Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitogen-activated protein kinase - putative

Species:

Leishmania infantum

UniProt:

A4I945_LEIIN

TriTrypDb:

LINF_330029600

Length:

912

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I945

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I945

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016310	phosphorylation	5	6
GO:0019538	protein metabolic process	3	6
GO:0036211	protein modification process	4	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6
GO:0007165	signal transduction	2	1
GO:0035556	intracellular signal transduction	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004672	protein kinase activity	3	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140096	catalytic activity, acting on a protein	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0004707	MAP kinase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.391
CLV_C14_Caspase3-7	466	470	PF00656	0.688
CLV_C14_Caspase3-7	524	528	PF00656	0.642
CLV_C14_Caspase3-7	616	620	PF00656	0.675
CLV_NRD_NRD_1	439	441	PF00675	0.531
CLV_NRD_NRD_1	49	51	PF00675	0.385
CLV_NRD_NRD_1	493	495	PF00675	0.560
CLV_NRD_NRD_1	674	676	PF00675	0.684
CLV_PCSK_KEX2_1	49	51	PF00082	0.385
CLV_PCSK_KEX2_1	493	495	PF00082	0.560
CLV_PCSK_KEX2_1	640	642	PF00082	0.716
CLV_PCSK_KEX2_1	673	675	PF00082	0.691
CLV_PCSK_PC1ET2_1	640	642	PF00082	0.672
CLV_PCSK_PC7_1	670	676	PF00082	0.677
CLV_PCSK_SKI1_1	207	211	PF00082	0.442
CLV_PCSK_SKI1_1	290	294	PF00082	0.385
CLV_PCSK_SKI1_1	7	11	PF00082	0.385
DEG_APCC_DBOX_1	610	618	PF00400	0.607
DEG_SCF_FBW7_1	409	414	PF00400	0.458
DEG_SCF_FBW7_2	315	321	PF00400	0.385
DEG_SPOP_SBC_1	411	415	PF00917	0.470
DOC_CKS1_1	315	320	PF01111	0.385
DOC_MAPK_gen_1	207	216	PF00069	0.495
DOC_MAPK_gen_1	49	60	PF00069	0.385
DOC_MAPK_MEF2A_6	210	218	PF00069	0.478
DOC_MAPK_MEF2A_6	303	312	PF00069	0.385
DOC_MAPK_MEF2A_6	701	710	PF00069	0.614
DOC_MAPK_NFAT4_5	303	311	PF00069	0.385
DOC_PP1_RVXF_1	370	377	PF00149	0.385
DOC_PP2B_PxIxI_1	265	271	PF00149	0.385
DOC_PP4_FxxP_1	91	94	PF00568	0.614
DOC_USP7_MATH_1	223	227	PF00917	0.385
DOC_USP7_MATH_1	239	243	PF00917	0.385
DOC_USP7_MATH_1	302	306	PF00917	0.385
DOC_USP7_MATH_1	341	345	PF00917	0.385
DOC_USP7_MATH_1	411	415	PF00917	0.470
