Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I915_LEIIN

TriTrypDb:

LINF_330022600

Length:

607

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I915

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I915

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	29	31	PF00675	0.651
CLV_NRD_NRD_1	321	323	PF00675	0.487
CLV_NRD_NRD_1	48	50	PF00675	0.455
CLV_NRD_NRD_1	485	487	PF00675	0.510
CLV_PCSK_FUR_1	27	31	PF00082	0.647
CLV_PCSK_KEX2_1	218	220	PF00082	0.420
CLV_PCSK_KEX2_1	253	255	PF00082	0.583
CLV_PCSK_KEX2_1	29	31	PF00082	0.651
CLV_PCSK_KEX2_1	320	322	PF00082	0.546
CLV_PCSK_KEX2_1	48	50	PF00082	0.455
CLV_PCSK_KEX2_1	485	487	PF00082	0.510
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.420
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.562
CLV_PCSK_SKI1_1	225	229	PF00082	0.459
DEG_Nend_UBRbox_3	1	3	PF02207	0.501
DEG_SCF_FBW7_2	353	359	PF00400	0.604
DEG_SPOP_SBC_1	246	250	PF00917	0.639
DOC_CDC14_PxL_1	282	290	PF14671	0.442
DOC_CDC14_PxL_1	576	584	PF14671	0.435
DOC_CKS1_1	353	358	PF01111	0.612
DOC_MAPK_DCC_7	533	541	PF00069	0.463
DOC_PP1_RVXF_1	20	27	PF00149	0.465
DOC_PP2B_LxvP_1	105	108	PF13499	0.642
DOC_PP2B_LxvP_1	380	383	PF13499	0.609
DOC_PP4_FxxP_1	202	205	PF00568	0.561
DOC_USP7_MATH_1	179	183	PF00917	0.572
DOC_USP7_MATH_1	246	250	PF00917	0.643
DOC_USP7_MATH_1	312	316	PF00917	0.486
DOC_USP7_MATH_1	451	455	PF00917	0.691
DOC_USP7_MATH_1	465	469	PF00917	0.494
DOC_USP7_UBL2_3	18	22	PF12436	0.474
DOC_WW_Pin1_4	106	111	PF00397	0.543
DOC_WW_Pin1_4	144	149	PF00397	0.675
DOC_WW_Pin1_4	209	214	PF00397	0.504
DOC_WW_Pin1_4	232	237	PF00397	0.581
DOC_WW_Pin1_4	352	357	PF00397	0.582
DOC_WW_Pin1_4	361	366	PF00397	0.778
DOC_WW_Pin1_4	467	472	PF00397	0.590
DOC_WW_Pin1_4	475	480	PF00397	0.538
LIG_14-3-3_CanoR_1	193	202	PF00244	0.590
LIG_14-3-3_CanoR_1	51	56	PF00244	0.507
LIG_14-3-3_CanoR_1	562	567	PF00244	0.454
LIG_14-3-3_CanoR_1	68	73	PF00244	0.689
LIG_BIR_III_4	126	130	PF00653	0.513
LIG_BIR_III_4	367	371	PF00653	0.513
LIG_BRCT_BRCA1_1	211	215	PF00533	0.433
LIG_deltaCOP1_diTrp_1	216	224	PF00928	0.430
LIG_FHA_1	209	215	PF00498	0.602
LIG_FHA_1	240	246	PF00498	0.649
LIG_FHA_1	290	296	PF00498	0.483
LIG_FHA_1	478	484	PF00498	0.635
LIG_FHA_1	594	600	PF00498	0.548
LIG_FHA_2	376	382	PF00498	0.613
LIG_FHA_2	519	525	PF00498	0.369
LIG_LIR_Gen_1	279	289	PF02991	0.432
LIG_LIR_Gen_1	384	393	PF02991	0.589
LIG_LIR_Gen_1	501	508	PF02991	0.344
LIG_LIR_Nem_3	279	285	PF02991	0.442
LIG_LIR_Nem_3	384	388	PF02991	0.646
LIG_LIR_Nem_3	501	506	PF02991	0.347
LIG_LIR_Nem_3	525	531	PF02991	0.356
LIG_LIR_Nem_3	578	582	PF02991	0.419
LIG_LYPXL_yS_3	579	582	PF13949	0.419
LIG_Pex14_2	581	585	PF04695	0.431
LIG_SH2_CRK	130	134	PF00017	0.517
LIG_SH2_CRK	282	286	PF00017	0.413
LIG_SH2_CRK	503	507	PF00017	0.341
LIG_SH2_CRK	577	581	PF00017	0.500
LIG_SH2_PTP2	441	444	PF00017	0.504
LIG_SH2_SRC	441	444	PF00017	0.569
LIG_SH2_SRC	577	580	PF00017	0.434
LIG_SH2_STAP1	503	507	PF00017	0.341
LIG_SH2_STAT5	441	444	PF00017	0.506
LIG_SH3_3	104	110	PF00018	0.549
LIG_SH3_3	240	246	PF00018	0.643
LIG_SH3_3	408	414	PF00018	0.608
LIG_SH3_3	473	479	PF00018	0.579
LIG_SUMO_SIM_par_1	377	384	PF11976	0.734
LIG_SUMO_SIM_par_1	495	501	PF11976	0.376
