Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I8X8_LEIIN

TriTrypDb:

LINF_330018800

Length:

681

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 0
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4I8X8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8X8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	610	614	PF00656	0.787
CLV_NRD_NRD_1	2	4	PF00675	0.754
CLV_NRD_NRD_1	560	562	PF00675	0.451
CLV_NRD_NRD_1	567	569	PF00675	0.445
CLV_NRD_NRD_1	583	585	PF00675	0.521
CLV_PCSK_FUR_1	565	569	PF00082	0.538
CLV_PCSK_KEX2_1	2	4	PF00082	0.756
CLV_PCSK_KEX2_1	567	569	PF00082	0.478
CLV_PCSK_KEX2_1	583	585	PF00082	0.508
CLV_PCSK_PC1ET2_1	569	571	PF00082	0.523
CLV_PCSK_PC7_1	565	571	PF00082	0.423
CLV_PCSK_SKI1_1	165	169	PF00082	0.650
CLV_PCSK_SKI1_1	171	175	PF00082	0.629
CLV_PCSK_SKI1_1	272	276	PF00082	0.655
CLV_PCSK_SKI1_1	569	573	PF00082	0.500
CLV_PCSK_SKI1_1	88	92	PF00082	0.666
CLV_Separin_Metazoa	593	597	PF03568	0.780
DEG_Nend_UBRbox_1	1	4	PF02207	0.677
DEG_SCF_FBW7_1	602	609	PF00400	0.749
DEG_SCF_FBW7_2	587	593	PF00400	0.771
DEG_SPOP_SBC_1	445	449	PF00917	0.395
DEG_SPOP_SBC_1	607	611	PF00917	0.789
DOC_CKS1_1	587	592	PF01111	0.823
DOC_CYCLIN_RxL_1	467	475	PF00134	0.416
DOC_MAPK_MEF2A_6	134	142	PF00069	0.367
DOC_MAPK_MEF2A_6	340	349	PF00069	0.444
DOC_PP1_RVXF_1	205	212	PF00149	0.370
DOC_PP1_RVXF_1	468	475	PF00149	0.421
DOC_PP4_FxxP_1	213	216	PF00568	0.384
DOC_USP7_MATH_1	163	167	PF00917	0.418
DOC_USP7_MATH_1	25	29	PF00917	0.579
DOC_USP7_MATH_1	468	472	PF00917	0.375
DOC_USP7_MATH_1	506	510	PF00917	0.441
DOC_USP7_MATH_1	519	523	PF00917	0.461
DOC_USP7_MATH_1	629	633	PF00917	0.752
DOC_USP7_MATH_1	664	668	PF00917	0.794
DOC_USP7_UBL2_3	569	573	PF12436	0.692
DOC_WW_Pin1_4	177	182	PF00397	0.359
DOC_WW_Pin1_4	338	343	PF00397	0.505
DOC_WW_Pin1_4	393	398	PF00397	0.375
DOC_WW_Pin1_4	481	486	PF00397	0.437
DOC_WW_Pin1_4	586	591	PF00397	0.810
DOC_WW_Pin1_4	602	607	PF00397	0.733
DOC_WW_Pin1_4	654	659	PF00397	0.820
LIG_14-3-3_CanoR_1	2	8	PF00244	0.715
LIG_14-3-3_CanoR_1	366	376	PF00244	0.457
LIG_14-3-3_CanoR_1	654	658	PF00244	0.783
LIG_APCC_ABBA_1	492	497	PF00400	0.405
LIG_BRCT_BRCA1_1	470	474	PF00533	0.411
LIG_FHA_1	101	107	PF00498	0.282
LIG_FHA_1	137	143	PF00498	0.471
LIG_FHA_1	145	151	PF00498	0.383
LIG_FHA_1	178	184	PF00498	0.415
LIG_FHA_1	201	207	PF00498	0.433
LIG_FHA_1	223	229	PF00498	0.433
LIG_FHA_1	260	266	PF00498	0.412
LIG_FHA_1	269	275	PF00498	0.399
LIG_FHA_1	331	337	PF00498	0.407
LIG_FHA_1	400	406	PF00498	0.447