DOC_USP7_MATH_1	500	504	PF00917	0.670
DOC_USP7_MATH_1	507	511	PF00917	0.620
DOC_USP7_MATH_1	525	529	PF00917	0.650
DOC_USP7_MATH_1	624	628	PF00917	0.591
DOC_USP7_MATH_1	724	728	PF00917	0.653
DOC_USP7_MATH_1	763	767	PF00917	0.562
DOC_USP7_MATH_1	859	863	PF00917	0.618
DOC_USP7_MATH_1	94	98	PF00917	0.556
DOC_USP7_UBL2_3	12	16	PF12436	0.342
DOC_WW_Pin1_4	262	267	PF00397	0.435
DOC_WW_Pin1_4	314	319	PF00397	0.385
DOC_WW_Pin1_4	407	412	PF00397	0.495
DOC_WW_Pin1_4	602	607	PF00397	0.682
DOC_WW_Pin1_4	655	660	PF00397	0.713
DOC_WW_Pin1_4	718	723	PF00397	0.652
DOC_WW_Pin1_4	794	799	PF00397	0.675
DOC_WW_Pin1_4	857	862	PF00397	0.626
DOC_WW_Pin1_4	877	882	PF00397	0.526
DOC_WW_Pin1_4	901	906	PF00397	0.651
LIG_14-3-3_CanoR_1	163	171	PF00244	0.385
LIG_14-3-3_CanoR_1	173	181	PF00244	0.292
LIG_14-3-3_CanoR_1	440	444	PF00244	0.549
LIG_14-3-3_CanoR_1	476	482	PF00244	0.674
LIG_14-3-3_CanoR_1	493	500	PF00244	0.566
LIG_14-3-3_CanoR_1	611	615	PF00244	0.624
LIG_14-3-3_CanoR_1	641	647	PF00244	0.713
LIG_14-3-3_CanoR_1	755	760	PF00244	0.631
LIG_14-3-3_CanoR_1	898	907	PF00244	0.663
LIG_Actin_WH2_2	427	442	PF00022	0.475
LIG_APCC_ABBA_1	125	130	PF00400	0.385
LIG_APCC_ABBAyCdc20_2	124	130	PF00400	0.385
LIG_BRCT_BRCA1_1	663	667	PF00533	0.663
LIG_BRCT_BRCA1_1	87	91	PF00533	0.646
LIG_Clathr_ClatBox_1	215	219	PF01394	0.385
LIG_deltaCOP1_diTrp_1	269	277	PF00928	0.385
LIG_eIF4E_1	224	230	PF01652	0.385
LIG_FHA_1	225	231	PF00498	0.385
LIG_FHA_1	24	30	PF00498	0.385
LIG_FHA_1	242	248	PF00498	0.385
LIG_FHA_1	369	375	PF00498	0.385
LIG_FHA_1	656	662	PF00498	0.735
LIG_FHA_2	103	109	PF00498	0.468
LIG_FHA_2	138	144	PF00498	0.477
LIG_FHA_2	356	362	PF00498	0.385
LIG_FHA_2	421	427	PF00498	0.471
LIG_FHA_2	554	560	PF00498	0.618
LIG_FHA_2	581	587	PF00498	0.717
LIG_FHA_2	664	670	PF00498	0.625
LIG_FHA_2	707	713	PF00498	0.742
LIG_IBAR_NPY_1	222	224	PF08397	0.385
LIG_LIR_Apic_2	249	255	PF02991	0.385
LIG_LIR_Apic_2	853	859	PF02991	0.658
LIG_LIR_Apic_2	88	94	PF02991	0.625
LIG_LIR_Gen_1	364	374	PF02991	0.385
LIG_LIR_Gen_1	521	527	PF02991	0.650
LIG_LIR_Gen_1	747	756	PF02991	0.545
LIG_LIR_Gen_1	766	777	PF02991	0.609
LIG_LIR_Gen_1	844	855	PF02991	0.678
LIG_LIR_Nem_3	114	119	PF02991	0.488
LIG_LIR_Nem_3	157	162	PF02991	0.442
LIG_LIR_Nem_3	364	369	PF02991	0.414
LIG_LIR_Nem_3	521	526	PF02991	0.785