LIG_TRFH_1	282	286	PF08558	0.415
LIG_TRFH_1	287	291	PF08558	0.443
LIG_TYR_ITIM	439	444	PF00017	0.572
LIG_WRC_WIRS_1	382	387	PF05994	0.640
LIG_WRC_WIRS_1	74	79	PF05994	0.563
MOD_CDK_SPK_2	361	366	PF00069	0.556
MOD_CK1_1	144	150	PF00069	0.600
MOD_CK1_1	194	200	PF00069	0.690
MOD_CK1_1	447	453	PF00069	0.560
MOD_CK1_1	456	462	PF00069	0.642
MOD_CK1_1	54	60	PF00069	0.557
MOD_CK1_1	561	567	PF00069	0.471
MOD_CK1_1	73	79	PF00069	0.609
MOD_CK2_1	144	150	PF00069	0.636
MOD_CK2_1	246	252	PF00069	0.613
MOD_CK2_1	302	308	PF00069	0.464
MOD_CK2_1	339	345	PF00069	0.567
MOD_CK2_1	375	381	PF00069	0.587
MOD_GlcNHglycan	102	105	PF01048	0.761
MOD_GlcNHglycan	174	177	PF01048	0.783
MOD_GlcNHglycan	187	190	PF01048	0.702
MOD_GlcNHglycan	230	233	PF01048	0.467
MOD_GlcNHglycan	249	252	PF01048	0.786
MOD_GlcNHglycan	314	317	PF01048	0.499
MOD_GlcNHglycan	35	38	PF01048	0.615
MOD_GlcNHglycan	429	433	PF01048	0.598
MOD_GlcNHglycan	44	47	PF01048	0.536
MOD_GlcNHglycan	448	452	PF01048	0.498
MOD_GlcNHglycan	514	517	PF01048	0.353
MOD_GSK3_1	140	147	PF00069	0.610
MOD_GSK3_1	187	194	PF00069	0.600
MOD_GSK3_1	2	9	PF00069	0.481
MOD_GSK3_1	228	235	PF00069	0.643
MOD_GSK3_1	237	244	PF00069	0.673
MOD_GSK3_1	339	346	PF00069	0.612
MOD_GSK3_1	447	454	PF00069	0.552
MOD_GSK3_1	459	466	PF00069	0.502
MOD_GSK3_1	477	484	PF00069	0.536
MOD_GSK3_1	518	525	PF00069	0.366
MOD_GSK3_1	558	565	PF00069	0.493
MOD_GSK3_1	589	596	PF00069	0.483
MOD_N-GLC_1	562	567	PF02516	0.454
MOD_NEK2_1	241	246	PF00069	0.686
MOD_NEK2_1	275	280	PF00069	0.577
MOD_NEK2_1	302	307	PF00069	0.702
MOD_NEK2_1	360	365	PF00069	0.720
MOD_NEK2_1	458	463	PF00069	0.554
MOD_NEK2_1	512	517	PF00069	0.402
MOD_NEK2_1	522	527	PF00069	0.447
MOD_NEK2_2	191	196	PF00069	0.557
MOD_PIKK_1	276	282	PF00454	0.521
MOD_PIKK_1	295	301	PF00454	0.537
MOD_PIKK_1	456	462	PF00454	0.591
MOD_PK_1	347	353	PF00069	0.537
MOD_PKA_2	343	349	PF00069	0.516
MOD_PKA_2	561	567	PF00069	0.471
MOD_PKB_1	320	328	PF00069	0.464
MOD_PKB_1	49	57	PF00069	0.503
MOD_Plk_1	276	282	PF00069	0.499
MOD_Plk_1	562	568	PF00069	0.461
MOD_Plk_2-3	252	258	PF00069	0.524
MOD_Plk_2-3	415	421	PF00069	0.662
MOD_Plk_4	375	381	PF00069	0.577
MOD_Plk_4	453	459	PF00069	0.544
MOD_Plk_4	562	568	PF00069	0.504
MOD_ProDKin_1	106	112	PF00069	0.541
MOD_ProDKin_1	144	150	PF00069	0.675
MOD_ProDKin_1	209	215	PF00069	0.499
MOD_ProDKin_1	232	238	PF00069	0.588
MOD_ProDKin_1	352	358	PF00069	0.592
MOD_ProDKin_1	361	367	PF00069	0.777
MOD_ProDKin_1	467	473	PF00069	0.592
MOD_ProDKin_1	475	481	PF00069	0.530
MOD_SUMO_rev_2	19	25	PF00179	0.465
MOD_SUMO_rev_2	80	87	PF00179	0.651
TRG_ENDOCYTIC_2	282	285	PF00928	0.449
TRG_ENDOCYTIC_2	441	444	PF00928	0.531
TRG_ENDOCYTIC_2	503	506	PF00928	0.341
TRG_ENDOCYTIC_2	579	582	PF00928	0.419
TRG_ER_diArg_1	26	29	PF00400	0.644
TRG_ER_diArg_1	320	322	PF00400	0.547
TRG_ER_diArg_1	47	49	PF00400	0.552
TRG_ER_diArg_1	533	536	PF00400	0.408
TRG_Pf-PMV_PEXEL_1	219	223	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	254	258	PF00026	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4L4	Leptomonas seymouri	40%	100%
A0A3Q8IEV6	Leishmania donovani	99%	100%
A4HLK4	Leishmania braziliensis	68%	100%
E9B3Y0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q444	Leishmania major	88%	100%