LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
ATPase family associated with various cellular activities (AAA)/AAA domain (dynein-related subfamily) - putative
Species:
Leishmania infantum
UniProt:
A4I8Y5_LEIIN
TriTrypDb:
LINF_330019600
Length:
656

Annotations

Annotations by Jardim et al.

ER/Golgi Proteins, AAA ATPase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 16
NetGPI no yes: 0, no: 16
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

A4I8Y5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8Y5

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 17
GO:0003824 catalytic activity 1 17
GO:0005488 binding 1 17
GO:0005524 ATP binding 5 17
GO:0016462 pyrophosphatase activity 5 17
GO:0016787 hydrolase activity 2 17
GO:0016817 hydrolase activity, acting on acid anhydrides 3 17
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 17
GO:0016887 ATP hydrolysis activity 7 17
GO:0017076 purine nucleotide binding 4 17
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 17
GO:0030554 adenyl nucleotide binding 5 17
GO:0032553 ribonucleotide binding 3 17
GO:0032555 purine ribonucleotide binding 4 17
GO:0032559 adenyl ribonucleotide binding 5 17
GO:0035639 purine ribonucleoside triphosphate binding 4 17
GO:0036094 small molecule binding 2 17
GO:0043167 ion binding 2 17
GO:0043168 anion binding 3 17
GO:0097159 organic cyclic compound binding 2 17
GO:0097367 carbohydrate derivative binding 2 17
GO:1901265 nucleoside phosphate binding 3 17
GO:1901363 heterocyclic compound binding 2 17

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 112 116 PF00656 0.617
CLV_C14_Caspase3-7 381 385 PF00656 0.741
CLV_C14_Caspase3-7 410 414 PF00656 0.506
CLV_C14_Caspase3-7 455 459 PF00656 0.785
CLV_C14_Caspase3-7 58 62 PF00656 0.565
CLV_NRD_NRD_1 261 263 PF00675 0.471
CLV_NRD_NRD_1 439 441 PF00675 0.533
CLV_PCSK_FUR_1 437 441 PF00082 0.579
CLV_PCSK_KEX2_1 261 263 PF00082 0.499
CLV_PCSK_KEX2_1 351 353 PF00082 0.285
CLV_PCSK_KEX2_1 382 384 PF00082 0.402
CLV_PCSK_KEX2_1 439 441 PF00082 0.540
CLV_PCSK_KEX2_1 507 509 PF00082 0.508
CLV_PCSK_PC1ET2_1 351 353 PF00082 0.322
CLV_PCSK_PC1ET2_1 382 384 PF00082 0.402
CLV_PCSK_PC1ET2_1 507 509 PF00082 0.543
CLV_PCSK_SKI1_1 244 248 PF00082 0.410
CLV_PCSK_SKI1_1 284 288 PF00082 0.355
CLV_PCSK_SKI1_1 326 330 PF00082 0.315
CLV_PCSK_SKI1_1 352 356 PF00082 0.301
CLV_PCSK_SKI1_1 370 374 PF00082 0.418
CLV_PCSK_SKI1_1 485 489 PF00082 0.595
CLV_PCSK_SKI1_1 513 517 PF00082 0.350
CLV_PCSK_SKI1_1 591 595 PF00082 0.394
CLV_PCSK_SKI1_1 83 87 PF00082 0.393
CLV_PCSK_SKI1_1 92 96 PF00082 0.424
CLV_Separin_Metazoa 645 649 PF03568 0.555
DEG_Nend_UBRbox_2 1 3 PF02207 0.392
DOC_CYCLIN_RxL_1 192 203 PF00134 0.634
DOC_CYCLIN_RxL_1 259 269 PF00134 0.601
DOC_CYCLIN_yCln2_LP_2 296 302 PF00134 0.530
DOC_CYCLIN_yCln2_LP_2 399 405 PF00134 0.525
DOC_MAPK_gen_1 351 359 PF00069 0.485
DOC_PP1_RVXF_1 260 267 PF00149 0.757
DOC_PP2B_LxvP_1 106 109 PF13499 0.655
DOC_SPAK_OSR1_1 376 380 PF12202 0.576
DOC_SPAK_OSR1_1 97 101 PF12202 0.664
DOC_USP7_MATH_1 176 180 PF00917 0.701
DOC_USP7_MATH_1 200 204 PF00917 0.619
DOC_USP7_MATH_1 205 209 PF00917 0.606
DOC_USP7_MATH_1 227 231 PF00917 0.578
DOC_USP7_MATH_1 32 36 PF00917 0.365
DOC_USP7_MATH_1 599 603 PF00917 0.603
DOC_USP7_MATH_1 615 619 PF00917 0.753
DOC_USP7_UBL2_3 313 317 PF12436 0.555
DOC_USP7_UBL2_3 378 382 PF12436 0.595
DOC_USP7_UBL2_3 503 507 PF12436 0.764
DOC_WW_Pin1_4 129 134 PF00397 0.671
DOC_WW_Pin1_4 489 494 PF00397 0.787
DOC_WW_Pin1_4 623 628 PF00397 0.515
LIG_14-3-3_CanoR_1 140 147 PF00244 0.678
LIG_14-3-3_CanoR_1 148 152 PF00244 0.694
LIG_14-3-3_CanoR_1 361 369 PF00244 0.545
LIG_14-3-3_CanoR_1 52 57 PF00244 0.614
LIG_14-3-3_CanoR_1 574 584 PF00244 0.631
LIG_14-3-3_CanoR_1 83 93 PF00244 0.552
LIG_Actin_WH2_2 134 150 PF00022 0.653
LIG_Actin_WH2_2 3 19 PF00022 0.451
LIG_Actin_WH2_2 538 553 PF00022 0.636
LIG_BRCT_BRCA1_1 294 298 PF00533 0.514
LIG_BRCT_BRCA1_1 373 377 PF00533 0.634
LIG_BRCT_BRCA1_1 63 67 PF00533 0.622
LIG_CSL_BTD_1 44 47 PF09270 0.634
LIG_eIF4E_1 253 259 PF01652 0.613
LIG_FHA_1 118 124 PF00498 0.651
LIG_FHA_1 140 146 PF00498 0.613
LIG_FHA_1 16 22 PF00498 0.415
LIG_FHA_1 3 9 PF00498 0.366
LIG_FHA_1 413 419 PF00498 0.600
LIG_FHA_1 486 492 PF00498 0.803
LIG_FHA_1 519 525 PF00498 0.535
LIG_FHA_1 537 543 PF00498 0.471
LIG_FHA_1 554 560 PF00498 0.511
LIG_FHA_1 578 584 PF00498 0.609
LIG_FHA_1 605 611 PF00498 0.778
LIG_FHA_1 79 85 PF00498 0.597
LIG_FHA_1 89 95 PF00498 0.602
LIG_FHA_2 150 156 PF00498 0.719
LIG_FHA_2 202 208 PF00498 0.693
LIG_FHA_2 348 354 PF00498 0.572