LIG_LIR_Nem_3	766	772	PF02991	0.676
LIG_LIR_Nem_3	844	850	PF02991	0.684
LIG_MYND_1	659	663	PF01753	0.663
LIG_Pex14_2	190	194	PF04695	0.385
LIG_SH2_CRK	116	120	PF00017	0.482
LIG_SH2_CRK	740	744	PF00017	0.653
LIG_SH2_CRK	769	773	PF00017	0.671
LIG_SH2_CRK	847	851	PF00017	0.642
LIG_SH2_GRB2like	43	46	PF00017	0.385
LIG_SH2_PTP2	8	11	PF00017	0.385
LIG_SH2_PTP2	856	859	PF00017	0.653
LIG_SH2_SRC	909	912	PF00017	0.652
LIG_SH2_STAP1	25	29	PF00017	0.385
LIG_SH2_STAP1	412	416	PF00017	0.474
LIG_SH2_STAP1	847	851	PF00017	0.686
LIG_SH2_STAT3	198	201	PF00017	0.385
LIG_SH2_STAT3	43	46	PF00017	0.385
LIG_SH2_STAT3	547	550	PF00017	0.600
LIG_SH2_STAT5	160	163	PF00017	0.435
LIG_SH2_STAT5	198	201	PF00017	0.527
LIG_SH2_STAT5	246	249	PF00017	0.385
LIG_SH2_STAT5	25	28	PF00017	0.227
LIG_SH2_STAT5	335	338	PF00017	0.463
LIG_SH2_STAT5	412	415	PF00017	0.458
LIG_SH2_STAT5	416	419	PF00017	0.479
LIG_SH2_STAT5	43	46	PF00017	0.218
LIG_SH2_STAT5	488	491	PF00017	0.586
LIG_SH2_STAT5	560	563	PF00017	0.773
LIG_SH2_STAT5	71	74	PF00017	0.520
LIG_SH2_STAT5	8	11	PF00017	0.385
LIG_SH2_STAT5	849	852	PF00017	0.683
LIG_SH2_STAT5	856	859	PF00017	0.588
LIG_SH2_STAT5	909	912	PF00017	0.652
LIG_SH3_3	516	522	PF00018	0.679
LIG_SH3_3	532	538	PF00018	0.653
LIG_SH3_3	615	621	PF00018	0.632
LIG_SH3_3	657	663	PF00018	0.672
LIG_SH3_3	711	717	PF00018	0.644
LIG_SH3_3	762	768	PF00018	0.635
LIG_SH3_3	821	827	PF00018	0.624
LIG_SUMO_SIM_anti_2	54	59	PF11976	0.385
LIG_TRAF2_1	21	24	PF00917	0.385
LIG_TRAF2_1	451	454	PF00917	0.652
LIG_TRAF2_1	647	650	PF00917	0.705
LIG_TRAF2_1	678	681	PF00917	0.699
LIG_TRFH_1	547	551	PF08558	0.718
LIG_TYR_ITIM	69	74	PF00017	0.385
MOD_CDK_SPK_2	262	267	PF00069	0.342
MOD_CK1_1	166	172	PF00069	0.385
MOD_CK1_1	262	268	PF00069	0.385
MOD_CK1_1	419	425	PF00069	0.524
MOD_CK1_1	457	463	PF00069	0.686
MOD_CK1_1	464	470	PF00069	0.632
MOD_CK1_1	528	534	PF00069	0.757
MOD_CK1_1	605	611	PF00069	0.725
MOD_CK1_1	613	619	PF00069	0.726
MOD_CK1_1	645	651	PF00069	0.836
MOD_CK1_1	791	797	PF00069	0.601
MOD_CK1_1	880	886	PF00069	0.678
MOD_CK1_1	901	907	PF00069	0.695
MOD_CK2_1	102	108	PF00069	0.540
MOD_CK2_1	356	362	PF00069	0.385
MOD_CK2_1	420	426	PF00069	0.534
MOD_CK2_1	447	453	PF00069	0.671
MOD_CK2_1	469	475	PF00069	0.722
MOD_CK2_1	515	521	PF00069	0.665
