Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I923_LEIIN

TriTrypDb:

LINF_330023300

Length:

632

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I923

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I923

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	423	427	PF00656	0.434
CLV_C14_Caspase3-7	506	510	PF00656	0.322
CLV_NRD_NRD_1	216	218	PF00675	0.534
CLV_NRD_NRD_1	311	313	PF00675	0.550
CLV_NRD_NRD_1	335	337	PF00675	0.415
CLV_NRD_NRD_1	394	396	PF00675	0.447
CLV_NRD_NRD_1	441	443	PF00675	0.460
CLV_NRD_NRD_1	573	575	PF00675	0.597
CLV_NRD_NRD_1	87	89	PF00675	0.473
CLV_PCSK_FUR_1	392	396	PF00082	0.391
CLV_PCSK_KEX2_1	215	217	PF00082	0.518
CLV_PCSK_KEX2_1	311	313	PF00082	0.553
CLV_PCSK_KEX2_1	335	337	PF00082	0.415
CLV_PCSK_KEX2_1	394	396	PF00082	0.447
CLV_PCSK_KEX2_1	441	443	PF00082	0.342
CLV_PCSK_KEX2_1	573	575	PF00082	0.599
CLV_PCSK_SKI1_1	178	182	PF00082	0.551
CLV_PCSK_SKI1_1	328	332	PF00082	0.539
CLV_PCSK_SKI1_1	453	457	PF00082	0.346
CLV_PCSK_SKI1_1	505	509	PF00082	0.413
CLV_Separin_Metazoa	212	216	PF03568	0.488
CLV_Separin_Metazoa	438	442	PF03568	0.437
DEG_Nend_UBRbox_1	1	4	PF02207	0.469
DEG_SPOP_SBC_1	483	487	PF00917	0.619
DOC_CDC14_PxL_1	158	166	PF14671	0.551
DOC_CYCLIN_RxL_1	341	352	PF00134	0.449
DOC_CYCLIN_RxL_1	370	380	PF00134	0.390
DOC_CYCLIN_yCln2_LP_2	180	186	PF00134	0.572
DOC_MAPK_gen_1	374	383	PF00069	0.399
DOC_MAPK_MEF2A_6	2	9	PF00069	0.439
DOC_MAPK_MEF2A_6	377	385	PF00069	0.390
DOC_PP2B_LxvP_1	184	187	PF13499	0.623
DOC_PP2B_LxvP_1	25	28	PF13499	0.560
DOC_USP7_MATH_1	109	113	PF00917	0.589
DOC_USP7_MATH_1	128	132	PF00917	0.493
DOC_USP7_MATH_1	189	193	PF00917	0.659
DOC_USP7_MATH_1	28	32	PF00917	0.691
DOC_USP7_MATH_1	294	298	PF00917	0.523
DOC_USP7_MATH_1	40	44	PF00917	0.573
DOC_USP7_MATH_1	429	433	PF00917	0.407
DOC_USP7_MATH_1	483	487	PF00917	0.629
DOC_USP7_MATH_1	598	602	PF00917	0.515
DOC_USP7_MATH_1	62	66	PF00917	0.361
DOC_USP7_MATH_1	90	94	PF00917	0.428
DOC_USP7_MATH_2	314	320	PF00917	0.421
DOC_WW_Pin1_4	167	172	PF00397	0.567
DOC_WW_Pin1_4	357	362	PF00397	0.637
DOC_WW_Pin1_4	363	368	PF00397	0.497
DOC_WW_Pin1_4	410	415	PF00397	0.390
DOC_WW_Pin1_4	558	563	PF00397	0.618
DOC_WW_Pin1_4	614	619	PF00397	0.443
LIG_14-3-3_CanoR_1	215	222	PF00244	0.579
LIG_14-3-3_CanoR_1	244	252	PF00244	0.524
LIG_14-3-3_CanoR_1	256	261	PF00244	0.709
LIG_14-3-3_CanoR_1	370	378	PF00244	0.502
LIG_14-3-3_CanoR_1	392	402	PF00244	0.440
LIG_14-3-3_CanoR_1	493	500	PF00244	0.557
LIG_14-3-3_CanoR_1	579	587	PF00244	0.603
LIG_14-3-3_CanoR_1	88	96	PF00244	0.464
LIG_Actin_WH2_2	228	246	PF00022	0.409
LIG_Actin_WH2_2	378	396	PF00022	0.410
LIG_Actin_WH2_2	454	469	PF00022	0.370
