Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I8X6_LEIIN

TriTrypDb:

LINF_330018600

Length:

761

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I8X6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8X6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	433	437	PF00656	0.639
CLV_C14_Caspase3-7	679	683	PF00656	0.751
CLV_NRD_NRD_1	162	164	PF00675	0.583
CLV_NRD_NRD_1	20	22	PF00675	0.519
CLV_NRD_NRD_1	520	522	PF00675	0.461
CLV_NRD_NRD_1	579	581	PF00675	0.564
CLV_NRD_NRD_1	86	88	PF00675	0.531
CLV_PCSK_KEX2_1	162	164	PF00082	0.533
CLV_PCSK_KEX2_1	341	343	PF00082	0.755
CLV_PCSK_KEX2_1	463	465	PF00082	0.480
CLV_PCSK_KEX2_1	520	522	PF00082	0.554
CLV_PCSK_KEX2_1	579	581	PF00082	0.564
CLV_PCSK_KEX2_1	586	588	PF00082	0.548
CLV_PCSK_PC1ET2_1	341	343	PF00082	0.744
CLV_PCSK_PC1ET2_1	463	465	PF00082	0.480
CLV_PCSK_PC1ET2_1	586	588	PF00082	0.583
CLV_PCSK_SKI1_1	225	229	PF00082	0.653
CLV_PCSK_SKI1_1	249	253	PF00082	0.611
CLV_PCSK_SKI1_1	269	273	PF00082	0.310
CLV_PCSK_SKI1_1	342	346	PF00082	0.741
CLV_PCSK_SKI1_1	489	493	PF00082	0.530
CLV_PCSK_SKI1_1	611	615	PF00082	0.503
CLV_Separin_Metazoa	222	226	PF03568	0.616
DEG_APCC_DBOX_1	170	178	PF00400	0.410
DEG_Nend_UBRbox_4	1	3	PF02207	0.436
DEG_SCF_FBW7_1	734	739	PF00400	0.577
DEG_SPOP_SBC_1	724	728	PF00917	0.707
DOC_CKS1_1	714	719	PF01111	0.699
DOC_CYCLIN_RxL_1	483	496	PF00134	0.555
DOC_CYCLIN_RxL_1	501	512	PF00134	0.521
DOC_MAPK_gen_1	267	275	PF00069	0.583
DOC_MAPK_RevD_3	74	88	PF00069	0.554
DOC_PP4_FxxP_1	69	72	PF00568	0.563
DOC_USP7_MATH_1	110	114	PF00917	0.678
DOC_USP7_MATH_1	120	124	PF00917	0.557
DOC_USP7_MATH_1	154	158	PF00917	0.688
DOC_USP7_MATH_1	256	260	PF00917	0.622
DOC_USP7_MATH_1	343	347	PF00917	0.789
DOC_USP7_MATH_1	398	402	PF00917	0.674
DOC_USP7_MATH_1	60	64	PF00917	0.527
DOC_USP7_MATH_1	705	709	PF00917	0.725
DOC_USP7_MATH_1	725	729	PF00917	0.607
DOC_USP7_MATH_1	736	740	PF00917	0.620
DOC_USP7_MATH_1	744	748	PF00917	0.699
DOC_USP7_MATH_1	749	753	PF00917	0.679
DOC_USP7_MATH_1	79	83	PF00917	0.500
DOC_WW_Pin1_4	132	137	PF00397	0.724
DOC_WW_Pin1_4	199	204	PF00397	0.636
DOC_WW_Pin1_4	259	264	PF00397	0.512
DOC_WW_Pin1_4	356	361	PF00397	0.766
DOC_WW_Pin1_4	630	635	PF00397	0.681
DOC_WW_Pin1_4	713	718	PF00397	0.695
DOC_WW_Pin1_4	732	737	PF00397	0.783
LIG_14-3-3_CanoR_1	277	287	PF00244	0.462
LIG_14-3-3_CanoR_1	322	331	PF00244	0.686
LIG_14-3-3_CanoR_1	405	409	PF00244	0.626