LIG_FHA_2 427 433 PF00498 0.729
LIG_FHA_2 453 459 PF00498 0.820
LIG_FHA_2 495 501 PF00498 0.734
LIG_FHA_2 637 643 PF00498 0.547
LIG_LIR_Apic_2 315 321 PF02991 0.558
LIG_LIR_Gen_1 102 113 PF02991 0.585
LIG_LIR_Gen_1 125 134 PF02991 0.600
LIG_LIR_Gen_1 2 12 PF02991 0.369
LIG_LIR_Gen_1 292 300 PF02991 0.489
LIG_LIR_Nem_3 102 108 PF02991 0.557
LIG_LIR_Nem_3 125 129 PF02991 0.545
LIG_LIR_Nem_3 189 193 PF02991 0.639
LIG_LIR_Nem_3 2 7 PF02991 0.373
LIG_LIR_Nem_3 242 246 PF02991 0.639
LIG_LIR_Nem_3 292 296 PF02991 0.498
LIG_LIR_Nem_3 44 49 PF02991 0.572
LIG_LIR_Nem_3 64 70 PF02991 0.436
LIG_MLH1_MIPbox_1 294 298 PF16413 0.513
LIG_NRBOX 326 332 PF00104 0.423
LIG_NRBOX 589 595 PF00104 0.556
LIG_Pex14_2 293 297 PF04695 0.476
LIG_Pex14_2 373 377 PF04695 0.634
LIG_PTB_Apo_2 6 13 PF02174 0.388
LIG_SH2_CRK 126 130 PF00017 0.628
LIG_SH2_CRK 255 259 PF00017 0.552
LIG_SH2_CRK 318 322 PF00017 0.597
LIG_SH2_CRK 332 336 PF00017 0.408
LIG_SH2_NCK_1 318 322 PF00017 0.627
LIG_SH2_SRC 318 321 PF00017 0.621
LIG_SH2_STAP1 119 123 PF00017 0.632
LIG_SH2_STAP1 4 8 PF00017 0.351
LIG_SH2_STAT3 253 256 PF00017 0.510
LIG_SH2_STAT5 105 108 PF00017 0.553
LIG_SH2_STAT5 119 122 PF00017 0.548
LIG_SH2_STAT5 126 129 PF00017 0.619
LIG_SH2_STAT5 253 256 PF00017 0.520
LIG_SH2_STAT5 285 288 PF00017 0.611
LIG_SH2_STAT5 4 7 PF00017 0.405
LIG_SH2_STAT5 40 43 PF00017 0.507
LIG_SH2_STAT5 407 410 PF00017 0.505
LIG_SH2_STAT5 56 59 PF00017 0.531
LIG_SH2_STAT5 576 579 PF00017 0.596
LIG_SH2_STAT5 89 92 PF00017 0.545
LIG_SH3_1 318 324 PF00018 0.624
LIG_SH3_2 321 326 PF14604 0.545
LIG_SH3_3 296 302 PF00018 0.603
LIG_SH3_3 318 324 PF00018 0.540
LIG_SH3_3 90 96 PF00018 0.624
LIG_SUMO_SIM_anti_2 641 648 PF11976 0.555
LIG_TRAF2_1 175 178 PF00917 0.636
LIG_TRAF2_1 364 367 PF00917 0.515
LIG_TRAF2_1 461 464 PF00917 0.816
LIG_TRAF2_1 639 642 PF00917 0.594
LIG_TYR_ITIM 103 108 PF00017 0.625
LIG_TYR_ITIM 241 246 PF00017 0.538
LIG_UBA3_1 180 187 PF00899 0.529
LIG_UBA3_1 304 313 PF00899 0.571
MOD_CDC14_SPxK_1 132 135 PF00782 0.663
MOD_CDK_SPxK_1 129 135 PF00069 0.666
MOD_CK1_1 15 21 PF00069 0.373
MOD_CK1_1 179 185 PF00069 0.668
MOD_CK1_1 189 195 PF00069 0.637
MOD_CK1_1 208 214 PF00069 0.630
MOD_CK1_1 394 400 PF00069 0.604
MOD_CK1_1 451 457 PF00069 0.773
MOD_CK1_1 55 61 PF00069 0.660
MOD_CK1_1 578 584 PF00069 0.635
MOD_CK2_1 200 206 PF00069 0.690
MOD_CK2_1 227 233 PF00069 0.642
MOD_CK2_1 361 367 PF00069 0.452
MOD_CK2_1 426 432 PF00069 0.732
MOD_CK2_1 454 460 PF00069 0.794
MOD_CK2_1 494 500 PF00069 0.735
MOD_CK2_1 589 595 PF00069 0.632
MOD_CK2_1 623 629 PF00069 0.544
MOD_CK2_1 636 642 PF00069 0.544
MOD_GlcNHglycan 35 38 PF01048 0.442
MOD_GlcNHglycan 373 376 PF01048 0.395
MOD_GlcNHglycan 471 474 PF01048 0.592
MOD_GlcNHglycan 597 600 PF01048 0.450
MOD_GlcNHglycan 61 64 PF01048 0.440
MOD_GlcNHglycan 616 620 PF01048 0.546
MOD_GlcNHglycan 73 76 PF01048 0.502
MOD_GSK3_1 201 208 PF00069 0.713
MOD_GSK3_1 334 341 PF00069 0.426
MOD_GSK3_1 357 364 PF00069 0.492
MOD_GSK3_1 448 455 PF00069 0.761
MOD_GSK3_1 485 492 PF00069 0.752
