Putative expression-site associated gene (ESAG3)

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

expression-site associated gene (ESAG3) - putative

Species:

Leishmania infantum

UniProt:

A4I8Z8_LEIIN

TriTrypDb:

LINF_330021000

Length:

670

Annotations

Annotations by Jardim et al.

Membrane associated proteins, expression-site associated gene (ESAG3)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4I8Z8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8Z8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.444
CLV_NRD_NRD_1	133	135	PF00675	0.557
CLV_NRD_NRD_1	155	157	PF00675	0.521
CLV_NRD_NRD_1	199	201	PF00675	0.519
CLV_NRD_NRD_1	237	239	PF00675	0.462
CLV_NRD_NRD_1	501	503	PF00675	0.540
CLV_NRD_NRD_1	629	631	PF00675	0.562
CLV_NRD_NRD_1	76	78	PF00675	0.631
CLV_NRD_NRD_1	98	100	PF00675	0.590
CLV_PCSK_FUR_1	131	135	PF00082	0.523
CLV_PCSK_KEX2_1	12	14	PF00082	0.447
CLV_PCSK_KEX2_1	133	135	PF00082	0.558
CLV_PCSK_KEX2_1	155	157	PF00082	0.521
CLV_PCSK_KEX2_1	199	201	PF00082	0.519
CLV_PCSK_KEX2_1	286	288	PF00082	0.566
CLV_PCSK_KEX2_1	29	31	PF00082	0.484
CLV_PCSK_KEX2_1	386	388	PF00082	0.559
CLV_PCSK_KEX2_1	501	503	PF00082	0.540
CLV_PCSK_KEX2_1	610	612	PF00082	0.566
CLV_PCSK_KEX2_1	629	631	PF00082	0.547
CLV_PCSK_KEX2_1	76	78	PF00082	0.635
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.575
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.523
CLV_PCSK_PC1ET2_1	386	388	PF00082	0.559
CLV_PCSK_PC1ET2_1	610	612	PF00082	0.579
CLV_PCSK_SKI1_1	287	291	PF00082	0.552
CLV_PCSK_SKI1_1	358	362	PF00082	0.578
CLV_PCSK_SKI1_1	42	46	PF00082	0.429
CLV_PCSK_SKI1_1	574	578	PF00082	0.557
CLV_PCSK_SKI1_1	610	614	PF00082	0.566
DEG_APCC_DBOX_1	41	49	PF00400	0.741
DEG_APCC_DBOX_1	461	469	PF00400	0.317
DOC_ANK_TNKS_1	489	496	PF00023	0.352
DOC_CKS1_1	480	485	PF01111	0.361
DOC_CKS1_1	566	571	PF01111	0.373
DOC_CYCLIN_RxL_1	197	211	PF00134	0.312
DOC_CYCLIN_RxL_1	36	49	PF00134	0.590
DOC_CYCLIN_yCln2_LP_2	313	319	PF00134	0.249
DOC_MAPK_gen_1	155	161	PF00069	0.324
DOC_MAPK_gen_1	199	207	PF00069	0.311
DOC_MAPK_gen_1	501	508	PF00069	0.336
DOC_MAPK_gen_1	99	105	PF00069	0.290
DOC_MAPK_MEF2A_6	402	409	PF00069	0.348
DOC_MAPK_MEF2A_6	52	61	PF00069	0.474
DOC_MAPK_MEF2A_6	641	648	PF00069	0.321
DOC_MAPK_RevD_3	61	77	PF00069	0.293
