Peptidyl-prolyl cis-trans isomerase

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclophilin 4 - putative

Species:

Leishmania infantum

UniProt:

A4I935_LEIIN

TriTrypDb:

LINF_330024700

Length:

258

Annotations

LeishMANIAdb annotations

A large collection of conserved eukaryotic peptidyl-prolyl cis-trans isomerases. Some members of this group are secreted (into the ER).. Localization: Cytoplasmic (by homology) / ER (by homology)

Annotations by Jardim et al.

Chaperone/Protein Folding, Peptidyl-prolyl cis-trans isomerase CYP4

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 30

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	4
GO:0005737	cytoplasm	2	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I935

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I935

PDB structure(s): 2hqj_A

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	14
GO:0006457	protein folding	2	14
GO:0006807	nitrogen compound metabolic process	2	14
GO:0008152	metabolic process	1	14
GO:0009987	cellular process	1	14
GO:0018193	peptidyl-amino acid modification	5	14
GO:0018208	peptidyl-proline modification	6	14
GO:0019538	protein metabolic process	3	14
GO:0036211	protein modification process	4	14
GO:0043170	macromolecule metabolic process	3	14
GO:0043412	macromolecule modification	4	14
GO:0044238	primary metabolic process	2	14
GO:0071704	organic substance metabolic process	2	14
GO:1901564	organonitrogen compound metabolic process	3	14

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	14
GO:0003824	catalytic activity	1	14
GO:0016853	isomerase activity	2	14
GO:0016859	cis-trans isomerase activity	3	14
GO:0140096	catalytic activity, acting on a protein	2	14
GO:0005488	binding	1	1
GO:0016018	cyclosporin A binding	4	1
GO:0033218	amide binding	2	1
GO:0042277	peptide binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	211	215	PF00656	0.299
CLV_NRD_NRD_1	4	6	PF00675	0.358
CLV_NRD_NRD_1	65	67	PF00675	0.482
CLV_NRD_NRD_1	73	75	PF00675	0.335
CLV_PCSK_KEX2_1	4	6	PF00082	0.343
CLV_PCSK_KEX2_1	65	67	PF00082	0.602
CLV_PCSK_KEX2_1	73	75	PF00082	0.447
CLV_PCSK_SKI1_1	56	60	PF00082	0.479
CLV_PCSK_SKI1_1	66	70	PF00082	0.468
DEG_Nend_Nbox_1	1	3	PF02207	0.366
DOC_ANK_TNKS_1	181	188	PF00023	0.354
DOC_MAPK_JIP1_4	51	57	PF00069	0.343
DOC_MAPK_MEF2A_6	51	59	PF00069	0.372
DOC_PP1_RVXF_1	130	137	PF00149	0.325
DOC_PP1_RVXF_1	214	221	PF00149	0.270
DOC_PP4_FxxP_1	49	52	PF00568	0.343
DOC_PP4_FxxP_1	58	61	PF00568	0.296
DOC_USP7_MATH_1	172	176	PF00917	0.271
DOC_USP7_MATH_1	79	83	PF00917	0.517
LIG_14-3-3_CanoR_1	244	250	PF00244	0.398
LIG_14-3-3_CanoR_1	44	49	PF00244	0.362
LIG_14-3-3_CanoR_1	51	56	PF00244	0.611
LIG_14-3-3_CanoR_1	65	69	PF00244	0.536
LIG_Actin_WH2_2	52	67	PF00022	0.336
LIG_APCC_ABBA_1	103	108	PF00400	0.270
LIG_BRCT_BRCA1_1	200	204	PF00533	0.270
LIG_FHA_1	208	214	PF00498	0.270
LIG_FHA_1	22	28	PF00498	0.351
LIG_FHA_2	159	165	PF00498	0.220
LIG_FHA_2	246	252	PF00498	0.244
LIG_LIR_Apic_2	47	52	PF02991	0.344
LIG_LIR_Gen_1	13	22	PF02991	0.344
LIG_LIR_Gen_1	139	149	PF02991	0.256
LIG_LIR_Gen_1	224	233	PF02991	0.282
LIG_LIR_Gen_1	24	34	PF02991	0.335
LIG_LIR_Gen_1	35	43	PF02991	0.326
LIG_LIR_Nem_3	104	109	PF02991	0.248
LIG_LIR_Nem_3	115	120	PF02991	0.270
LIG_LIR_Nem_3	13	17	PF02991	0.346
LIG_LIR_Nem_3	139	144	PF02991	0.256
LIG_LIR_Nem_3	224	230	PF02991	0.282
LIG_LIR_Nem_3	24	29	PF02991	0.330
LIG_LIR_Nem_3	33	39	PF02991	0.313
LIG_MLH1_MIPbox_1	200	204	PF16413	0.270
LIG_SH2_CRK	227	231	PF00017	0.345
LIG_SH2_PTP2	26	29	PF00017	0.352
LIG_SH2_STAP1	227	231	PF00017	0.354
LIG_SH2_STAT5	14	17	PF00017	0.342
LIG_SH2_STAT5	26	29	PF00017	0.331
LIG_SH2_STAT5	34	37	PF00017	0.320
LIG_SH2_STAT5	48	51	PF00017	0.344
LIG_SH3_1	73	79	PF00018	0.320
LIG_SH3_3	54	60	PF00018	0.494
LIG_SH3_3	73	79	PF00018	0.351
LIG_SUMO_SIM_par_1	245	251	PF11976	0.245
LIG_TYR_ITSM	22	29	PF00017	0.351
MOD_CK1_1	240	246	PF00069	0.297
MOD_CK1_1	47	53	PF00069	0.509
MOD_CK1_1	92	98	PF00069	0.291
MOD_CK2_1	158	164	PF00069	0.220
MOD_GlcNHglycan	129	132	PF01048	0.238
MOD_GlcNHglycan	239	242	PF01048	0.284
MOD_GlcNHglycan	69	72	PF01048	0.420
MOD_GSK3_1	158	165	PF00069	0.273
MOD_GSK3_1	17	24	PF00069	0.354
MOD_GSK3_1	28	35	PF00069	0.326
MOD_GSK3_1	47	54	PF00069	0.548
MOD_N-GLC_1	158	163	PF02516	0.270
MOD_N-GLC_1	198	203	PF02516	0.270
MOD_NEK2_1	136	141	PF00069	0.319
MOD_NEK2_1	16	21	PF00069	0.357
MOD_NEK2_1	204	209	PF00069	0.271
MOD_NEK2_1	30	35	PF00069	0.324
MOD_NEK2_1	64	69	PF00069	0.439
MOD_NEK2_1	89	94	PF00069	0.232
MOD_NEK2_2	162	167	PF00069	0.270
MOD_PIKK_1	198	204	PF00454	0.270
MOD_PIKK_1	232	238	PF00454	0.335
MOD_PIKK_1	92	98	PF00454	0.263
MOD_PKA_2	64	70	PF00069	0.562
MOD_Plk_1	172	178	PF00069	0.264
MOD_Plk_1	89	95	PF00069	0.220
MOD_Plk_4	10	16	PF00069	0.356
MOD_Plk_4	162	168	PF00069	0.259
MOD_Plk_4	17	23	PF00069	0.339
MOD_SUMO_for_1	231	234	PF00179	0.225
MOD_SUMO_for_1	255	258	PF00179	0.545
MOD_SUMO_rev_2	211	218	PF00179	0.305
TRG_ENDOCYTIC_2	14	17	PF00928	0.342
TRG_ENDOCYTIC_2	227	230	PF00928	0.284
TRG_ENDOCYTIC_2	26	29	PF00928	0.331
TRG_ENDOCYTIC_2	36	39	PF00928	0.326
TRG_ER_diArg_1	3	5	PF00400	0.352
TRG_ER_diArg_1	64	66	PF00400	0.599
TRG_ER_diArg_1	73	75	PF00400	0.440
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.284

