LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I909_LEIIN
TriTrypDb:
LINF_330022000
Length:
424

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I909
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I909

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 297 301 PF00656 0.688
CLV_C14_Caspase3-7 419 423 PF00656 0.579
CLV_NRD_NRD_1 170 172 PF00675 0.555
CLV_NRD_NRD_1 203 205 PF00675 0.681
CLV_NRD_NRD_1 293 295 PF00675 0.716
CLV_NRD_NRD_1 346 348 PF00675 0.595
CLV_NRD_NRD_1 413 415 PF00675 0.579
CLV_PCSK_KEX2_1 203 205 PF00082 0.596
CLV_PCSK_KEX2_1 274 276 PF00082 0.588
CLV_PCSK_KEX2_1 293 295 PF00082 0.759
CLV_PCSK_KEX2_1 345 347 PF00082 0.603
CLV_PCSK_KEX2_1 413 415 PF00082 0.579
CLV_PCSK_PC1ET2_1 203 205 PF00082 0.596
CLV_PCSK_PC1ET2_1 274 276 PF00082 0.557
CLV_PCSK_PC1ET2_1 345 347 PF00082 0.603
CLV_PCSK_PC7_1 270 276 PF00082 0.604
CLV_PCSK_SKI1_1 118 122 PF00082 0.628
DEG_APCC_DBOX_1 292 300 PF00400 0.537
DEG_COP1_1 319 329 PF00400 0.599
DOC_CKS1_1 69 74 PF01111 0.388
DOC_CYCLIN_yCln2_LP_2 153 159 PF00134 0.531
DOC_USP7_MATH_1 174 178 PF00917 0.640
DOC_USP7_MATH_1 187 191 PF00917 0.604
DOC_USP7_MATH_1 244 248 PF00917 0.759
DOC_USP7_MATH_1 26 30 PF00917 0.524
DOC_USP7_MATH_1 262 266 PF00917 0.473
DOC_USP7_MATH_1 64 68 PF00917 0.398
DOC_USP7_UBL2_3 168 172 PF12436 0.562
DOC_WW_Pin1_4 221 226 PF00397 0.631
DOC_WW_Pin1_4 254 259 PF00397 0.681
DOC_WW_Pin1_4 345 350 PF00397 0.680
DOC_WW_Pin1_4 369 374 PF00397 0.637
DOC_WW_Pin1_4 392 397 PF00397 0.708
DOC_WW_Pin1_4 68 73 PF00397 0.403
LIG_14-3-3_CanoR_1 18 22 PF00244 0.403
LIG_14-3-3_CanoR_1 220 225 PF00244 0.678
LIG_14-3-3_CanoR_1 279 288 PF00244 0.625
LIG_14-3-3_CanoR_1 293 302 PF00244 0.683
LIG_14-3-3_CanoR_1 390 399 PF00244 0.714
LIG_14-3-3_CanoR_1 408 413 PF00244 0.583
LIG_14-3-3_CanoR_1 42 46 PF00244 0.593
LIG_14-3-3_CanoR_1 75 79 PF00244 0.475
LIG_BIR_II_1 1 5 PF00653 0.349
LIG_BIR_III_4 63 67 PF00653 0.411
LIG_Clathr_ClatBox_1 59 63 PF01394 0.405
LIG_FHA_1 254 260 PF00498 0.680
LIG_FHA_1 280 286 PF00498 0.538
LIG_FHA_1 384 390 PF00498 0.636
LIG_FHA_1 407 413 PF00498 0.650
LIG_FHA_1 75 81 PF00498 0.510
LIG_FHA_2 262 268 PF00498 0.696
LIG_FHA_2 378 384 PF00498 0.572
LIG_FHA_2 417 423 PF00498 0.579
LIG_HCF-1_HBM_1 181 184 PF13415 0.536
LIG_LIR_Nem_3 20 24 PF02991 0.462
LIG_SH2_CRK 76 80 PF00017 0.389
LIG_SH2_STAP1 76 80 PF00017 0.389
LIG_SH2_STAT3 315 318 PF00017 0.667
LIG_SH2_STAT5 5 8 PF00017 0.366
LIG_SH2_STAT5 76 79 PF00017 0.548
LIG_SH3_2 288 293 PF14604 0.569
LIG_SH3_3 122 128 PF00018 0.720
LIG_SH3_3 135 141 PF00018 0.750
LIG_SH3_3 153 159 PF00018 0.486
LIG_SH3_3 256 262 PF00018 0.677
LIG_SH3_3 282 288 PF00018 0.615
LIG_SH3_3 321 327 PF00018 0.625
LIG_SH3_3 365 371 PF00018 0.672
LIG_SH3_3 398 404 PF00018 0.554
LIG_SH3_3 55 61 PF00018 0.451
LIG_SH3_3 66 72 PF00018 0.333
LIG_SH3_CIN85_PxpxPR_1 364 369 PF14604 0.544
LIG_SUMO_SIM_anti_2 77 84 PF11976 0.517
LIG_SUMO_SIM_par_1 77 84 PF11976 0.427
LIG_TRAF2_1 178 181 PF00917 0.644
LIG_TRAF2_1 332 335 PF00917 0.689
MOD_CDC14_SPxK_1 395 398 PF00782 0.672
MOD_CDK_SPxK_1 392 398 PF00069 0.679
MOD_CDK_SPxxK_3 345 352 PF00069 0.672
MOD_CDK_SPxxK_3 68 75 PF00069 0.476
MOD_CK1_1 102 108 PF00069 0.663
MOD_CK1_1 111 117 PF00069 0.549
MOD_CK1_1 190 196 PF00069 0.627
MOD_CK1_1 223 229 PF00069 0.594
MOD_CK1_1 233 239 PF00069 0.709
MOD_CK1_1 247 253 PF00069 0.553
MOD_CK1_1 254 260 PF00069 0.585
MOD_CK1_1 265 271 PF00069 0.553
MOD_CK1_1 277 283 PF00069 0.530
MOD_CK1_1 295 301 PF00069 0.748
MOD_CK1_1 30 36 PF00069 0.536
MOD_CK1_1 316 322 PF00069 0.673
MOD_CK1_1 350 356 PF00069 0.652
MOD_CK1_1 358 364 PF00069 0.573
MOD_CK1_1 406 412 PF00069 0.672
MOD_CK2_1 145 151 PF00069 0.668
MOD_CK2_1 164 170 PF00069 0.621
MOD_CK2_1 174 180 PF00069 0.587
MOD_CK2_1 261 267 PF00069 0.701
MOD_CK2_1 277 283 PF00069 0.532
MOD_CK2_1 345 351 PF00069 0.686
MOD_CK2_1 377 383 PF00069 0.570
MOD_DYRK1A_RPxSP_1 369 373 PF00069 0.596
MOD_GlcNHglycan 100 104 PF01048 0.649
MOD_GlcNHglycan 110 113 PF01048 0.510
MOD_GlcNHglycan 121 124 PF01048 0.626
MOD_GlcNHglycan 146 150 PF01048 0.635
MOD_GlcNHglycan 176 179 PF01048 0.678
MOD_GlcNHglycan 232 235 PF01048 0.596
MOD_GlcNHglycan 264 267 PF01048 0.702
MOD_GlcNHglycan 315 318 PF01048 0.591
MOD_GlcNHglycan 32 35 PF01048 0.519
MOD_GlcNHglycan 357 360 PF01048 0.698
MOD_GlcNHglycan 392 395 PF01048 0.642
MOD_GlcNHglycan 43 46 PF01048 0.527
MOD_GlcNHglycan 54 57 PF01048 0.387
MOD_GlcNHglycan 90 93 PF01048 0.690
MOD_GSK3_1 190 197 PF00069 0.599
MOD_GSK3_1 245 252 PF00069 0.607
MOD_GSK3_1 26 33 PF00069 0.655
MOD_GSK3_1 261 268 PF00069 0.581
MOD_GSK3_1 270 277 PF00069 0.582
MOD_GSK3_1 347 354 PF00069 0.676
MOD_GSK3_1 358 365 PF00069 0.698
MOD_GSK3_1 399 406 PF00069 0.610
MOD_GSK3_1 416 423 PF00069 0.551
MOD_GSK3_1 64 71 PF00069 0.393
MOD_GSK3_1 81 88 PF00069 0.581
MOD_N-GLC_1 164 169 PF02516 0.614
MOD_N-GLC_2 41 43 PF02516 0.597
MOD_NEK2_1 27 32 PF00069 0.521
MOD_NEK2_2 385 390 PF00069 0.660
MOD_PIKK_1 245 251 PF00454 0.644
MOD_PIKK_1 319 325 PF00454 0.644
MOD_PKA_1 274 280 PF00069 0.531
MOD_PKA_2 17 23 PF00069 0.405
MOD_PKA_2 174 180 PF00069 0.545
MOD_PKA_2 245 251 PF00069 0.620
MOD_PKA_2 274 280 PF00069 0.610
MOD_PKA_2 292 298 PF00069 0.610
MOD_PKA_2 337 343 PF00069 0.737
MOD_PKA_2 407 413 PF00069 0.591
MOD_PKA_2 41 47 PF00069 0.592
MOD_PKA_2 74 80 PF00069 0.427
MOD_PKA_2 81 87 PF00069 0.454
MOD_Plk_1 334 340 PF00069 0.629
MOD_Plk_2-3 418 424 PF00069 0.583
MOD_Plk_4 281 287 PF00069 0.564
MOD_Plk_4 64 70 PF00069 0.391
MOD_Plk_4 74 80 PF00069 0.390
MOD_ProDKin_1 221 227 PF00069 0.630
MOD_ProDKin_1 254 260 PF00069 0.680
MOD_ProDKin_1 345 351 PF00069 0.680
MOD_ProDKin_1 369 375 PF00069 0.638
MOD_ProDKin_1 392 398 PF00069 0.708
MOD_ProDKin_1 68 74 PF00069 0.401
MOD_SUMO_rev_2 111 120 PF00179 0.553
MOD_SUMO_rev_2 167 174 PF00179 0.549
MOD_SUMO_rev_2 322 332 PF00179 0.630
TRG_ENDOCYTIC_2 76 79 PF00928 0.403
TRG_ER_diArg_1 412 414 PF00400 0.586
TRG_NLS_MonoCore_2 201 206 PF00514 0.590
TRG_NLS_MonoCore_2 343 348 PF00514 0.629
TRG_NLS_MonoExtC_3 201 206 PF00514 0.588
TRG_NLS_MonoExtC_3 344 349 PF00514 0.619
TRG_NLS_MonoExtN_4 200 207 PF00514 0.589
TRG_NLS_MonoExtN_4 344 349 PF00514 0.633

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HWS2 Leptomonas seymouri 41% 100%
A0A3S7X6S8 Leishmania donovani 100% 100%
E9AIV5 Leishmania braziliensis 67% 97%
E9B3X4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
Q4Q450 Leishmania major 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS