Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain - G-beta repeat - putative

Species:

Leishmania infantum

UniProt:

A4I8Y8_LEIIN

TriTrypDb:

LINF_330019900

Length:

621

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	10
GO:0032991	protein-containing complex	1	10
GO:0043226	organelle	2	10
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:1990904	ribonucleoprotein complex	2	10
GO:0035869	ciliary transition zone	2	2

Expansion

Sequence features

A4I8Y8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8Y8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	375	379	PF00656	0.434
CLV_NRD_NRD_1	116	118	PF00675	0.440
CLV_NRD_NRD_1	253	255	PF00675	0.361
CLV_NRD_NRD_1	420	422	PF00675	0.549
CLV_NRD_NRD_1	430	432	PF00675	0.474
CLV_NRD_NRD_1	617	619	PF00675	0.691
CLV_NRD_NRD_1	77	79	PF00675	0.448
CLV_PCSK_FUR_1	75	79	PF00082	0.455
CLV_PCSK_KEX2_1	116	118	PF00082	0.346
CLV_PCSK_KEX2_1	403	405	PF00082	0.584
CLV_PCSK_KEX2_1	430	432	PF00082	0.606
CLV_PCSK_KEX2_1	617	619	PF00082	0.645
CLV_PCSK_KEX2_1	77	79	PF00082	0.448
CLV_PCSK_PC1ET2_1	403	405	PF00082	0.553
CLV_PCSK_SKI1_1	17	21	PF00082	0.491
CLV_PCSK_SKI1_1	238	242	PF00082	0.429
CLV_PCSK_SKI1_1	374	378	PF00082	0.426
CLV_Separin_Metazoa	427	431	PF03568	0.435
DEG_APCC_DBOX_1	373	381	PF00400	0.417
DEG_APCC_DBOX_1	429	437	PF00400	0.470
DEG_SPOP_SBC_1	449	453	PF00917	0.490
DEG_SPOP_SBC_1	497	501	PF00917	0.705
DOC_MAPK_gen_1	233	242	PF00069	0.440
DOC_MAPK_gen_1	421	428	PF00069	0.438
DOC_MAPK_gen_1	77	87	PF00069	0.459
DOC_PP2B_LxvP_1	537	540	PF13499	0.602
DOC_PP2B_LxvP_1	575	578	PF13499	0.660
DOC_USP7_MATH_1	139	143	PF00917	0.403
DOC_USP7_MATH_1	161	165	PF00917	0.476
DOC_USP7_MATH_1	176	180	PF00917	0.543
DOC_USP7_MATH_1	366	370	PF00917	0.402
DOC_USP7_MATH_1	372	376	PF00917	0.363
DOC_USP7_MATH_1	448	452	PF00917	0.611
DOC_USP7_MATH_1	455	459	PF00917	0.506
DOC_USP7_MATH_1	464	468	PF00917	0.616
DOC_USP7_MATH_1	507	511	PF00917	0.557
DOC_USP7_MATH_1	531	535	PF00917	0.695
DOC_USP7_MATH_1	608	612	PF00917	0.590
DOC_USP7_UBL2_3	399	403	PF12436	0.530
DOC_WW_Pin1_4	466	471	PF00397	0.528
DOC_WW_Pin1_4	487	492	PF00397	0.747
DOC_WW_Pin1_4	499	504	PF00397	0.754
DOC_WW_Pin1_4	521	526	PF00397	0.647
DOC_WW_Pin1_4	8	13	PF00397	0.649
LIG_14-3-3_CanoR_1	249	254	PF00244	0.405
LIG_14-3-3_CanoR_1	336	346	PF00244	0.499
LIG_14-3-3_CanoR_1	421	427	PF00244	0.464
LIG_14-3-3_CanoR_1	511	516	PF00244	0.604
LIG_14-3-3_CanoR_1	549	554	PF00244	0.639
LIG_14-3-3_CterR_2	617	621	PF00244	0.701
LIG_Actin_WH2_2	239	256	PF00022	0.452
LIG_APCC_ABBA_1	106	111	PF00400	0.431
LIG_BRCT_BRCA1_1	140	144	PF00533	0.326
LIG_CtBP_PxDLS_1	492	496	PF00389	0.515
LIG_EVH1_1	575	579	PF00568	0.655
LIG_FHA_1	183	189	PF00498	0.470
LIG_FHA_1	338	344	PF00498	0.472
LIG_FHA_1	410	416	PF00498	0.448
LIG_FHA_1	421	427	PF00498	0.478