LIG_FHA_1	478	484	PF00498	0.426
LIG_FHA_1	494	500	PF00498	0.317
LIG_FHA_1	531	537	PF00498	0.550
LIG_FHA_1	607	613	PF00498	0.819
LIG_FHA_1	7	13	PF00498	0.456
LIG_FHA_1	81	87	PF00498	0.441
LIG_FHA_2	106	112	PF00498	0.419
LIG_FHA_2	608	614	PF00498	0.670
LIG_FHA_2	64	70	PF00498	0.430
LIG_LIR_Apic_2	212	216	PF02991	0.415
LIG_LIR_Apic_2	36	42	PF02991	0.386
LIG_LIR_Apic_2	475	479	PF02991	0.366
LIG_LIR_Apic_2	59	64	PF02991	0.416
LIG_LIR_Gen_1	324	334	PF02991	0.478
LIG_LIR_Gen_1	396	406	PF02991	0.339
LIG_LIR_Gen_1	427	437	PF02991	0.367
LIG_LIR_Gen_1	487	495	PF02991	0.380
LIG_LIR_Gen_1	631	642	PF02991	0.755
LIG_LIR_Nem_3	324	330	PF02991	0.449
LIG_LIR_Nem_3	427	433	PF02991	0.345
LIG_LIR_Nem_3	440	446	PF02991	0.350
LIG_LIR_Nem_3	471	476	PF02991	0.351
LIG_LIR_Nem_3	487	492	PF02991	0.382
LIG_LIR_Nem_3	493	498	PF02991	0.397
LIG_LIR_Nem_3	631	637	PF02991	0.756
LIG_LIR_Nem_3	71	76	PF02991	0.450
LIG_MYND_1	250	254	PF01753	0.383
LIG_NRBOX	12	18	PF00104	0.595
LIG_Pex3_1	13	24	PF04882	0.632
LIG_PTAP_UEV_1	216	221	PF05743	0.401
LIG_PTB_Apo_2	196	203	PF02174	0.382
LIG_PTB_Apo_2	454	461	PF02174	0.388
LIG_PTB_Phospho_1	454	460	PF10480	0.390
LIG_RPA_C_Fungi	556	568	PF08784	0.613
LIG_SH2_CRK	39	43	PF00017	0.590
LIG_SH2_CRK	476	480	PF00017	0.474
LIG_SH2_CRK	545	549	PF00017	0.472
LIG_SH2_CRK	61	65	PF00017	0.603
LIG_SH2_CRK	634	638	PF00017	0.799
LIG_SH2_NCK_1	634	638	PF00017	0.788
LIG_SH2_PTP2	346	349	PF00017	0.455
LIG_SH2_PTP2	489	492	PF00017	0.486
LIG_SH2_SRC	489	492	PF00017	0.482
LIG_SH2_STAP1	361	365	PF00017	0.569
LIG_SH2_STAP1	495	499	PF00017	0.401
LIG_SH2_STAP1	634	638	PF00017	0.575
LIG_SH2_STAT5	117	120	PF00017	0.483
LIG_SH2_STAT5	346	349	PF00017	0.494
LIG_SH2_STAT5	39	42	PF00017	0.612
LIG_SH2_STAT5	460	463	PF00017	0.473
LIG_SH2_STAT5	489	492	PF00017	0.475
LIG_SH2_STAT5	495	498	PF00017	0.558
LIG_SH3_3	214	220	PF00018	0.571
LIG_SH3_3	244	250	PF00018	0.552
LIG_SH3_3	339	345	PF00018	0.514
LIG_SH3_3	403	409	PF00018	0.598
LIG_SH3_3	584	590	PF00018	0.807
LIG_SH3_3	656	662	PF00018	0.787
LIG_SH3_5	485	489	PF00018	0.506
LIG_SUMO_SIM_anti_2	139	144	PF11976	0.451
LIG_SUMO_SIM_anti_2	14	21	PF11976	0.598
LIG_SUMO_SIM_anti_2	667	675	PF11976	0.632
LIG_SUMO_SIM_par_1	102	108	PF11976	0.492
LIG_SUMO_SIM_par_1	138	144	PF11976	0.490
LIG_SUMO_SIM_par_1	17	23	PF11976	0.481
LIG_SUMO_SIM_par_1	225	231	PF11976	0.536
LIG_TYR_ITIM	543	548	PF00017	0.505
LIG_WRC_WIRS_1	21	26	PF05994	0.609
LIG_WRC_WIRS_1	210	215	PF05994	0.519
LIG_WRC_WIRS_1	223	228	PF05994	0.466
MOD_CDC14_SPxK_1	341	344	PF00782	0.522
MOD_CDK_SPxK_1	338	344	PF00069	0.511
MOD_CK1_1	105	111	PF00069	0.401
MOD_CK1_1	136	142	PF00069	0.513
MOD_CK1_1	144	150	PF00069	0.519
MOD_CK1_1	192	198	PF00069	0.494
MOD_CK1_1	260	266	PF00069	0.453
MOD_CK1_1	380	386	PF00069	0.676
MOD_CK1_1	396	402	PF00069	0.549
MOD_CK1_1	423	429	PF00069	0.492
MOD_CK1_1	438	444	PF00069	0.514
MOD_CK1_1	453	459	PF00069	0.262
MOD_CK1_1	493	499	PF00069	0.581
MOD_CK1_1	6	12	PF00069	0.628
MOD_CK1_1	600	606	PF00069	0.762
MOD_CK1_1	653	659	PF00069	0.813
MOD_CK1_1	80	86	PF00069	0.530
MOD_CK2_1	356	362	PF00069	0.576
MOD_CK2_1	446	452	PF00069	0.494
MOD_DYRK1A_RPxSP_1	654	658	PF00069	0.755
MOD_GlcNHglycan	135	138	PF01048	0.505
MOD_GlcNHglycan	165	168	PF01048	0.460
MOD_GlcNHglycan	185	188	PF01048	0.581
MOD_GlcNHglycan	193	197	PF01048	0.455
MOD_GlcNHglycan	203	206	PF01048	0.284
MOD_GlcNHglycan	27	30	PF01048	0.575
MOD_GlcNHglycan	280	283	PF01048	0.551
MOD_GlcNHglycan	319	322	PF01048	0.685
MOD_GlcNHglycan	382	385	PF01048	0.657
MOD_GlcNHglycan	422	425	PF01048	0.458
MOD_GlcNHglycan	437	440	PF01048	0.473
MOD_GlcNHglycan	502	505	PF01048	0.558
MOD_GlcNHglycan	523	526	PF01048	0.721
MOD_GlcNHglycan	599	602	PF01048	0.687
MOD_GlcNHglycan	631	634	PF01048	0.794
MOD_GlcNHglycan	88	91	PF01048	0.552
MOD_GSK3_1	100	107	PF00069	0.392
MOD_GSK3_1	141	148	PF00069	0.528
MOD_GSK3_1	153	160	PF00069	0.484
MOD_GSK3_1	175	182	PF00069	0.547
MOD_GSK3_1	211	218	PF00069	0.411
MOD_GSK3_1	222	229	PF00069	0.420
MOD_GSK3_1	268	275	PF00069	0.593
MOD_GSK3_1	285	292	PF00069	0.500
MOD_GSK3_1	313	320	PF00069	0.691
MOD_GSK3_1	328	335	PF00069	0.474
MOD_GSK3_1	380	387	PF00069	0.667
MOD_GSK3_1	416	423	PF00069	0.485
MOD_GSK3_1	446	453	PF00069	0.473
MOD_GSK3_1	468	475	PF00069	0.416
MOD_GSK3_1	477	484	PF00069	0.461
MOD_GSK3_1	521	528	PF00069	0.665
MOD_GSK3_1	602	609	PF00069	0.712
MOD_GSK3_1	629	636	PF00069	0.714
MOD_GSK3_1	650	657	PF00069	0.781
MOD_GSK3_1	76	83	PF00069	0.535
MOD_GSK3_1	92	99	PF00069	0.429
MOD_N-GLC_1	289	294	PF02516	0.557
MOD_N-GLC_1	317	322	PF02516	0.761
MOD_N-GLC_1	424	429	PF02516	0.429
MOD_N-GLC_1	456	461	PF02516	0.492
MOD_N-GLC_1	629	634	PF02516	0.701
MOD_N-GLC_1	80	85	PF02516	0.519
MOD_N-GLC_1	96	101	PF02516	0.303
MOD_NEK2_1	102	107	PF00069	0.395
MOD_NEK2_1	12	17	PF00069	0.493
MOD_NEK2_1	200	205	PF00069	0.474
MOD_NEK2_1	209	214	PF00069	0.382
MOD_NEK2_1	222	227	PF00069	0.470
MOD_NEK2_1	228	233	PF00069	0.397
MOD_NEK2_1	259	264	PF00069	0.567
MOD_NEK2_1	289	294	PF00069	0.596
MOD_NEK2_1	334	339	PF00069	0.489
MOD_NEK2_1	356	361	PF00069	0.423
MOD_NEK2_1	472	477	PF00069	0.480
MOD_NEK2_1	544	549	PF00069	0.453
MOD_NEK2_1	672	677	PF00069	0.672
MOD_NEK2_1	76	81	PF00069	0.577
MOD_NEK2_2	409	414	PF00069	0.396
MOD_PK_1	451	457	PF00069	0.606
MOD_PKA_2	133	139	PF00069	0.470
MOD_PKA_2	313	319	PF00069	0.770
MOD_PKA_2	33	39	PF00069	0.457
MOD_PKA_2	380	386	PF00069	0.477
MOD_PKA_2	416	422	PF00069	0.495
MOD_PKA_2	450	456	PF00069	0.601
MOD_PKA_2	653	659	PF00069	0.731
MOD_PKA_2	77	83	PF00069	0.606
MOD_PKA_2	92	98	PF00069	0.561
MOD_Plk_1	192	198	PF00069	0.486
MOD_Plk_1	289	295	PF00069	0.540
MOD_Plk_1	298	304	PF00069	0.520
MOD_Plk_1	356	362	PF00069	0.602
MOD_Plk_1	424	430	PF00069	0.499
MOD_Plk_1	451	457	PF00069	0.489
MOD_Plk_1	490	496	PF00069	0.527
MOD_Plk_1	80	86	PF00069	0.519
MOD_Plk_1	96	102	PF00069	0.319
MOD_Plk_4	12	18	PF00069	0.498
MOD_Plk_4	138	144	PF00069	0.395
MOD_Plk_4	179	185	PF00069	0.485
MOD_Plk_4	33	39	PF00069	0.480
MOD_Plk_4	356	362	PF00069	0.581
MOD_Plk_4	396	402	PF00069	0.380
MOD_Plk_4	416	422	PF00069	0.502
MOD_Plk_4	456	462	PF00069	0.537
MOD_Plk_4	490	496	PF00069	0.578
MOD_Plk_4	544	550	PF00069	0.396
MOD_Plk_4	96	102	PF00069	0.431
MOD_ProDKin_1	177	183	PF00069	0.424
MOD_ProDKin_1	338	344	PF00069	0.638
MOD_ProDKin_1	393	399	PF00069	0.459
MOD_ProDKin_1	481	487	PF00069	0.542
MOD_ProDKin_1	586	592	PF00069	0.785
MOD_ProDKin_1	602	608	PF00069	0.677
MOD_ProDKin_1	654	660	PF00069	0.796
MOD_SUMO_for_1	354	357	PF00179	0.447
MOD_SUMO_rev_2	351	356	PF00179	0.590
TRG_DiLeu_BaEn_1	46	51	PF01217	0.492
TRG_DiLeu_BaLyEn_6	8	13	PF01217	0.563
TRG_ENDOCYTIC_2	346	349	PF00928	0.572
TRG_ENDOCYTIC_2	398	401	PF00928	0.488
TRG_ENDOCYTIC_2	489	492	PF00928	0.527
TRG_ENDOCYTIC_2	495	498	PF00928	0.571
TRG_ENDOCYTIC_2	545	548	PF00928	0.472
TRG_ENDOCYTIC_2	634	637	PF00928	0.804
TRG_ER_diArg_1	1	3	PF00400	0.724
TRG_ER_diArg_1	294	297	PF00400	0.539
TRG_ER_diArg_1	364	367	PF00400	0.542
TRG_ER_diArg_1	565	568	PF00400	0.579
TRG_NLS_MonoExtN_4	565	572	PF00514	0.482
TRG_Pf-PMV_PEXEL_1	570	574	PF00026	0.620

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILM2	Leptomonas seymouri	49%	100%
A0A0S4J6Q6	Bodo saltans	31%	100%
A0A1X0P168	Trypanosomatidae	33%	100%
A0A3Q8IHQ4	Leishmania donovani	99%	100%
A0A3R7N2S1	Trypanosoma rangeli	34%	100%
A4HLG7	Leishmania braziliensis	65%	96%
E9B3U7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q477	Leishmania major	88%	100%
V5BJT9	Trypanosoma cruzi	31%	100%