Protein HGH1 homolog

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I943_LEIIN

TriTrypDb:

LINF_330029400

Length:

411

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4I943

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I943

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	397	401	PF00656	0.511
CLV_C14_Caspase3-7	70	74	PF00656	0.521
CLV_NRD_NRD_1	109	111	PF00675	0.430
CLV_NRD_NRD_1	113	115	PF00675	0.379
CLV_NRD_NRD_1	40	42	PF00675	0.420
CLV_PCSK_KEX2_1	335	337	PF00082	0.346
CLV_PCSK_PC1ET2_1	335	337	PF00082	0.346
CLV_PCSK_SKI1_1	224	228	PF00082	0.377
CLV_PCSK_SKI1_1	335	339	PF00082	0.464
CLV_PCSK_SKI1_1	84	88	PF00082	0.487
DEG_APCC_DBOX_1	223	231	PF00400	0.413
DEG_APCC_KENBOX_2	52	56	PF00400	0.556
DOC_MAPK_gen_1	110	119	PF00069	0.410
DOC_MAPK_gen_1	53	62	PF00069	0.445
DOC_MAPK_MEF2A_6	134	143	PF00069	0.396
DOC_MAPK_MEF2A_6	224	233	PF00069	0.356
DOC_MAPK_MEF2A_6	53	62	PF00069	0.554
DOC_USP7_MATH_1	16	20	PF00917	0.600
DOC_USP7_MATH_1	211	215	PF00917	0.749
DOC_USP7_MATH_1	49	53	PF00917	0.408
DOC_USP7_MATH_1	99	103	PF00917	0.484
DOC_USP7_UBL2_3	111	115	PF12436	0.444
DOC_WW_Pin1_4	256	261	PF00397	0.523
DOC_WW_Pin1_4	275	280	PF00397	0.477
DOC_WW_Pin1_4	61	66	PF00397	0.397
LIG_14-3-3_CanoR_1	250	260	PF00244	0.509
LIG_14-3-3_CanoR_1	263	268	PF00244	0.389
LIG_APCC_ABBA_1	174	179	PF00400	0.485
LIG_APCC_ABBA_1	391	396	PF00400	0.427
LIG_APCC_ABBAyCdc20_2	173	179	PF00400	0.489
LIG_deltaCOP1_diTrp_1	57	61	PF00928	0.460
LIG_FHA_1	138	144	PF00498	0.382
LIG_FHA_1	232	238	PF00498	0.491
LIG_FHA_1	372	378	PF00498	0.636
LIG_FHA_1	90	96	PF00498	0.352
LIG_FHA_2	151	157	PF00498	0.474
LIG_FHA_2	292	298	PF00498	0.524
LIG_GBD_Chelix_1	312	320	PF00786	0.428
LIG_LIR_Apic_2	400	405	PF02991	0.609
LIG_LIR_Gen_1	28	36	PF02991	0.473
LIG_LIR_Gen_1	57	67	PF02991	0.440
LIG_LIR_Nem_3	28	33	PF02991	0.442
LIG_LIR_Nem_3	57	62	PF02991	0.428
LIG_MYND_3	392	396	PF01753	0.433
LIG_NRBOX	226	232	PF00104	0.368
LIG_PCNA_yPIPBox_3	302	316	PF02747	0.510
LIG_Rb_LxCxE_1	294	314	PF01857	0.539
LIG_RPA_C_Fungi	215	227	PF08784	0.377
LIG_SH2_CRK	283	287	PF00017	0.501
LIG_SH2_PTP2	402	405	PF00017	0.643
LIG_SH2_SRC	78	81	PF00017	0.493
LIG_SH2_STAP1	178	182	PF00017	0.505
LIG_SH2_STAT5	132	135	PF00017	0.537
LIG_SH2_STAT5	170	173	PF00017	0.389
LIG_SH2_STAT5	394	397	PF00017	0.461
LIG_SH2_STAT5	402	405	PF00017	0.532
LIG_SH2_STAT5	78	81	PF00017	0.488
LIG_SUMO_SIM_anti_2	138	143	PF11976	0.376
LIG_SUMO_SIM_anti_2	89	95	PF11976	0.401
LIG_TRAF2_1	135	138	PF00917	0.424
LIG_UBA3_1	75	84	PF00899	0.508
MOD_CDK_SPK_2	275	280	PF00069	0.513
