Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I929_LEIIN

TriTrypDb:

LINF_330024100

Length:

512

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I929

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I929

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.458
CLV_NRD_NRD_1	462	464	PF00675	0.618
CLV_NRD_NRD_1	487	489	PF00675	0.524
CLV_NRD_NRD_1	496	498	PF00675	0.453
CLV_NRD_NRD_1	8	10	PF00675	0.639
CLV_PCSK_KEX2_1	104	106	PF00082	0.499
CLV_PCSK_KEX2_1	15	17	PF00082	0.635
CLV_PCSK_KEX2_1	462	464	PF00082	0.614
CLV_PCSK_KEX2_1	496	498	PF00082	0.492
CLV_PCSK_KEX2_1	8	10	PF00082	0.660
CLV_PCSK_PC1ET2_1	104	106	PF00082	0.425
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.603
CLV_PCSK_PC7_1	4	10	PF00082	0.507
CLV_PCSK_SKI1_1	237	241	PF00082	0.490
CLV_PCSK_SKI1_1	244	248	PF00082	0.485
CLV_PCSK_SKI1_1	302	306	PF00082	0.468
CLV_PCSK_SKI1_1	42	46	PF00082	0.643
CLV_PCSK_SKI1_1	8	12	PF00082	0.696
CLV_PCSK_SKI1_1	85	89	PF00082	0.396
DEG_MDM2_SWIB_1	156	163	PF02201	0.439
DEG_Nend_UBRbox_3	1	3	PF02207	0.537
DEG_SPOP_SBC_1	166	170	PF00917	0.600
DEG_SPOP_SBC_1	44	48	PF00917	0.634
DOC_CKS1_1	207	212	PF01111	0.460
DOC_CYCLIN_RxL_1	383	391	PF00134	0.337
DOC_MAPK_MEF2A_6	424	432	PF00069	0.622
DOC_PP1_RVXF_1	7	14	PF00149	0.512
DOC_PP2B_LxvP_1	327	330	PF13499	0.500
DOC_USP7_MATH_1	143	147	PF00917	0.362
DOC_USP7_MATH_1	166	170	PF00917	0.550
DOC_USP7_MATH_1	255	259	PF00917	0.407
DOC_USP7_MATH_1	284	288	PF00917	0.658
DOC_USP7_MATH_1	44	48	PF00917	0.590
DOC_USP7_MATH_1	54	58	PF00917	0.575
DOC_USP7_MATH_1	70	74	PF00917	0.389
DOC_WW_Pin1_4	168	173	PF00397	0.606
DOC_WW_Pin1_4	199	204	PF00397	0.558
DOC_WW_Pin1_4	206	211	PF00397	0.412
DOC_WW_Pin1_4	322	327	PF00397	0.601
DOC_WW_Pin1_4	338	343	PF00397	0.306
DOC_WW_Pin1_4	431	436	PF00397	0.512
DOC_WW_Pin1_4	467	472	PF00397	0.635
DOC_WW_Pin1_4	79	84	PF00397	0.586
LIG_14-3-3_CanoR_1	105	110	PF00244	0.352
LIG_14-3-3_CanoR_1	231	239	PF00244	0.562
LIG_14-3-3_CanoR_1	386	391	PF00244	0.475
LIG_14-3-3_CanoR_1	42	51	PF00244	0.679
LIG_14-3-3_CanoR_1	443	448	PF00244	0.562
LIG_14-3-3_CanoR_1	488	498	PF00244	0.512
LIG_14-3-3_CanoR_1	506	512	PF00244	0.603
LIG_14-3-3_CanoR_1	74	80	PF00244	0.433
LIG_BRCT_BRCA1_1	152	156	PF00533	0.373
LIG_BRCT_BRCA1_1	47	51	PF00533	0.654
LIG_DLG_GKlike_1	386	393	PF00625	0.412
LIG_FHA_1	212	218	PF00498	0.391
LIG_FHA_1	249	255	PF00498	0.411
LIG_FHA_1	396	402	PF00498	0.381
LIG_FHA_1	403	409	PF00498	0.370
LIG_FHA_1	423	429	PF00498	0.641
LIG_FHA_2	293	299	PF00498	0.488
LIG_FHA_2	480	486	PF00498	0.540
LIG_LIR_Apic_2	265	270	PF02991	0.447
LIG_LIR_Gen_1	343	353	PF02991	0.365
LIG_LIR_Nem_3	343	349	PF02991	0.378
LIG_LIR_Nem_3	94	99	PF02991	0.371
LIG_Pex14_1	95	99	PF04695	0.316
LIG_Pex14_2	156	160	PF04695	0.431
LIG_Pex14_2	256	260	PF04695	0.304
LIG_Pex14_2	71	75	PF04695	0.478
LIG_SH2_STAT5	403	406	PF00017	0.325
LIG_SH2_STAT5	99	102	PF00017	0.372
LIG_SH3_2	37	42	PF14604	0.527
LIG_SH3_3	336	342	PF00018	0.350
LIG_SH3_3	34	40	PF00018	0.531
LIG_SH3_3	379	385	PF00018	0.514
LIG_SH3_3	429	435	PF00018	0.445
LIG_SUMO_SIM_par_1	134	140	PF11976	0.379
LIG_SUMO_SIM_par_1	202	209	PF11976	0.404
LIG_TRAF2_1	295	298	PF00917	0.445
LIG_TRAF2_1	342	345	PF00917	0.430
LIG_TRAF2_2	342	347	PF00917	0.382
LIG_WW_3	383	387	PF00397	0.413
MOD_CDC14_SPxK_1	82	85	PF00782	0.452
MOD_CDK_SPxK_1	79	85	PF00069	0.448
MOD_CK1_1	185	191	PF00069	0.592
