Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I941_LEIIN

TriTrypDb:

LINF_330029100

Length:

817

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I941

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I941

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0030030	cell projection organization	4	1
GO:0044782	cilium organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	640	644	PF00656	0.454
CLV_NRD_NRD_1	303	305	PF00675	0.504
CLV_NRD_NRD_1	605	607	PF00675	0.371
CLV_NRD_NRD_1	778	780	PF00675	0.660
CLV_PCSK_KEX2_1	303	305	PF00082	0.504
CLV_PCSK_KEX2_1	778	780	PF00082	0.660
CLV_PCSK_SKI1_1	149	153	PF00082	0.400
CLV_PCSK_SKI1_1	543	547	PF00082	0.372
CLV_PCSK_SKI1_1	592	596	PF00082	0.359
CLV_PCSK_SKI1_1	803	807	PF00082	0.552
DEG_SPOP_SBC_1	310	314	PF00917	0.694
DEG_SPOP_SBC_1	399	403	PF00917	0.581
DOC_CDC14_PxL_1	374	382	PF14671	0.514
DOC_CYCLIN_RxL_1	146	155	PF00134	0.501
DOC_MAPK_DCC_7	592	601	PF00069	0.518
DOC_MAPK_gen_1	606	613	PF00069	0.584
DOC_MAPK_MEF2A_6	457	464	PF00069	0.480
DOC_MAPK_MEF2A_6	55	64	PF00069	0.540
DOC_MAPK_MEF2A_6	592	601	PF00069	0.554
DOC_PP1_RVXF_1	459	465	PF00149	0.481
DOC_PP2B_LxvP_1	354	357	PF13499	0.645
DOC_PP2B_LxvP_1	562	565	PF13499	0.612
DOC_PP2B_LxvP_1	7	10	PF13499	0.748
DOC_PP4_FxxP_1	271	274	PF00568	0.668
DOC_USP7_MATH_1	128	132	PF00917	0.715
DOC_USP7_MATH_1	133	137	PF00917	0.714
DOC_USP7_MATH_1	147	151	PF00917	0.425
DOC_USP7_MATH_1	242	246	PF00917	0.594
DOC_USP7_MATH_1	28	32	PF00917	0.702
DOC_USP7_MATH_1	399	403	PF00917	0.602
DOC_USP7_MATH_1	406	410	PF00917	0.506
DOC_USP7_MATH_1	485	489	PF00917	0.559
DOC_USP7_MATH_1	498	502	PF00917	0.556
DOC_USP7_MATH_1	51	55	PF00917	0.612
DOC_USP7_MATH_1	518	522	PF00917	0.467
DOC_USP7_MATH_1	631	635	PF00917	0.379
DOC_USP7_MATH_1	637	641	PF00917	0.453
DOC_WW_Pin1_4	24	29	PF00397	0.689
DOC_WW_Pin1_4	270	275	PF00397	0.684
DOC_WW_Pin1_4	332	337	PF00397	0.659
DOC_WW_Pin1_4	494	499	PF00397	0.616
DOC_WW_Pin1_4	564	569	PF00397	0.551
DOC_WW_Pin1_4	580	585	PF00397	0.567
DOC_WW_Pin1_4	592	597	PF00397	0.520
DOC_WW_Pin1_4	605	610	PF00397	0.530
DOC_WW_Pin1_4	726	731	PF00397	0.350
DOC_WW_Pin1_4	77	82	PF00397	0.593
LIG_14-3-3_CanoR_1	118	125	PF00244	0.739
LIG_14-3-3_CanoR_1	132	142	PF00244	0.597
LIG_14-3-3_CanoR_1	265	274	PF00244	0.714
LIG_14-3-3_CanoR_1	382	388	PF00244	0.546
LIG_14-3-3_CanoR_1	398	407	PF00244	0.533
LIG_14-3-3_CanoR_1	543	548	PF00244	0.585
LIG_14-3-3_CanoR_1	749	756	PF00244	0.423
LIG_Actin_WH2_2	698	715	PF00022	0.327
LIG_Actin_WH2_2	797	815	PF00022	0.301
LIG_BIR_III_4	197	201	PF00653	0.509
LIG_BRCT_BRCA1_1	267	271	PF00533	0.664
