LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I8X9_LEIIN
TriTrypDb:
LINF_330019000
Length:
432

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. yes yes: 8
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 2, no: 5
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0016020 membrane 2 4
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 4

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I8X9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8X9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 137 141 PF00656 0.359
CLV_NRD_NRD_1 392 394 PF00675 0.424
CLV_NRD_NRD_1 399 401 PF00675 0.407
CLV_NRD_NRD_1 421 423 PF00675 0.458
CLV_PCSK_FUR_1 397 401 PF00082 0.424
CLV_PCSK_KEX2_1 397 399 PF00082 0.394
CLV_PCSK_PC7_1 393 399 PF00082 0.314
CLV_PCSK_SKI1_1 56 60 PF00082 0.553
DOC_ANK_TNKS_1 398 405 PF00023 0.620
DOC_MAPK_DCC_7 82 90 PF00069 0.264
DOC_MAPK_RevD_3 379 394 PF00069 0.323
DOC_PP4_MxPP_1 320 323 PF00568 0.328
DOC_SPAK_OSR1_1 200 204 PF12202 0.377
DOC_USP7_MATH_1 238 242 PF00917 0.339
DOC_USP7_MATH_1 243 247 PF00917 0.346
DOC_USP7_MATH_1 274 278 PF00917 0.417
DOC_USP7_MATH_1 302 306 PF00917 0.315
DOC_USP7_MATH_1 417 421 PF00917 0.692
DOC_USP7_MATH_1 76 80 PF00917 0.380
DOC_USP7_UBL2_3 204 208 PF12436 0.329
DOC_WW_Pin1_4 279 284 PF00397 0.297
DOC_WW_Pin1_4 298 303 PF00397 0.447
DOC_WW_Pin1_4 318 323 PF00397 0.324
LIG_14-3-3_CanoR_1 393 401 PF00244 0.525
LIG_Actin_WH2_2 377 395 PF00022 0.323
LIG_BRCT_BRCA1_1 144 148 PF00533 0.312
LIG_BRCT_BRCA1_1 154 158 PF00533 0.327
LIG_BRCT_BRCA1_1 253 257 PF00533 0.241
LIG_deltaCOP1_diTrp_1 134 142 PF00928 0.327
LIG_FHA_1 17 23 PF00498 0.365
LIG_FHA_1 172 178 PF00498 0.339
LIG_FHA_1 184 190 PF00498 0.352
LIG_FHA_1 208 214 PF00498 0.317
LIG_FHA_1 290 296 PF00498 0.394
LIG_FHA_1 87 93 PF00498 0.382
LIG_FHA_2 49 55 PF00498 0.381
LIG_FHA_2 57 63 PF00498 0.319
LIG_HCF-1_HBM_1 261 264 PF13415 0.332
LIG_LIR_Gen_1 261 271 PF02991 0.312
LIG_LIR_Gen_1 363 374 PF02991 0.275
LIG_LIR_Nem_3 155 161 PF02991 0.311
LIG_LIR_Nem_3 261 267 PF02991 0.315
LIG_LIR_Nem_3 305 309 PF02991 0.293
LIG_LIR_Nem_3 363 369 PF02991 0.292
LIG_PCNA_APIM_2 198 204 PF02747 0.377
LIG_PCNA_yPIPBox_3 311 320 PF02747 0.391
LIG_Pex14_2 376 380 PF04695 0.384
LIG_SH2_CRK 154 158 PF00017 0.295
LIG_SH2_CRK 199 203 PF00017 0.296
LIG_SH2_PTP2 366 369 PF00017 0.323
LIG_SH2_STAP1 154 158 PF00017 0.295
LIG_SH2_STAT5 325 328 PF00017 0.307
LIG_SH2_STAT5 366 369 PF00017 0.384
LIG_SH3_3 1 7 PF00018 0.414
LIG_SH3_3 220 226 PF00018 0.310
LIG_SUMO_SIM_anti_2 370 376 PF11976 0.338
LIG_SUMO_SIM_par_1 176 181 PF11976 0.335
LIG_SUMO_SIM_par_1 209 217 PF11976 0.317