MOD_GSK3_1 503 510 PF00069 0.569
MOD_GSK3_1 55 62 PF00069 0.652
MOD_GSK3_1 595 602 PF00069 0.625
MOD_GSK3_1 604 611 PF00069 0.764
MOD_GSK3_1 615 622 PF00069 0.670
MOD_GSK3_1 84 91 PF00069 0.591
MOD_LATS_1 167 173 PF00433 0.605
MOD_N-GLC_1 117 122 PF02516 0.425
MOD_N-GLC_1 129 134 PF02516 0.440
MOD_N-GLC_1 469 474 PF02516 0.601
MOD_N-GLC_1 604 609 PF02516 0.491
MOD_N-GLC_1 71 76 PF02516 0.460
MOD_NEK2_1 12 17 PF00069 0.432
MOD_NEK2_1 147 152 PF00069 0.646
MOD_NEK2_1 181 186 PF00069 0.653
MOD_NEK2_1 33 38 PF00069 0.369
MOD_NEK2_1 355 360 PF00069 0.492
MOD_NEK2_1 41 46 PF00069 0.432
MOD_NEK2_1 577 582 PF00069 0.636
MOD_NEK2_2 176 181 PF00069 0.543
MOD_NEK2_2 553 558 PF00069 0.533
MOD_NEK2_2 63 68 PF00069 0.486
MOD_NEK2_2 78 83 PF00069 0.639
MOD_PIKK_1 170 176 PF00454 0.642
MOD_PIKK_1 181 187 PF00454 0.638
MOD_PIKK_1 494 500 PF00454 0.789
MOD_PK_1 104 110 PF00069 0.586
MOD_PKA_1 507 513 PF00069 0.731
MOD_PKA_2 139 145 PF00069 0.626
MOD_PKA_2 147 153 PF00069 0.644
MOD_PKA_2 507 513 PF00069 0.723
MOD_Plk_1 232 238 PF00069 0.560
MOD_Plk_1 615 621 PF00069 0.642
MOD_Plk_2-3 458 464 PF00069 0.786
MOD_Plk_2-3 589 595 PF00069 0.589
MOD_Plk_2-3 636 642 PF00069 0.604
MOD_Plk_4 176 182 PF00069 0.652
MOD_Plk_4 189 195 PF00069 0.648
MOD_Plk_4 227 233 PF00069 0.562
MOD_Plk_4 292 298 PF00069 0.474
MOD_Plk_4 52 58 PF00069 0.654
MOD_Plk_4 545 551 PF00069 0.608
MOD_Plk_4 578 584 PF00069 0.666
MOD_Plk_4 85 91 PF00069 0.587
MOD_ProDKin_1 129 135 PF00069 0.676
MOD_ProDKin_1 489 495 PF00069 0.785
MOD_ProDKin_1 623 629 PF00069 0.512
MOD_SUMO_for_1 420 423 PF00179 0.639
MOD_SUMO_rev_2 237 246 PF00179 0.631
MOD_SUMO_rev_2 309 315 PF00179 0.545
MOD_SUMO_rev_2 99 106 PF00179 0.616
TRG_DiLeu_BaEn_1 589 594 PF01217 0.627
TRG_DiLeu_BaLyEn_6 254 259 PF01217 0.613
TRG_DiLeu_BaLyEn_6 300 305 PF01217 0.610
TRG_ENDOCYTIC_2 105 108 PF00928 0.537
TRG_ENDOCYTIC_2 126 129 PF00928 0.608
TRG_ENDOCYTIC_2 243 246 PF00928 0.581
TRG_ENDOCYTIC_2 255 258 PF00928 0.505
TRG_ENDOCYTIC_2 4 7 PF00928 0.387
TRG_NES_CRM1_1 136 149 PF08389 0.596
TRG_NES_CRM1_1 367 381 PF08389 0.630
TRG_NES_CRM1_1 99 112 PF08389 0.538
TRG_NLS_MonoExtN_4 261 266 PF00514 0.566
TRG_Pf-PMV_PEXEL_1 252 256 PF00026 0.311
TRG_Pf-PMV_PEXEL_1 513 518 PF00026 0.367
TRG_Pf-PMV_PEXEL_1 591 595 PF00026 0.407

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4V2 Leptomonas seymouri 59% 98%
A0A0S4JAD3 Bodo saltans 32% 100%
A0A1X0NTT2 Trypanosomatidae 28% 97%
A0A1X0P2Y3 Trypanosomatidae 28% 100%
A0A1X0P9I4 Trypanosomatidae 29% 81%
A0A3S7X6K2 Leishmania donovani 100% 100%
A0A422NUH1 Trypanosoma rangeli 30% 97%
A0A422P3P3 Trypanosoma rangeli 30% 100%
A4HLH5 Leishmania braziliensis 73% 96%
C9ZQW4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
C9ZSJ9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 98%
D0A1W6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 91%
E9B3V4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4Q470 Leishmania major 93% 100%
V5DQN5 Trypanosoma cruzi 31% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS