Complex1_LYR_dom domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

iron-sulfur cluster assembly protein - putative

Species:

Leishmania infantum

UniProt:

A4I907_LEIIN

TriTrypDb:

LINF_330021600

Length:

163

Annotations

Annotations by Jardim et al.

Metal Binding, iron-sulfur cluster assembly Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1
GO:1990221	L-cysteine desulfurase complex	3	1

Expansion

Sequence features

A4I907

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I907

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	4
GO:0008152	metabolic process	1	4
GO:0009987	cellular process	1	4
GO:0016043	cellular component organization	3	4
GO:0016226	iron-sulfur cluster assembly	4	4
GO:0022607	cellular component assembly	4	4
GO:0031163	metallo-sulfur cluster assembly	5	4
GO:0044237	cellular metabolic process	2	4
GO:0071840	cellular component organization or biogenesis	2	4
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006399	tRNA metabolic process	7	1
GO:0006400	tRNA modification	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008033	tRNA processing	8	1
GO:0009451	RNA modification	5	1
GO:0016070	RNA metabolic process	5	1
GO:0034227	tRNA thio-modification	7	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0051536	iron-sulfur cluster binding	3	1
GO:0051540	metal cluster binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.287
CLV_NRD_NRD_1	151	153	PF00675	0.766
CLV_NRD_NRD_1	20	22	PF00675	0.481
CLV_NRD_NRD_1	47	49	PF00675	0.530
CLV_NRD_NRD_1	80	82	PF00675	0.287
CLV_PCSK_KEX2_1	137	139	PF00082	0.453
CLV_PCSK_KEX2_1	151	153	PF00082	0.489
CLV_PCSK_KEX2_1	20	22	PF00082	0.481
CLV_PCSK_KEX2_1	80	82	PF00082	0.287
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.453
CLV_PCSK_SKI1_1	111	115	PF00082	0.287
CLV_PCSK_SKI1_1	127	131	PF00082	0.318
DEG_APCC_DBOX_1	118	126	PF00400	0.480
DEG_APCC_DBOX_1	19	27	PF00400	0.412
DEG_APCC_DBOX_1	4	12	PF00400	0.475
DOC_MAPK_gen_1	121	130	PF00069	0.381
DOC_MAPK_gen_1	20	28	PF00069	0.489
DOC_MAPK_RevD_3	6	21	PF00069	0.478
DOC_PP1_RVXF_1	136	143	PF00149	0.436
DOC_USP7_MATH_1	31	35	PF00917	0.499
DOC_USP7_MATH_1	37	41	PF00917	0.471
DOC_USP7_UBL2_3	62	66	PF12436	0.386
DOC_WW_Pin1_4	35	40	PF00397	0.465
LIG_14-3-3_CanoR_1	20	24	PF00244	0.407
LIG_14-3-3_CanoR_1	5	9	PF00244	0.475
LIG_Actin_WH2_2	4	22	PF00022	0.479
LIG_APCC_ABBAyCdc20_2	137	143	PF00400	0.444
LIG_BRCT_BRCA1_1	39	43	PF00533	0.500
LIG_FHA_1	12	18	PF00498	0.481
LIG_FHA_1	39	45	PF00498	0.501
LIG_LIR_Gen_1	97	105	PF02991	0.287
LIG_LIR_Nem_3	84	90	PF02991	0.287
LIG_LIR_Nem_3	97	102	PF02991	0.230
LIG_Pex14_2	87	91	PF04695	0.287
LIG_PTB_Apo_2	129	136	PF02174	0.386
LIG_PTB_Phospho_1	129	135	PF10480	0.387
LIG_SH2_STAT3	90	93	PF00017	0.412
LIG_SH2_STAT5	141	144	PF00017	0.447
LIG_SH2_STAT5	90	93	PF00017	0.412
LIG_TRAF2_1	106	109	PF00917	0.378
MOD_CK1_1	27	33	PF00069	0.527
MOD_CK1_1	38	44	PF00069	0.449
MOD_CK2_1	103	109	PF00069	0.287
MOD_GlcNHglycan	33	36	PF01048	0.498
MOD_GlcNHglycan	57	60	PF01048	0.451
MOD_GSK3_1	27	34	PF00069	0.502
MOD_GSK3_1	60	67	PF00069	0.404
MOD_NEK2_1	11	16	PF00069	0.442
MOD_NEK2_1	19	24	PF00069	0.406
MOD_NEK2_1	4	9	PF00069	0.475
MOD_NEK2_1	75	80	PF00069	0.287
MOD_PKA_2	19	25	PF00069	0.409
MOD_PKA_2	4	10	PF00069	0.476
MOD_Plk_4	38	44	PF00069	0.496
MOD_ProDKin_1	35	41	PF00069	0.465
TRG_DiLeu_BaEn_3	108	114	PF01217	0.287
TRG_ER_diArg_1	19	21	PF00400	0.477
TRG_ER_diArg_1	80	82	PF00400	0.287
TRG_NES_CRM1_1	120	133	PF08389	0.383

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X6M0	Leishmania donovani	99%	100%
Q4Q452	Leishmania major	95%	99%