Pre-mRNA-splicing factor CWC15

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I8Z7_LEIIN

TriTrypDb:

LINF_330020900

Length:

211

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0005681	spliceosomal complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4I8Z7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8Z7

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	34	38	PF00656	0.583
CLV_NRD_NRD_1	113	115	PF00675	0.571
CLV_NRD_NRD_1	19	21	PF00675	0.563
CLV_NRD_NRD_1	29	31	PF00675	0.619
CLV_PCSK_FUR_1	111	115	PF00082	0.556
CLV_PCSK_KEX2_1	113	115	PF00082	0.617
CLV_PCSK_KEX2_1	17	19	PF00082	0.552
CLV_PCSK_KEX2_1	184	186	PF00082	0.601
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.552
CLV_PCSK_PC1ET2_1	184	186	PF00082	0.608
CLV_PCSK_SKI1_1	103	107	PF00082	0.591
CLV_PCSK_SKI1_1	207	211	PF00082	0.539
CLV_PCSK_SKI1_1	76	80	PF00082	0.662
DEG_SPOP_SBC_1	56	60	PF00917	0.545
DEG_SPOP_SBC_1	80	84	PF00917	0.637
DOC_USP7_MATH_1	11	15	PF00917	0.601
DOC_USP7_MATH_1	130	134	PF00917	0.614
DOC_USP7_MATH_1	146	150	PF00917	0.613
DOC_USP7_MATH_1	56	60	PF00917	0.643
DOC_USP7_MATH_1	70	74	PF00917	0.587
DOC_USP7_MATH_1	80	84	PF00917	0.602
DOC_USP7_UBL2_3	184	188	PF12436	0.574
DOC_USP7_UBL2_3	207	211	PF12436	0.406
DOC_USP7_UBL2_3	72	76	PF12436	0.623
DOC_WW_Pin1_4	142	147	PF00397	0.784
LIG_Actin_WH2_2	54	69	PF00022	0.550
LIG_BIR_II_1	1	5	PF00653	0.561
LIG_BRCT_BRCA1_1	198	202	PF00533	0.536
LIG_eIF4E_1	161	167	PF01652	0.494
LIG_FHA_1	58	64	PF00498	0.655
LIG_FHA_2	178	184	PF00498	0.573
LIG_Integrin_RGD_1	35	37	PF01839	0.539
LIG_LIR_Nem_3	199	205	PF02991	0.470
LIG_Pex14_2	205	209	PF04695	0.489
LIG_REV1ctd_RIR_1	207	211	PF16727	0.500
LIG_SH2_STAP1	161	165	PF00017	0.551
LIG_SUMO_SIM_par_1	58	64	PF11976	0.493
MOD_CK1_1	125	131	PF00069	0.617
MOD_CK1_1	144	150	PF00069	0.669
MOD_CK1_1	176	182	PF00069	0.496
MOD_CK1_1	82	88	PF00069	0.611
MOD_CK2_1	177	183	PF00069	0.549
MOD_CK2_1	85	91	PF00069	0.624
MOD_GlcNHglycan	1	4	PF01048	0.622
MOD_GlcNHglycan	125	128	PF01048	0.583
MOD_GlcNHglycan	132	135	PF01048	0.605
MOD_GlcNHglycan	146	149	PF01048	0.651
MOD_GlcNHglycan	63	66	PF01048	0.645
MOD_GlcNHglycan	68	71	PF01048	0.625
MOD_GlcNHglycan	73	76	PF01048	0.602
MOD_GSK3_1	118	125	PF00069	0.558
MOD_GSK3_1	126	133	PF00069	0.614
MOD_GSK3_1	140	147	PF00069	0.539
MOD_GSK3_1	173	180	PF00069	0.607
MOD_GSK3_1	20	27	PF00069	0.689
MOD_GSK3_1	57	64	PF00069	0.625
MOD_GSK3_1	66	73	PF00069	0.572
MOD_GSK3_1	79	86	PF00069	0.566
MOD_N-GLC_1	193	198	PF02516	0.487
MOD_NEK2_1	66	71	PF00069	0.646
MOD_NEK2_1	79	84	PF00069	0.691
MOD_PIKK_1	193	199	PF00454	0.538
MOD_PIKK_1	20	26	PF00454	0.621
MOD_PK_1	188	194	PF00069	0.543
MOD_PKA_2	66	72	PF00069	0.535
MOD_PKA_2	80	86	PF00069	0.679
MOD_PKB_1	18	26	PF00069	0.615
MOD_Plk_4	11	17	PF00069	0.563
MOD_Plk_4	188	194	PF00069	0.685
MOD_ProDKin_1	142	148	PF00069	0.779
TRG_ER_diArg_1	111	114	PF00400	0.604
TRG_ER_diArg_1	167	170	PF00400	0.515
TRG_ER_diArg_1	18	20	PF00400	0.563
TRG_NLS_MonoCore_2	16	21	PF00514	0.561
TRG_NLS_MonoExtC_3	16	22	PF00514	0.624

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U6	Leptomonas seymouri	48%	100%
A0A3S7X6R7	Leishmania donovani	95%	98%
A4HLI7	Leishmania braziliensis	72%	100%
D0A4Z8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B3W6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q458	Leishmania major	90%	100%
V5BLV0	Trypanosoma cruzi	30%	100%