Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I8Z0_LEIIN

TriTrypDb:

LINF_330020100

Length:

404

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I8Z0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8Z0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	124	126	PF00675	0.692
CLV_NRD_NRD_1	311	313	PF00675	0.697
CLV_NRD_NRD_1	359	361	PF00675	0.694
CLV_NRD_NRD_1	393	395	PF00675	0.737
CLV_NRD_NRD_1	73	75	PF00675	0.657
CLV_PCSK_KEX2_1	311	313	PF00082	0.697
CLV_PCSK_KEX2_1	359	361	PF00082	0.694
CLV_PCSK_KEX2_1	393	395	PF00082	0.737
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.697
CLV_PCSK_PC7_1	389	395	PF00082	0.597
CLV_PCSK_SKI1_1	76	80	PF00082	0.579
DEG_SPOP_SBC_1	353	357	PF00917	0.669
DOC_CKS1_1	77	82	PF01111	0.682
DOC_CYCLIN_yCln2_LP_2	212	218	PF00134	0.857
DOC_MAPK_MEF2A_6	46	54	PF00069	0.698
DOC_PP2B_LxvP_1	212	215	PF13499	0.850
DOC_PP2B_LxvP_1	225	228	PF13499	0.586
DOC_PP4_FxxP_1	396	399	PF00568	0.613
DOC_PP4_FxxP_1	4	7	PF00568	0.641
DOC_USP7_MATH_1	148	152	PF00917	0.706
DOC_USP7_MATH_1	163	167	PF00917	0.704
DOC_USP7_MATH_1	180	184	PF00917	0.635
DOC_USP7_MATH_1	193	197	PF00917	0.691
DOC_USP7_MATH_1	228	232	PF00917	0.636
DOC_USP7_MATH_1	319	323	PF00917	0.631
DOC_USP7_MATH_1	334	338	PF00917	0.523
DOC_USP7_MATH_1	353	357	PF00917	0.535
DOC_USP7_MATH_1	65	69	PF00917	0.687
DOC_USP7_MATH_1	88	92	PF00917	0.751
DOC_USP7_UBL2_3	62	66	PF12436	0.704
DOC_WW_Pin1_4	103	108	PF00397	0.586
DOC_WW_Pin1_4	133	138	PF00397	0.747
DOC_WW_Pin1_4	202	207	PF00397	0.661
DOC_WW_Pin1_4	226	231	PF00397	0.720
DOC_WW_Pin1_4	253	258	PF00397	0.659
DOC_WW_Pin1_4	277	282	PF00397	0.631
DOC_WW_Pin1_4	30	35	PF00397	0.624
DOC_WW_Pin1_4	332	337	PF00397	0.672
DOC_WW_Pin1_4	76	81	PF00397	0.695
DOC_WW_Pin1_4	82	87	PF00397	0.695
DOC_WW_Pin1_4	89	94	PF00397	0.624
LIG_14-3-3_CanoR_1	125	133	PF00244	0.691
LIG_14-3-3_CanoR_1	359	368	PF00244	0.678
LIG_BIR_II_1	1	5	PF00653	0.607
LIG_BRCT_BRCA1_1	334	338	PF00533	0.680
LIG_BRCT_BRCA1_1	54	58	PF00533	0.691
LIG_FHA_1	128	134	PF00498	0.812
LIG_FHA_1	222	228	PF00498	0.696
LIG_FHA_1	261	267	PF00498	0.600
LIG_LIR_Apic_2	2	7	PF02991	0.655
LIG_LIR_Apic_2	296	302	PF02991	0.673
LIG_LIR_Nem_3	379	385	PF02991	0.621
LIG_MYND_1	302	306	PF01753	0.678
LIG_Pex14_1	326	330	PF04695	0.649
LIG_Pex14_1	377	381	PF04695	0.633
LIG_SH2_STAP1	145	149	PF00017	0.645
LIG_SH2_STAT3	330	333	PF00017	0.557
LIG_SH2_STAT5	145	148	PF00017	0.644
LIG_SH2_STAT5	277	280	PF00017	0.532
LIG_SH2_STAT5	390	393	PF00017	0.707
LIG_SH2_STAT5	395	398	PF00017	0.655
LIG_SH3_3	10	16	PF00018	0.580
LIG_SH3_3	101	107	PF00018	0.631
LIG_SH3_3	114	120	PF00018	0.576
LIG_SH3_3	136	142	PF00018	0.638
