Amino acid permease-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amino acid permease-like protein

Species:

Leishmania infantum

UniProt:

A4I914_LEIIN

TriTrypDb:

LINF_330022500

Length:

488

Annotations

LeishMANIAdb annotations

An enormously expanded group of various amino acid transporters.. Localization: Cell surface (by feature)

Annotations by Jardim et al.

Transporters, Amino acid permease-like AAT26

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 23
NetGPI	no	yes: 0, no: 23

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	20
GO:0110165	cellular anatomical entity	1	20

Expansion

Sequence features

A4I914

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I914

Function

Biological processes
Term	Name	Level	Count
GO:0003333	amino acid transmembrane transport	5	4
GO:0006810	transport	3	4
GO:0006865	amino acid transport	5	4
GO:0009987	cellular process	1	4
GO:0015849	organic acid transport	5	4
GO:0051179	localization	1	4
GO:0051234	establishment of localization	2	4
GO:0055085	transmembrane transport	2	4
GO:0071702	organic substance transport	4	4
GO:0071705	nitrogen compound transport	4	4
GO:1903825	organic acid transmembrane transport	3	4
GO:1905039	carboxylic acid transmembrane transport	4	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0016787	hydrolase activity	2	9
GO:0005215	transporter activity	1	4
GO:0005342	organic acid transmembrane transporter activity	3	4
GO:0015171	amino acid transmembrane transporter activity	5	4
GO:0015179	L-amino acid transmembrane transporter activity	6	4
GO:0022857	transmembrane transporter activity	2	4
GO:0046943	carboxylic acid transmembrane transporter activity	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	236	238	PF00675	0.193
CLV_PCSK_KEX2_1	236	238	PF00082	0.202
CLV_PCSK_SKI1_1	332	336	PF00082	0.189
CLV_PCSK_SKI1_1	80	84	PF00082	0.257
CLV_PCSK_SKI1_1	92	96	PF00082	0.281
CLV_Separin_Metazoa	5	9	PF03568	0.507
CLV_Separin_Metazoa	89	93	PF03568	0.286
DEG_Nend_Nbox_1	1	3	PF02207	0.550
DEG_SCF_FBW7_1	128	134	PF00400	0.354
DOC_ANK_TNKS_1	175	182	PF00023	0.351
DOC_CDC14_PxL_1	146	154	PF14671	0.351
DOC_CDC14_PxL_1	204	212	PF14671	0.245
DOC_CKS1_1	128	133	PF01111	0.383
DOC_CYCLIN_yCln2_LP_2	113	119	PF00134	0.224
DOC_CYCLIN_yCln2_LP_2	210	216	PF00134	0.289
DOC_CYCLIN_yCln2_LP_2	264	270	PF00134	0.249
DOC_MAPK_gen_1	236	243	PF00069	0.412
DOC_MAPK_MEF2A_6	206	214	PF00069	0.267
DOC_MAPK_MEF2A_6	236	245	PF00069	0.454
DOC_MAPK_MEF2A_6	395	404	PF00069	0.393
DOC_PP2B_LxvP_1	113	116	PF13499	0.314
DOC_PP2B_LxvP_1	210	213	PF13499	0.289
DOC_PP2B_LxvP_1	31	34	PF13499	0.274
DOC_PP2B_LxvP_1	413	416	PF13499	0.323
DOC_PP4_FxxP_1	142	145	PF00568	0.328
DOC_PP4_FxxP_1	435	438	PF00568	0.308
DOC_USP7_MATH_1	131	135	PF00917	0.339
DOC_WW_Pin1_4	127	132	PF00397	0.319
LIG_14-3-3_CanoR_1	236	240	PF00244	0.474
LIG_14-3-3_CanoR_1	72	76	PF00244	0.488
LIG_14-3-3_CanoR_1	8	15	PF00244	0.514
LIG_APCC_ABBA_1	107	112	PF00400	0.181
LIG_BRCT_BRCA1_1	222	226	PF00533	0.308
LIG_BRCT_BRCA1_1	330	334	PF00533	0.491
LIG_Clathr_ClatBox_1	107	111	PF01394	0.351
LIG_FHA_1	120	126	PF00498	0.333
LIG_FHA_1	164	170	PF00498	0.284
LIG_FHA_1	188	194	PF00498	0.278
LIG_FHA_1	249	255	PF00498	0.385
LIG_FHA_1	333	339	PF00498	0.487
LIG_FHA_1	404	410	PF00498	0.357
LIG_FHA_1	44	50	PF00498	0.346
LIG_FHA_1	77	83	PF00498	0.463
LIG_GBD_Chelix_1	224	232	PF00786	0.351
LIG_IRF3_LxIS_1	152	158	PF10401	0.466
LIG_IRF3_LxIS_1	394	401	PF10401	0.475
LIG_LIR_Apic_2	432	438	PF02991	0.305
LIG_LIR_Gen_1	137	146	PF02991	0.377
LIG_LIR_Gen_1	158	168	PF02991	0.231
LIG_LIR_Gen_1	331	338	PF02991	0.466
LIG_LIR_Gen_1	59	70	PF02991	0.252
LIG_LIR_Gen_1	74	83	PF02991	0.471
LIG_LIR_Nem_3	137	142	PF02991	0.347
LIG_LIR_Nem_3	158	163	PF02991	0.231
LIG_LIR_Nem_3	166	171	PF02991	0.247
LIG_LIR_Nem_3	223	229	PF02991	0.286
LIG_LIR_Nem_3	331	337	PF02991	0.466
LIG_LIR_Nem_3	59	65	PF02991	0.287
LIG_LIR_Nem_3	74	78	PF02991	0.483
LIG_LYPXL_yS_3	207	210	PF13949	0.192
LIG_OCRL_FandH_1	361	373	PF00620	0.365
LIG_PCNA_PIPBox_1	118	127	PF02747	0.263
LIG_PCNA_yPIPBox_3	118	132	PF02747	0.291
LIG_Pex14_1	203	207	PF04695	0.178
LIG_Pex14_1	443	447	PF04695	0.445
LIG_Pex14_2	138	142	PF04695	0.343
LIG_Pex14_2	464	468	PF04695	0.192
LIG_SH2_CRK	293	297	PF00017	0.339
LIG_SH2_CRK	369	373	PF00017	0.373
LIG_SH2_CRK	447	451	PF00017	0.457
LIG_SH2_NCK_1	319	323	PF00017	0.409
LIG_SH2_NCK_1	37	41	PF00017	0.288
LIG_SH2_PTP2	62	65	PF00017	0.203
LIG_SH2_SRC	124	127	PF00017	0.375
LIG_SH2_SRC	37	40	PF00017	0.288
LIG_SH2_STAT3	441	444	PF00017	0.351
LIG_SH2_STAT5	106	109	PF00017	0.271
LIG_SH2_STAT5	124	127	PF00017	0.253
LIG_SH2_STAT5	177	180	PF00017	0.249
LIG_SH2_STAT5	263	266	PF00017	0.298
LIG_SH2_STAT5	290	293	PF00017	0.315
LIG_SH2_STAT5	62	65	PF00017	0.368
LIG_SH3_3	113	119	PF00018	0.259
LIG_SH3_3	176	182	PF00018	0.276
LIG_SUMO_SIM_anti_2	341	348	PF11976	0.491
LIG_SUMO_SIM_anti_2	420	426	PF11976	0.259
LIG_SUMO_SIM_anti_2	46	51	PF11976	0.384
LIG_SUMO_SIM_par_1	265	272	PF11976	0.189
LIG_SUMO_SIM_par_1	29	35	PF11976	0.302
LIG_SUMO_SIM_par_1	398	403	PF11976	0.220
LIG_SUMO_SIM_par_1	417	423	PF11976	0.181
LIG_SUMO_SIM_par_1	53	59	PF11976	0.281
LIG_TRAF2_1	74	77	PF00917	0.488
LIG_TYR_ITIM	104	109	PF00017	0.288
LIG_TYR_ITIM	445	450	PF00017	0.548
LIG_TYR_ITIM	60	65	PF00017	0.270
LIG_Vh1_VBS_1	239	257	PF01044	0.378
LIG_WRC_WIRS_1	135	140	PF05994	0.285
LIG_WRC_WIRS_1	157	162	PF05994	0.353
LIG_WRC_WIRS_1	216	221	PF05994	0.284
MOD_CDK_SPK_2	127	132	PF00069	0.291
MOD_CK1_1	10	16	PF00069	0.519
MOD_CK1_1	134	140	PF00069	0.207
MOD_CK1_1	164	170	PF00069	0.272