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P364	Leptomonas seymouri	49%	100%
A0A0N0P523	Leptomonas seymouri	66%	93%
A0A0N0P839	Leptomonas seymouri	90%	100%
A0A0N1I0P5	Leptomonas seymouri	70%	100%
A0A0N1I8P9	Leptomonas seymouri	53%	88%
A0A0N1IAQ4	Leptomonas seymouri	53%	73%
A0A0N1IL84	Leptomonas seymouri	34%	81%
A0A0N1PC19	Leptomonas seymouri	36%	100%
A0A0N1PDY0	Leptomonas seymouri	32%	100%
A0A0S4IKA5	Bodo saltans	36%	85%
A0A0S4J0W0	Bodo saltans	63%	100%
A0A0S4J4A4	Bodo saltans	64%	100%
A0A0S4J7K8	Bodo saltans	68%	100%
A0A0S4J8W7	Bodo saltans	48%	100%
A0A0S4J9U9	Bodo saltans	34%	100%
A0A0S4JAB5	Bodo saltans	49%	72%
A0A0S4KLH0	Bodo saltans	83%	100%
A0A1X0NTQ9	Trypanosomatidae	56%	100%
A0A1X0NTS4	Trypanosomatidae	52%	100%
A0A1X0NXG7	Trypanosomatidae	74%	100%
A0A1X0P184	Trypanosomatidae	87%	100%
A0A1X0P2K2	Trypanosomatidae	35%	98%
A0A1X0P4X3	Trypanosomatidae	38%	100%
A0A1X0P563	Trypanosomatidae	49%	73%
A0A1X0P5F9	Trypanosomatidae	69%	100%
A0A1X0P6T5	Trypanosomatidae	27%	68%
A0A3Q8ICB3	Leishmania donovani	46%	100%
A0A3Q8IIG9	Leishmania donovani	53%	73%
A0A3R7M7E5	Trypanosoma rangeli	37%	84%
A0A3R7MP70	Trypanosoma rangeli	41%	100%
A0A3R7NMR3	Trypanosoma rangeli	69%	100%
A0A3R7RC31	Trypanosoma rangeli	84%	100%
A0A3R7RE54	Trypanosoma rangeli	66%	100%
A0A3S5H5N2	Leishmania donovani	55%	100%
A0A3S5H7U6	Leishmania donovani	100%	100%
A0A3S5IQL2	Trypanosoma rangeli	36%	99%
A0A3S7WXF4	Leishmania donovani	66%	87%
A0A3S7WYD9	Leishmania donovani	26%	100%
A0A3S7WYY5	Leishmania donovani	71%	100%
A0A3S7X325	Leishmania donovani	33%	100%
A0A3S7X410	Leishmania donovani	55%	100%
A0A3S7XB52	Leishmania donovani	37%	97%
A0A422N1Z9	Trypanosoma rangeli	56%	100%
A0A422N490	Trypanosoma rangeli	47%	100%
A0A422NQ98	Trypanosoma rangeli	28%	72%
A0A422P185	Trypanosoma rangeli	48%	73%
A0A451EJ79	Leishmania donovani	38%	77%
A4FV72	Bos taurus	63%	86%
A4H346	Leishmania braziliensis	36%	77%
A4H4H8	Leishmania braziliensis	53%	100%
A4HCI8	Leishmania braziliensis	47%	100%
A4HCL8	Leishmania braziliensis	66%	100%
A4HE26	Leishmania braziliensis	72%	98%
A4HHU7	Leishmania braziliensis	33%	100%
A4HIW9	Leishmania braziliensis	54%	100%
A4HLM4	Leishmania braziliensis	92%	100%
A4HNE1	Leishmania braziliensis	52%	73%
A4HPH9	Leishmania braziliensis	37%	100%
A4HRE3	Leishmania infantum	38%	77%
A4HSQ3	Leishmania infantum	55%	100%
A4I004	Leishmania infantum	46%	100%
A4I042	Leishmania infantum	66%	100%
A4I0X0	Leishmania infantum	26%	100%
A4I1D2	Leishmania infantum	71%	98%
A4I4Z7	Leishmania infantum	33%	100%
A4I698	Leishmania infantum	55%	100%
A4IC14	Leishmania infantum	53%	73%
A4IDA1	Leishmania infantum	37%	97%
A8X8D0	Caenorhabditis briggsae	49%	82%
B3A0R0	Lottia gigantea	52%	100%
C9ZIV0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	86%	100%
C9ZQE6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	99%
C9ZRQ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
C9ZSQ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
C9ZT99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
C9ZUX8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	86%
C9ZZI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	67%
D0A5M6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
D0A8E1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AC11	Leishmania major	37%	77%
E9AFI5	Leishmania major	30%	100%
E9AFV2	Leishmania major	53%	73%
E9AJA8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	77%
E9AKP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%
E9AT91	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9AVX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9AW05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
E9AWX4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AXG9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	98%
E9B0C7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9B1F3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
E9B400	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O02614	Leishmania major	69%	98%
O43447	Homo sapiens	55%	100%
O49605	Arabidopsis thaliana	50%	100%
O49886	Lupinus luteus	69%	100%
O74729	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	50%	100%
O94273	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	53%	100%
P0C1H9	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	50%	100%