MOD_CK2_1	580	586	PF00069	0.844
MOD_CK2_1	644	650	PF00069	0.813
MOD_CK2_1	706	712	PF00069	0.738
MOD_CK2_1	794	800	PF00069	0.677
MOD_CK2_1	880	886	PF00069	0.601
MOD_GlcNHglycan	261	264	PF01048	0.429
MOD_GlcNHglycan	328	331	PF01048	0.385
MOD_GlcNHglycan	338	341	PF01048	0.292
MOD_GlcNHglycan	461	464	PF01048	0.679
MOD_GlcNHglycan	466	469	PF01048	0.640
MOD_GlcNHglycan	489	492	PF01048	0.635
MOD_GlcNHglycan	507	510	PF01048	0.689
MOD_GlcNHglycan	514	518	PF01048	0.704
MOD_GlcNHglycan	523	526	PF01048	0.675
MOD_GlcNHglycan	531	534	PF01048	0.644
MOD_GlcNHglycan	597	600	PF01048	0.710
MOD_GlcNHglycan	607	610	PF01048	0.651
MOD_GlcNHglycan	626	629	PF01048	0.641
MOD_GlcNHglycan	649	653	PF01048	0.707
MOD_GlcNHglycan	663	666	PF01048	0.555
MOD_GlcNHglycan	676	679	PF01048	0.541
MOD_GlcNHglycan	692	695	PF01048	0.527
MOD_GlcNHglycan	718	721	PF01048	0.673
MOD_GlcNHglycan	761	764	PF01048	0.596
MOD_GSK3_1	163	170	PF00069	0.446
MOD_GSK3_1	23	30	PF00069	0.385
MOD_GSK3_1	407	414	PF00069	0.533
MOD_GSK3_1	416	423	PF00069	0.537
MOD_GSK3_1	448	455	PF00069	0.747
MOD_GSK3_1	457	464	PF00069	0.768
MOD_GSK3_1	477	484	PF00069	0.618
MOD_GSK3_1	521	528	PF00069	0.792
MOD_GSK3_1	644	651	PF00069	0.815
MOD_GSK3_1	669	676	PF00069	0.675
MOD_GSK3_1	686	693	PF00069	0.543
MOD_GSK3_1	70	77	PF00069	0.385
MOD_GSK3_1	751	758	PF00069	0.709
MOD_GSK3_1	759	766	PF00069	0.591
MOD_GSK3_1	814	821	PF00069	0.635
MOD_GSK3_1	876	883	PF00069	0.670
MOD_GSK3_1	901	908	PF00069	0.729
MOD_GSK3_1	94	101	PF00069	0.547
MOD_N-GLC_1	458	463	PF02516	0.662
MOD_N-GLC_1	469	474	PF02516	0.598
MOD_N-GLC_1	553	558	PF02516	0.667
MOD_N-GLC_1	85	90	PF02516	0.641
MOD_NEK2_1	164	169	PF00069	0.385
MOD_NEK2_1	174	179	PF00069	0.321
MOD_NEK2_1	218	223	PF00069	0.385
MOD_NEK2_1	336	341	PF00069	0.392
MOD_NEK2_1	399	404	PF00069	0.571
MOD_NEK2_1	439	444	PF00069	0.508
MOD_NEK2_1	458	463	PF00069	0.529
MOD_NEK2_1	526	531	PF00069	0.692
MOD_NEK2_1	552	557	PF00069	0.649
MOD_NEK2_1	610	615	PF00069	0.580
MOD_NEK2_1	642	647	PF00069	0.709
MOD_NEK2_1	706	711	PF00069	0.644
MOD_NEK2_1	744	749	PF00069	0.698
MOD_NEK2_2	663	668	PF00069	0.643
MOD_NEK2_2	70	75	PF00069	0.385
MOD_PIKK_1	164	170	PF00454	0.385
MOD_PIKK_1	341	347	PF00454	0.470
MOD_PIKK_1	477	483	PF00454	0.617
MOD_PIKK_1	770	776	PF00454	0.635
MOD_PK_1	755	761	PF00069	0.615