MOD_CK1_1	186	192	PF00069	0.214
MOD_CK1_1	320	326	PF00069	0.410
MOD_CK1_1	420	426	PF00069	0.291
MOD_CK2_1	368	374	PF00069	0.465
MOD_CK2_1	71	77	PF00069	0.473
MOD_Cter_Amidation	83	86	PF01082	0.245
MOD_GlcNHglycan	10	13	PF01048	0.316
MOD_GlcNHglycan	101	104	PF01048	0.244
MOD_GlcNHglycan	163	166	PF01048	0.291
MOD_GlcNHglycan	184	188	PF01048	0.454
MOD_GlcNHglycan	198	201	PF01048	0.440
MOD_GlcNHglycan	320	323	PF01048	0.203
MOD_GlcNHglycan	34	37	PF01048	0.338
MOD_GSK3_1	127	134	PF00069	0.197
MOD_GSK3_1	144	151	PF00069	0.265
MOD_GSK3_1	17	24	PF00069	0.305
MOD_GSK3_1	183	190	PF00069	0.289
MOD_GSK3_1	244	251	PF00069	0.310
MOD_GSK3_1	328	335	PF00069	0.491
MOD_GSK3_1	398	405	PF00069	0.289
MOD_N-GLC_1	194	199	PF02516	0.433
MOD_NEK2_1	120	125	PF00069	0.289
MOD_NEK2_1	155	160	PF00069	0.431
MOD_NEK2_1	161	166	PF00069	0.296
MOD_NEK2_1	21	26	PF00069	0.278
MOD_NEK2_1	235	240	PF00069	0.465
MOD_NEK2_1	248	253	PF00069	0.313
MOD_NEK2_1	291	296	PF00069	0.192
MOD_NEK2_1	398	403	PF00069	0.298
MOD_NEK2_1	428	433	PF00069	0.266
MOD_NEK2_1	7	12	PF00069	0.621
MOD_NEK2_2	53	58	PF00069	0.370
MOD_PKA_2	235	241	PF00069	0.485
MOD_PKA_2	308	314	PF00069	0.484
MOD_PKA_2	7	13	PF00069	0.576
MOD_PKA_2	71	77	PF00069	0.488
MOD_Plk_1	183	189	PF00069	0.278
MOD_Plk_1	332	338	PF00069	0.520
MOD_Plk_4	10	16	PF00069	0.496
MOD_Plk_4	120	126	PF00069	0.225
MOD_Plk_4	131	137	PF00069	0.217
MOD_Plk_4	156	162	PF00069	0.438
MOD_Plk_4	164	170	PF00069	0.299
MOD_Plk_4	220	226	PF00069	0.319
MOD_Plk_4	308	314	PF00069	0.495
MOD_Plk_4	417	423	PF00069	0.230
MOD_Plk_4	43	49	PF00069	0.319
MOD_Plk_4	53	59	PF00069	0.288
MOD_ProDKin_1	127	133	PF00069	0.319
MOD_SUMO_for_1	372	375	PF00179	0.378
TRG_DiLeu_BaEn_1	342	347	PF01217	0.491
TRG_DiLeu_BaLyEn_6	205	210	PF01217	0.210
TRG_ENDOCYTIC_2	106	109	PF00928	0.289
TRG_ENDOCYTIC_2	207	210	PF00928	0.425
TRG_ENDOCYTIC_2	229	232	PF00928	0.459
TRG_ENDOCYTIC_2	369	372	PF00928	0.475
TRG_ENDOCYTIC_2	447	450	PF00928	0.489
TRG_ENDOCYTIC_2	62	65	PF00928	0.268
TRG_ENDOCYTIC_2	75	78	PF00928	0.448
TRG_ER_diArg_1	235	237	PF00400	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5D2	Leptomonas seymouri	25%	100%
A0A0N1IAJ0	Leptomonas seymouri	30%	100%
A0A0N1IJ81	Leptomonas seymouri	76%	100%
A0A0N1PA98	Leptomonas seymouri	20%	79%
A0A0S4IV32	Bodo saltans	30%	99%
A0A1X0P1N2	Trypanosomatidae	56%	100%
A0A1X0P4S1	Trypanosomatidae	40%	100%
A0A3Q8ICL1	Leishmania donovani	20%	81%
A0A3Q8ID74	Leishmania donovani	24%	91%
A0A3Q8IGE6	Leishmania donovani	20%	83%
A0A3Q8IHH7	Leishmania donovani	100%	100%
A0A3R7MWF1	Trypanosoma rangeli	49%	100%
A0A3S7X443	Leishmania donovani	27%	100%
A0A3S7X4L2	Leishmania donovani	20%	81%
A0A3S7X4N4	Leishmania donovani	20%	81%
A0A3S7XA86	Leishmania donovani	36%	100%
A0A3S7XCE3	Leishmania donovani	27%	100%
A1YG32	Pan paniscus	26%	96%