MOD_CDK_SPxxK_3	256	263	PF00069	0.524
MOD_CK1_1	150	156	PF00069	0.487
MOD_CK1_1	19	25	PF00069	0.571
MOD_CK1_1	214	220	PF00069	0.484
MOD_CK1_1	255	261	PF00069	0.537
MOD_CK1_1	3	9	PF00069	0.699
MOD_CK2_1	132	138	PF00069	0.466
MOD_CK2_1	180	186	PF00069	0.453
MOD_CK2_1	308	314	PF00069	0.479
MOD_CK2_1	315	321	PF00069	0.504
MOD_CK2_1	356	362	PF00069	0.645
MOD_CK2_1	379	385	PF00069	0.526
MOD_CK2_1	99	105	PF00069	0.453
MOD_GlcNHglycan	18	21	PF01048	0.559
MOD_GlcNHglycan	182	185	PF01048	0.483
MOD_GlcNHglycan	204	208	PF01048	0.623
MOD_GlcNHglycan	6	9	PF01048	0.738
MOD_GlcNHglycan	97	100	PF01048	0.454
MOD_GSK3_1	146	153	PF00069	0.495
MOD_GSK3_1	2	9	PF00069	0.686
MOD_GSK3_1	210	217	PF00069	0.704
MOD_GSK3_1	249	256	PF00069	0.455
MOD_GSK3_1	315	322	PF00069	0.470
MOD_GSK3_1	371	378	PF00069	0.643
MOD_GSK3_1	67	74	PF00069	0.514
MOD_GSK3_1	95	102	PF00069	0.502
MOD_N-GLC_1	145	150	PF02516	0.374
MOD_N-GLC_1	231	236	PF02516	0.379
MOD_N-GLC_1	95	100	PF02516	0.406
MOD_NEK2_1	147	152	PF00069	0.393
MOD_NEK2_1	215	220	PF00069	0.538
MOD_NEK2_1	231	236	PF00069	0.339
MOD_NEK2_1	253	258	PF00069	0.473
MOD_NEK2_1	315	320	PF00069	0.461
MOD_NEK2_1	342	347	PF00069	0.538
MOD_NEK2_1	387	392	PF00069	0.522
MOD_OFUCOSY	97	103	PF10250	0.468
MOD_PIKK_1	342	348	PF00454	0.485
MOD_PK_1	328	334	PF00069	0.532
MOD_PKA_2	249	255	PF00069	0.552
MOD_Plk_1	137	143	PF00069	0.385
MOD_Plk_1	220	226	PF00069	0.493
MOD_Plk_4	137	143	PF00069	0.376
MOD_Plk_4	315	321	PF00069	0.485
MOD_Plk_4	379	385	PF00069	0.459
MOD_Plk_4	387	393	PF00069	0.465
MOD_Plk_4	71	77	PF00069	0.497
MOD_Plk_4	89	95	PF00069	0.279
MOD_ProDKin_1	256	262	PF00069	0.524
MOD_ProDKin_1	275	281	PF00069	0.477
MOD_ProDKin_1	61	67	PF00069	0.396
TRG_DiLeu_BaEn_2	27	33	PF01217	0.431
TRG_DiLeu_BaLyEn_6	115	120	PF01217	0.393
TRG_ENDOCYTIC_2	178	181	PF00928	0.415
TRG_ENDOCYTIC_2	283	286	PF00928	0.538
TRG_ER_diArg_1	262	265	PF00400	0.442
TRG_Pf-PMV_PEXEL_1	235	240	PF00026	0.465
TRG_Pf-PMV_PEXEL_1	265	270	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	310	314	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	336	340	PF00026	0.347

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMC4	Leptomonas seymouri	69%	94%
A0A0S4J7H7	Bodo saltans	36%	100%
A0A1X0P3N1	Trypanosomatidae	49%	100%
A0A3Q8IGP7	Leishmania donovani	100%	100%
A0A422N467	Trypanosoma rangeli	48%	100%
A4HLR7	Leishmania braziliensis	76%	100%
D0A6A8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B443	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
Q4Q3Y2	Leishmania major	88%	97%
V5BTV3	Trypanosoma cruzi	48%	92%