LIG_BRCT_BRCA1_1	487	491	PF00533	0.551
LIG_BRCT_BRCA1_1	625	629	PF00533	0.319
LIG_CtBP_PxDLS_1	426	430	PF00389	0.529
LIG_EH1_1	160	168	PF00400	0.573
LIG_eIF4E_1	146	152	PF01652	0.483
LIG_eIF4E_1	655	661	PF01652	0.319
LIG_EVH1_1	562	566	PF00568	0.578
LIG_FHA_1	137	143	PF00498	0.542
LIG_FHA_1	153	159	PF00498	0.467
LIG_FHA_1	162	168	PF00498	0.513
LIG_FHA_1	177	183	PF00498	0.494
LIG_FHA_1	194	200	PF00498	0.497
LIG_FHA_1	228	234	PF00498	0.514
LIG_FHA_1	283	289	PF00498	0.688
LIG_FHA_1	437	443	PF00498	0.550
LIG_FHA_1	474	480	PF00498	0.567
LIG_FHA_1	529	535	PF00498	0.555
LIG_FHA_1	540	546	PF00498	0.535
LIG_FHA_1	593	599	PF00498	0.510
LIG_FHA_1	676	682	PF00498	0.321
LIG_FHA_1	78	84	PF00498	0.584
LIG_FHA_1	91	97	PF00498	0.468
LIG_FHA_2	357	363	PF00498	0.618
LIG_FHA_2	461	467	PF00498	0.618
LIG_FHA_2	491	497	PF00498	0.724
LIG_FHA_2	749	755	PF00498	0.362
LIG_FHA_2	758	764	PF00498	0.361
LIG_GBD_Chelix_1	506	514	PF00786	0.310
LIG_LIR_Apic_2	268	274	PF02991	0.665
LIG_LIR_Gen_1	172	180	PF02991	0.480
LIG_LIR_Gen_1	40	48	PF02991	0.541
LIG_LIR_Gen_1	541	551	PF02991	0.637
LIG_LIR_Gen_1	614	625	PF02991	0.330
LIG_LIR_Gen_1	653	663	PF02991	0.354
LIG_LIR_Nem_3	40	44	PF02991	0.561
LIG_LIR_Nem_3	416	421	PF02991	0.503
LIG_LIR_Nem_3	541	547	PF02991	0.607
LIG_LIR_Nem_3	626	632	PF02991	0.330
LIG_LIR_Nem_3	653	658	PF02991	0.354
LIG_MLH1_MIPbox_1	625	629	PF16413	0.319
LIG_NRBOX	657	663	PF00104	0.301
LIG_PCNA_yPIPBox_3	606	617	PF02747	0.551
LIG_PDZ_Class_1	812	817	PF00595	0.420
LIG_Pex14_2	628	632	PF04695	0.319
LIG_Pex14_2	98	102	PF04695	0.533
LIG_PTB_Apo_2	321	328	PF02174	0.701
LIG_PTB_Apo_2	621	628	PF02174	0.319
LIG_PTB_Apo_2	680	687	PF02174	0.326
LIG_PTB_Phospho_1	621	627	PF10480	0.319
LIG_PTB_Phospho_1	680	686	PF10480	0.328
LIG_SH2_CRK	655	659	PF00017	0.350
LIG_SH2_GRB2like	686	689	PF00017	0.348
LIG_SH2_NCK_1	686	690	PF00017	0.342
LIG_SH2_PTP2	544	547	PF00017	0.566
LIG_SH2_STAP1	646	650	PF00017	0.385
LIG_SH2_STAP1	746	750	PF00017	0.339
LIG_SH2_STAT3	750	753	PF00017	0.393
LIG_SH2_STAT5	114	117	PF00017	0.680
LIG_SH2_STAT5	527	530	PF00017	0.637
LIG_SH2_STAT5	544	547	PF00017	0.467
LIG_SH2_STAT5	617	620	PF00017	0.335
LIG_SH2_STAT5	627	630	PF00017	0.349
LIG_SH2_STAT5	665	668	PF00017	0.326
LIG_SH2_STAT5	686	689	PF00017	0.348
LIG_SH2_STAT5	746	749	PF00017	0.343
LIG_SH2_STAT5	750	753	PF00017	0.356
LIG_SH3_3	164	170	PF00018	0.546
LIG_SH3_3	544	550	PF00018	0.599
LIG_SH3_3	560	566	PF00018	0.558
LIG_SH3_3	581	587	PF00018	0.561
LIG_SH3_3	591	597	PF00018	0.497
LIG_SH3_3	731	737	PF00018	0.361
LIG_SUMO_SIM_anti_2	500	508	PF11976	0.586
LIG_SUMO_SIM_anti_2	700	706	PF11976	0.325