LIG_14-3-3_CanoR_1	468	473	PF00244	0.617
LIG_14-3-3_CanoR_1	483	489	PF00244	0.489
LIG_14-3-3_CanoR_1	509	518	PF00244	0.449
LIG_14-3-3_CanoR_1	539	544	PF00244	0.451
LIG_14-3-3_CanoR_1	580	589	PF00244	0.548
LIG_14-3-3_CanoR_1	664	672	PF00244	0.693
LIG_14-3-3_CanoR_1	698	704	PF00244	0.737
LIG_14-3-3_CanoR_1	745	749	PF00244	0.654
LIG_14-3-3_CanoR_1	94	98	PF00244	0.553
LIG_14-3-3_CterR_2	757	761	PF00244	0.687
LIG_APCC_ABBA_1	472	477	PF00400	0.602
LIG_BIR_III_2	144	148	PF00653	0.709
LIG_Clathr_ClatBox_1	39	43	PF01394	0.493
LIG_deltaCOP1_diTrp_1	257	266	PF00928	0.608
LIG_eIF4E_1	34	40	PF01652	0.509
LIG_EVH1_1	69	73	PF00568	0.571
LIG_FHA_1	15	21	PF00498	0.507
LIG_FHA_1	196	202	PF00498	0.660
LIG_FHA_1	335	341	PF00498	0.823
LIG_FHA_1	349	355	PF00498	0.581
LIG_FHA_1	373	379	PF00498	0.740
LIG_FHA_1	469	475	PF00498	0.640
LIG_FHA_1	56	62	PF00498	0.485
LIG_FHA_1	563	569	PF00498	0.542
LIG_FHA_1	646	652	PF00498	0.783
LIG_FHA_1	658	664	PF00498	0.604
LIG_FHA_2	110	116	PF00498	0.695
LIG_FHA_2	133	139	PF00498	0.748
LIG_FHA_2	357	363	PF00498	0.764
LIG_FHA_2	388	394	PF00498	0.731
LIG_FHA_2	405	411	PF00498	0.501
LIG_FHA_2	485	491	PF00498	0.555
LIG_FHA_2	508	514	PF00498	0.472
LIG_FHA_2	540	546	PF00498	0.500
LIG_FHA_2	618	624	PF00498	0.644
LIG_FHA_2	679	685	PF00498	0.739
LIG_FHA_2	733	739	PF00498	0.728
LIG_LIR_Apic_2	257	263	PF02991	0.539
LIG_LIR_Gen_1	237	248	PF02991	0.604
LIG_LIR_Gen_1	270	280	PF02991	0.533
LIG_LIR_Gen_1	500	508	PF02991	0.463
LIG_LIR_Gen_1	512	519	PF02991	0.456
LIG_LIR_Nem_3	237	243	PF02991	0.616
LIG_LIR_Nem_3	270	275	PF02991	0.453
LIG_LIR_Nem_3	289	293	PF02991	0.493
LIG_LIR_Nem_3	455	460	PF02991	0.454
LIG_LIR_Nem_3	487	491	PF02991	0.533
LIG_LIR_Nem_3	500	505	PF02991	0.438
LIG_LIR_Nem_3	512	518	PF02991	0.453
LIG_NRBOX	35	41	PF00104	0.567
LIG_PCNA_yPIPBox_3	586	595	PF02747	0.547
LIG_Pex14_1	286	290	PF04695	0.444
LIG_Pex14_2	488	492	PF04695	0.505
LIG_SH2_CRK	290	294	PF00017	0.526
LIG_SH2_CRK	502	506	PF00017	0.467
LIG_SH2_CRK	515	519	PF00017	0.452
LIG_SH2_NCK_1	50	54	PF00017	0.488
LIG_SH2_STAP1	30	34	PF00017	0.563
LIG_SH2_STAP1	502	506	PF00017	0.502
LIG_SH2_STAP1	515	519	PF00017	0.487
LIG_SH2_STAP1	543	547	PF00017	0.456
LIG_SH3_1	631	637	PF00018	0.667
LIG_SH3_3	197	203	PF00018	0.667
LIG_SH3_3	293	299	PF00018	0.494
LIG_SH3_3	337	343	PF00018	0.787
LIG_SH3_3	42	48	PF00018	0.576
LIG_SH3_3	631	637	PF00018	0.715
LIG_SH3_3	67	73	PF00018	0.474
LIG_Sin3_3	231	238	PF02671	0.673
LIG_SUMO_SIM_anti_2	169	176	PF11976	0.419
LIG_SUMO_SIM_anti_2	51	59	PF11976	0.344
LIG_SUMO_SIM_anti_2	592	598	PF11976	0.621
LIG_SUMO_SIM_par_1	37	44	PF11976	0.512
LIG_SUMO_SIM_par_1	76	82	PF11976	0.460
LIG_TRAF2_1	407	410	PF00917	0.673
LIG_TRAF2_1	683	686	PF00917	0.757
LIG_WRC_WIRS_1	485	490	PF05994	0.546
LIG_WRC_WIRS_1	750	755	PF05994	0.752
MOD_CK1_1	113	119	PF00069	0.579
MOD_CK1_1	134	140	PF00069	0.660
MOD_CK1_1	259	265	PF00069	0.581
MOD_CK1_1	276	282	PF00069	0.335
MOD_CK1_1	401	407	PF00069	0.646
MOD_CK1_1	500	506	PF00069	0.476
MOD_CK1_1	653	659	PF00069	0.657
MOD_CK1_1	727	733	PF00069	0.771
MOD_CK1_1	752	758	PF00069	0.715
MOD_CK2_1	109	115	PF00069	0.730
MOD_CK2_1	124	130	PF00069	0.752
MOD_CK2_1	3	9	PF00069	0.382
MOD_CK2_1	320	326	PF00069	0.756
MOD_CK2_1	387	393	PF00069	0.746
MOD_CK2_1	404	410	PF00069	0.526
MOD_CK2_1	48	54	PF00069	0.411
MOD_CK2_1	484	490	PF00069	0.593
MOD_CK2_1	507	513	PF00069	0.468
MOD_CK2_1	539	545	PF00069	0.486
MOD_CK2_1	602	608	PF00069	0.459
MOD_CK2_1	617	623	PF00069	0.548
MOD_CK2_1	678	684	PF00069	0.751
MOD_CK2_1	732	738	PF00069	0.734
MOD_GlcNHglycan	112	115	PF01048	0.626
MOD_GlcNHglycan	122	125	PF01048	0.528
MOD_GlcNHglycan	156	159	PF01048	0.676
MOD_GlcNHglycan	192	196	PF01048	0.598
MOD_GlcNHglycan	213	216	PF01048	0.698
MOD_GlcNHglycan	225	228	PF01048	0.567
MOD_GlcNHglycan	369	372	PF01048	0.752
MOD_GlcNHglycan	400	403	PF01048	0.734
MOD_GlcNHglycan	50	53	PF01048	0.410
MOD_GlcNHglycan	58	61	PF01048	0.398
MOD_GlcNHglycan	645	648	PF01048	0.657
MOD_GlcNHglycan	655	658	PF01048	0.801
MOD_GlcNHglycan	666	669	PF01048	0.742
MOD_GlcNHglycan	705	708	PF01048	0.714
MOD_GlcNHglycan	727	730	PF01048	0.765
MOD_GSK3_1	109	116	PF00069	0.625
MOD_GSK3_1	120	127	PF00069	0.670
MOD_GSK3_1	149	156	PF00069	0.641
MOD_GSK3_1	187	194	PF00069	0.521
MOD_GSK3_1	195	202	PF00069	0.615
MOD_GSK3_1	223	230	PF00069	0.641
MOD_GSK3_1	255	262	PF00069	0.530
MOD_GSK3_1	275	282	PF00069	0.345
MOD_GSK3_1	372	379	PF00069	0.805
MOD_GSK3_1	400	407	PF00069	0.654
MOD_GSK3_1	509	516	PF00069	0.577
MOD_GSK3_1	56	63	PF00069	0.448
MOD_GSK3_1	653	660	PF00069	0.607
MOD_GSK3_1	699	706	PF00069	0.719
MOD_GSK3_1	723	730	PF00069	0.788
MOD_GSK3_1	732	739	PF00069	0.699
MOD_GSK3_1	744	751	PF00069	0.714
MOD_GSK3_1	79	86	PF00069	0.486
MOD_NEK2_1	3	8	PF00069	0.402
MOD_NEK2_1	331	336	PF00069	0.766
MOD_NEK2_1	514	519	PF00069	0.555
MOD_NEK2_1	532	537	PF00069	0.455
MOD_NEK2_1	574	579	PF00069	0.548
MOD_NEK2_1	617	622	PF00069	0.640
MOD_NEK2_2	470	475	PF00069	0.593
MOD_PIKK_1	334	340	PF00454	0.742
MOD_PIKK_1	379	385	PF00454	0.773
MOD_PIKK_1	507	513	PF00454	0.468
MOD_PIKK_1	581	587	PF00454	0.482
MOD_PIKK_1	602	608	PF00454	0.463
MOD_PKA_2	276	282	PF00069	0.449
MOD_PKA_2	321	327	PF00069	0.687
MOD_PKA_2	367	373	PF00069	0.689
MOD_PKA_2	404	410	PF00069	0.629
MOD_PKA_2	477	483	PF00069	0.580
MOD_PKA_2	744	750	PF00069	0.657
MOD_PKA_2	93	99	PF00069	0.549
MOD_Plk_1	114	120	PF00069	0.730
MOD_Plk_1	13	19	PF00069	0.557
MOD_Plk_1	191	197	PF00069	0.687
MOD_Plk_1	236	242	PF00069	0.660
MOD_Plk_1	256	262	PF00069	0.349
MOD_Plk_1	331	337	PF00069	0.766
MOD_Plk_1	379	385	PF00069	0.831
MOD_Plk_2-3	350	356	PF00069	0.680
MOD_Plk_4	14	20	PF00069	0.484
MOD_Plk_4	177	183	PF00069	0.522
MOD_Plk_4	196	202	PF00069	0.515
MOD_Plk_4	470	476	PF00069	0.623
MOD_Plk_4	497	503	PF00069	0.520
MOD_Plk_4	514	520	PF00069	0.550
MOD_Plk_4	62	68	PF00069	0.492
MOD_Plk_4	79	85	PF00069	0.329
MOD_ProDKin_1	132	138	PF00069	0.724
MOD_ProDKin_1	199	205	PF00069	0.637
MOD_ProDKin_1	259	265	PF00069	0.506
MOD_ProDKin_1	356	362	PF00069	0.769
MOD_ProDKin_1	630	636	PF00069	0.682
MOD_ProDKin_1	713	719	PF00069	0.697
MOD_ProDKin_1	732	738	PF00069	0.782
MOD_SUMO_rev_2	455	465	PF00179	0.500
MOD_SUMO_rev_2	538	547	PF00179	0.454
TRG_AP2beta_CARGO_1	455	464	PF09066	0.548
TRG_DiLeu_BaEn_1	592	597	PF01217	0.578
TRG_DiLeu_BaEn_1	608	613	PF01217	0.363
TRG_DiLeu_BaEn_4	496	502	PF01217	0.521
TRG_DiLeu_BaLyEn_6	501	506	PF01217	0.543
TRG_DiLeu_BaLyEn_6	635	640	PF01217	0.728
TRG_DiLeu_LyEn_5	608	613	PF01217	0.562
TRG_ENDOCYTIC_2	290	293	PF00928	0.560
TRG_ENDOCYTIC_2	50	53	PF00928	0.396
TRG_ENDOCYTIC_2	502	505	PF00928	0.473
TRG_ENDOCYTIC_2	515	518	PF00928	0.448
TRG_ER_diArg_1	161	163	PF00400	0.630
TRG_ER_diArg_1	266	269	PF00400	0.545
TRG_ER_diArg_1	519	521	PF00400	0.555
TRG_NLS_MonoExtC_3	387	393	PF00514	0.697
TRG_NLS_MonoExtN_4	385	392	PF00514	0.711
TRG_Pf-PMV_PEXEL_1	489	494	PF00026	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6S9	Leptomonas seymouri	57%	95%
A0A3Q8IDP5	Leishmania donovani	99%	100%
A4HLG5	Leishmania braziliensis	83%	99%
D0A4X2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B3U5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q479	Leishmania major	94%	100%
V5BPB5	Trypanosoma cruzi	36%	100%