Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I956_LEIIN

TriTrypDb:

LINF_330028100

Length:

650

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

A4I956

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I956

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.755
CLV_C14_Caspase3-7	197	201	PF00656	0.704
CLV_C14_Caspase3-7	454	458	PF00656	0.486
CLV_C14_Caspase3-7	635	639	PF00656	0.582
CLV_C14_Caspase3-7	91	95	PF00656	0.603
CLV_NRD_NRD_1	13	15	PF00675	0.563
CLV_NRD_NRD_1	30	32	PF00675	0.435
CLV_NRD_NRD_1	339	341	PF00675	0.491
CLV_NRD_NRD_1	626	628	PF00675	0.509
CLV_PCSK_FUR_1	375	379	PF00082	0.406
CLV_PCSK_KEX2_1	13	15	PF00082	0.563
CLV_PCSK_KEX2_1	231	233	PF00082	0.401
CLV_PCSK_KEX2_1	30	32	PF00082	0.435
CLV_PCSK_KEX2_1	339	341	PF00082	0.405
CLV_PCSK_KEX2_1	377	379	PF00082	0.328
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.298
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.383
CLV_PCSK_SKI1_1	169	173	PF00082	0.419
CLV_PCSK_SKI1_1	31	35	PF00082	0.506
CLV_PCSK_SKI1_1	378	382	PF00082	0.375
CLV_PCSK_SKI1_1	631	635	PF00082	0.510
DEG_MDM2_SWIB_1	312	320	PF02201	0.282
DEG_SCF_TRCP1_1	638	643	PF00400	0.600
DOC_MAPK_FxFP_2	400	403	PF00069	0.282
DOC_MAPK_gen_1	372	381	PF00069	0.541
DOC_MAPK_gen_1	423	432	PF00069	0.286
DOC_MAPK_MEF2A_6	423	431	PF00069	0.286
DOC_MAPK_RevD_3	362	378	PF00069	0.535
DOC_PP1_RVXF_1	542	548	PF00149	0.457
DOC_PP1_RVXF_1	573	580	PF00149	0.437
DOC_PP1_RVXF_1	618	624	PF00149	0.679
DOC_PP2B_LxvP_1	346	349	PF13499	0.612
DOC_PP4_FxxP_1	215	218	PF00568	0.551
DOC_PP4_FxxP_1	400	403	PF00568	0.345
DOC_PP4_FxxP_1	57	60	PF00568	0.777
DOC_USP7_MATH_1	143	147	PF00917	0.539
DOC_USP7_MATH_1	18	22	PF00917	0.712
DOC_USP7_MATH_1	252	256	PF00917	0.519
DOC_USP7_MATH_1	48	52	PF00917	0.796
DOC_USP7_MATH_1	645	649	PF00917	0.760
DOC_USP7_MATH_1	82	86	PF00917	0.677
DOC_WW_Pin1_4	12	17	PF00397	0.667
DOC_WW_Pin1_4	128	133	PF00397	0.531
DOC_WW_Pin1_4	347	352	PF00397	0.511
LIG_14-3-3_CanoR_1	126	132	PF00244	0.497
LIG_14-3-3_CanoR_1	17	23	PF00244	0.703
LIG_14-3-3_CanoR_1	221	230	PF00244	0.623
LIG_14-3-3_CanoR_1	300	305	PF00244	0.382
LIG_14-3-3_CanoR_1	475	483	PF00244	0.492
LIG_14-3-3_CanoR_1	511	520	PF00244	0.234
LIG_14-3-3_CanoR_1	544	554	PF00244	0.522
LIG_14-3-3_CanoR_1	77	84	PF00244	0.721
LIG_Actin_WH2_2	215	233	PF00022	0.588
LIG_BIR_II_1	1	5	PF00653	0.738
LIG_BIR_III_2	47	51	PF00653	0.650
LIG_Clathr_ClatBox_1	63	67	PF01394	0.598
LIG_CORNRBOX	391	399	PF00104	0.246
LIG_CtBP_PxDLS_1	60	64	PF00389	0.596
LIG_deltaCOP1_diTrp_1	421	426	PF00928	0.303
LIG_EH1_1	165	173	PF00400	0.507
LIG_eIF4E_1	304	310	PF01652	0.282
LIG_eIF4E_1	593	599	PF01652	0.445
LIG_FHA_1	306	312	PF00498	0.308
LIG_FHA_1	498	504	PF00498	0.467
LIG_FHA_1	514	520	PF00498	0.287
LIG_FHA_1	540	546	PF00498	0.564
LIG_FHA_1	6	12	PF00498	0.801
LIG_FHA_1	632	638	PF00498	0.574
LIG_FHA_1	644	650	PF00498	0.556
LIG_FHA_1	68	74	PF00498	0.665
LIG_FHA_2	174	180	PF00498	0.521
LIG_FHA_2	189	195	PF00498	0.560
LIG_FHA_2	5	11	PF00498	0.641
LIG_FHA_2	89	95	PF00498	0.720
LIG_GBD_Chelix_1	479	487	PF00786	0.282
LIG_HP1_1	427	431	PF01393	0.218
LIG_IBAR_NPY_1	164	166	PF08397	0.481
LIG_LIR_Apic_2	212	218	PF02991	0.550
LIG_LIR_Apic_2	54	60	PF02991	0.784
LIG_LIR_Gen_1	225	235	PF02991	0.559
LIG_LIR_Gen_1	236	242	PF02991	0.471
LIG_LIR_Gen_1	250	258	PF02991	0.632
LIG_LIR_Gen_1	278	289	PF02991	0.429
LIG_LIR_Gen_1	342	353	PF02991	0.627
LIG_LIR_Gen_1	363	373	PF02991	0.560
LIG_LIR_Gen_1	493	503	PF02991	0.349
LIG_LIR_Gen_1	530	540	PF02991	0.378
LIG_LIR_Gen_1	546	555	PF02991	0.456
LIG_LIR_Gen_1	573	584	PF02991	0.355
LIG_LIR_LC3C_4	62	65	PF02991	0.593
LIG_LIR_Nem_3	133	139	PF02991	0.575
LIG_LIR_Nem_3	225	230	PF02991	0.548
LIG_LIR_Nem_3	233	238	PF02991	0.527
LIG_LIR_Nem_3	250	256	PF02991	0.640
LIG_LIR_Nem_3	278	284	PF02991	0.354
LIG_LIR_Nem_3	303	307	PF02991	0.268
LIG_LIR_Nem_3	342	348	PF02991	0.632
LIG_LIR_Nem_3	350	355	PF02991	0.618
LIG_LIR_Nem_3	363	368	PF02991	0.405
LIG_LIR_Nem_3	493	499	PF02991	0.408
LIG_LIR_Nem_3	530	535	PF02991	0.378
LIG_LIR_Nem_3	546	550	PF02991	0.386
LIG_LIR_Nem_3	573	579	PF02991	0.336
LIG_LIR_Nem_3	582	588	PF02991	0.254
LIG_LIR_Nem_3	589	593	PF02991	0.267
LIG_PCNA_PIPBox_1	189	198	PF02747	0.531
LIG_PCNA_yPIPBox_3	186	196	PF02747	0.581
LIG_PCNA_yPIPBox_3	199	211	PF02747	0.563
LIG_Pex14_1	590	594	PF04695	0.426
LIG_Pex14_1	607	611	PF04695	0.532
LIG_Pex14_2	215	219	PF04695	0.550
LIG_Pex14_2	312	316	PF04695	0.282
LIG_Pex14_2	444	448	PF04695	0.426
LIG_Pex14_2	579	583	PF04695	0.418
LIG_PTB_Apo_2	265	272	PF02174	0.444
LIG_Rb_pABgroove_1	236	244	PF01858	0.473
LIG_REV1ctd_RIR_1	212	217	PF16727	0.470
LIG_SH2_CRK	227	231	PF00017	0.621
LIG_SH2_CRK	307	311	PF00017	0.330
LIG_SH2_GRB2like	410	413	PF00017	0.374
LIG_SH2_GRB2like	512	515	PF00017	0.265
LIG_SH2_PTP2	237	240	PF00017	0.594
LIG_SH2_PTP2	352	355	PF00017	0.499
LIG_SH2_PTP2	428	431	PF00017	0.462
LIG_SH2_PTP2	532	535	PF00017	0.249
LIG_SH2_SRC	532	535	PF00017	0.222
LIG_SH2_STAP1	307	311	PF00017	0.308
LIG_SH2_STAP1	370	374	PF00017	0.610
LIG_SH2_STAP1	446	450	PF00017	0.441
LIG_SH2_STAT3	242	245	PF00017	0.497
LIG_SH2_STAT5	117	120	PF00017	0.662
LIG_SH2_STAT5	166	169	PF00017	0.500
LIG_SH2_STAT5	210	213	PF00017	0.503
LIG_SH2_STAT5	237	240	PF00017	0.581
LIG_SH2_STAT5	307	310	PF00017	0.329
LIG_SH2_STAT5	345	348	PF00017	0.503
LIG_SH2_STAT5	352	355	PF00017	0.465
LIG_SH2_STAT5	410	413	PF00017	0.293
LIG_SH2_STAT5	428	431	PF00017	0.441
LIG_SH2_STAT5	485	488	PF00017	0.361
LIG_SH2_STAT5	527	530	PF00017	0.449
LIG_SH2_STAT5	532	535	PF00017	0.439
LIG_SH2_STAT5	576	579	PF00017	0.355
LIG_SH2_STAT5	587	590	PF00017	0.276
LIG_SH2_STAT5	593	596	PF00017	0.229
LIG_SH3_3	129	135	PF00018	0.653
LIG_SH3_3	246	252	PF00018	0.547
LIG_SH3_3	30	36	PF00018	0.686
LIG_SH3_3	345	351	PF00018	0.573
LIG_SH3_3	354	360	PF00018	0.515
LIG_SH3_3	62	68	PF00018	0.599
LIG_SUMO_SIM_anti_2	515	521	PF11976	0.419
LIG_SUMO_SIM_anti_2	62	67	PF11976	0.596
LIG_SUMO_SIM_par_1	117	123	PF11976	0.628
LIG_SUMO_SIM_par_1	515	521	PF11976	0.403
LIG_SUMO_SIM_par_1	532	539	PF11976	0.317
LIG_SUMO_SIM_par_1	557	564	PF11976	0.409
LIG_SUMO_SIM_par_1	62	67	PF11976	0.596
LIG_UBA3_1	621	628	PF00899	0.584
LIG_WRC_WIRS_1	211	216	PF05994	0.469
LIG_WRC_WIRS_1	83	88	PF05994	0.596
MOD_CDK_SPK_2	12	17	PF00069	0.704
MOD_CK1_1	130	136	PF00069	0.654
MOD_CK1_1	2	8	PF00069	0.671
MOD_CK1_1	21	27	PF00069	0.702
MOD_CK1_1	389	395	PF00069	0.429
MOD_CK1_1	506	512	PF00069	0.364
MOD_CK1_1	521	527	PF00069	0.297
MOD_CK1_1	53	59	PF00069	0.780
MOD_CK2_1	128	134	PF00069	0.580
MOD_CK2_1	173	179	PF00069	0.516
MOD_CK2_1	188	194	PF00069	0.441
MOD_CK2_1	230	236	PF00069	0.474
MOD_CK2_1	48	54	PF00069	0.747
MOD_CK2_1	486	492	PF00069	0.448
MOD_CK2_1	636	642	PF00069	0.750
MOD_GlcNHglycan	102	105	PF01048	0.582
MOD_GlcNHglycan	122	125	PF01048	0.363
MOD_GlcNHglycan	173	176	PF01048	0.349
MOD_GlcNHglycan	2	5	PF01048	0.585
MOD_GlcNHglycan	232	235	PF01048	0.332
MOD_GlcNHglycan	391	394	PF01048	0.246
MOD_GlcNHglycan	476	479	PF01048	0.319
MOD_GlcNHglycan	505	508	PF01048	0.617
MOD_GlcNHglycan	520	523	PF01048	0.325
MOD_GlcNHglycan	638	641	PF01048	0.567
MOD_GSK3_1	17	24	PF00069	0.689
MOD_GSK3_1	173	180	PF00069	0.630
MOD_GSK3_1	195	202	PF00069	0.634
MOD_GSK3_1	275	282	PF00069	0.422
MOD_GSK3_1	486	493	PF00069	0.459
MOD_GSK3_1	535	542	PF00069	0.496
MOD_GSK3_1	627	634	PF00069	0.578
MOD_GSK3_1	636	643	PF00069	0.600
MOD_GSK3_1	88	95	PF00069	0.719
MOD_N-GLC_1	100	105	PF02516	0.349
MOD_N-GLC_1	258	263	PF02516	0.402
MOD_N-GLC_1	37	42	PF02516	0.544
MOD_N-GLC_1	513	518	PF02516	0.570
MOD_N-GLC_1	75	80	PF02516	0.473
MOD_N-GLC_1	92	97	PF02516	0.437
MOD_NEK2_1	22	27	PF00069	0.761
MOD_NEK2_1	222	227	PF00069	0.572
MOD_NEK2_1	230	235	PF00069	0.542
MOD_NEK2_1	497	502	PF00069	0.376
MOD_NEK2_1	505	510	PF00069	0.352
MOD_NEK2_1	579	584	PF00069	0.390
MOD_NEK2_1	632	637	PF00069	0.703
MOD_NEK2_1	92	97	PF00069	0.637
MOD_NEK2_2	210	215	PF00069	0.502
MOD_NEK2_2	527	532	PF00069	0.393
MOD_NEK2_2	592	597	PF00069	0.455
MOD_PIKK_1	222	228	PF00454	0.601
MOD_PIKK_1	404	410	PF00454	0.490
MOD_PIKK_1	434	440	PF00454	0.470
MOD_PKA_1	627	633	PF00069	0.596
MOD_PKA_2	220	226	PF00069	0.620
MOD_PKA_2	389	395	PF00069	0.435
MOD_PKA_2	474	480	PF00069	0.567
MOD_PKA_2	503	509	PF00069	0.446
MOD_PKA_2	543	549	PF00069	0.529
MOD_PKA_2	579	585	PF00069	0.302
MOD_PKA_2	76	82	PF00069	0.752
MOD_Plk_1	38	44	PF00069	0.798
MOD_Plk_1	414	420	PF00069	0.432
MOD_Plk_1	513	519	PF00069	0.346
MOD_Plk_1	538	544	PF00069	0.601
MOD_Plk_1	640	646	PF00069	0.603
MOD_Plk_1	92	98	PF00069	0.737
MOD_Plk_2-3	173	179	PF00069	0.656
MOD_Plk_4	210	216	PF00069	0.488
MOD_Plk_4	252	258	PF00069	0.583
MOD_Plk_4	275	281	PF00069	0.276
MOD_Plk_4	305	311	PF00069	0.392
MOD_Plk_4	486	492	PF00069	0.363
MOD_Plk_4	513	519	PF00069	0.250
MOD_Plk_4	527	533	PF00069	0.365
MOD_Plk_4	579	585	PF00069	0.364
MOD_Plk_4	82	88	PF00069	0.769
MOD_Plk_4	92	98	PF00069	0.768
MOD_ProDKin_1	12	18	PF00069	0.666
MOD_ProDKin_1	128	134	PF00069	0.536
MOD_ProDKin_1	347	353	PF00069	0.511
MOD_SUMO_rev_2	337	346	PF00179	0.578
TRG_DiLeu_BaEn_1	236	241	PF01217	0.470
TRG_DiLeu_BaEn_2	491	497	PF01217	0.426
TRG_DiLeu_BaEn_4	569	575	PF01217	0.276
TRG_DiLeu_BaLyEn_6	166	171	PF01217	0.463
TRG_DiLeu_BaLyEn_6	617	622	PF01217	0.570
TRG_ENDOCYTIC_2	208	211	PF00928	0.486
TRG_ENDOCYTIC_2	227	230	PF00928	0.557
TRG_ENDOCYTIC_2	237	240	PF00928	0.537
TRG_ENDOCYTIC_2	307	310	PF00928	0.335
TRG_ENDOCYTIC_2	345	348	PF00928	0.566
TRG_ENDOCYTIC_2	352	355	PF00928	0.591
TRG_ENDOCYTIC_2	428	431	PF00928	0.387
TRG_ENDOCYTIC_2	446	449	PF00928	0.331
TRG_ENDOCYTIC_2	532	535	PF00928	0.297
TRG_ENDOCYTIC_2	576	579	PF00928	0.321
TRG_ENDOCYTIC_2	593	596	PF00928	0.297
TRG_ER_diArg_1	327	330	PF00400	0.601
TRG_ER_diArg_1	338	340	PF00400	0.663
TRG_ER_diArg_1	422	425	PF00400	0.337
TRG_Pf-PMV_PEXEL_1	169	173	PF00026	0.327
TRG_Pf-PMV_PEXEL_1	372	376	PF00026	0.291

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IIV3	Bodo saltans	24%	85%
A0A0S4IZJ9	Bodo saltans	27%	68%
A0A1X0NUP0	Trypanosomatidae	20%	100%
A0A1X0P3P0	Trypanosomatidae	36%	95%
A0A3Q8IDV0	Leishmania donovani	100%	100%
A0A3R7R847	Trypanosoma rangeli	32%	98%
A0A3S7X5M8	Leishmania donovani	22%	100%
A0A422MY34	Trypanosoma rangeli	22%	100%
A4HKK2	Leishmania braziliensis	22%	100%
A4HLQ6	Leishmania braziliensis	77%	100%
A4I834	Leishmania infantum	22%	100%
D0A6B6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	98%
E9B2Z2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	100%
Q4Q3Z3	Leishmania major	92%	100%
Q4Q564	Leishmania major	22%	100%
V5B8R5	Trypanosoma cruzi	32%	98%
V5BBK9	Trypanosoma cruzi	24%	100%