Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain - G-beta repeat - putative

Species:

Leishmania infantum

UniProt:

A4I8Y9_LEIIN

TriTrypDb:

LINF_330020000

Length:

856

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	8
GO:0032991	protein-containing complex	1	8
GO:0043226	organelle	2	8
GO:0043228	non-membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043232	intracellular non-membrane-bounded organelle	4	8
GO:0110165	cellular anatomical entity	1	8
GO:1990904	ribonucleoprotein complex	2	8
GO:0035869	ciliary transition zone	2	2

Expansion

Sequence features

A4I8Y9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8Y9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	39	43	PF00656	0.424
CLV_C14_Caspase3-7	427	431	PF00656	0.535
CLV_C14_Caspase3-7	551	555	PF00656	0.591
CLV_NRD_NRD_1	178	180	PF00675	0.556
CLV_NRD_NRD_1	456	458	PF00675	0.446
CLV_NRD_NRD_1	57	59	PF00675	0.573
CLV_NRD_NRD_1	776	778	PF00675	0.638
CLV_NRD_NRD_1	796	798	PF00675	0.458
CLV_PCSK_FUR_1	793	797	PF00082	0.555
CLV_PCSK_KEX2_1	103	105	PF00082	0.598
CLV_PCSK_KEX2_1	456	458	PF00082	0.494
CLV_PCSK_KEX2_1	479	481	PF00082	0.529
CLV_PCSK_KEX2_1	57	59	PF00082	0.573
CLV_PCSK_KEX2_1	776	778	PF00082	0.638
CLV_PCSK_KEX2_1	792	794	PF00082	0.466
CLV_PCSK_KEX2_1	795	797	PF00082	0.462
CLV_PCSK_KEX2_1	834	836	PF00082	0.641
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.598
CLV_PCSK_PC1ET2_1	479	481	PF00082	0.529
CLV_PCSK_PC1ET2_1	792	794	PF00082	0.543
CLV_PCSK_PC1ET2_1	834	836	PF00082	0.641
CLV_PCSK_PC7_1	475	481	PF00082	0.493
CLV_PCSK_SKI1_1	123	127	PF00082	0.405
CLV_PCSK_SKI1_1	475	479	PF00082	0.636
CLV_PCSK_SKI1_1	834	838	PF00082	0.655
CLV_PCSK_SKI1_1	841	845	PF00082	0.584
CLV_Separin_Metazoa	54	58	PF03568	0.540
DEG_APCC_DBOX_1	500	508	PF00400	0.508
DEG_APCC_DBOX_1	796	804	PF00400	0.656
DEG_SPOP_SBC_1	594	598	PF00917	0.580
DEG_SPOP_SBC_1	847	851	PF00917	0.612
DOC_CYCLIN_RxL_1	117	130	PF00134	0.429
DOC_CYCLIN_yCln2_LP_2	20	26	PF00134	0.517
DOC_CYCLIN_yCln2_LP_2	567	573	PF00134	0.636
DOC_CYCLIN_yCln2_LP_2	588	594	PF00134	0.502
DOC_CYCLIN_yCln2_LP_2	612	618	PF00134	0.587
DOC_MAPK_DCC_7	795	805	PF00069	0.657
DOC_MAPK_gen_1	795	805	PF00069	0.657
DOC_MAPK_MEF2A_6	501	508	PF00069	0.513
DOC_MAPK_MEF2A_6	796	805	PF00069	0.659
DOC_MAPK_NFAT4_5	501	509	PF00069	0.518
DOC_PP1_RVXF_1	360	367	PF00149	0.482
DOC_PP2B_LxvP_1	126	129	PF13499	0.452
DOC_PP2B_LxvP_1	20	23	PF13499	0.545
DOC_PP2B_LxvP_1	506	509	PF13499	0.573
DOC_PP2B_LxvP_1	571	574	PF13499	0.669
DOC_PP2B_LxvP_1	588	591	PF13499	0.610
DOC_PP2B_LxvP_1	610	613	PF13499	0.707
DOC_SPAK_OSR1_1	362	366	PF12202	0.464
DOC_USP7_MATH_1	155	159	PF00917	0.613
DOC_USP7_MATH_1	184	188	PF00917	0.451
DOC_USP7_MATH_1	237	241	PF00917	0.515
DOC_USP7_MATH_1	383	387	PF00917	0.560
DOC_USP7_MATH_1	563	567	PF00917	0.580
DOC_USP7_MATH_1	594	598	PF00917	0.647
DOC_USP7_MATH_1	61	65	PF00917	0.454
DOC_USP7_MATH_1	71	75	PF00917	0.508
DOC_USP7_MATH_1	749	753	PF00917	0.603
DOC_USP7_MATH_1	781	785	PF00917	0.635
DOC_WW_Pin1_4	400	405	PF00397	0.556
DOC_WW_Pin1_4	528	533	PF00397	0.719
DOC_WW_Pin1_4	753	758	PF00397	0.559
DOC_WW_Pin1_4	779	784	PF00397	0.633
DOC_WW_Pin1_4	814	819	PF00397	0.641
LIG_14-3-3_CanoR_1	104	108	PF00244	0.527
LIG_14-3-3_CanoR_1	179	188	PF00244	0.436
LIG_14-3-3_CanoR_1	216	223	PF00244	0.300
LIG_14-3-3_CanoR_1	309	314	PF00244	0.419
LIG_14-3-3_CanoR_1	342	350	PF00244	0.456
LIG_14-3-3_CanoR_1	409	413	PF00244	0.541
LIG_14-3-3_CanoR_1	438	444	PF00244	0.552
LIG_14-3-3_CanoR_1	514	520	PF00244	0.559
LIG_14-3-3_CanoR_1	86	92	PF00244	0.583
LIG_BIR_III_4	284	288	PF00653	0.420
LIG_BRCT_BRCA1_1	440	444	PF00533	0.552
LIG_deltaCOP1_diTrp_1	34	40	PF00928	0.448
LIG_EVH1_1	610	614	PF00568	0.715
LIG_FHA_1	169	175	PF00498	0.530
LIG_FHA_1	180	186	PF00498	0.360
LIG_FHA_1	244	250	PF00498	0.508
LIG_FHA_1	326	332	PF00498	0.434
LIG_FHA_1	414	420	PF00498	0.554
LIG_FHA_1	50	56	PF00498	0.562
LIG_FHA_1	522	528	PF00498	0.544
LIG_FHA_1	529	535	PF00498	0.656
LIG_FHA_1	573	579	PF00498	0.570
LIG_FHA_1	594	600	PF00498	0.586
LIG_FHA_1	653	659	PF00498	0.693
LIG_FHA_1	785	791	PF00498	0.621
LIG_FHA_1	842	848	PF00498	0.673
LIG_FHA_2	29	35	PF00498	0.465
LIG_FHA_2	37	43	PF00498	0.386
LIG_FHA_2	498	504	PF00498	0.500
LIG_FHA_2	521	527	PF00498	0.648
LIG_FHA_2	549	555	PF00498	0.590
LIG_FHA_2	818	824	PF00498	0.691
LIG_LIR_Gen_1	34	45	PF02991	0.609
LIG_LIR_Gen_1	380	390	PF02991	0.583
LIG_LIR_LC3C_4	17	22	PF02991	0.566
LIG_LIR_Nem_3	190	194	PF02991	0.404
LIG_LIR_Nem_3	34	40	PF02991	0.448
LIG_LIR_Nem_3	402	408	PF02991	0.563
LIG_MAD2	18	26	PF02301	0.488
LIG_NRBOX	173	179	PF00104	0.475
LIG_SH2_SRC	194	197	PF00017	0.352
LIG_SH2_SRC	232	235	PF00017	0.508
LIG_SH2_STAP1	214	218	PF00017	0.396
LIG_SH2_STAT5	194	197	PF00017	0.434
LIG_SH2_STAT5	262	265	PF00017	0.463
LIG_SH2_STAT5	530	533	PF00017	0.633
LIG_SH2_STAT5	773	776	PF00017	0.627
LIG_SH3_3	19	25	PF00018	0.473
LIG_SH3_3	351	357	PF00018	0.453
LIG_SH3_3	567	573	PF00018	0.646
LIG_SH3_3	598	604	PF00018	0.669