P0C1I0	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	50%	100%
P0C1I1	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	62%	71%
P0C1I3	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	53%	100%
P0C1I7	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	63%	100%
P0C1I8	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	62%	100%
P0C1I9	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	57%	76%
P0CP78	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	54%	100%
P0CP79	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	54%	100%
P0CP82	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	56%	100%
P0CP83	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	56%	100%
P15425	Drosophila melanogaster	40%	100%
P21569	Zea mays	69%	100%
P23284	Homo sapiens	55%	100%
P23285	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	50%	100%
P24367	Gallus gallus	58%	100%
P24368	Rattus norvegicus	56%	100%
P24369	Mus musculus	55%	100%
P26882	Bos taurus	59%	70%
P28517	Calliphora vicina	39%	100%
P29117	Rattus norvegicus	65%	100%
P30404	Bos taurus	66%	100%
P30405	Homo sapiens	65%	100%
P34791	Arabidopsis thaliana	54%	99%
P52009	Caenorhabditis elegans	71%	100%
P52014	Caenorhabditis elegans	50%	100%
P52018	Caenorhabditis elegans	52%	100%
P53691	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	54%	70%
P80311	Bos taurus	56%	100%
Q08752	Homo sapiens	59%	70%
Q0P5D0	Bos taurus	55%	100%
Q1RMP7	Bos taurus	40%	84%
Q26516	Schistosoma japonicum	61%	100%
Q26548	Schistosoma mansoni	62%	95%
Q26551	Schistosoma mansoni	51%	100%
Q27774	Schistosoma japonicum	52%	100%
Q2TZ33	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	52%	100%
Q2UGK2	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	51%	100%
Q38867	Arabidopsis thaliana	66%	100%
Q38900	Arabidopsis thaliana	66%	100%
Q39613	Catharanthus roseus	72%	100%
Q42406	Arabidopsis thaliana	69%	100%
Q4HXF6	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	64%	69%
Q4I5R9	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	56%	100%
Q4IPH4	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	57%	100%
Q4L4W9	Staphylococcus haemolyticus (strain JCSC1435)	39%	100%
Q4Q1A6	Leishmania major	37%	100%
Q4Q424	Leishmania major	98%	100%
Q4Q6Q9	Leishmania major	55%	100%
Q4Q7V7	Leishmania major	33%	100%
Q4QBH1	Leishmania major	67%	100%
Q4QBK2	Leishmania major	46%	100%
Q4QJ67	Leishmania major	54%	100%
Q4WCM6	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	54%	100%
Q4WIF3	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	63%	68%
Q4WMB6	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	34%	100%
Q4WP12	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	55%	100%
Q54SM3	Dictyostelium discoideum	70%	100%
Q5ACI8	Candida albicans (strain SC5314 / ATCC MYA-2876)	59%	70%
Q5AQL0	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	54%	100%
Q5B4E7	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	64%	69%
Q5B4R3	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	54%	100%
Q5BAH7	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	36%	100%
Q5HQK8	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	40%	100%
Q5R723	Pongo abelii	63%	86%
Q5U8Z7	Amanita muscaria	63%	70%
Q5UP71	Acanthamoeba polyphaga mimivirus	28%	100%
Q6BXZ7	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	59%	70%
Q6C4W6	Yarrowia lipolytica (strain CLIB 122 / E 150)	58%	100%
Q6CBP4	Yarrowia lipolytica (strain CLIB 122 / E 150)	61%	70%
Q6CL78	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	56%	69%
Q6DGG0	Rattus norvegicus	61%	70%
Q6FNU6	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	55%	70%
Q7SG06	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	57%	100%
Q8CT84	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	40%	100%
Q8IXY8	Homo sapiens	43%	83%
Q8X166	Aspergillus niger	55%	100%
Q99KR7	Mus musculus	65%	100%
Q9ASS6	Arabidopsis thaliana	57%	100%
Q9CR16	Mus musculus	61%	70%
Q9D6D8	Mus musculus	39%	82%
Q9LIK6	Arabidopsis thaliana	41%	100%
Q9QZH3	Mus musculus	63%	86%
Q9SKQ0	Arabidopsis thaliana	71%	100%
Q9UNP9	Homo sapiens	61%	86%
Q9V3G3	Drosophila melanogaster	62%	86%
Q9ZVJ4	Arabidopsis thaliana	55%	100%
V5B2A0	Trypanosoma cruzi	71%	100%
V5B9Y6	Trypanosoma cruzi	38%	84%
V5BHF5	Trypanosoma cruzi	85%	100%
V5BP10	Trypanosoma cruzi	28%	68%
V5D7H4	Trypanosoma cruzi	49%	73%