Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I908_LEIIN

TriTrypDb:

LINF_330021900

Length:

464

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I908

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I908

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.624
CLV_C14_Caspase3-7	257	261	PF00656	0.620
CLV_C14_Caspase3-7	51	55	PF00656	0.761
CLV_NRD_NRD_1	137	139	PF00675	0.596
CLV_NRD_NRD_1	221	223	PF00675	0.648
CLV_NRD_NRD_1	286	288	PF00675	0.523
CLV_PCSK_KEX2_1	137	139	PF00082	0.596
CLV_PCSK_KEX2_1	219	221	PF00082	0.670
CLV_PCSK_KEX2_1	286	288	PF00082	0.523
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.735
CLV_PCSK_PC7_1	216	222	PF00082	0.701
CLV_PCSK_SKI1_1	252	256	PF00082	0.504
CLV_PCSK_SKI1_1	341	345	PF00082	0.751
DEG_APCC_DBOX_1	249	257	PF00400	0.621
DEG_SCF_FBW7_1	20	26	PF00400	0.661
DEG_SCF_FBW7_1	396	402	PF00400	0.760
DEG_SPOP_SBC_1	227	231	PF00917	0.700
DEG_SPOP_SBC_1	79	83	PF00917	0.626
DOC_CKS1_1	20	25	PF01111	0.659
DOC_CKS1_1	305	310	PF01111	0.744
DOC_CKS1_1	396	401	PF01111	0.666
DOC_CYCLIN_RxL_1	247	260	PF00134	0.537
DOC_CYCLIN_yCln2_LP_2	385	391	PF00134	0.612
DOC_MAPK_gen_1	247	256	PF00069	0.632
DOC_MAPK_gen_1	286	293	PF00069	0.543
DOC_PP2B_LxvP_1	107	110	PF13499	0.699
DOC_USP7_MATH_1	110	114	PF00917	0.519
DOC_USP7_MATH_1	184	188	PF00917	0.712
DOC_USP7_MATH_1	227	231	PF00917	0.728
DOC_USP7_MATH_1	300	304	PF00917	0.671
DOC_USP7_MATH_1	317	321	PF00917	0.589
DOC_USP7_MATH_1	368	372	PF00917	0.724
DOC_USP7_MATH_1	397	401	PF00917	0.691
DOC_USP7_MATH_1	407	411	PF00917	0.663
DOC_USP7_MATH_1	77	81	PF00917	0.720
DOC_USP7_MATH_1	91	95	PF00917	0.656
DOC_WW_Pin1_4	153	158	PF00397	0.501
DOC_WW_Pin1_4	19	24	PF00397	0.655
DOC_WW_Pin1_4	220	225	PF00397	0.847
DOC_WW_Pin1_4	232	237	PF00397	0.720
DOC_WW_Pin1_4	304	309	PF00397	0.747
DOC_WW_Pin1_4	313	318	PF00397	0.741
DOC_WW_Pin1_4	395	400	PF00397	0.664
DOC_WW_Pin1_4	56	61	PF00397	0.703
DOC_WW_Pin1_4	89	94	PF00397	0.754
LIG_14-3-3_CanoR_1	225	234	PF00244	0.674
LIG_14-3-3_CanoR_1	24	30	PF00244	0.724
LIG_14-3-3_CanoR_1	295	299	PF00244	0.553
LIG_14-3-3_CanoR_1	408	416	PF00244	0.677
LIG_14-3-3_CanoR_1	417	423	PF00244	0.779
LIG_14-3-3_CanoR_1	447	453	PF00244	0.745
LIG_BIR_III_2	183	187	PF00653	0.666
LIG_Clathr_ClatBox_1	253	257	PF01394	0.508
LIG_FHA_1	243	249	PF00498	0.707
LIG_FHA_1	380	386	PF00498	0.605
LIG_FHA_1	430	436	PF00498	0.622
LIG_FHA_1	449	455	PF00498	0.628
LIG_FHA_1	81	87	PF00498	0.699
LIG_FHA_2	178	184	PF00498	0.604
LIG_FHA_2	26	32	PF00498	0.744
LIG_FHA_2	49	55	PF00498	0.754
LIG_FHA_2	60	66	PF00498	0.574
LIG_LIR_Apic_2	260	266	PF02991	0.534
LIG_LIR_Gen_1	320	331	PF02991	0.567
LIG_LIR_Gen_1	68	77	PF02991	0.528
LIG_LIR_Nem_3	320	326	PF02991	0.590
LIG_LIR_Nem_3	65	70	PF02991	0.545
LIG_Pex14_2	237	241	PF04695	0.599
LIG_SH2_CRK	323	327	PF00017	0.638
LIG_SH2_NCK_1	310	314	PF00017	0.698
LIG_SH2_PTP2	70	73	PF00017	0.508
LIG_SH2_STAP1	29	33	PF00017	0.735
LIG_SH2_STAP1	310	314	PF00017	0.712
LIG_SH2_STAP1	327	331	PF00017	0.455
LIG_SH2_STAT3	144	147	PF00017	0.699
LIG_SH2_STAT5	403	406	PF00017	0.794
LIG_SH2_STAT5	70	73	PF00017	0.508
LIG_SH3_3	122	128	PF00018	0.764
LIG_SH3_3	151	157	PF00018	0.603
LIG_SH3_3	17	23	PF00018	0.690
LIG_SH3_3	187	193	PF00018	0.774
LIG_SH3_3	288	294	PF00018	0.649
LIG_SH3_3	302	308	PF00018	0.682
LIG_SH3_3	385	391	PF00018	0.584
LIG_SH3_3	87	93	PF00018	0.793
LIG_SUMO_SIM_anti_2	436	443	PF11976	0.763
LIG_SUMO_SIM_par_1	252	257	PF11976	0.484
LIG_SUMO_SIM_par_1	392	398	PF11976	0.747
LIG_TRAF2_1	63	66	PF00917	0.688
LIG_TYR_ITSM	323	330	PF00017	0.576
MOD_CDC14_SPxK_1	235	238	PF00782	0.647
MOD_CDK_SPK_2	19	24	PF00069	0.655
MOD_CDK_SPK_2	220	225	PF00069	0.693
MOD_CDK_SPxK_1	232	238	PF00069	0.651
MOD_CDK_SPxxK_3	94	101	PF00069	0.732
MOD_CK1_1	113	119	PF00069	0.557
MOD_CK1_1	176	182	PF00069	0.719
MOD_CK1_1	207	213	PF00069	0.822
MOD_CK1_1	223	229	PF00069	0.685
MOD_CK1_1	230	236	PF00069	0.721
MOD_CK1_1	25	31	PF00069	0.684
MOD_CK1_1	309	315	PF00069	0.691
MOD_CK1_1	316	322	PF00069	0.616
MOD_CK1_1	395	401	PF00069	0.676
MOD_CK1_1	434	440	PF00069	0.749
MOD_CK1_1	59	65	PF00069	0.723
MOD_CK1_1	80	86	PF00069	0.602
MOD_CK1_1	94	100	PF00069	0.677
MOD_CK2_1	153	159	PF00069	0.498
MOD_CK2_1	41	47	PF00069	0.703
MOD_CK2_1	59	65	PF00069	0.464
MOD_CK2_1	99	105	PF00069	0.532
MOD_GlcNHglycan	167	170	PF01048	0.489
MOD_GlcNHglycan	175	178	PF01048	0.635
MOD_GlcNHglycan	210	213	PF01048	0.617
MOD_GlcNHglycan	302	305	PF01048	0.577
MOD_GlcNHglycan	370	373	PF01048	0.710
MOD_GlcNHglycan	405	408	PF01048	0.687
MOD_GlcNHglycan	74	77	PF01048	0.486
MOD_GSK3_1	173	180	PF00069	0.638
MOD_GSK3_1	19	26	PF00069	0.652
MOD_GSK3_1	200	207	PF00069	0.791
MOD_GSK3_1	223	230	PF00069	0.791
MOD_GSK3_1	294	301	PF00069	0.654
MOD_GSK3_1	309	316	PF00069	0.698
MOD_GSK3_1	322	329	PF00069	0.515
MOD_GSK3_1	395	402	PF00069	0.675
MOD_GSK3_1	403	410	PF00069	0.720
MOD_GSK3_1	423	430	PF00069	0.788
MOD_GSK3_1	48	55	PF00069	0.711
MOD_GSK3_1	80	87	PF00069	0.716
MOD_N-GLC_1	336	341	PF02516	0.655
MOD_N-GLC_2	270	272	PF02516	0.560
MOD_N-GLC_2	334	336	PF02516	0.695
MOD_NEK2_1	111	116	PF00069	0.749
MOD_NEK2_1	194	199	PF00069	0.707
MOD_NEK2_1	204	209	PF00069	0.560
MOD_NEK2_1	326	331	PF00069	0.657
MOD_NEK2_1	416	421	PF00069	0.759
MOD_NEK2_1	423	428	PF00069	0.680
MOD_NEK2_2	322	327	PF00069	0.590
MOD_PIKK_1	194	200	PF00454	0.817
MOD_PKA_2	23	29	PF00069	0.721
MOD_PKA_2	294	300	PF00069	0.550
MOD_PKA_2	368	374	PF00069	0.724
MOD_PKA_2	407	413	PF00069	0.673
MOD_PKA_2	416	422	PF00069	0.756
MOD_Plk_2-3	99	105	PF00069	0.611
MOD_Plk_4	184	190	PF00069	0.763
MOD_Plk_4	322	328	PF00069	0.594
MOD_Plk_4	399	405	PF00069	0.748
MOD_Plk_4	434	440	PF00069	0.677
MOD_Plk_4	448	454	PF00069	0.618
MOD_Plk_4	91	97	PF00069	0.761
MOD_ProDKin_1	153	159	PF00069	0.498
MOD_ProDKin_1	19	25	PF00069	0.656
MOD_ProDKin_1	220	226	PF00069	0.847
MOD_ProDKin_1	232	238	PF00069	0.720
MOD_ProDKin_1	304	310	PF00069	0.749
MOD_ProDKin_1	313	319	PF00069	0.735
MOD_ProDKin_1	395	401	PF00069	0.667
MOD_ProDKin_1	56	62	PF00069	0.696
MOD_ProDKin_1	89	95	PF00069	0.752
TRG_DiLeu_BaEn_2	158	164	PF01217	0.433
TRG_DiLeu_BaLyEn_6	249	254	PF01217	0.507
TRG_ENDOCYTIC_2	323	326	PF00928	0.644
TRG_ENDOCYTIC_2	327	330	PF00928	0.628
TRG_ENDOCYTIC_2	70	73	PF00928	0.508
TRG_ER_diArg_1	220	222	PF00400	0.700
TRG_ER_diArg_1	250	253	PF00400	0.626
TRG_ER_diArg_1	286	289	PF00400	0.535
TRG_NLS_MonoCore_2	218	223	PF00514	0.700
TRG_NLS_MonoExtN_4	216	223	PF00514	0.717
TRG_Pf-PMV_PEXEL_1	252	257	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	383	387	PF00026	0.608

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4L8	Leptomonas seymouri	35%	81%
A0A3S7X6N2	Leishmania donovani	99%	100%
A4HLJ8	Leishmania braziliensis	67%	100%
E9B3X3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q451	Leishmania major	90%	100%