LIG_SH3_3	605	611	PF00018	0.600
LIG_SH3_3	626	632	PF00018	0.782
LIG_SH3_3	639	645	PF00018	0.710
LIG_SUMO_SIM_anti_2	17	23	PF11976	0.567
LIG_SUMO_SIM_anti_2	173	179	PF11976	0.385
LIG_SUMO_SIM_par_1	124	130	PF11976	0.515
LIG_SUMO_SIM_par_1	25	31	PF11976	0.435
LIG_UBA3_1	174	180	PF00899	0.476
MOD_CDK_SPxK_1	400	406	PF00069	0.560
MOD_CDK_SPxxK_3	779	786	PF00069	0.635
MOD_CK1_1	158	164	PF00069	0.730
MOD_CK1_1	170	176	PF00069	0.423
MOD_CK1_1	28	34	PF00069	0.560
MOD_CK1_1	322	328	PF00069	0.448
MOD_CK1_1	400	406	PF00069	0.560
MOD_CK1_1	547	553	PF00069	0.702
MOD_CK1_1	565	571	PF00069	0.505
MOD_CK1_1	634	640	PF00069	0.790
MOD_CK1_1	643	649	PF00069	0.610
MOD_CK1_1	69	75	PF00069	0.643
MOD_CK1_1	784	790	PF00069	0.618
MOD_CK1_1	8	14	PF00069	0.680
MOD_CK1_1	81	87	PF00069	0.534
MOD_CK1_1	817	823	PF00069	0.638
MOD_CK2_1	184	190	PF00069	0.413
MOD_CK2_1	194	200	PF00069	0.313
MOD_CK2_1	349	355	PF00069	0.418
MOD_CK2_1	38	44	PF00069	0.422
MOD_CK2_1	383	389	PF00069	0.707
MOD_CK2_1	444	450	PF00069	0.537
MOD_CK2_1	497	503	PF00069	0.451
MOD_CK2_1	817	823	PF00069	0.688
MOD_CK2_1	827	833	PF00069	0.585
MOD_DYRK1A_RPxSP_1	814	818	PF00069	0.598
MOD_GlcNHglycan	117	120	PF01048	0.387
MOD_GlcNHglycan	157	160	PF01048	0.708
MOD_GlcNHglycan	196	199	PF01048	0.350
MOD_GlcNHglycan	239	242	PF01048	0.326
MOD_GlcNHglycan	266	269	PF01048	0.521
MOD_GlcNHglycan	281	284	PF01048	0.357
MOD_GlcNHglycan	285	288	PF01048	0.374
MOD_GlcNHglycan	306	309	PF01048	0.516
MOD_GlcNHglycan	321	324	PF01048	0.348
MOD_GlcNHglycan	335	338	PF01048	0.475
MOD_GlcNHglycan	351	354	PF01048	0.419
MOD_GlcNHglycan	385	388	PF01048	0.461
MOD_GlcNHglycan	399	402	PF01048	0.474
MOD_GlcNHglycan	535	538	PF01048	0.636
MOD_GlcNHglycan	541	544	PF01048	0.606
MOD_GlcNHglycan	580	583	PF01048	0.711
MOD_GlcNHglycan	585	588	PF01048	0.560
MOD_GlcNHglycan	605	608	PF01048	0.668
MOD_GlcNHglycan	63	66	PF01048	0.534
MOD_GlcNHglycan	633	636	PF01048	0.786
MOD_GlcNHglycan	68	71	PF01048	0.602
MOD_GlcNHglycan	73	76	PF01048	0.614
MOD_GlcNHglycan	736	739	PF01048	0.592
MOD_GlcNHglycan	750	754	PF01048	0.546
MOD_GlcNHglycan	827	830	PF01048	0.651
MOD_GlcNHglycan	87	90	PF01048	0.520
MOD_GlcNHglycan	98	101	PF01048	0.564
MOD_GSK3_1	103	110	PF00069	0.625
MOD_GSK3_1	163	170	PF00069	0.654
MOD_GSK3_1	179	186	PF00069	0.418
MOD_GSK3_1	239	246	PF00069	0.527
MOD_GSK3_1	253	260	PF00069	0.359
MOD_GSK3_1	279	286	PF00069	0.440
MOD_GSK3_1	321	328	PF00069	0.397
MOD_GSK3_1	393	400	PF00069	0.552
MOD_GSK3_1	544	551	PF00069	0.696