DOC_PP1_RVXF_1	156	162	PF00149	0.361
DOC_PP1_RVXF_1	201	208	PF00149	0.309
DOC_PP2B_LxvP_1	290	293	PF13499	0.310
DOC_PP2B_LxvP_1	667	670	PF13499	0.441
DOC_PP2B_LxvP_1	87	90	PF13499	0.388
DOC_PP4_FxxP_1	104	107	PF00568	0.322
DOC_PP4_FxxP_1	184	187	PF00568	0.318
DOC_USP7_MATH_1	109	113	PF00917	0.478
DOC_USP7_MATH_1	385	389	PF00917	0.356
DOC_USP7_MATH_1	486	490	PF00917	0.313
DOC_USP7_MATH_1	530	534	PF00917	0.323
DOC_USP7_MATH_1	554	558	PF00917	0.374
DOC_USP7_MATH_1	604	608	PF00917	0.412
DOC_USP7_MATH_1	631	635	PF00917	0.396
DOC_USP7_MATH_1	90	94	PF00917	0.387
DOC_WW_Pin1_4	241	246	PF00397	0.363
DOC_WW_Pin1_4	36	41	PF00397	0.586
DOC_WW_Pin1_4	376	381	PF00397	0.397
DOC_WW_Pin1_4	433	438	PF00397	0.377
DOC_WW_Pin1_4	479	484	PF00397	0.386
DOC_WW_Pin1_4	565	570	PF00397	0.377
DOC_WW_Pin1_4	665	670	PF00397	0.443
LIG_14-3-3_CanoR_1	160	165	PF00244	0.258
LIG_14-3-3_CanoR_1	171	177	PF00244	0.239
LIG_14-3-3_CanoR_1	330	338	PF00244	0.418
LIG_14-3-3_CanoR_1	373	382	PF00244	0.300
LIG_14-3-3_CanoR_1	47	55	PF00244	0.576
LIG_14-3-3_CanoR_1	501	508	PF00244	0.302
LIG_14-3-3_CanoR_1	611	619	PF00244	0.353
LIG_14-3-3_CanoR_1	99	107	PF00244	0.330
LIG_AP2alpha_2	391	393	PF02296	0.267
LIG_APCC_ABBAyCdc20_2	210	216	PF00400	0.306
LIG_BRCT_BRCA1_1	100	104	PF00533	0.316
LIG_BRCT_BRCA1_1	223	227	PF00533	0.287
LIG_BRCT_BRCA1_1	308	312	PF00533	0.337
LIG_BRCT_BRCA1_1	581	585	PF00533	0.378
LIG_Clathr_ClatBox_1	496	500	PF01394	0.325
LIG_CSL_BTD_1	32	35	PF09270	0.656
LIG_CtBP_PxDLS_1	477	481	PF00389	0.341
LIG_deltaCOP1_diTrp_1	225	233	PF00928	0.316
LIG_deltaCOP1_diTrp_1	645	654	PF00928	0.327
LIG_eIF4E_1	491	497	PF01652	0.332
LIG_FAT_LD_1	368	376	PF03623	0.265
LIG_FHA_1	121	127	PF00498	0.445
LIG_FHA_1	36	42	PF00498	0.586
LIG_FHA_1	395	401	PF00498	0.387
LIG_FHA_1	404	410	PF00498	0.322
LIG_FHA_1	480	486	PF00498	0.406
LIG_FHA_1	539	545	PF00498	0.388
LIG_FHA_1	566	572	PF00498	0.361
LIG_FHA_1	634	640	PF00498	0.424
LIG_FHA_1	68	74	PF00498	0.378
LIG_FHA_2	117	123	PF00498	0.398
LIG_FHA_2	227	233	PF00498	0.354
LIG_FHA_2	245	251	PF00498	0.391
LIG_FHA_2	575	581	PF00498	0.357
LIG_GBD_Chelix_1	57	65	PF00786	0.259
LIG_LIR_Apic_2	101	107	PF02991	0.305
LIG_LIR_Apic_2	488	494	PF02991	0.396
LIG_LIR_Gen_1	193	201	PF02991	0.372
LIG_LIR_Gen_1	202	208	PF02991	0.364
LIG_LIR_Gen_1	6	11	PF02991	0.638