LIG_SUMO_SIM_par_1	154	160	PF11976	0.506
LIG_TRAF2_1	360	363	PF00917	0.759
LIG_TRAF2_1	497	500	PF00917	0.652
LIG_TRAF2_1	761	764	PF00917	0.402
LIG_TRFH_1	352	356	PF08558	0.530
LIG_TYR_ITSM	540	547	PF00017	0.382
LIG_UBA3_1	601	607	PF00899	0.422
LIG_UBA3_1	62	67	PF00899	0.369
LIG_WW_3	355	359	PF00397	0.548
MOD_CDC14_SPxK_1	729	732	PF00782	0.412
MOD_CDK_SPxK_1	726	732	PF00069	0.403
MOD_CDK_SPxxK_3	270	277	PF00069	0.571
MOD_CK1_1	117	123	PF00069	0.486
MOD_CK1_1	136	142	PF00069	0.382
MOD_CK1_1	269	275	PF00069	0.666
MOD_CK1_1	330	336	PF00069	0.594
MOD_CK1_1	623	629	PF00069	0.407
MOD_CK1_1	653	659	PF00069	0.387
MOD_CK1_1	73	79	PF00069	0.509
MOD_CK1_1	745	751	PF00069	0.454
MOD_CK1_1	788	794	PF00069	0.428
MOD_CK2_1	117	123	PF00069	0.471
MOD_CK2_1	356	362	PF00069	0.566
MOD_CK2_1	421	427	PF00069	0.374
MOD_CK2_1	494	500	PF00069	0.567
MOD_CK2_1	51	57	PF00069	0.501
MOD_CK2_1	757	763	PF00069	0.486
MOD_CMANNOS	223	226	PF00535	0.354
MOD_DYRK1A_RPxSP_1	592	596	PF00069	0.370
MOD_GlcNHglycan	126	129	PF01048	0.622
MOD_GlcNHglycan	135	138	PF01048	0.485
MOD_GlcNHglycan	2	5	PF01048	0.636
MOD_GlcNHglycan	213	217	PF01048	0.404
MOD_GlcNHglycan	244	247	PF01048	0.487
MOD_GlcNHglycan	268	271	PF01048	0.667
MOD_GlcNHglycan	279	282	PF01048	0.561
MOD_GlcNHglycan	290	293	PF01048	0.580
MOD_GlcNHglycan	30	33	PF01048	0.570
MOD_GlcNHglycan	332	335	PF01048	0.540
MOD_GlcNHglycan	341	344	PF01048	0.629
MOD_GlcNHglycan	547	550	PF01048	0.475
MOD_GlcNHglycan	814	817	PF01048	0.475
MOD_GSK3_1	124	131	PF00069	0.623
MOD_GSK3_1	133	140	PF00069	0.471
MOD_GSK3_1	157	164	PF00069	0.347
MOD_GSK3_1	238	245	PF00069	0.463
MOD_GSK3_1	24	31	PF00069	0.601
MOD_GSK3_1	265	272	PF00069	0.660
MOD_GSK3_1	273	280	PF00069	0.606
MOD_GSK3_1	335	342	PF00069	0.545
MOD_GSK3_1	444	451	PF00069	0.577
MOD_GSK3_1	490	497	PF00069	0.487
MOD_GSK3_1	539	546	PF00069	0.456
MOD_GSK3_1	650	657	PF00069	0.367
MOD_GSK3_1	671	678	PF00069	0.359
MOD_GSK3_1	69	76	PF00069	0.492
MOD_GSK3_1	744	751	PF00069	0.403
MOD_GSK3_1	785	792	PF00069	0.489
MOD_LATS_1	309	315	PF00433	0.606
MOD_N-GLC_1	137	142	PF02516	0.450
MOD_N-GLC_1	266	271	PF02516	0.559
MOD_N-GLC_1	623	628	PF02516	0.319
MOD_N-GLC_1	682	687	PF02516	0.378
MOD_N-GLC_1	723	728	PF02516	0.374
MOD_N-GLC_2	366	368	PF02516	0.370
MOD_N-GLC_2	443	445	PF02516	0.438
MOD_N-GLC_2	697	699	PF02516	0.400
MOD_N-GLC_2	717	719	PF02516	0.226
MOD_NEK2_1	152	157	PF00069	0.502
MOD_NEK2_1	176	181	PF00069	0.548
MOD_NEK2_1	266	271	PF00069	0.659
MOD_NEK2_1	327	332	PF00069	0.768
MOD_NEK2_1	339	344	PF00069	0.634
MOD_NEK2_1	421	426	PF00069	0.381
MOD_NEK2_1	490	495	PF00069	0.629