LIG_Actin_WH2_2	519	535	PF00022	0.394
LIG_APCC_ABBA_1	5	10	PF00400	0.426
LIG_BRCT_BRCA1_1	305	309	PF00533	0.434
LIG_BRCT_BRCA1_1	53	57	PF00533	0.464
LIG_deltaCOP1_diTrp_1	301	309	PF00928	0.394
LIG_deltaCOP1_diTrp_1	503	511	PF00928	0.458
LIG_FHA_1	179	185	PF00498	0.542
LIG_FHA_1	197	203	PF00498	0.461
LIG_FHA_1	288	294	PF00498	0.495
LIG_FHA_1	322	328	PF00498	0.366
LIG_FHA_1	343	349	PF00498	0.464
LIG_FHA_1	370	376	PF00498	0.428
LIG_FHA_1	4	10	PF00498	0.430
LIG_FHA_2	221	227	PF00498	0.528
LIG_FHA_2	263	269	PF00498	0.588
LIG_FHA_2	421	427	PF00498	0.432
LIG_FHA_2	468	474	PF00498	0.494
LIG_FHA_2	580	586	PF00498	0.697
LIG_LIR_Gen_1	152	162	PF02991	0.466
LIG_LIR_Nem_3	152	158	PF02991	0.419
LIG_LYPXL_yS_3	449	452	PF13949	0.395
LIG_NRBOX	288	294	PF00104	0.412
LIG_NRBOX	326	332	PF00104	0.441
LIG_PCNA_PIPBox_1	1	10	PF02747	0.505
LIG_SH2_CRK	430	434	PF00017	0.349
LIG_SH2_NCK_1	275	279	PF00017	0.532
LIG_SH2_NCK_1	91	95	PF00017	0.420
LIG_SH2_SRC	103	106	PF00017	0.450
LIG_SH2_STAP1	275	279	PF00017	0.532
LIG_SH2_STAP1	430	434	PF00017	0.389
LIG_SH2_STAP1	91	95	PF00017	0.437
LIG_SH2_STAT5	460	463	PF00017	0.355
LIG_SH2_STAT5	95	98	PF00017	0.405
LIG_SH3_3	122	128	PF00018	0.577
LIG_SH3_3	263	269	PF00018	0.724
LIG_Sin3_3	72	79	PF02671	0.475
LIG_SUMO_SIM_anti_2	345	350	PF11976	0.439
LIG_TRAF2_1	171	174	PF00917	0.705
LIG_TYR_ITIM	447	452	PF00017	0.468
MOD_CDK_SPxxK_3	363	370	PF00069	0.553
MOD_CK1_1	112	118	PF00069	0.563
MOD_CK1_1	192	198	PF00069	0.568
MOD_CK1_1	31	37	PF00069	0.645
MOD_CK1_1	352	358	PF00069	0.707
MOD_CK1_1	369	375	PF00069	0.369
MOD_CK1_1	39	45	PF00069	0.643
MOD_CK1_1	558	564	PF00069	0.671
MOD_CK1_1	61	67	PF00069	0.476
MOD_CK2_1	167	173	PF00069	0.689
MOD_CK2_1	188	194	PF00069	0.711
MOD_CK2_1	220	226	PF00069	0.531
MOD_CK2_1	467	473	PF00069	0.441
MOD_CK2_1	579	585	PF00069	0.754
MOD_Cter_Amidation	571	574	PF01082	0.562
MOD_Cter_Amidation	86	89	PF01082	0.484
MOD_GlcNHglycan	111	114	PF01048	0.469
MOD_GlcNHglycan	130	133	PF01048	0.655
MOD_GlcNHglycan	159	162	PF01048	0.580
MOD_GlcNHglycan	22	25	PF01048	0.531
MOD_GlcNHglycan	318	321	PF01048	0.553
MOD_GlcNHglycan	351	354	PF01048	0.699
MOD_GlcNHglycan	38	41	PF01048	0.689
MOD_GlcNHglycan	414	417	PF01048	0.385
MOD_GlcNHglycan	42	45	PF01048	0.689
MOD_GlcNHglycan	443	447	PF01048	0.389
MOD_GlcNHglycan	486	489	PF01048	0.592
MOD_GlcNHglycan	495	498	PF01048	0.492
MOD_GlcNHglycan	505	508	PF01048	0.441
MOD_GlcNHglycan	596	599	PF01048	0.583
MOD_GlcNHglycan	60	63	PF01048	0.293
MOD_GlcNHglycan	600	603	PF01048	0.634
MOD_GlcNHglycan	92	95	PF01048	0.440
MOD_GSK3_1	105	112	PF00069	0.437
MOD_GSK3_1	136	143	PF00069	0.589
MOD_GSK3_1	188	195	PF00069	0.614
