD_GlcNHglycan	19	22	PF01048	0.713
MOD_GlcNHglycan	236	239	PF01048	0.753
MOD_GlcNHglycan	30	33	PF01048	0.636
MOD_GlcNHglycan	320	323	PF01048	0.672
MOD_GlcNHglycan	454	458	PF01048	0.640
MOD_GlcNHglycan	535	538	PF01048	0.820
MOD_GlcNHglycan	86	89	PF01048	0.743
MOD_GlcNHglycan	91	95	PF01048	0.715
MOD_GSK3_1	109	116	PF00069	0.660
MOD_GSK3_1	17	24	PF00069	0.717
MOD_GSK3_1	261	268	PF00069	0.801
MOD_GSK3_1	27	34	PF00069	0.643
MOD_GSK3_1	329	336	PF00069	0.843
MOD_GSK3_1	361	368	PF00069	0.746
MOD_GSK3_1	385	392	PF00069	0.636
MOD_GSK3_1	421	428	PF00069	0.763
MOD_GSK3_1	446	453	PF00069	0.565
MOD_N-GLC_1	36	41	PF02516	0.791
MOD_N-GLC_1	62	67	PF02516	0.727
MOD_N-GLC_2	293	295	PF02516	0.791
MOD_NEK2_1	17	22	PF00069	0.718
MOD_NEK2_1	421	426	PF00069	0.687
MOD_PIKK_1	113	119	PF00454	0.656
MOD_PIKK_1	261	267	PF00454	0.839
MOD_PKA_2	109	115	PF00069	0.789
MOD_PKA_2	117	123	PF00069	0.703
MOD_PKA_2	265	271	PF00069	0.826
MOD_PKA_2	334	340	PF00069	0.784
MOD_PKA_2	450	456	PF00069	0.764
MOD_PKA_2	524	530	PF00069	0.774
MOD_Plk_1	241	247	PF00069	0.697
MOD_Plk_1	301	307	PF00069	0.778
MOD_Plk_1	384	390	PF00069	0.779
MOD_Plk_2-3	62	68	PF00069	0.627
MOD_Plk_4	149	155	PF00069	0.818
MOD_Plk_4	206	212	PF00069	0.846
MOD_Plk_4	76	82	PF00069	0.709
MOD_ProDKin_1	170	176	PF00069	0.751
MOD_ProDKin_1	23	29	PF00069	0.643
MOD_ProDKin_1	283	289	PF00069	0.753
MOD_ProDKin_1	347	353	PF00069	0.807
MOD_ProDKin_1	361	367	PF00069	0.828
MOD_ProDKin_1	426	432	PF00069	0.740
MOD_ProDKin_1	488	494	PF00069	0.752
MOD_SUMO_rev_2	511	517	PF00179	0.691
MOD_SUMO_rev_2	62	70	PF00179	0.665
TRG_DiLeu_BaEn_1	374	379	PF01217	0.795
TRG_ENDOCYTIC_2	2	5	PF00928	0.757

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X6Z0	Leishmania donovani	100%	100%
A4HLQ8	Leishmania braziliensis	63%	100%
E9B434	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q3Z1	Leishmania major	86%	100%