A2VE31	Bos taurus	25%	96%
A4HFT5	Leishmania braziliensis	26%	100%
A4HJ35	Leishmania braziliensis	26%	100%
A4HJF8	Leishmania braziliensis	21%	100%
A4HJF9	Leishmania braziliensis	21%	100%
A4HJG1	Leishmania braziliensis	21%	100%
A4HJG3	Leishmania braziliensis	22%	100%
A4HJG5	Leishmania braziliensis	22%	100%
A4HLK3	Leishmania braziliensis	85%	100%
A4HNJ6	Leishmania braziliensis	38%	87%
A4HNJ7	Leishmania braziliensis	39%	86%
A4I6J8	Leishmania infantum	23%	91%
A4I6J9	Leishmania infantum	27%	100%
A4I6W4	Leishmania infantum	20%	100%
A4IC53	Leishmania infantum	36%	100%
A4IC66	Leishmania infantum	38%	100%
A4ICC3	Leishmania infantum	26%	100%
C9ZMB9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
C9ZWR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E8NHF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E8NHS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	100%
E9AD45	Leishmania major	24%	91%
E9ADD7	Leishmania major	27%	100%
E9AG08	Leishmania major	37%	86%
E9AG09	Leishmania major	38%	85%
E9AHD9	Leishmania infantum	24%	91%
E9AHL1	Leishmania infantum	20%	81%
E9AHL2	Leishmania infantum	21%	100%
E9AHL3	Leishmania infantum	20%	81%
E9AUB8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AZ62	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B1I4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B1Y0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
E9B3X9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9B761	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	86%
E9B762	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	86%
F4KBM7	Arabidopsis thaliana	24%	100%
G3UVW3	Mus musculus	24%	100%
P38176	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P40074	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
P40501	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
Q28HE5	Xenopus tropicalis	27%	100%
Q3U1J0	Mus musculus	23%	100%
Q4Q072	Leishmania major	26%	100%
Q4Q445	Leishmania major	95%	100%
Q4Q680	Leishmania major	20%	100%
Q4Q683	Leishmania major	20%	100%
Q4Q6M9	Leishmania major	27%	100%
Q4Q6N1	Leishmania major	22%	91%
Q503G8	Danio rerio	26%	100%
Q5E9S9	Bos taurus	24%	100%
Q5F468	Gallus gallus	25%	97%
Q5R9F5	Pongo abelii	22%	100%
Q5XH90	Xenopus tropicalis	26%	99%
Q6DEL1	Danio rerio	22%	100%
Q6DFE7	Xenopus laevis	23%	100%
Q6JWR2	Rattus norvegicus	23%	100%
Q6WWW3	Rattus norvegicus	25%	100%
Q8BWH0	Mus musculus	24%	100%
Q8R1S9	Mus musculus	24%	89%
Q8WUX1	Homo sapiens	24%	100%
Q96QD8	Homo sapiens	26%	96%
Q99624	Homo sapiens	24%	97%
Q9DCP2	Mus musculus	25%	97%
Q9JHE5	Rattus norvegicus	27%	97%
Q9JHZ9	Rattus norvegicus	25%	97%
Q9LI61	Arabidopsis thaliana	23%	100%
Q9LYM2	Arabidopsis thaliana	24%	100%
Q9NVC3	Homo sapiens	22%	100%
V5AXD0	Trypanosoma cruzi	49%	100%
V5BQ72	Trypanosoma cruzi	23%	87%