MOD_GSK3_1	574	581	PF00069	0.661
MOD_GSK3_1	730	737	PF00069	0.576
MOD_GSK3_1	749	756	PF00069	0.507
MOD_GSK3_1	781	788	PF00069	0.628
MOD_GSK3_1	81	88	PF00069	0.659
MOD_GSK3_1	810	817	PF00069	0.659
MOD_GSK3_1	823	830	PF00069	0.591
MOD_GSK3_1	837	844	PF00069	0.548
MOD_GSK3_1	849	856	PF00069	0.548
MOD_N-GLC_1	594	599	PF02516	0.477
MOD_N-GLC_2	143	145	PF02516	0.445
MOD_NEK2_1	139	144	PF00069	0.497
MOD_NEK2_1	217	222	PF00069	0.404
MOD_NEK2_1	257	262	PF00069	0.452
MOD_NEK2_1	408	413	PF00069	0.486
MOD_NEK2_1	444	449	PF00069	0.530
MOD_NEK2_1	497	502	PF00069	0.502
MOD_NEK2_1	538	543	PF00069	0.746
MOD_NEK2_1	763	768	PF00069	0.618
MOD_NEK2_1	79	84	PF00069	0.605
MOD_NEK2_2	253	258	PF00069	0.391
MOD_PIKK_1	262	268	PF00454	0.429
MOD_PIKK_1	413	419	PF00454	0.535
MOD_PKA_1	103	109	PF00069	0.587
MOD_PKA_1	179	185	PF00069	0.447
MOD_PKA_1	834	840	PF00069	0.634
MOD_PKA_2	103	109	PF00069	0.485
MOD_PKA_2	167	173	PF00069	0.557
MOD_PKA_2	257	263	PF00069	0.523
MOD_PKA_2	341	347	PF00069	0.451
MOD_PKA_2	408	414	PF00069	0.469
MOD_PKA_2	47	53	PF00069	0.588
MOD_PKA_2	763	769	PF00069	0.612
MOD_PKA_2	785	791	PF00069	0.621
MOD_PKA_2	834	840	PF00069	0.625
MOD_PKA_2	85	91	PF00069	0.583
MOD_PKB_1	810	818	PF00069	0.644
MOD_Plk_1	243	249	PF00069	0.507
MOD_Plk_1	594	600	PF00069	0.477
MOD_Plk_2-3	393	399	PF00069	0.552
MOD_Plk_4	170	176	PF00069	0.487
MOD_Plk_4	393	399	PF00069	0.598
MOD_Plk_4	439	445	PF00069	0.550
MOD_ProDKin_1	400	406	PF00069	0.560
MOD_ProDKin_1	528	534	PF00069	0.721
MOD_ProDKin_1	753	759	PF00069	0.559
MOD_ProDKin_1	779	785	PF00069	0.634
MOD_ProDKin_1	814	820	PF00069	0.640
MOD_SUMO_for_1	791	794	PF00179	0.615
MOD_SUMO_for_1	803	806	PF00179	0.577
MOD_SUMO_rev_2	817	826	PF00179	0.665
TRG_DiLeu_BaEn_1	234	239	PF01217	0.621
TRG_DiLeu_BaEn_1	503	508	PF01217	0.518
TRG_ENDOCYTIC_2	214	217	PF00928	0.405
TRG_ENDOCYTIC_2	382	385	PF00928	0.690
TRG_ENDOCYTIC_2	405	408	PF00928	0.538
TRG_ER_diArg_1	456	458	PF00400	0.477
TRG_ER_diArg_1	468	471	PF00400	0.405
TRG_ER_diArg_1	56	58	PF00400	0.593
TRG_ER_diArg_1	776	778	PF00400	0.638
TRG_ER_diArg_1	795	797	PF00400	0.462
TRG_Pf-PMV_PEXEL_1	229	234	PF00026	0.308
TRG_Pf-PMV_PEXEL_1	456	460	PF00026	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P0X2	Trypanosomatidae	31%	100%
A0A3S7X6R5	Leishmania donovani	97%	99%
A4HLH8	Leishmania braziliensis	28%	95%
A4HLH9	Leishmania braziliensis	75%	100%
E9B3V8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q466	Leishmania major	94%	100%
Q4Q467	Leishmania major	30%	100%