Uncharacterized protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I8X2_LEIIN

TriTrypDb:

LINF_330018200

Length:

243

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I8X2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8X2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	217	219	PF00675	0.591
CLV_NRD_NRD_1	223	225	PF00675	0.558
CLV_PCSK_KEX2_1	217	219	PF00082	0.591
CLV_PCSK_SKI1_1	122	126	PF00082	0.628
CLV_PCSK_SKI1_1	25	29	PF00082	0.402
DOC_PP1_RVXF_1	120	126	PF00149	0.320
DOC_PP1_RVXF_1	78	85	PF00149	0.565
DOC_PP4_FxxP_1	125	128	PF00568	0.334
LIG_14-3-3_CanoR_1	12	18	PF00244	0.623
LIG_BIR_II_1	1	5	PF00653	0.649
LIG_BRCT_BRCA1_1	68	72	PF00533	0.657
LIG_deltaCOP1_diTrp_1	52	59	PF00928	0.516
LIG_FHA_2	14	20	PF00498	0.489
LIG_FHA_2	33	39	PF00498	0.509
LIG_HCF-1_HBM_1	19	22	PF13415	0.487
LIG_IBAR_NPY_1	30	32	PF08397	0.498
LIG_IBAR_NPY_1	76	78	PF08397	0.581
LIG_LIR_Nem_3	116	121	PF02991	0.345
LIG_LIR_Nem_3	158	163	PF02991	0.452
LIG_PDZ_Class_2	238	243	PF00595	0.532
LIG_Pex14_1	55	59	PF04695	0.562
LIG_REV1ctd_RIR_1	70	76	PF16727	0.562
LIG_SH2_CRK	61	65	PF00017	0.604
LIG_SH2_NCK_1	209	213	PF00017	0.307
LIG_SH2_STAP1	209	213	PF00017	0.297
LIG_SH2_STAT5	209	212	PF00017	0.375
LIG_SH2_STAT5	23	26	PF00017	0.536
LIG_SH2_STAT5	32	35	PF00017	0.500
LIG_SH2_STAT5	81	84	PF00017	0.579
LIG_SH3_3	136	142	PF00018	0.406
LIG_SH3_4	141	148	PF00018	0.411
LIG_SUMO_SIM_anti_2	106	112	PF11976	0.339
LIG_SUMO_SIM_par_1	109	116	PF11976	0.258
LIG_TRFH_1	22	26	PF08558	0.593
LIG_TRFH_1	61	65	PF08558	0.638
MOD_CK1_1	106	112	PF00069	0.425
MOD_CK1_1	2	8	PF00069	0.645
MOD_CK1_1	200	206	PF00069	0.332
MOD_CK1_1	230	236	PF00069	0.391
MOD_CK2_1	85	91	PF00069	0.544
MOD_GlcNHglycan	210	213	PF01048	0.502
MOD_GlcNHglycan	237	240	PF01048	0.669
MOD_GlcNHglycan	68	71	PF01048	0.384
MOD_GlcNHglycan	8	11	PF01048	0.463
MOD_GSK3_1	113	120	PF00069	0.238
MOD_GSK3_1	2	9	PF00069	0.699
MOD_GSK3_1	227	234	PF00069	0.490
MOD_GSK3_1	99	106	PF00069	0.481
MOD_NEK2_1	113	118	PF00069	0.345
MOD_NEK2_1	85	90	PF00069	0.530
MOD_NEK2_2	128	133	PF00069	0.328
MOD_PIKK_1	197	203	PF00454	0.328
MOD_PIKK_1	228	234	PF00454	0.375
MOD_PIKK_1	32	38	PF00454	0.595
MOD_PKA_2	2	8	PF00069	0.630
MOD_PKA_2	228	234	PF00069	0.337
MOD_Plk_1	128	134	PF00069	0.316
MOD_Plk_1	85	91	PF00069	0.532
MOD_Plk_2-3	86	92	PF00069	0.526
MOD_Plk_4	103	109	PF00069	0.270
MOD_Plk_4	13	19	PF00069	0.522
TRG_ENDOCYTIC_2	160	163	PF00928	0.403
TRG_ENDOCYTIC_2	61	64	PF00928	0.608
TRG_ER_diArg_1	216	218	PF00400	0.380
TRG_NES_CRM1_1	173	187	PF08389	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYK0	Leptomonas seymouri	71%	100%
A0A0S4IVH5	Bodo saltans	54%	100%
A0A0S4IXX7	Bodo saltans	44%	92%
A0A1X0NYZ9	Trypanosomatidae	63%	100%
A0A3Q8IGT4	Leishmania donovani	100%	100%
A0A422MZK8	Trypanosoma rangeli	58%	100%
A4HGE2	Leishmania braziliensis	62%	100%
A4HLG1	Leishmania braziliensis	80%	100%
A4I3H5	Leishmania infantum	61%	100%
E9AZR4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
E9B3U1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
I1ZAQ0	Leishmania donovani	61%	100%
Q4Q483	Leishmania major	95%	100%
Q4Q8G9	Leishmania major	60%	100%
V5AL49	Trypanosoma cruzi	60%	95%