Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I950_LEIIN

TriTrypDb:

LINF_330027400

Length:

553

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4I950

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I950

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	461	465	PF00656	0.515
CLV_MEL_PAP_1	546	552	PF00089	0.556
CLV_NRD_NRD_1	153	155	PF00675	0.719
CLV_NRD_NRD_1	189	191	PF00675	0.676
CLV_NRD_NRD_1	304	306	PF00675	0.658
CLV_NRD_NRD_1	426	428	PF00675	0.782
CLV_NRD_NRD_1	480	482	PF00675	0.672
CLV_NRD_NRD_1	548	550	PF00675	0.445
CLV_NRD_NRD_1	65	67	PF00675	0.730
CLV_PCSK_KEX2_1	153	155	PF00082	0.716
CLV_PCSK_KEX2_1	189	191	PF00082	0.732
CLV_PCSK_KEX2_1	304	306	PF00082	0.620
CLV_PCSK_KEX2_1	426	428	PF00082	0.782
CLV_PCSK_KEX2_1	480	482	PF00082	0.672
CLV_PCSK_KEX2_1	548	550	PF00082	0.445
CLV_PCSK_KEX2_1	65	67	PF00082	0.730
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.782
CLV_PCSK_PC7_1	422	428	PF00082	0.855
CLV_PCSK_SKI1_1	128	132	PF00082	0.612
CLV_PCSK_SKI1_1	193	197	PF00082	0.639
CLV_PCSK_SKI1_1	480	484	PF00082	0.625
DEG_SPOP_SBC_1	332	336	PF00917	0.641
DEG_SPOP_SBC_1	449	453	PF00917	0.565
DEG_SPOP_SBC_1	76	80	PF00917	0.566
DEG_SPOP_SBC_1	88	92	PF00917	0.336
DOC_CYCLIN_RxL_1	477	486	PF00134	0.391
DOC_MAPK_gen_1	128	136	PF00069	0.416
DOC_MAPK_MEF2A_6	369	376	PF00069	0.574
DOC_MAPK_RevD_3	536	549	PF00069	0.436
DOC_PP4_FxxP_1	358	361	PF00568	0.430
DOC_USP7_MATH_1	165	169	PF00917	0.395
DOC_USP7_MATH_1	217	221	PF00917	0.585
DOC_USP7_MATH_1	244	248	PF00917	0.573
DOC_USP7_MATH_1	286	290	PF00917	0.550
DOC_USP7_MATH_1	328	332	PF00917	0.578
DOC_USP7_MATH_1	384	388	PF00917	0.561
DOC_USP7_MATH_1	398	402	PF00917	0.541
DOC_USP7_MATH_1	4	8	PF00917	0.509
DOC_USP7_MATH_1	441	445	PF00917	0.593
DOC_USP7_MATH_1	449	453	PF00917	0.626
DOC_USP7_MATH_1	499	503	PF00917	0.575
DOC_USP7_MATH_1	77	81	PF00917	0.595
DOC_USP7_MATH_1	88	92	PF00917	0.354
DOC_USP7_MATH_1	9	13	PF00917	0.502
DOC_USP7_UBL2_3	365	369	PF12436	0.451
DOC_USP7_UBL2_3	426	430	PF12436	0.583
DOC_USP7_UBL2_3	99	103	PF12436	0.519
DOC_WW_Pin1_4	112	117	PF00397	0.477
DOC_WW_Pin1_4	238	243	PF00397	0.632
DOC_WW_Pin1_4	313	318	PF00397	0.437
DOC_WW_Pin1_4	444	449	PF00397	0.648
DOC_WW_Pin1_4	470	475	PF00397	0.486
DOC_WW_Pin1_4	97	102	PF00397	0.411
LIG_14-3-3_CanoR_1	189	193	PF00244	0.459
LIG_14-3-3_CanoR_1	262	271	PF00244	0.471
LIG_14-3-3_CanoR_1	28	33	PF00244	0.460
LIG_14-3-3_CanoR_1	305	315	PF00244	0.397
LIG_14-3-3_CanoR_1	330	340	PF00244	0.488
LIG_14-3-3_CanoR_1	429	437	PF00244	0.581
LIG_14-3-3_CanoR_1	548	553	PF00244	0.653
LIG_14-3-3_CanoR_1	65	71	PF00244	0.554
LIG_Actin_WH2_2	142	158	PF00022	0.452
LIG_Actin_WH2_2	90	107	PF00022	0.494
LIG_BRCT_BRCA1_1	132	136	PF00533	0.401
LIG_deltaCOP1_diTrp_1	178	185	PF00928	0.400
LIG_eIF4E_1	525	531	PF01652	0.545
LIG_FHA_1	265	271	PF00498	0.461
LIG_FHA_1	307	313	PF00498	0.408
LIG_FHA_1	411	417	PF00498	0.539
LIG_FHA_1	88	94	PF00498	0.364
LIG_FHA_2	31	37	PF00498	0.461
LIG_FHA_2	456	462	PF00498	0.616
LIG_Integrin_RGD_1	19	21	PF01839	0.757
LIG_LIR_Gen_1	169	176	PF02991	0.460
LIG_LIR_Gen_1	291	302	PF02991	0.499
LIG_LIR_Nem_3	133	139	PF02991	0.400
LIG_LIR_Nem_3	169	175	PF02991	0.461
LIG_LIR_Nem_3	291	297	PF02991	0.504
LIG_LIR_Nem_3	354	360	PF02991	0.434
LIG_PDZ_Class_1	548	553	PF00595	0.653
LIG_SH2_NCK_1	325	329	PF00017	0.493
LIG_SH2_STAP1	525	529	PF00017	0.548
LIG_SH2_STAT3	106	109	PF00017	0.453
LIG_SH2_STAT5	106	109	PF00017	0.453
LIG_SH2_STAT5	357	360	PF00017	0.427
LIG_SH3_3	236	242	PF00018	0.571
LIG_SH3_3	373	379	PF00018	0.571
LIG_SUMO_SIM_anti_2	115	122	PF11976	0.425
LIG_SUMO_SIM_par_1	172	179	PF11976	0.312
LIG_SUMO_SIM_par_1	90	98	PF11976	0.405
LIG_TYR_ITIM	355	360	PF00017	0.634
LIG_WRC_WIRS_1	29	34	PF05994	0.535
MOD_CDK_SPK_2	313	318	PF00069	0.538
MOD_CDK_SPxK_1	97	103	PF00069	0.498
MOD_CK1_1	115	121	PF00069	0.523
MOD_CK1_1	188	194	PF00069	0.562
MOD_CK1_1	248	254	PF00069	0.646
MOD_CK1_1	331	337	PF00069	0.820
MOD_CK1_1	387	393	PF00069	0.758
MOD_CK1_1	401	407	PF00069	0.601
MOD_CK1_1	411	417	PF00069	0.686
MOD_CK1_1	418	424	PF00069	0.760
MOD_CK1_1	444	450	PF00069	0.836
MOD_CK1_1	452	458	PF00069	0.694
MOD_CK1_1	78	84	PF00069	0.728
MOD_CK2_1	188	194	PF00069	0.585
MOD_CK2_1	197	203	PF00069	0.495
MOD_CK2_1	286	292	PF00069	0.579
MOD_CK2_1	30	36	PF00069	0.546
MOD_CK2_1	418	424	PF00069	0.726
MOD_CK2_1	455	461	PF00069	0.754
MOD_Cter_Amidation	424	427	PF01082	0.744
MOD_GlcNHglycan	11	14	PF01048	0.669
MOD_GlcNHglycan	247	250	PF01048	0.698
MOD_GlcNHglycan	329	333	PF01048	0.753
MOD_GlcNHglycan	347	350	PF01048	0.505
MOD_GlcNHglycan	392	396	PF01048	0.716
MOD_GlcNHglycan	403	406	PF01048	0.693
MOD_GlcNHglycan	409	413	PF01048	0.670
MOD_GlcNHglycan	432	435	PF01048	0.774
MOD_GlcNHglycan	440	444	PF01048	0.682
MOD_GlcNHglycan	501	504	PF01048	0.763
MOD_GlcNHglycan	525	528	PF01048	0.743
MOD_GlcNHglycan	531	534	PF01048	0.371
MOD_GlcNHglycan	6	9	PF01048	0.659
MOD_GlcNHglycan	85	88	PF01048	0.750
MOD_GSK3_1	115	122	PF00069	0.540
MOD_GSK3_1	197	204	PF00069	0.561
MOD_GSK3_1	217	224	PF00069	0.803
MOD_GSK3_1	244	251	PF00069	0.678
MOD_GSK3_1	328	335	PF00069	0.791
MOD_GSK3_1	338	345	PF00069	0.676
MOD_GSK3_1	364	371	PF00069	0.611
MOD_GSK3_1	384	391	PF00069	0.703
MOD_GSK3_1	407	414	PF00069	0.695
MOD_GSK3_1	439	446	PF00069	0.699
MOD_GSK3_1	448	455	PF00069	0.681
MOD_GSK3_1	75	82	PF00069	0.712
MOD_GSK3_1	83	90	PF00069	0.494
MOD_N-GLC_1	207	212	PF02516	0.769
MOD_NEK2_1	185	190	PF00069	0.547
MOD_NEK2_1	273	278	PF00069	0.507
MOD_NEK2_1	30	35	PF00069	0.593
MOD_NEK2_1	364	369	PF00069	0.682
MOD_NEK2_1	483	488	PF00069	0.509
MOD_NEK2_1	494	499	PF00069	0.622
MOD_PIKK_1	197	203	PF00454	0.554
MOD_PIKK_1	264	270	PF00454	0.560
MOD_PKA_1	430	436	PF00069	0.732
MOD_PKA_1	65	71	PF00069	0.721
MOD_PKA_2	188	194	PF00069	0.562
MOD_PKA_2	398	404	PF00069	0.737
MOD_PKA_2	64	70	PF00069	0.682
MOD_Plk_1	178	184	PF00069	0.492
MOD_Plk_1	292	298	PF00069	0.618
MOD_Plk_4	115	121	PF00069	0.473
MOD_Plk_4	22	28	PF00069	0.578
MOD_Plk_4	275	281	PF00069	0.489
MOD_Plk_4	89	95	PF00069	0.461
MOD_ProDKin_1	112	118	PF00069	0.594
MOD_ProDKin_1	238	244	PF00069	0.812
MOD_ProDKin_1	313	319	PF00069	0.533
MOD_ProDKin_1	444	450	PF00069	0.836
MOD_ProDKin_1	470	476	PF00069	0.595
MOD_ProDKin_1	97	103	PF00069	0.503
MOD_SUMO_rev_2	188	198	PF00179	0.559
TRG_DiLeu_BaEn_1	36	41	PF01217	0.533
TRG_DiLeu_BaLyEn_6	478	483	PF01217	0.553
TRG_ENDOCYTIC_2	357	360	PF00928	0.524
TRG_ER_diArg_1	153	156	PF00400	0.751
TRG_ER_diArg_1	256	259	PF00400	0.649
TRG_ER_diArg_1	303	305	PF00400	0.577
TRG_ER_diArg_1	479	481	PF00400	0.580
TRG_ER_diArg_1	547	549	PF00400	0.545
TRG_ER_diArg_1	64	66	PF00400	0.619
TRG_NLS_MonoCore_2	425	430	PF00514	0.732
TRG_NLS_MonoExtC_3	425	430	PF00514	0.742
TRG_NLS_MonoExtN_4	426	433	PF00514	0.742
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.636
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	58	63	PF00026	0.571

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I907	Leptomonas seymouri	42%	89%
A0A3S7X6X8	Leishmania donovani	99%	100%
A4HLQ0	Leishmania braziliensis	69%	100%
E9B425	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q3Z9	Leishmania major	89%	100%