LIG_FHA_1	43	49	PF00498	0.388
LIG_FHA_1	435	441	PF00498	0.452
LIG_FHA_1	60	66	PF00498	0.533
LIG_FHA_2	405	411	PF00498	0.418
LIG_FHA_2	469	475	PF00498	0.723
LIG_Integrin_RGD_1	133	135	PF01839	0.374
LIG_LIR_Gen_1	211	220	PF02991	0.266
LIG_LIR_Gen_1	44	55	PF02991	0.498
LIG_LIR_Gen_1	86	95	PF02991	0.459
LIG_LIR_Nem_3	211	216	PF02991	0.259
LIG_LIR_Nem_3	565	571	PF02991	0.673
LIG_LIR_Nem_3	86	91	PF02991	0.456
LIG_LYPXL_SIV_4	344	352	PF13949	0.536
LIG_PCNA_yPIPBox_3	225	238	PF02747	0.333
LIG_SH2_CRK	88	92	PF00017	0.461
LIG_SH2_SRC	171	174	PF00017	0.487
LIG_SH2_SRC	568	571	PF00017	0.593
LIG_SH2_STAP1	109	113	PF00017	0.464
LIG_SH2_STAP1	339	343	PF00017	0.482
LIG_SH2_STAT3	339	342	PF00017	0.544
LIG_SH2_STAT5	109	112	PF00017	0.497
LIG_SH2_STAT5	127	130	PF00017	0.332
LIG_SH2_STAT5	166	169	PF00017	0.465
LIG_SH2_STAT5	270	273	PF00017	0.394
LIG_SH2_STAT5	303	306	PF00017	0.455
LIG_SH2_STAT5	339	342	PF00017	0.532
LIG_SH2_STAT5	345	348	PF00017	0.538
LIG_SH3_1	444	450	PF00018	0.561
LIG_SH3_2	536	541	PF14604	0.585
LIG_SH3_2	593	598	PF14604	0.571
LIG_SH3_3	444	450	PF00018	0.651
LIG_SH3_3	479	485	PF00018	0.654
LIG_SH3_3	486	492	PF00018	0.713
LIG_SH3_3	506	512	PF00018	0.660
LIG_SH3_3	517	523	PF00018	0.589
LIG_SH3_3	533	539	PF00018	0.722
LIG_SH3_3	541	547	PF00018	0.758
LIG_SH3_3	573	579	PF00018	0.645
LIG_SH3_3	580	586	PF00018	0.676
LIG_SH3_3	588	594	PF00018	0.751
LIG_SH3_CIN85_PxpxPR_1	536	541	PF14604	0.537
LIG_SUMO_SIM_anti_2	361	367	PF11976	0.573
LIG_SUMO_SIM_anti_2	425	430	PF11976	0.407
LIG_SUMO_SIM_par_1	485	490	PF11976	0.606
LIG_SUMO_SIM_par_1	83	89	PF11976	0.449
LIG_TRAF2_1	407	410	PF00917	0.514
LIG_WRC_WIRS_1	373	378	PF05994	0.513
LIG_WRC_WIRS_1	66	71	PF05994	0.387
LIG_WW_3	538	542	PF00397	0.539
MOD_CDK_SPxxK_3	8	15	PF00069	0.530
MOD_CK1_1	142	148	PF00069	0.331
MOD_CK1_1	181	187	PF00069	0.450
MOD_CK1_1	193	199	PF00069	0.346
MOD_CK1_1	289	295	PF00069	0.451
MOD_CK1_1	41	47	PF00069	0.491
MOD_CK1_1	496	502	PF00069	0.709
MOD_CK1_1	510	516	PF00069	0.591
MOD_CK2_1	404	410	PF00069	0.506
MOD_CK2_1	468	474	PF00069	0.739
MOD_DYRK1A_RPxSP_1	8	12	PF00069	0.534
MOD_GlcNHglycan	102	105	PF01048	0.449
MOD_GlcNHglycan	123	126	PF01048	0.406
MOD_GlcNHglycan	178	181	PF01048	0.278
MOD_GlcNHglycan	192	195	PF01048	0.463
MOD_GlcNHglycan	206	209	PF01048	0.590
MOD_GlcNHglycan	210	213	PF01048	0.359
MOD_GlcNHglycan	221	224	PF01048	0.442
MOD_GlcNHglycan	225	228	PF01048	0.400
MOD_GlcNHglycan	263	266	PF01048	0.397
MOD_GlcNHglycan	291	294	PF01048	0.419
MOD_GlcNHglycan	306	309	PF01048	0.421
MOD_GlcNHglycan	366	369	PF01048	0.540
MOD_GlcNHglycan	441	444	PF01048	0.676
MOD_GlcNHglycan	457	460	PF01048	0.492
MOD_GlcNHglycan	466	469	PF01048	0.619
MOD_GlcNHglycan	494	498	PF01048	0.791
MOD_GlcNHglycan	516	519	PF01048	0.690
MOD_GlcNHglycan	533	536	PF01048	0.662
MOD_GlcNHglycan	551	554	PF01048	0.697
MOD_GlcNHglycan	609	613	PF01048	0.672
MOD_GSK3_1	117	124	PF00069	0.544
MOD_GSK3_1	138	145	PF00069	0.386
MOD_GSK3_1	17	24	PF00069	0.552
MOD_GSK3_1	178	185	PF00069	0.546
MOD_GSK3_1	204	211	PF00069	0.488
MOD_GSK3_1	215	222	PF00069	0.559
MOD_GSK3_1	306	313	PF00069	0.392
MOD_GSK3_1	37	44	PF00069	0.482
MOD_GSK3_1	372	379	PF00069	0.424
MOD_GSK3_1	405	412	PF00069	0.538
MOD_GSK3_1	434	441	PF00069	0.537
MOD_GSK3_1	462	469	PF00069	0.528
MOD_GSK3_1	493	500	PF00069	0.787
MOD_GSK3_1	503	510	PF00069	0.689
MOD_GSK3_1	527	534	PF00069	0.818
MOD_GSK3_1	560	567	PF00069	0.606
MOD_GSK3_1	613	620	PF00069	0.756
MOD_N-GLC_1	42	47	PF02516	0.462
MOD_NEK2_1	144	149	PF00069	0.417
MOD_NEK2_1	304	309	PF00069	0.426
MOD_NEK2_1	376	381	PF00069	0.431
MOD_NEK2_1	38	43	PF00069	0.427
MOD_NEK2_1	436	441	PF00069	0.436
MOD_NEK2_1	498	503	PF00069	0.772
MOD_NEK2_1	99	104	PF00069	0.382
MOD_NEK2_2	83	88	PF00069	0.352
MOD_PIKK_1	144	150	PF00454	0.392
MOD_PIKK_1	338	344	PF00454	0.548
MOD_PKA_2	204	210	PF00069	0.481
MOD_PKA_2	383	389	PF00069	0.478
MOD_PKA_2	420	426	PF00069	0.444
MOD_PKA_2	434	440	PF00069	0.404
MOD_PKA_2	510	516	PF00069	0.631
MOD_PKA_2	548	554	PF00069	0.729
MOD_Plk_1	142	148	PF00069	0.419
MOD_Plk_1	17	23	PF00069	0.627
MOD_Plk_1	181	187	PF00069	0.471
MOD_Plk_1	275	281	PF00069	0.481
MOD_Plk_1	310	316	PF00069	0.451
MOD_Plk_1	42	48	PF00069	0.458
MOD_Plk_1	493	499	PF00069	0.770
MOD_Plk_4	275	281	PF00069	0.481
MOD_Plk_4	42	48	PF00069	0.458
MOD_Plk_4	511	517	PF00069	0.759
MOD_Plk_4	83	89	PF00069	0.420
MOD_ProDKin_1	466	472	PF00069	0.528
MOD_ProDKin_1	487	493	PF00069	0.748
MOD_ProDKin_1	499	505	PF00069	0.751
MOD_ProDKin_1	521	527	PF00069	0.647
MOD_ProDKin_1	8	14	PF00069	0.646
MOD_SUMO_rev_2	24	29	PF00179	0.446
MOD_SUMO_rev_2	416	423	PF00179	0.441
TRG_DiLeu_BaEn_1	173	178	PF01217	0.551
TRG_DiLeu_BaEn_1	358	363	PF01217	0.473
TRG_DiLeu_BaLyEn_6	152	157	PF01217	0.286
TRG_ENDOCYTIC_2	200	203	PF00928	0.473
TRG_ENDOCYTIC_2	391	394	PF00928	0.454
TRG_ENDOCYTIC_2	568	571	PF00928	0.596
TRG_ENDOCYTIC_2	88	91	PF00928	0.490
TRG_ER_diArg_1	115	117	PF00400	0.346
TRG_ER_diArg_1	429	431	PF00400	0.452
TRG_ER_diArg_1	617	619	PF00400	0.703
TRG_ER_diArg_1	74	77	PF00400	0.609
TRG_Pf-PMV_PEXEL_1	168	173	PF00026	0.287
TRG_Pf-PMV_PEXEL_1	357	361	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I367	Leptomonas seymouri	68%	91%
A0A1X0P0X2	Trypanosomatidae	39%	94%
A0A1X0P178	Trypanosomatidae	37%	100%
A0A3Q8IGU1	Leishmania donovani	99%	100%
A0A422N1N7	Trypanosoma rangeli	22%	72%
A4HLH8	Leishmania braziliensis	74%	98%
A4HLH9	Leishmania braziliensis	30%	100%
E9B3V7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
E9B3V8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	71%
Q4Q466	Leishmania major	29%	73%
Q4Q467	Leishmania major	92%	100%