MOD_CK1_1	367	373	PF00069	0.643
MOD_CK1_1	374	380	PF00069	0.616
MOD_CK1_1	434	440	PF00069	0.466
MOD_CK1_1	446	452	PF00069	0.490
MOD_CK1_1	47	53	PF00069	0.621
MOD_CK1_1	472	478	PF00069	0.654
MOD_CK1_1	479	485	PF00069	0.576
MOD_CK1_1	57	63	PF00069	0.483
MOD_CK1_1	73	79	PF00069	0.527
MOD_CK2_1	292	298	PF00069	0.432
MOD_CK2_1	359	365	PF00069	0.401
MOD_CK2_1	446	452	PF00069	0.558
MOD_CK2_1	479	485	PF00069	0.551
MOD_CK2_1	496	502	PF00069	0.463
MOD_DYRK1A_RPxSP_1	431	435	PF00069	0.440
MOD_GlcNHglycan	117	120	PF01048	0.705
MOD_GlcNHglycan	187	190	PF01048	0.552
MOD_GlcNHglycan	233	236	PF01048	0.502
MOD_GlcNHglycan	24	27	PF01048	0.638
MOD_GlcNHglycan	264	267	PF01048	0.444
MOD_GlcNHglycan	270	273	PF01048	0.539
MOD_GlcNHglycan	280	284	PF01048	0.607
MOD_GlcNHglycan	286	289	PF01048	0.614
MOD_GlcNHglycan	361	364	PF01048	0.493
MOD_GlcNHglycan	367	370	PF01048	0.524
MOD_GlcNHglycan	47	50	PF01048	0.555
MOD_GlcNHglycan	471	474	PF01048	0.712
MOD_GlcNHglycan	478	481	PF01048	0.624
MOD_GlcNHglycan	52	55	PF01048	0.705
MOD_GlcNHglycan	75	78	PF01048	0.524
MOD_GSK3_1	111	118	PF00069	0.585
MOD_GSK3_1	158	165	PF00069	0.479
MOD_GSK3_1	168	175	PF00069	0.683
MOD_GSK3_1	244	251	PF00069	0.576
MOD_GSK3_1	279	286	PF00069	0.764
MOD_GSK3_1	288	295	PF00069	0.610
MOD_GSK3_1	364	371	PF00069	0.642
MOD_GSK3_1	43	50	PF00069	0.630
MOD_GSK3_1	441	448	PF00069	0.502
MOD_GSK3_1	451	458	PF00069	0.434
MOD_GSK3_1	472	479	PF00069	0.648
MOD_GSK3_1	54	61	PF00069	0.457
MOD_LATS_1	441	447	PF00433	0.441
MOD_N-GLC_1	288	293	PF02516	0.660
MOD_N-GLC_1	371	376	PF02516	0.520
MOD_NEK2_1	150	155	PF00069	0.351
MOD_NEK2_1	187	192	PF00069	0.478
MOD_NEK2_1	218	223	PF00069	0.446
MOD_NEK2_1	32	37	PF00069	0.564
MOD_NEK2_1	388	393	PF00069	0.383
MOD_NEK2_1	414	419	PF00069	0.523
MOD_NEK2_1	445	450	PF00069	0.516
MOD_NEK2_1	456	461	PF00069	0.505
MOD_NEK2_1	58	63	PF00069	0.568
MOD_PIKK_1	137	143	PF00454	0.552
MOD_PIKK_1	340	346	PF00454	0.428
MOD_PK_1	443	449	PF00069	0.409
MOD_PKA_1	496	502	PF00069	0.496
MOD_PKA_2	182	188	PF00069	0.532
MOD_PKA_2	230	236	PF00069	0.546
MOD_PKA_2	268	274	PF00069	0.550
MOD_PKA_2	32	38	PF00069	0.692
MOD_PKA_2	496	502	PF00069	0.496
MOD_PKA_2	505	511	PF00069	0.513
MOD_PKA_2	73	79	PF00069	0.431
MOD_PKB_1	103	111	PF00069	0.350
MOD_Plk_1	244	250	PF00069	0.483
MOD_Plk_1	451	457	PF00069	0.589
MOD_Plk_1	85	91	PF00069	0.411
MOD_Plk_4	151	157	PF00069	0.351
MOD_Plk_4	182	188	PF00069	0.507
MOD_Plk_4	255	261	PF00069	0.336
MOD_ProDKin_1	168	174	PF00069	0.606
MOD_ProDKin_1	199	205	PF00069	0.543
MOD_ProDKin_1	206	212	PF00069	0.410
MOD_ProDKin_1	322	328	PF00069	0.606
MOD_ProDKin_1	338	344	PF00069	0.309
MOD_ProDKin_1	431	437	PF00069	0.524
MOD_ProDKin_1	467	473	PF00069	0.639
MOD_ProDKin_1	79	85	PF00069	0.583
TRG_DiLeu_BaLyEn_6	213	218	PF01217	0.384
TRG_DiLeu_BaLyEn_6	6	11	PF01217	0.554
TRG_ER_diArg_1	103	106	PF00400	0.315
TRG_ER_diArg_1	495	497	PF00400	0.481
TRG_ER_diArg_1	8	10	PF00400	0.634
TRG_NES_CRM1_1	303	318	PF08389	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U7	Leptomonas seymouri	51%	100%
A0A3Q8IHT9	Leishmania donovani	98%	100%
A0A3R7LW25	Trypanosoma rangeli	29%	100%
A4HLL8	Leishmania braziliensis	75%	100%
D0A532	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9B3Z4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q430	Leishmania major	92%	100%
V5DDH0	Trypanosoma cruzi	27%	100%