MOD_PKA_1	493	499	PF00069	0.559
MOD_PKA_1	673	679	PF00069	0.683
MOD_PKA_2	341	347	PF00069	0.385
MOD_PKA_2	380	386	PF00069	0.385
MOD_PKA_2	439	445	PF00069	0.519
MOD_PKA_2	475	481	PF00069	0.705
MOD_PKA_2	493	499	PF00069	0.545
MOD_PKA_2	500	506	PF00069	0.715
MOD_PKA_2	580	586	PF00069	0.701
MOD_PKA_2	595	601	PF00069	0.569
MOD_PKA_2	610	616	PF00069	0.561
MOD_PKA_2	669	675	PF00069	0.677
MOD_Plk_1	102	108	PF00069	0.496
MOD_Plk_1	453	459	PF00069	0.702
MOD_Plk_1	706	712	PF00069	0.646
MOD_Plk_2-3	448	454	PF00069	0.642
MOD_Plk_2-3	469	475	PF00069	0.678
MOD_Plk_2-3	515	521	PF00069	0.619
MOD_Plk_2-3	840	846	PF00069	0.649
MOD_Plk_4	200	206	PF00069	0.331
MOD_Plk_4	241	247	PF00069	0.385
MOD_Plk_4	282	288	PF00069	0.485
MOD_Plk_4	560	566	PF00069	0.697
MOD_Plk_4	686	692	PF00069	0.684
MOD_Plk_4	905	911	PF00069	0.625
MOD_ProDKin_1	262	268	PF00069	0.435
MOD_ProDKin_1	314	320	PF00069	0.385
MOD_ProDKin_1	407	413	PF00069	0.503
MOD_ProDKin_1	602	608	PF00069	0.680
MOD_ProDKin_1	655	661	PF00069	0.714
MOD_ProDKin_1	718	724	PF00069	0.651
MOD_ProDKin_1	794	800	PF00069	0.677
MOD_ProDKin_1	857	863	PF00069	0.625
MOD_ProDKin_1	877	883	PF00069	0.528
MOD_ProDKin_1	901	907	PF00069	0.649
MOD_SUMO_for_1	685	688	PF00179	0.639
MOD_SUMO_rev_2	203	211	PF00179	0.331
MOD_SUMO_rev_2	420	430	PF00179	0.509
MOD_SUMO_rev_2	681	687	PF00179	0.665
TRG_DiLeu_BaEn_1	47	52	PF01217	0.385
TRG_DiLeu_BaEn_3	130	136	PF01217	0.385
TRG_DiLeu_BaEn_4	453	459	PF01217	0.702
TRG_DiLeu_BaEn_4	682	688	PF01217	0.687
TRG_DiLeu_BaLyEn_6	160	165	PF01217	0.385
TRG_DiLeu_BaLyEn_6	732	737	PF01217	0.519
TRG_ENDOCYTIC_2	116	119	PF00928	0.481
TRG_ENDOCYTIC_2	396	399	PF00928	0.464
TRG_ENDOCYTIC_2	71	74	PF00928	0.385
TRG_ENDOCYTIC_2	749	752	PF00928	0.616
TRG_ENDOCYTIC_2	769	772	PF00928	0.535
TRG_ENDOCYTIC_2	8	11	PF00928	0.385
TRG_ENDOCYTIC_2	847	850	PF00928	0.687
TRG_ER_diArg_1	124	127	PF00400	0.517
TRG_ER_diArg_1	49	51	PF00400	0.385
TRG_ER_diArg_1	673	675	PF00400	0.675
TRG_Pf-PMV_PEXEL_1	163	168	PF00026	0.385
TRG_Pf-PMV_PEXEL_1	347	351	PF00026	0.385
TRG_Pf-PMV_PEXEL_1	49	54	PF00026	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X6U9	Leishmania donovani	99%	91%
A4HLR9	Leishmania braziliensis	76%	100%
E9B445	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q3Y0	Leishmania major	90%	100%