MOD_NEK2_1	505	510	PF00069	0.344
MOD_NEK2_1	528	533	PF00069	0.421
MOD_NEK2_1	558	563	PF00069	0.557
MOD_NEK2_1	590	595	PF00069	0.361
MOD_NEK2_1	611	616	PF00069	0.420
MOD_NEK2_1	620	625	PF00069	0.319
MOD_NEK2_1	654	659	PF00069	0.405
MOD_NEK2_1	70	75	PF00069	0.420
MOD_NEK2_1	723	728	PF00069	0.388
MOD_NEK2_1	739	744	PF00069	0.565
MOD_NEK2_1	812	817	PF00069	0.454
MOD_NEK2_1	91	96	PF00069	0.360
MOD_PIKK_1	39	45	PF00454	0.423
MOD_PIKK_1	485	491	PF00454	0.388
MOD_PKA_1	304	310	PF00069	0.628
MOD_PKA_2	11	17	PF00069	0.652
MOD_PKA_2	117	123	PF00069	0.477
MOD_PKA_2	193	199	PF00069	0.413
MOD_PKA_2	288	294	PF00069	0.616
MOD_PKA_2	381	387	PF00069	0.375
MOD_PKA_2	748	754	PF00069	0.435
MOD_PKB_1	263	271	PF00069	0.607
MOD_Plk_1	137	143	PF00069	0.505
MOD_Plk_1	255	261	PF00069	0.791
MOD_Plk_1	39	45	PF00069	0.441
MOD_Plk_1	499	505	PF00069	0.489
MOD_Plk_1	623	629	PF00069	0.319
MOD_Plk_1	671	677	PF00069	0.359
MOD_Plk_1	682	688	PF00069	0.386
MOD_Plk_1	700	706	PF00069	0.372
MOD_Plk_2-3	169	175	PF00069	0.435
MOD_Plk_2-3	448	454	PF00069	0.379
MOD_Plk_4	137	143	PF00069	0.399
MOD_Plk_4	152	158	PF00069	0.318
MOD_Plk_4	255	261	PF00069	0.551
MOD_Plk_4	335	341	PF00069	0.497
MOD_Plk_4	406	412	PF00069	0.370
MOD_Plk_4	413	419	PF00069	0.337
MOD_Plk_4	437	443	PF00069	0.368
MOD_Plk_4	460	466	PF00069	0.485
MOD_Plk_4	529	535	PF00069	0.408
MOD_Plk_4	623	629	PF00069	0.319
MOD_Plk_4	650	656	PF00069	0.423
MOD_Plk_4	700	706	PF00069	0.348
MOD_Plk_4	739	745	PF00069	0.398
MOD_Plk_4	91	97	PF00069	0.366
MOD_ProDKin_1	24	30	PF00069	0.601
MOD_ProDKin_1	270	276	PF00069	0.595
MOD_ProDKin_1	332	338	PF00069	0.563
MOD_ProDKin_1	494	500	PF00069	0.494
MOD_ProDKin_1	564	570	PF00069	0.400
MOD_ProDKin_1	580	586	PF00069	0.310
MOD_ProDKin_1	592	598	PF00069	0.360
MOD_ProDKin_1	605	611	PF00069	0.373
MOD_ProDKin_1	726	732	PF00069	0.403
MOD_ProDKin_1	77	83	PF00069	0.457
TRG_DiLeu_BaEn_1	204	209	PF01217	0.431
TRG_DiLeu_BaEn_4	362	368	PF01217	0.466
TRG_DiLeu_BaEn_4	427	433	PF01217	0.418
TRG_DiLeu_BaLyEn_6	140	145	PF01217	0.428
TRG_DiLeu_BaLyEn_6	597	602	PF01217	0.343
TRG_DiLeu_LyEn_5	204	209	PF01217	0.431
TRG_ENDOCYTIC_2	418	421	PF00928	0.340
TRG_ENDOCYTIC_2	544	547	PF00928	0.480
TRG_ENDOCYTIC_2	617	620	PF00928	0.365
TRG_ENDOCYTIC_2	655	658	PF00928	0.411
TRG_ER_diArg_1	260	263	PF00400	0.648
TRG_ER_diArg_1	302	304	PF00400	0.620

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8G1	Leptomonas seymouri	46%	75%
A0A3S7X6Z4	Leishmania donovani	100%	100%
A4HLR5	Leishmania braziliensis	70%	100%
E9B441	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q3Y4	Leishmania major	92%	100%