LIG_SH3_3	156	162	PF00018	0.698
LIG_SH3_3	164	170	PF00018	0.710
LIG_SH3_3	198	204	PF00018	0.789
LIG_SH3_3	21	27	PF00018	0.522
LIG_SH3_3	28	34	PF00018	0.624
LIG_SH3_3	282	288	PF00018	0.651
LIG_SH3_3	297	303	PF00018	0.516
LIG_SH3_3	3	9	PF00018	0.648
LIG_SH3_3	41	47	PF00018	0.556
LIG_SH3_3	91	97	PF00018	0.746
LIG_TRFH_1	277	281	PF08558	0.538
LIG_TRFH_1	330	334	PF08558	0.649
LIG_WRC_WIRS_1	1	6	PF05994	0.582
LIG_WW_3	200	204	PF00397	0.696
MOD_CDK_SPK_2	82	87	PF00069	0.747
MOD_CK1_1	127	133	PF00069	0.725
MOD_CK1_1	144	150	PF00069	0.852
MOD_CK1_1	151	157	PF00069	0.740
MOD_CK1_1	184	190	PF00069	0.719
MOD_CK1_1	217	223	PF00069	0.649
MOD_CK1_1	253	259	PF00069	0.564
MOD_CK1_1	322	328	PF00069	0.626
MOD_CK1_1	352	358	PF00069	0.582
MOD_CK1_1	82	88	PF00069	0.747
MOD_CK2_1	35	41	PF00069	0.731
MOD_GlcNHglycan	146	149	PF01048	0.740
MOD_GlcNHglycan	150	153	PF01048	0.701
MOD_GlcNHglycan	183	186	PF01048	0.830
MOD_GlcNHglycan	197	200	PF01048	0.611
MOD_GlcNHglycan	216	219	PF01048	0.784
MOD_GlcNHglycan	234	237	PF01048	0.662
MOD_GlcNHglycan	252	255	PF01048	0.495
MOD_GlcNHglycan	316	319	PF01048	0.696
MOD_GlcNHglycan	321	324	PF01048	0.630
MOD_GlcNHglycan	351	354	PF01048	0.747
MOD_GlcNHglycan	369	372	PF01048	0.565
MOD_GlcNHglycan	37	40	PF01048	0.722
MOD_GlcNHglycan	81	84	PF01048	0.733
MOD_GSK3_1	127	134	PF00069	0.726
MOD_GSK3_1	143	150	PF00069	0.824
MOD_GSK3_1	180	187	PF00069	0.796
MOD_GSK3_1	216	223	PF00069	0.642
MOD_GSK3_1	226	233	PF00069	0.572
MOD_GSK3_1	244	251	PF00069	0.711
MOD_GSK3_1	277	284	PF00069	0.636
MOD_GSK3_1	348	355	PF00069	0.811
MOD_GSK3_1	99	106	PF00069	0.707
MOD_N-GLC_1	89	94	PF02516	0.750
MOD_NEK2_1	194	199	PF00069	0.732
MOD_NEK2_1	252	257	PF00069	0.587
MOD_NEK2_1	349	354	PF00069	0.594
MOD_NEK2_1	52	57	PF00069	0.781
MOD_PIKK_1	230	236	PF00454	0.587
MOD_PKA_2	124	130	PF00069	0.726
MOD_PKA_2	377	383	PF00069	0.736
MOD_Plk_4	281	287	PF00069	0.625
MOD_Plk_4	377	383	PF00069	0.650
MOD_ProDKin_1	103	109	PF00069	0.586
MOD_ProDKin_1	133	139	PF00069	0.746
MOD_ProDKin_1	202	208	PF00069	0.661
MOD_ProDKin_1	226	232	PF00069	0.718
MOD_ProDKin_1	253	259	PF00069	0.651
MOD_ProDKin_1	277	283	PF00069	0.632
MOD_ProDKin_1	30	36	PF00069	0.625
MOD_ProDKin_1	332	338	PF00069	0.673
MOD_ProDKin_1	76	82	PF00069	0.701
MOD_ProDKin_1	89	95	PF00069	0.624
MOD_SUMO_rev_2	68	77	PF00179	0.666
TRG_ER_diArg_1	393	395	PF00400	0.735
TRG_NLS_MonoCore_2	310	315	PF00514	0.692
TRG_NLS_MonoExtC_3	311	316	PF00514	0.609
TRG_NLS_MonoExtN_4	308	315	PF00514	0.689

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ITZ0	Leishmania donovani	99%	71%
E9B3V9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q465	Leishmania major	89%	100%