LIG_SUMO_SIM_par_1 88 94 PF11976 0.363
LIG_TRAF2_1 52 55 PF00917 0.335
LIG_Vh1_VBS_1 371 389 PF01044 0.292
LIG_WW_1 322 325 PF00397 0.343
LIG_WW_2 225 228 PF00397 0.327
LIG_WW_3 321 325 PF00397 0.334
MOD_CAAXbox 429 432 PF01239 0.656
MOD_CDC14_SPxK_1 321 324 PF00782 0.411
MOD_CDK_SPxK_1 318 324 PF00069 0.411
MOD_CK1_1 113 119 PF00069 0.377
MOD_CK1_1 171 177 PF00069 0.461
MOD_CK1_1 183 189 PF00069 0.317
MOD_CK1_1 410 416 PF00069 0.626
MOD_CK2_1 48 54 PF00069 0.378
MOD_GlcNHglycan 122 125 PF01048 0.641
MOD_GlcNHglycan 144 147 PF01048 0.539
MOD_GlcNHglycan 192 195 PF01048 0.453
MOD_GlcNHglycan 240 243 PF01048 0.546
MOD_GlcNHglycan 245 248 PF01048 0.570
MOD_GlcNHglycan 276 279 PF01048 0.536
MOD_GlcNHglycan 30 33 PF01048 0.510
MOD_GlcNHglycan 332 335 PF01048 0.568
MOD_GlcNHglycan 363 366 PF01048 0.652
MOD_GlcNHglycan 79 82 PF01048 0.611
MOD_GSK3_1 113 120 PF00069 0.345
MOD_GSK3_1 126 133 PF00069 0.350
MOD_GSK3_1 140 147 PF00069 0.317
MOD_GSK3_1 176 183 PF00069 0.351
MOD_GSK3_1 203 210 PF00069 0.344
MOD_GSK3_1 248 255 PF00069 0.379
MOD_GSK3_1 289 296 PF00069 0.439
MOD_GSK3_1 298 305 PF00069 0.362
MOD_GSK3_1 338 345 PF00069 0.375
MOD_GSK3_1 35 42 PF00069 0.341
MOD_N-GLC_1 293 298 PF02516 0.472
MOD_N-GLC_1 346 351 PF02516 0.732
MOD_NEK2_1 178 183 PF00069 0.335
MOD_NEK2_1 185 190 PF00069 0.294
MOD_NEK2_1 212 217 PF00069 0.307
MOD_NEK2_1 250 255 PF00069 0.269
MOD_NEK2_1 407 412 PF00069 0.620
MOD_NEK2_1 64 69 PF00069 0.352
MOD_NEK2_1 77 82 PF00069 0.330
MOD_PKA_2 392 398 PF00069 0.546
MOD_Plk_1 293 299 PF00069 0.282
MOD_Plk_4 152 158 PF00069 0.304
MOD_Plk_4 185 191 PF00069 0.376
MOD_Plk_4 207 213 PF00069 0.309
MOD_Plk_4 367 373 PF00069 0.326
MOD_Plk_4 86 92 PF00069 0.281
MOD_Plk_4 99 105 PF00069 0.281
MOD_ProDKin_1 279 285 PF00069 0.299
MOD_ProDKin_1 298 304 PF00069 0.442
MOD_ProDKin_1 318 324 PF00069 0.325
MOD_SUMO_for_1 33 36 PF00179 0.342
MOD_SUMO_rev_2 420 425 PF00179 0.653
MOD_SUMO_rev_2 50 58 PF00179 0.351
TRG_ENDOCYTIC_2 154 157 PF00928 0.296
TRG_ENDOCYTIC_2 199 202 PF00928 0.297
TRG_ENDOCYTIC_2 264 267 PF00928 0.306
TRG_ENDOCYTIC_2 306 309 PF00928 0.290
TRG_ENDOCYTIC_2 366 369 PF00928 0.341
TRG_ER_diArg_1 397 400 PF00400 0.602
TRG_Pf-PMV_PEXEL_1 200 205 PF00026 0.576
TRG_Pf-PMV_PEXEL_1 399 403 PF00026 0.422

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I8J7 Leptomonas seymouri 53% 89%
A0A3S7X6Q5 Leishmania donovani 99% 100%
A4HLG8 Leishmania braziliensis 71% 100%
A4HLG9 Leishmania braziliensis 71% 100%
E9B3U8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4Q476 Leishmania major 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS