LeishMANIAdb
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Peptidase_S9 domain-containing protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Peptidase_S9 domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I8X0_LEIIN
TriTrypDb:
LINF_330018000 *
Length:
359

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Amastigote: 41

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I8X0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8X0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 15 17 PF00675 0.592
CLV_NRD_NRD_1 164 166 PF00675 0.427
CLV_NRD_NRD_1 310 312 PF00675 0.433
CLV_NRD_NRD_1 5 7 PF00675 0.512
CLV_NRD_NRD_1 53 55 PF00675 0.659
CLV_NRD_NRD_1 8 10 PF00675 0.592
CLV_PCSK_FUR_1 308 312 PF00082 0.473
CLV_PCSK_FUR_1 6 10 PF00082 0.522
CLV_PCSK_KEX2_1 15 17 PF00082 0.559
CLV_PCSK_KEX2_1 164 166 PF00082 0.423
CLV_PCSK_KEX2_1 295 297 PF00082 0.443
CLV_PCSK_KEX2_1 310 312 PF00082 0.288
CLV_PCSK_KEX2_1 5 7 PF00082 0.573
CLV_PCSK_KEX2_1 53 55 PF00082 0.659
CLV_PCSK_KEX2_1 8 10 PF00082 0.547
CLV_PCSK_PC1ET2_1 295 297 PF00082 0.533
CLV_PCSK_SKI1_1 125 129 PF00082 0.486
CLV_PCSK_SKI1_1 168 172 PF00082 0.497
CLV_PCSK_SKI1_1 207 211 PF00082 0.354
CLV_PCSK_SKI1_1 8 12 PF00082 0.558
DOC_CYCLIN_yCln2_LP_2 282 288 PF00134 0.320
DOC_CYCLIN_yCln2_LP_2 76 82 PF00134 0.332
DOC_MAPK_gen_1 164 172 PF00069 0.426
DOC_MAPK_gen_1 194 203 PF00069 0.447
DOC_MAPK_MEF2A_6 38 47 PF00069 0.607
DOC_MAPK_RevD_3 280 296 PF00069 0.446
DOC_USP7_MATH_1 187 191 PF00917 0.663
DOC_USP7_MATH_1 335 339 PF00917 0.447
DOC_USP7_MATH_1 48 52 PF00917 0.703
DOC_WW_Pin1_4 217 222 PF00397 0.465
DOC_WW_Pin1_4 39 44 PF00397 0.681
DOC_WW_Pin1_4 97 102 PF00397 0.540
LIG_14-3-3_CanoR_1 207 217 PF00244 0.317
LIG_14-3-3_CanoR_1 38 43 PF00244 0.729
LIG_14-3-3_CanoR_1 63 69 PF00244 0.609
LIG_14-3-3_CanoR_1 84 91 PF00244 0.599
LIG_Clathr_ClatBox_1 229 233 PF01394 0.324
LIG_FHA_1 158 164 PF00498 0.468
LIG_FHA_1 300 306 PF00498 0.357
LIG_FHA_1 331 337 PF00498 0.524
LIG_FHA_1 75 81 PF00498 0.534
LIG_FHA_1 84 90 PF00498 0.572
LIG_FHA_2 172 178 PF00498 0.544
LIG_FHA_2 264 270 PF00498 0.471
LIG_FHA_2 39 45 PF00498 0.706
LIG_FHA_2 55 61 PF00498 0.724
LIG_GBD_Chelix_1 3 11 PF00786 0.589
LIG_Integrin_RGD_1 58 60 PF01839 0.588
LIG_LIR_Gen_1 211 221 PF02991 0.346
LIG_LIR_Gen_1 233 243 PF02991 0.355
LIG_LIR_Nem_3 233 239 PF02991 0.350
LIG_LIR_Nem_3 350 356 PF02991 0.410
LIG_Pex14_2 256 260 PF04695 0.437
LIG_Rb_pABgroove_1 347 355 PF01858 0.378
LIG_SH2_CRK 112 116 PF00017 0.555
LIG_SH2_NCK_1 142 146 PF00017 0.483
LIG_SH2_STAT5 345 348 PF00017 0.369
LIG_SH2_STAT5 356 359 PF00017 0.398
LIG_SH3_3 229 235 PF00018 0.389
LIG_SUMO_SIM_anti_2 228 233 PF11976 0.379
LIG_SUMO_SIM_anti_2 322 327 PF11976 0.477
LIG_SUMO_SIM_par_1 228 233 PF11976 0.340
LIG_TRAF2_1 220 223 PF00917 0.511
LIG_TRAF2_1 266 269 PF00917 0.479
LIG_WRC_WIRS_1 257 262 PF05994 0.451
MOD_CK1_1 192 198 PF00069 0.630
MOD_CK1_1 20 26 PF00069 0.688
MOD_CK2_1 171 177 PF00069 0.514
MOD_CK2_1 217 223 PF00069 0.423
MOD_CK2_1 263 269 PF00069 0.484
MOD_GlcNHglycan 19 22 PF01048 0.555
MOD_GlcNHglycan 214 217 PF01048 0.417
MOD_GlcNHglycan 328 331 PF01048 0.512
MOD_GSK3_1 171 178 PF00069 0.517
MOD_GSK3_1 188 195 PF00069 0.577
MOD_GSK3_1 203 210 PF00069 0.289
MOD_GSK3_1 326 333 PF00069 0.484
MOD_GSK3_1 352 359 PF00069 0.496
MOD_GSK3_1 61 68 PF00069 0.456
MOD_LATS_1 169 175 PF00433 0.457
MOD_N-GLC_2 299 301 PF02516 0.461
MOD_NEK2_1 203 208 PF00069 0.337
MOD_NEK2_1 256 261 PF00069 0.412
MOD_NEK2_1 288 293 PF00069 0.337
MOD_NEK2_1 326 331 PF00069 0.376
MOD_NEK2_1 352 357 PF00069 0.384
MOD_NEK2_2 131 136 PF00069 0.517
MOD_NEK2_2 208 213 PF00069 0.351
MOD_NEK2_2 83 88 PF00069 0.535
MOD_PIKK_1 299 305 PF00454 0.441
MOD_PKA_2 187 193 PF00069 0.561
MOD_PKA_2 263 269 PF00069 0.451
MOD_PKA_2 62 68 PF00069 0.490
MOD_PKA_2 83 89 PF00069 0.608
MOD_Plk_1 188 194 PF00069 0.683
MOD_Plk_1 243 249 PF00069 0.415
MOD_Plk_4 225 231 PF00069 0.445
MOD_ProDKin_1 217 223 PF00069 0.461
MOD_ProDKin_1 39 45 PF00069 0.682
MOD_ProDKin_1 97 103 PF00069 0.534
MOD_SUMO_rev_2 220 227 PF00179 0.459
MOD_SUMO_rev_2 262 272 PF00179 0.425
MOD_SUMO_rev_2 274 280 PF00179 0.257
TRG_DiLeu_BaLyEn_6 89 94 PF01217 0.516
TRG_ENDOCYTIC_2 112 115 PF00928 0.542
TRG_ENDOCYTIC_2 214 217 PF00928 0.345
TRG_ENDOCYTIC_2 345 348 PF00928 0.369
TRG_ER_diArg_1 106 109 PF00400 0.547
TRG_ER_diArg_1 14 16 PF00400 0.584
TRG_ER_diArg_1 163 165 PF00400 0.420
TRG_ER_diArg_1 308 311 PF00400 0.417
TRG_ER_diArg_1 5 8 PF00400 0.588
TRG_ER_diArg_1 53 56 PF00400 0.697
TRG_Pf-PMV_PEXEL_1 9 13 PF00026 0.403

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I5H7 Leptomonas seymouri 55% 79%
A0A0S4ITL2 Bodo saltans 40% 100%
A0A0S4J4Y0 Bodo saltans 41% 100%
A0A1X0P162 Trypanosomatidae 49% 89%
A0A3Q8IGI7 Leishmania donovani 99% 84%
A0A422P2L6 Trypanosoma rangeli 57% 100%
A4HLF9 Leishmania braziliensis 76% 100%
D0A4W5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
E9B3T9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
Q4Q485 Leishmania major 95% 100%
V5BF92 Trypanosoma cruzi 53% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS