Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I932_LEIIN

TriTrypDb:

LINF_330024400

Length:

900

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I932

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I932

Function

Biological processes
Term	Name	Level	Count
GO:0001522	pseudouridine synthesis	6	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009451	RNA modification	5	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0009982	pseudouridine synthase activity	4	11
GO:0016853	isomerase activity	2	11
GO:0016866	intramolecular transferase activity	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.612
CLV_C14_Caspase3-7	33	37	PF00656	0.583
CLV_C14_Caspase3-7	655	659	PF00656	0.653
CLV_C14_Caspase3-7	894	898	PF00656	0.609
CLV_MEL_PAP_1	876	882	PF00089	0.464
CLV_NRD_NRD_1	217	219	PF00675	0.520
CLV_NRD_NRD_1	277	279	PF00675	0.671
CLV_NRD_NRD_1	375	377	PF00675	0.471
CLV_NRD_NRD_1	547	549	PF00675	0.500
CLV_NRD_NRD_1	606	608	PF00675	0.557
CLV_NRD_NRD_1	724	726	PF00675	0.717
CLV_PCSK_FUR_1	275	279	PF00082	0.666
CLV_PCSK_KEX2_1	217	219	PF00082	0.520
CLV_PCSK_KEX2_1	275	277	PF00082	0.676
CLV_PCSK_KEX2_1	340	342	PF00082	0.751
CLV_PCSK_KEX2_1	375	377	PF00082	0.471
CLV_PCSK_KEX2_1	546	548	PF00082	0.558
CLV_PCSK_KEX2_1	605	607	PF00082	0.530
CLV_PCSK_KEX2_1	723	725	PF00082	0.695
CLV_PCSK_KEX2_1	831	833	PF00082	0.600
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.743
CLV_PCSK_PC1ET2_1	546	548	PF00082	0.558
CLV_PCSK_PC1ET2_1	831	833	PF00082	0.626
CLV_PCSK_SKI1_1	26	30	PF00082	0.742
CLV_PCSK_SKI1_1	282	286	PF00082	0.554
CLV_PCSK_SKI1_1	32	36	PF00082	0.768
CLV_PCSK_SKI1_1	421	425	PF00082	0.534
CLV_PCSK_SKI1_1	458	462	PF00082	0.528
CLV_PCSK_SKI1_1	636	640	PF00082	0.611
CLV_PCSK_SKI1_1	662	666	PF00082	0.727
CLV_PCSK_SKI1_1	754	758	PF00082	0.405
CLV_PCSK_SKI1_1	787	791	PF00082	0.687
CLV_PCSK_SKI1_1	834	838	PF00082	0.571
CLV_PCSK_SKI1_1	99	103	PF00082	0.580
CLV_Separin_Metazoa	214	218	PF03568	0.486
CLV_Separin_Metazoa	72	76	PF03568	0.711
DEG_APCC_DBOX_1	457	465	PF00400	0.511
DEG_Nend_UBRbox_1	1	4	PF02207	0.714
DEG_SCF_FBW7_1	234	241	PF00400	0.545
DEG_SCF_TRCP1_1	658	663	PF00400	0.660
DEG_SIAH_1	821	829	PF03145	0.614
DOC_CDC14_PxL_1	70	78	PF14671	0.711
DOC_CKS1_1	346	351	PF01111	0.580
DOC_CKS1_1	81	86	PF01111	0.711
DOC_CYCLIN_RxL_1	751	761	PF00134	0.536
DOC_CYCLIN_yCln2_LP_2	671	677	PF00134	0.536
DOC_MAPK_DCC_7	662	671	PF00069	0.562
DOC_MAPK_MEF2A_6	445	452	PF00069	0.403
DOC_MAPK_MEF2A_6	454	463	PF00069	0.371
DOC_PP2B_LxvP_1	671	674	PF13499	0.575
DOC_PP4_FxxP_1	346	349	PF00568	0.654
DOC_PP4_FxxP_1	774	777	PF00568	0.563
DOC_PP4_FxxP_1	783	786	PF00568	0.743
DOC_USP7_MATH_1	101	105	PF00917	0.561
DOC_USP7_MATH_1	113	117	PF00917	0.674
DOC_USP7_MATH_1	119	123	PF00917	0.700
DOC_USP7_MATH_1	142	146	PF00917	0.578
DOC_USP7_MATH_1	150	154	PF00917	0.489
DOC_USP7_MATH_1	247	251	PF00917	0.637
DOC_USP7_MATH_1	252	256	PF00917	0.474
DOC_USP7_MATH_1	320	324	PF00917	0.763
DOC_USP7_MATH_1	330	334	PF00917	0.738
DOC_USP7_MATH_1	39	43	PF00917	0.688
DOC_USP7_MATH_1	565	569	PF00917	0.657
DOC_USP7_MATH_1	656	660	PF00917	0.752
DOC_USP7_MATH_1	735	739	PF00917	0.670
DOC_USP7_MATH_1	775	779	PF00917	0.565
DOC_USP7_MATH_1	789	793	PF00917	0.610
DOC_USP7_MATH_1	816	820	PF00917	0.655
DOC_USP7_MATH_1	850	854	PF00917	0.641
DOC_USP7_MATH_1	878	882	PF00917	0.486
DOC_USP7_MATH_2	311	317	PF00917	0.596
DOC_WW_Pin1_4	234	239	PF00397	0.740
DOC_WW_Pin1_4	345	350	PF00397	0.718
DOC_WW_Pin1_4	360	365	PF00397	0.499
DOC_WW_Pin1_4	41	46	PF00397	0.657
DOC_WW_Pin1_4	453	458	PF00397	0.533
DOC_WW_Pin1_4	481	486	PF00397	0.653
DOC_WW_Pin1_4	520	525	PF00397	0.423
DOC_WW_Pin1_4	80	85	PF00397	0.761
LIG_14-3-3_CanoR_1	169	178	PF00244	0.455
LIG_14-3-3_CanoR_1	286	293	PF00244	0.408
LIG_14-3-3_CanoR_1	345	349	PF00244	0.734
LIG_14-3-3_CanoR_1	375	381	PF00244	0.448
LIG_14-3-3_CanoR_1	662	667	PF00244	0.585
LIG_14-3-3_CanoR_1	686	690	PF00244	0.513
LIG_14-3-3_CanoR_1	723	731	PF00244	0.726
LIG_14-3-3_CanoR_1	736	745	PF00244	0.687
LIG_14-3-3_CanoR_1	834	841	PF00244	0.462
LIG_14-3-3_CanoR_1	879	883	PF00244	0.523
LIG_Actin_WH2_2	163	179	PF00022	0.451
LIG_Actin_WH2_2	882	898	PF00022	0.559
LIG_BIR_III_4	469	473	PF00653	0.540
LIG_BRCT_BRCA1_1	700	704	PF00533	0.587
LIG_deltaCOP1_diTrp_1	589	596	PF00928	0.481
LIG_DLG_GKlike_1	376	384	PF00625	0.475
LIG_EVH1_1	131	135	PF00568	0.727
LIG_FHA_1	286	292	PF00498	0.481
LIG_FHA_1	364	370	PF00498	0.442
LIG_FHA_1	454	460	PF00498	0.511
LIG_FHA_1	535	541	PF00498	0.472
LIG_FHA_1	8	14	PF00498	0.665
LIG_FHA_1	835	841	PF00498	0.543
LIG_FHA_2	307	313	PF00498	0.524
LIG_FHA_2	31	37	PF00498	0.681
LIG_FHA_2	561	567	PF00498	0.538
LIG_FHA_2	799	805	PF00498	0.383
LIG_FHA_2	98	104	PF00498	0.636
LIG_GBD_Chelix_1	178	186	PF00786	0.445
LIG_HP1_1	457	461	PF01393	0.525
LIG_IRF3_LxIS_1	166	173	PF10401	0.343
LIG_LIR_Apic_2	44	50	PF02991	0.705
LIG_LIR_Apic_2	773	777	PF02991	0.559
LIG_LIR_Gen_1	614	625	PF02991	0.401
LIG_LIR_Nem_3	614	620	PF02991	0.402
LIG_LIR_Nem_3	750	756	PF02991	0.507
LIG_PDZ_Class_1	895	900	PF00595	0.671
LIG_Pex14_1	770	774	PF04695	0.541
LIG_REV1ctd_RIR_1	532	540	PF16727	0.487
LIG_RPA_C_Fungi	175	187	PF08784	0.469
LIG_RPA_C_Fungi	681	693	PF08784	0.492
LIG_SH2_CRK	490	494	PF00017	0.369
LIG_SH2_NCK_1	549	553	PF00017	0.471
LIG_SH2_NCK_1	679	683	PF00017	0.522
LIG_SH2_SRC	47	50	PF00017	0.734
LIG_SH2_SRC	549	552	PF00017	0.456
LIG_SH2_SRC	77	80	PF00017	0.565
LIG_SH2_STAP1	287	291	PF00017	0.479
LIG_SH2_STAP1	490	494	PF00017	0.369
LIG_SH2_STAP1	549	553	PF00017	0.454
LIG_SH2_STAP1	77	81	PF00017	0.668
LIG_SH2_STAT5	185	188	PF00017	0.552
LIG_SH2_STAT5	227	230	PF00017	0.671
LIG_SH2_STAT5	287	290	PF00017	0.455
LIG_SH2_STAT5	47	50	PF00017	0.724
LIG_SH2_STAT5	521	524	PF00017	0.517
LIG_SH3_1	129	135	PF00018	0.730
LIG_SH3_3	129	135	PF00018	0.730
LIG_SH3_3	237	243	PF00018	0.740
LIG_SH3_3	419	425	PF00018	0.489
LIG_SH3_3	647	653	PF00018	0.553
LIG_SH3_3	749	755	PF00018	0.548
LIG_SUMO_SIM_anti_2	708	714	PF11976	0.452
LIG_SUMO_SIM_par_1	667	672	PF11976	0.635
LIG_SUMO_SIM_par_1	694	699	PF11976	0.573
LIG_SUMO_SIM_par_1	754	759	PF11976	0.494
LIG_TYR_ITIM	488	493	PF00017	0.479
LIG_WRC_WIRS_1	106	111	PF05994	0.607
LIG_WRC_WIRS_1	302	307	PF05994	0.443
LIG_WW_3	342	346	PF00397	0.549
MOD_CDC14_SPxK_1	484	487	PF00782	0.588
MOD_CDK_SPK_2	234	239	PF00069	0.654
MOD_CDK_SPK_2	41	46	PF00069	0.705
MOD_CDK_SPK_2	453	458	PF00069	0.533
MOD_CDK_SPxK_1	481	487	PF00069	0.631
MOD_CK1_1	105	111	PF00069	0.617
MOD_CK1_1	355	361	PF00069	0.547
MOD_CK1_1	362	368	PF00069	0.547
MOD_CK1_1	379	385	PF00069	0.426
MOD_CK1_1	738	744	PF00069	0.698
MOD_CK1_1	792	798	PF00069	0.602
MOD_CK2_1	140	146	PF00069	0.628
MOD_CK2_1	306	312	PF00069	0.610
MOD_CK2_1	32	38	PF00069	0.726
MOD_CK2_1	348	354	PF00069	0.625
MOD_CK2_1	560	566	PF00069	0.524
MOD_CK2_1	66	72	PF00069	0.755
MOD_CK2_1	699	705	PF00069	0.581
MOD_CK2_1	770	776	PF00069	0.509
MOD_CK2_1	97	103	PF00069	0.610
MOD_CMANNOS	592	595	PF00535	0.508
MOD_DYRK1A_RPxSP_1	239	243	PF00069	0.692
MOD_GlcNHglycan	117	120	PF01048	0.746
MOD_GlcNHglycan	121	124	PF01048	0.761
MOD_GlcNHglycan	188	191	PF01048	0.582
MOD_GlcNHglycan	230	233	PF01048	0.680
MOD_GlcNHglycan	249	252	PF01048	0.286
MOD_GlcNHglycan	254	257	PF01048	0.502
MOD_GlcNHglycan	264	267	PF01048	0.615
MOD_GlcNHglycan	331	335	PF01048	0.758
MOD_GlcNHglycan	395	398	PF01048	0.523
MOD_GlcNHglycan	658	661	PF01048	0.729
MOD_GlcNHglycan	662	665	PF01048	0.737
MOD_GlcNHglycan	671	674	PF01048	0.637
MOD_GlcNHglycan	848	851	PF01048	0.608
MOD_GlcNHglycan	859	862	PF01048	0.617
MOD_GSK3_1	115	122	PF00069	0.737
MOD_GSK3_1	136	143	PF00069	0.676
MOD_GSK3_1	150	157	PF00069	0.444
MOD_GSK3_1	234	241	PF00069	0.686
MOD_GSK3_1	344	351	PF00069	0.681
MOD_GSK3_1	355	362	PF00069	0.535
MOD_GSK3_1	534	541	PF00069	0.417
MOD_GSK3_1	656	663	PF00069	0.766
MOD_GSK3_1	669	676	PF00069	0.634
MOD_GSK3_1	725	732	PF00069	0.744
MOD_GSK3_1	846	853	PF00069	0.537
MOD_GSK3_1	97	104	PF00069	0.602
MOD_N-GLC_1	124	129	PF02516	0.790
MOD_N-GLC_1	30	35	PF02516	0.589
MOD_N-GLC_1	398	403	PF02516	0.512
MOD_N-GLC_1	748	753	PF02516	0.639
MOD_N-GLC_1	792	797	PF02516	0.674
MOD_NEK2_1	1	6	PF00069	0.747
MOD_NEK2_1	102	107	PF00069	0.564
MOD_NEK2_1	186	191	PF00069	0.579
MOD_NEK2_1	262	267	PF00069	0.598
MOD_NEK2_1	534	539	PF00069	0.389
MOD_NEK2_1	669	674	PF00069	0.516
MOD_NEK2_1	895	900	PF00069	0.594
MOD_NEK2_2	685	690	PF00069	0.477
MOD_PIKK_1	113	119	PF00454	0.739
MOD_PIKK_1	425	431	PF00454	0.603
MOD_PIKK_1	475	481	PF00454	0.667
MOD_PIKK_1	677	683	PF00454	0.459
MOD_PIKK_1	729	735	PF00454	0.759
MOD_PKA_1	724	730	PF00069	0.563
MOD_PKA_2	238	244	PF00069	0.694
MOD_PKA_2	252	258	PF00069	0.475
MOD_PKA_2	285	291	PF00069	0.503
MOD_PKA_2	344	350	PF00069	0.700
MOD_PKA_2	352	358	PF00069	0.540
MOD_PKA_2	656	662	PF00069	0.678
MOD_PKA_2	685	691	PF00069	0.516
MOD_PKA_2	724	730	PF00069	0.665
MOD_PKA_2	735	741	PF00069	0.664
MOD_PKA_2	764	770	PF00069	0.510
MOD_PKA_2	878	884	PF00069	0.522
MOD_PKB_1	723	731	PF00069	0.662
MOD_PKB_1	832	840	PF00069	0.543
MOD_Plk_1	102	108	PF00069	0.621
MOD_Plk_1	398	404	PF00069	0.464
MOD_Plk_1	748	754	PF00069	0.628
MOD_Plk_1	792	798	PF00069	0.665
MOD_Plk_2-3	560	566	PF00069	0.496
MOD_Plk_2-3	699	705	PF00069	0.585
MOD_Plk_4	241	247	PF00069	0.622
MOD_Plk_4	725	731	PF00069	0.757
MOD_Plk_4	748	754	PF00069	0.566
MOD_Plk_4	792	798	PF00069	0.627
MOD_Plk_4	851	857	PF00069	0.643
MOD_ProDKin_1	234	240	PF00069	0.737
MOD_ProDKin_1	345	351	PF00069	0.697
MOD_ProDKin_1	360	366	PF00069	0.534
MOD_ProDKin_1	41	47	PF00069	0.651
MOD_ProDKin_1	453	459	PF00069	0.521
MOD_ProDKin_1	481	487	PF00069	0.637
MOD_ProDKin_1	520	526	PF00069	0.428
MOD_ProDKin_1	80	86	PF00069	0.761
TRG_DiLeu_BaLyEn_6	752	757	PF01217	0.525
TRG_ENDOCYTIC_2	490	493	PF00928	0.368
TRG_ER_diArg_1	216	218	PF00400	0.518
TRG_ER_diArg_1	275	278	PF00400	0.669
TRG_ER_diArg_1	374	376	PF00400	0.455
TRG_ER_diArg_1	547	549	PF00400	0.500
TRG_ER_diArg_1	605	607	PF00400	0.530
TRG_ER_diArg_1	723	725	PF00400	0.689
TRG_NES_CRM1_1	614	627	PF08389	0.403
TRG_NLS_MonoExtC_3	545	551	PF00514	0.496
TRG_NLS_MonoExtN_4	828	835	PF00514	0.551
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.736
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	184	188	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	445	449	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	46	51	PF00026	0.636
TRG_Pf-PMV_PEXEL_1	754	759	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	834	838	PF00026	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0E0	Leptomonas seymouri	47%	99%
A0A1X0P134	Trypanosomatidae	26%	100%
A0A3Q8IEW6	Leishmania donovani	100%	100%
A0A3R7KAP3	Trypanosoma rangeli	28%	100%
A4HLM1	Leishmania braziliensis	78%	100%
D0A535	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B3Z7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
Q4Q427	Leishmania major	93%	100%
V5BLS1	Trypanosoma cruzi	28%	100%