MOD_GSK3_1	217	224	PF00069	0.590
MOD_GSK3_1	251	258	PF00069	0.619
MOD_GSK3_1	28	35	PF00069	0.711
MOD_GSK3_1	357	364	PF00069	0.593
MOD_GSK3_1	36	43	PF00069	0.621
MOD_GSK3_1	456	463	PF00069	0.391
MOD_GSK3_1	489	496	PF00069	0.525
MOD_GSK3_1	57	64	PF00069	0.477
MOD_GSK3_1	594	601	PF00069	0.511
MOD_LATS_1	454	460	PF00433	0.366
MOD_N-GLC_1	262	267	PF02516	0.748
MOD_N-GLC_1	467	472	PF02516	0.459
MOD_NEK2_1	292	297	PF00069	0.372
MOD_NEK2_1	342	347	PF00069	0.428
MOD_NEK2_1	349	354	PF00069	0.568
MOD_NEK2_1	420	425	PF00069	0.424
MOD_NEK2_1	466	471	PF00069	0.399
MOD_NEK2_1	548	553	PF00069	0.592
MOD_NEK2_1	555	560	PF00069	0.639
MOD_NEK2_1	57	62	PF00069	0.553
MOD_PIKK_1	28	34	PF00454	0.623
MOD_PIKK_1	294	300	PF00454	0.601
MOD_PIKK_1	604	610	PF00454	0.478
MOD_PK_1	377	383	PF00069	0.438
MOD_PKA_1	215	221	PF00069	0.552
MOD_PKA_2	126	132	PF00069	0.663
MOD_PKA_2	215	221	PF00069	0.571
MOD_PKA_2	255	261	PF00069	0.665
MOD_PKA_2	28	34	PF00069	0.578
MOD_PKA_2	369	375	PF00069	0.523
MOD_PKA_2	393	399	PF00069	0.420
MOD_PKA_2	466	472	PF00069	0.433
MOD_PKA_2	57	63	PF00069	0.542
MOD_PKA_2	594	600	PF00069	0.532
MOD_PKB_1	215	223	PF00069	0.553
MOD_Plk_1	140	146	PF00069	0.474
MOD_Plk_1	262	268	PF00069	0.567
MOD_Plk_1	442	448	PF00069	0.543
MOD_Plk_1	9	15	PF00069	0.425
MOD_Plk_2-3	140	146	PF00069	0.510
MOD_Plk_4	270	276	PF00069	0.497
MOD_Plk_4	3	9	PF00069	0.471
MOD_Plk_4	305	311	PF00069	0.388
MOD_Plk_4	377	383	PF00069	0.420
MOD_Plk_4	429	435	PF00069	0.353
MOD_Plk_4	456	462	PF00069	0.341
MOD_ProDKin_1	167	173	PF00069	0.569
MOD_ProDKin_1	357	363	PF00069	0.620
MOD_ProDKin_1	410	416	PF00069	0.387
MOD_ProDKin_1	558	564	PF00069	0.622
MOD_ProDKin_1	614	620	PF00069	0.438
MOD_SUMO_for_1	14	17	PF00179	0.453
TRG_DiLeu_BaEn_1	338	343	PF01217	0.440
TRG_DiLeu_BaLyEn_6	447	452	PF01217	0.406
TRG_DiLeu_BaLyEn_6	527	532	PF01217	0.366
TRG_ENDOCYTIC_2	103	106	PF00928	0.388
TRG_ENDOCYTIC_2	430	433	PF00928	0.390
TRG_ENDOCYTIC_2	449	452	PF00928	0.276
TRG_ER_diArg_1	214	217	PF00400	0.530
TRG_ER_diArg_1	310	312	PF00400	0.471
TRG_ER_diArg_1	392	395	PF00400	0.427
TRG_ER_diArg_1	440	442	PF00400	0.322
TRG_Pf-PMV_PEXEL_1	244	248	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	311	316	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	328	332	PF00026	0.420
TRG_Pf-PMV_PEXEL_1	374	379	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	530	534	PF00026	0.382

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P490	Leptomonas seymouri	36%	100%
A0A3Q8IGM0	Leishmania donovani	100%	100%
A4HLL1	Leishmania braziliensis	71%	98%
E9B3Y7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q437	Leishmania major	87%	100%