LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Major Facilitator Superfamily/Nucleoside H+ symporter/LacY proton/sugar symporter - putative
Species:
Leishmania infantum
UniProt:
A4I8Z5_LEIIN
TriTrypDb:
LINF_330020600
Length:
591

Annotations

LeishMANIAdb annotations

Appears to be a transporter, related to vertebrate MFSD6 proteins (whose function is likewise unexplored).. Only expanded in Leptomonas.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0016020 membrane 2 13
GO:0110165 cellular anatomical entity 1 13

Expansion

Sequence features

A4I8Z5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8Z5

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 3
GO:0022857 transmembrane transporter activity 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 16 20 PF00656 0.715
CLV_C14_Caspase3-7 329 333 PF00656 0.419
CLV_C14_Caspase3-7 91 95 PF00656 0.650
CLV_NRD_NRD_1 10 12 PF00675 0.495
CLV_NRD_NRD_1 466 468 PF00675 0.539
CLV_NRD_NRD_1 526 528 PF00675 0.537
CLV_NRD_NRD_1 544 546 PF00675 0.508
CLV_NRD_NRD_1 567 569 PF00675 0.454
CLV_NRD_NRD_1 88 90 PF00675 0.415
CLV_PCSK_FUR_1 8 12 PF00082 0.495
CLV_PCSK_KEX2_1 10 12 PF00082 0.495
CLV_PCSK_KEX2_1 312 314 PF00082 0.263
CLV_PCSK_KEX2_1 544 546 PF00082 0.509
CLV_PCSK_KEX2_1 566 568 PF00082 0.424
CLV_PCSK_KEX2_1 88 90 PF00082 0.414
CLV_PCSK_PC1ET2_1 312 314 PF00082 0.339
CLV_PCSK_SKI1_1 201 205 PF00082 0.445
CLV_PCSK_SKI1_1 313 317 PF00082 0.242
CLV_PCSK_SKI1_1 372 376 PF00082 0.254
CLV_PCSK_SKI1_1 467 471 PF00082 0.462
DEG_SIAH_1 32 40 PF03145 0.608
DOC_CDC14_PxL_1 161 169 PF14671 0.355
DOC_MAPK_gen_1 173 182 PF00069 0.505
DOC_MAPK_gen_1 293 301 PF00069 0.499
DOC_MAPK_gen_1 312 318 PF00069 0.352
DOC_MAPK_gen_1 566 572 PF00069 0.626
DOC_MAPK_MEF2A_6 377 384 PF00069 0.450
DOC_MAPK_MEF2A_6 399 406 PF00069 0.330
DOC_MAPK_NFAT4_5 399 407 PF00069 0.246
DOC_USP7_MATH_1 46 50 PF00917 0.702
DOC_USP7_MATH_1 538 542 PF00917 0.657
DOC_USP7_MATH_1 548 552 PF00917 0.611
DOC_USP7_MATH_1 93 97 PF00917 0.712
DOC_WW_Pin1_4 99 104 PF00397 0.744
LIG_14-3-3_CanoR_1 175 181 PF00244 0.497
LIG_14-3-3_CanoR_1 235 242 PF00244 0.525
LIG_14-3-3_CanoR_1 550 554 PF00244 0.630
LIG_AP2alpha_1 330 334 PF02296 0.419
LIG_BIR_III_4 503 507 PF00653 0.547
LIG_BIR_III_4 94 98 PF00653 0.638
LIG_BRCT_BRCA1_1 123 127 PF00533 0.440
LIG_BRCT_BRCA1_1 135 139 PF00533 0.189
LIG_BRCT_BRCA1_1 257 261 PF00533 0.462
LIG_BRCT_BRCA1_1 30 34 PF00533 0.625
LIG_BRCT_BRCA1_1 64 68 PF00533 0.661
LIG_CSL_BTD_1 417 420 PF09270 0.338
LIG_EH1_1 146 154 PF00400 0.339
LIG_eIF4E_1 147 153 PF01652 0.339
LIG_FHA_1 108 114 PF00498 0.679
LIG_FHA_1 177 183 PF00498 0.489
LIG_FHA_1 350 356 PF00498 0.336
LIG_FHA_1 411 417 PF00498 0.287
LIG_FHA_1 436 442 PF00498 0.495
LIG_FHA_1 443 449 PF00498 0.376
LIG_FHA_1 476 482 PF00498 0.436
LIG_FHA_1 567 573 PF00498 0.701
LIG_FHA_2 14 20 PF00498 0.684
LIG_FHA_2 194 200 PF00498 0.458
LIG_FHA_2 38 44 PF00498 0.687
LIG_GBD_Chelix_1 268 276 PF00786 0.398
LIG_LIR_Gen_1 236 247 PF02991 0.514
LIG_LIR_Gen_1 264 275 PF02991 0.331
LIG_LIR_Gen_1 31 39 PF02991 0.610
LIG_LIR_Gen_1 326 336 PF02991 0.313
LIG_LIR_Gen_1 398 409 PF02991 0.284
LIG_LIR_Gen_1 413 422 PF02991 0.226
LIG_LIR_Gen_1 459 469 PF02991 0.274
LIG_LIR_Gen_1 65 74 PF02991 0.612
LIG_LIR_Nem_3 236 242 PF02991 0.458
LIG_LIR_Nem_3 244 248 PF02991 0.244
LIG_LIR_Nem_3 264 270 PF02991 0.141
LIG_LIR_Nem_3 31 37 PF02991 0.633
LIG_LIR_Nem_3 326 331 PF02991 0.314
LIG_LIR_Nem_3 332 337 PF02991 0.239
LIG_LIR_Nem_3 398 404 PF02991 0.277
LIG_LIR_Nem_3 459 464 PF02991 0.274
LIG_LIR_Nem_3 65 71 PF02991 0.608
LIG_Pex14_2 123 127 PF04695 0.293
LIG_Pex14_2 330 334 PF04695 0.290
LIG_Pex14_2 414 418 PF04695 0.265
LIG_PTB_Apo_2 330 337 PF02174 0.371
LIG_PTB_Apo_2 67 74 PF02174 0.607
LIG_SH2_CRK 135 139 PF00017 0.239
LIG_SH2_CRK 283 287 PF00017 0.343
LIG_SH2_CRK 394 398 PF00017 0.265
LIG_SH2_CRK 461 465 PF00017 0.304
LIG_SH2_NCK_1 135 139 PF00017 0.278
LIG_SH2_NCK_1 291 295 PF00017 0.450
LIG_SH2_NCK_1 461 465 PF00017 0.339
LIG_SH2_SRC 147 150 PF00017 0.339
LIG_SH2_STAP1 135 139 PF00017 0.339
LIG_SH2_STAT5 169 172 PF00017 0.463
LIG_SH2_STAT5 195 198 PF00017 0.377
LIG_SH2_STAT5 241 244 PF00017 0.524
LIG_SH2_STAT5 263 266 PF00017 0.308
LIG_SH2_STAT5 274 277 PF00017 0.236
LIG_SH2_STAT5 283 286 PF00017 0.141
LIG_SH2_STAT5 461 464 PF00017 0.388
LIG_SH3_3 214 220 PF00018 0.244
LIG_SH3_3 284 290 PF00018 0.384
LIG_SH3_3 496 502 PF00018 0.680
LIG_SUMO_SIM_anti_2 181 189 PF11976 0.384
LIG_SUMO_SIM_par_1 351 356 PF11976 0.303
LIG_SUMO_SIM_par_1 401 407 PF11976 0.307
LIG_SUMO_SIM_par_1 568 576 PF11976 0.665
LIG_TYR_ITIM 281 286 PF00017 0.371
LIG_TYR_ITSM 324 331 PF00017 0.402
LIG_TYR_ITSM 457 464 PF00017 0.419
LIG_UBA3_1 226 232 PF00899 0.438
LIG_WRC_WIRS_1 252 257 PF05994 0.390
LIG_WRC_WIRS_1 441 446 PF05994 0.390
MOD_CK1_1 181 187 PF00069 0.302
MOD_CK1_1 188 194 PF00069 0.238
MOD_CK1_1 22 28 PF00069 0.640
MOD_CK1_1 237 243 PF00069 0.521
MOD_CK1_1 435 441 PF00069 0.460
MOD_CK1_1 540 546 PF00069 0.758
MOD_CK1_1 69 75 PF00069 0.693
MOD_CK2_1 142 148 PF00069 0.278
MOD_CK2_1 193 199 PF00069 0.265
MOD_CK2_1 54 60 PF00069 0.677
MOD_CK2_1 558 564 PF00069 0.601
MOD_Cter_Amidation 564 567 PF01082 0.452
MOD_Cter_Amidation 8 11 PF01082 0.496
MOD_Cter_Amidation 86 89 PF01082 0.403
MOD_GlcNHglycan 144 147 PF01048 0.539
MOD_GlcNHglycan 153 156 PF01048 0.277
MOD_GlcNHglycan 236 239 PF01048 0.312
MOD_GlcNHglycan 366 369 PF01048 0.262
MOD_GlcNHglycan 435 438 PF01048 0.267
MOD_GlcNHglycan 445 448 PF01048 0.272
MOD_GlcNHglycan 540 543 PF01048 0.559
MOD_GlcNHglycan 545 548 PF01048 0.539
MOD_GlcNHglycan 64 67 PF01048 0.555
MOD_GlcNHglycan 82 85 PF01048 0.388