LIG_LIR_Gen_1	651	660	PF02991	0.360
LIG_LIR_Nem_3	193	198	PF02991	0.336
LIG_LIR_Nem_3	202	207	PF02991	0.325
LIG_LIR_Nem_3	232	236	PF02991	0.287
LIG_LIR_Nem_3	6	10	PF02991	0.638
LIG_LIR_Nem_3	651	657	PF02991	0.359
LIG_PCNA_yPIPBox_3	453	464	PF02747	0.286
LIG_Pex14_1	74	78	PF04695	0.414
LIG_Pex14_2	236	240	PF04695	0.392
LIG_SH2_CRK	491	495	PF00017	0.335
LIG_SH2_CRK	603	607	PF00017	0.332
LIG_SH2_CRK	78	82	PF00017	0.396
LIG_SH2_NCK_1	603	607	PF00017	0.357
LIG_SH2_SRC	145	148	PF00017	0.308
LIG_SH2_STAP1	487	491	PF00017	0.367
LIG_SH2_STAP1	619	623	PF00017	0.340
LIG_SH2_STAT3	381	384	PF00017	0.368
LIG_SH2_STAT5	145	148	PF00017	0.389
LIG_SH2_STAT5	204	207	PF00017	0.363
LIG_SH2_STAT5	431	434	PF00017	0.361
LIG_SH2_STAT5	460	463	PF00017	0.281
LIG_SH2_STAT5	524	527	PF00017	0.389
LIG_SH3_3	282	288	PF00018	0.409
LIG_SH3_3	504	510	PF00018	0.329
LIG_SH3_3	564	570	PF00018	0.308
LIG_SH3_3	593	599	PF00018	0.354
LIG_SH3_3	663	669	PF00018	0.345
LIG_SUMO_SIM_par_1	215	225	PF11976	0.349
LIG_SUMO_SIM_par_1	63	71	PF11976	0.375
MOD_CDC14_SPxK_1	39	42	PF00782	0.572
MOD_CDK_SPxK_1	36	42	PF00069	0.586
MOD_CK1_1	244	250	PF00069	0.377
MOD_CK1_1	403	409	PF00069	0.350
MOD_CK1_1	479	485	PF00069	0.379
MOD_CK1_1	557	563	PF00069	0.297
MOD_CK1_1	6	12	PF00069	0.641
MOD_CK2_1	116	122	PF00069	0.397
MOD_CMANNOS	535	538	PF00535	0.593
MOD_Cter_Amidation	27	30	PF01082	0.520
MOD_GlcNHglycan	100	103	PF01048	0.524
MOD_GlcNHglycan	13	16	PF01048	0.456
MOD_GlcNHglycan	177	180	PF01048	0.501
MOD_GlcNHglycan	26	29	PF01048	0.436
MOD_GlcNHglycan	574	577	PF01048	0.566
MOD_GSK3_1	11	18	PF00069	0.642
MOD_GSK3_1	116	123	PF00069	0.397
MOD_GSK3_1	171	178	PF00069	0.297
MOD_GSK3_1	182	189	PF00069	0.266
MOD_GSK3_1	332	339	PF00069	0.322
MOD_GSK3_1	376	383	PF00069	0.393
MOD_GSK3_1	427	434	PF00069	0.335
MOD_GSK3_1	46	53	PF00069	0.601
MOD_GSK3_1	554	561	PF00069	0.362
MOD_N-GLC_1	191	196	PF02516	0.534
MOD_N-GLC_1	395	400	PF02516	0.553
MOD_N-GLC_1	50	55	PF02516	0.358
MOD_N-GLC_1	538	543	PF02516	0.616
MOD_N-GLC_1	655	660	PF02516	0.610
MOD_NEK2_1	17	22	PF00069	0.703
MOD_NEK2_1	172	177	PF00069	0.285
MOD_NEK2_1	191	196	PF00069	0.279
MOD_NEK2_1	336	341	PF00069	0.319
MOD_NEK2_1	356	361	PF00069	0.312
MOD_NEK2_1	394	399	PF00069	0.474
MOD_NEK2_1	413	418	PF00069	0.315
MOD_NEK2_1	424	429	PF00069	0.310
MOD_NEK2_1	558	563	PF00069	0.368
MOD_NEK2_1	572	577	PF00069	0.363
MOD_PIKK_1	380	386	PF00454	0.372
MOD_PIKK_1	444	450	PF00454	0.348
MOD_PIKK_1	500	506	PF00454	0.287
MOD_PK_1	85	91	PF00069	0.343
MOD_PKA_1	610	616	PF00069	0.321
MOD_PKA_2	109	115	PF00069	0.325
MOD_PKA_2	11	17	PF00069	0.699
MOD_PKA_2	154	160	PF00069	0.325
MOD_PKA_2	46	52	PF00069	0.588
MOD_PKA_2	500	506	PF00069	0.304
MOD_PKA_2	610	616	PF00069	0.352
MOD_PKA_2	631	637	PF00069	0.393
MOD_PKA_2	98	104	PF00069	0.320
MOD_PKB_1	158	166	PF00069	0.261
MOD_Plk_1	191	197	PF00069	0.367
MOD_Plk_1	395	401	PF00069	0.358
MOD_Plk_1	50	56	PF00069	0.414
MOD_Plk_1	655	661	PF00069	0.366
MOD_Plk_2-3	246	252	PF00069	0.380
MOD_Plk_4	395	401	PF00069	0.407
MOD_Plk_4	403	409	PF00069	0.336
MOD_Plk_4	427	433	PF00069	0.301
MOD_Plk_4	6	12	PF00069	0.650
MOD_Plk_4	662	668	PF00069	0.398
MOD_ProDKin_1	241	247	PF00069	0.366
MOD_ProDKin_1	36	42	PF00069	0.586
MOD_ProDKin_1	376	382	PF00069	0.399
MOD_ProDKin_1	433	439	PF00069	0.377
MOD_ProDKin_1	479	485	PF00069	0.382
MOD_ProDKin_1	565	571	PF00069	0.378
MOD_SUMO_rev_2	260	268	PF00179	0.337
TRG_DiLeu_BaEn_2	649	655	PF01217	0.331
TRG_DiLeu_BaLyEn_6	285	290	PF01217	0.370
TRG_DiLeu_BaLyEn_6	39	44	PF01217	0.581
TRG_DiLeu_BaLyEn_6	567	572	PF01217	0.342
TRG_ENDOCYTIC_2	195	198	PF00928	0.371
TRG_ENDOCYTIC_2	204	207	PF00928	0.363
TRG_ENDOCYTIC_2	619	622	PF00928	0.318
TRG_ENDOCYTIC_2	78	81	PF00928	0.487
TRG_ER_diArg_1	11	13	PF00400	0.657
TRG_ER_diArg_1	131	134	PF00400	0.327
TRG_ER_diArg_1	155	158	PF00400	0.339
TRG_ER_diArg_1	198	200	PF00400	0.324
TRG_ER_diArg_1	461	464	PF00400	0.322
TRG_ER_diArg_1	629	632	PF00400	0.424
TRG_ER_diArg_1	75	77	PF00400	0.466
TRG_Pf-PMV_PEXEL_1	287	291	PF00026	0.627
TRG_Pf-PMV_PEXEL_1	641	645	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGZ4	Leptomonas seymouri	63%	100%
A0A0N1PDD7	Leptomonas seymouri	22%	100%
A0A3Q8ID98	Leishmania donovani	33%	100%
A0A3Q8IM92	Leishmania donovani	99%	100%
A4H7X2	Leishmania braziliensis	32%	100%
A4HLI8	Leishmania braziliensis	79%	100%
A4HLJ0	Leishmania braziliensis	75%	100%
A4HLJ2	Leishmania braziliensis	79%	100%
A4HW99	Leishmania infantum	33%	100%
E9APZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9B3W7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q457	Leishmania major	91%	100%
Q4QFI2	Leishmania major	33%	100%