Putative phosphoribosylpyrophosphate synthetase

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphoribosylpyrophosphate synthetase - putative

Species:

Leishmania infantum

UniProt:

A4I955_LEIIN

TriTrypDb:

LINF_330028000

Length:

356

Annotations

Annotations by Jardim et al.

Purine metabolism, phosphoribosylpyrophosphate synthetase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 75

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 33
NetGPI	no	yes: 0, no: 33

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Cellular components
Term	Name	Level	Count
GO:0002189	ribose phosphate diphosphokinase complex	5	3
GO:0005737	cytoplasm	2	3
GO:0016020	membrane	2	1
GO:0032991	protein-containing complex	1	3
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	3
GO:0110165	cellular anatomical entity	1	4
GO:1902494	catalytic complex	2	3
GO:1990234	transferase complex	3	3

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I955

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I955

Function

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Biological processes
Term	Name	Level	Count
GO:0006015	5-phosphoribose 1-diphosphate biosynthetic process	6	3
GO:0006139	nucleobase-containing compound metabolic process	3	34
GO:0006163	purine nucleotide metabolic process	5	3
GO:0006164	purine nucleotide biosynthetic process	6	3
GO:0006725	cellular aromatic compound metabolic process	3	34
GO:0006753	nucleoside phosphate metabolic process	4	34
GO:0006793	phosphorus metabolic process	3	34
GO:0006796	phosphate-containing compound metabolic process	4	34
GO:0006807	nitrogen compound metabolic process	2	34
GO:0008152	metabolic process	1	34

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Molecular functions
Term	Name	Level	Count
GO:0000287	magnesium ion binding	5	34
GO:0003824	catalytic activity	1	34
GO:0004749	ribose phosphate diphosphokinase activity	5	34
GO:0005488	binding	1	34
GO:0016301	kinase activity	4	3
GO:0016740	transferase activity	2	34
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	34
GO:0016778	diphosphotransferase activity	4	34
GO:0043167	ion binding	2	34
GO:0043169	cation binding	3	34

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	46	50	PF00656	0.503
CLV_NRD_NRD_1	134	136	PF00675	0.229
CLV_NRD_NRD_1	234	236	PF00675	0.452
CLV_PCSK_KEX2_1	119	121	PF00082	0.192
CLV_PCSK_KEX2_1	233	235	PF00082	0.395
CLV_PCSK_KEX2_1	65	67	PF00082	0.238
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.202
CLV_PCSK_PC1ET2_1	233	235	PF00082	0.402
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.238
CLV_PCSK_PC7_1	61	67	PF00082	0.255

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8G4	Leptomonas seymouri	93%	99%
A0A0N1I914	Leptomonas seymouri	57%	99%
A0A0N1PE41	Leptomonas seymouri	56%	97%
A0A0S4IME5	Bodo saltans	76%	100%
A0A0S4IQW2	Bodo saltans	51%	78%
A0A0S4IW81	Bodo saltans	57%	96%
A0A1X0NFA8	Trypanosomatidae	53%	91%
A0A1X0P0G5	Trypanosomatidae	55%	91%
A0A1X0P3L9	Trypanosomatidae	82%	100%
A0A3Q8IHV7	Leishmania donovani	55%	99%

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