MOD_GlcNHglycan 94 98 PF01048 0.485
MOD_GlcNHglycan 99 102 PF01048 0.459
MOD_GSK3_1 15 22 PF00069 0.766
MOD_GSK3_1 181 188 PF00069 0.274
MOD_GSK3_1 233 240 PF00069 0.508
MOD_GSK3_1 251 258 PF00069 0.255
MOD_GSK3_1 319 326 PF00069 0.335
MOD_GSK3_1 349 356 PF00069 0.269
MOD_GSK3_1 378 385 PF00069 0.481
MOD_GSK3_1 431 438 PF00069 0.443
MOD_GSK3_1 46 53 PF00069 0.697
MOD_GSK3_1 572 579 PF00069 0.661
MOD_GSK3_1 62 69 PF00069 0.605
MOD_GSK3_1 93 100 PF00069 0.712
MOD_N-GLC_1 19 24 PF02516 0.447
MOD_N-GLC_1 51 56 PF02516 0.537
MOD_N-GLC_1 69 74 PF02516 0.430
MOD_NEK2_1 123 128 PF00069 0.324
MOD_NEK2_1 159 164 PF00069 0.362
MOD_NEK2_1 186 191 PF00069 0.311
MOD_NEK2_1 193 198 PF00069 0.277
MOD_NEK2_1 209 214 PF00069 0.342
MOD_NEK2_1 255 260 PF00069 0.322
MOD_NEK2_1 261 266 PF00069 0.306
MOD_NEK2_1 318 323 PF00069 0.280
MOD_NEK2_1 349 354 PF00069 0.367
MOD_NEK2_1 364 369 PF00069 0.488
MOD_NEK2_1 433 438 PF00069 0.484
MOD_NEK2_1 440 445 PF00069 0.265
MOD_NEK2_1 456 461 PF00069 0.238
MOD_NEK2_1 51 56 PF00069 0.746
MOD_PIKK_1 520 526 PF00454 0.645
MOD_PKA_1 566 572 PF00069 0.626
MOD_PKA_2 234 240 PF00069 0.527
MOD_PKA_2 46 52 PF00069 0.754
MOD_PKA_2 538 544 PF00069 0.765
MOD_PKA_2 549 555 PF00069 0.729
MOD_PKA_2 566 572 PF00069 0.626
MOD_PKA_2 87 93 PF00069 0.717
MOD_Plk_1 19 25 PF00069 0.626
MOD_Plk_1 69 75 PF00069 0.710
MOD_Plk_4 159 165 PF00069 0.311
MOD_Plk_4 178 184 PF00069 0.183
MOD_Plk_4 188 194 PF00069 0.281
MOD_Plk_4 251 257 PF00069 0.354
MOD_Plk_4 319 325 PF00069 0.332
MOD_Plk_4 326 332 PF00069 0.285
MOD_Plk_4 349 355 PF00069 0.331
MOD_Plk_4 382 388 PF00069 0.285
MOD_Plk_4 456 462 PF00069 0.312
MOD_Plk_4 46 52 PF00069 0.736
MOD_ProDKin_1 99 105 PF00069 0.744
TRG_DiLeu_BaEn_1 148 153 PF01217 0.278
TRG_DiLeu_BaEn_1 303 308 PF01217 0.527
TRG_DiLeu_BaLyEn_6 154 159 PF01217 0.419
TRG_DiLeu_BaLyEn_6 217 222 PF01217 0.371
TRG_ENDOCYTIC_2 135 138 PF00928 0.269
TRG_ENDOCYTIC_2 283 286 PF00928 0.293
TRG_ENDOCYTIC_2 291 294 PF00928 0.435
TRG_ENDOCYTIC_2 328 331 PF00928 0.293
TRG_ENDOCYTIC_2 394 397 PF00928 0.265
TRG_ENDOCYTIC_2 461 464 PF00928 0.248
TRG_ER_diArg_1 566 568 PF00400 0.624
TRG_ER_diArg_1 7 10 PF00400 0.695
TRG_NES_CRM1_1 346 360 PF08389 0.371
TRG_NES_CRM1_1 488 501 PF08389 0.525
TRG_Pf-PMV_PEXEL_1 372 376 PF00026 0.336

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4U9 Leptomonas seymouri 57% 100%
A0A0S4J6V2 Bodo saltans 36% 100%
A0A0S4JFI6 Bodo saltans 34% 100%
A0A1X0P0X3 Trypanosomatidae 45% 100%
A0A1X0P2H7 Trypanosomatidae 35% 100%
A0A3R7NAF7 Trypanosoma rangeli 37% 100%
A0A3S7X6L2 Leishmania donovani 99% 100%
A4HLI5 Leishmania braziliensis 70% 100%
D0A4Z3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
E9B3W4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
Q4Q460 Leishmania major 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS