Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I8W9_LEIIN

TriTrypDb:

LINF_330017900

Length:

450

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I8W9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8W9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	20	24	PF00656	0.710
CLV_NRD_NRD_1	153	155	PF00675	0.589
CLV_NRD_NRD_1	218	220	PF00675	0.515
CLV_NRD_NRD_1	45	47	PF00675	0.523
CLV_NRD_NRD_1	84	86	PF00675	0.543
CLV_PCSK_FUR_1	82	86	PF00082	0.539
CLV_PCSK_KEX2_1	152	154	PF00082	0.576
CLV_PCSK_KEX2_1	45	47	PF00082	0.531
CLV_PCSK_KEX2_1	81	83	PF00082	0.518
CLV_PCSK_KEX2_1	84	86	PF00082	0.540
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.648
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.518
CLV_PCSK_SKI1_1	78	82	PF00082	0.436
CLV_Separin_Metazoa	60	64	PF03568	0.478
DEG_APCC_DBOX_1	260	268	PF00400	0.707
DEG_Nend_UBRbox_2	1	3	PF02207	0.706
DEG_SCF_FBW7_1	235	240	PF00400	0.533
DEG_SPOP_SBC_1	104	108	PF00917	0.553
DOC_CKS1_1	309	314	PF01111	0.578
DOC_MAPK_gen_1	152	160	PF00069	0.639
DOC_MAPK_gen_1	193	202	PF00069	0.442
DOC_MAPK_gen_1	219	227	PF00069	0.484
DOC_MAPK_JIP1_4	154	160	PF00069	0.660
DOC_MAPK_MEF2A_6	324	331	PF00069	0.612
DOC_PP2B_LxvP_1	213	216	PF13499	0.484
DOC_PP4_FxxP_1	306	309	PF00568	0.585
DOC_PP4_FxxP_1	36	39	PF00568	0.630
DOC_USP7_MATH_1	136	140	PF00917	0.771
DOC_USP7_MATH_1	195	199	PF00917	0.566
DOC_USP7_MATH_1	285	289	PF00917	0.695
DOC_USP7_MATH_1	297	301	PF00917	0.697
DOC_USP7_MATH_1	393	397	PF00917	0.698
DOC_WW_Pin1_4	100	105	PF00397	0.683
DOC_WW_Pin1_4	233	238	PF00397	0.548
DOC_WW_Pin1_4	308	313	PF00397	0.586
LIG_14-3-3_CanoR_1	114	120	PF00244	0.671
LIG_14-3-3_CanoR_1	161	165	PF00244	0.517
LIG_14-3-3_CanoR_1	255	259	PF00244	0.635
LIG_14-3-3_CanoR_1	50	59	PF00244	0.473
LIG_Actin_WH2_2	62	80	PF00022	0.491
LIG_BIR_III_4	365	369	PF00653	0.642
LIG_BRCT_BRCA1_1	161	165	PF00533	0.481
LIG_FHA_1	128	134	PF00498	0.718
LIG_FHA_1	175	181	PF00498	0.587
LIG_FHA_1	234	240	PF00498	0.537
LIG_FHA_1	27	33	PF00498	0.609
LIG_FHA_1	314	320	PF00498	0.462
LIG_FHA_1	374	380	PF00498	0.640
LIG_FHA_1	89	95	PF00498	0.539
LIG_FHA_2	122	128	PF00498	0.728
LIG_FHA_2	238	244	PF00498	0.481
LIG_FHA_2	270	276	PF00498	0.654
LIG_FHA_2	372	378	PF00498	0.623
LIG_FHA_2	440	446	PF00498	0.585
LIG_FXI_DFP_1	33	37	PF00024	0.674
LIG_LIR_Apic_2	35	39	PF02991	0.524
LIG_LIR_Gen_1	58	67	PF02991	0.470
LIG_LIR_Gen_1	70	80	PF02991	0.313
LIG_LIR_Nem_3	162	168	PF02991	0.570
LIG_LIR_Nem_3	332	337	PF02991	0.406
LIG_LIR_Nem_3	58	62	PF02991	0.474
LIG_LIR_Nem_3	70	76	PF02991	0.312
LIG_MYND_1	305	309	PF01753	0.612
LIG_PCNA_PIPBox_1	245	254	PF02747	0.549
LIG_PDZ_Class_3	445	450	PF00595	0.622
LIG_Pex14_2	306	310	PF04695	0.682
LIG_SH2_SRC	273	276	PF00017	0.654
LIG_SH2_SRC	9	12	PF00017	0.713
LIG_SH2_STAP1	221	225	PF00017	0.527
LIG_SH2_STAP1	315	319	PF00017	0.486
LIG_SH2_STAP1	9	13	PF00017	0.712
LIG_SH2_STAT5	315	318	PF00017	0.490
LIG_SH2_STAT5	334	337	PF00017	0.283
LIG_SH2_STAT5	73	76	PF00017	0.445
LIG_SH3_3	117	123	PF00018	0.732
LIG_SH3_3	306	312	PF00018	0.663
LIG_SUMO_SIM_par_1	236	244	PF11976	0.518
LIG_TRAF2_1	231	234	PF00917	0.522
LIG_TRAF2_1	281	284	PF00917	0.747
LIG_UBA3_1	213	220	PF00899	0.575
LIG_UBA3_1	76	81	PF00899	0.465
MOD_CK1_1	139	145	PF00069	0.669
MOD_CK1_1	163	169	PF00069	0.513
MOD_CK1_1	254	260	PF00069	0.581
MOD_CK1_1	396	402	PF00069	0.641
MOD_CK2_1	121	127	PF00069	0.699
MOD_CK2_1	237	243	PF00069	0.470
MOD_CK2_1	269	275	PF00069	0.714
MOD_CK2_1	371	377	PF00069	0.690
MOD_CK2_1	405	411	PF00069	0.622
MOD_CK2_1	90	96	PF00069	0.482
MOD_GlcNHglycan	137	141	PF01048	0.693
MOD_GlcNHglycan	165	168	PF01048	0.432
MOD_GlcNHglycan	23	26	PF01048	0.631
MOD_GlcNHglycan	299	302	PF01048	0.727
MOD_GSK3_1	100	107	PF00069	0.627
MOD_GSK3_1	135	142	PF00069	0.710
MOD_GSK3_1	159	166	PF00069	0.590
MOD_GSK3_1	233	240	PF00069	0.530
MOD_GSK3_1	285	292	PF00069	0.671
MOD_GSK3_1	293	300	PF00069	0.687
MOD_N-GLC_1	21	26	PF02516	0.663
MOD_NEK2_1	159	164	PF00069	0.502
MOD_NEK2_1	348	353	PF00069	0.564
MOD_NEK2_1	90	95	PF00069	0.617
MOD_NEK2_2	26	31	PF00069	0.673
MOD_NEK2_2	393	398	PF00069	0.649
MOD_PIKK_1	201	207	PF00454	0.456
MOD_PIKK_1	348	354	PF00454	0.535
MOD_PIKK_1	50	56	PF00454	0.542
MOD_PKA_2	115	121	PF00069	0.688
MOD_PKA_2	160	166	PF00069	0.571
MOD_PKA_2	195	201	PF00069	0.595
MOD_PKA_2	254	260	PF00069	0.533
MOD_Plk_1	289	295	PF00069	0.530
MOD_Plk_2-3	405	411	PF00069	0.710
MOD_Plk_4	160	166	PF00069	0.526
MOD_Plk_4	237	243	PF00069	0.503
MOD_ProDKin_1	100	106	PF00069	0.685
MOD_ProDKin_1	233	239	PF00069	0.548
MOD_ProDKin_1	308	314	PF00069	0.587
MOD_SUMO_for_1	175	178	PF00179	0.424
MOD_SUMO_rev_2	178	184	PF00179	0.579
TRG_DiLeu_BaEn_1	282	287	PF01217	0.598
TRG_DiLeu_BaLyEn_6	263	268	PF01217	0.635
TRG_DiLeu_LyEn_5	234	239	PF01217	0.536
TRG_ENDOCYTIC_2	59	62	PF00928	0.463
TRG_ENDOCYTIC_2	73	76	PF00928	0.299
TRG_ER_diArg_1	113	116	PF00400	0.669
TRG_ER_diArg_1	153	155	PF00400	0.590
TRG_ER_diArg_1	337	340	PF00400	0.390
TRG_ER_diArg_1	82	85	PF00400	0.501
TRG_NES_CRM1_1	318	333	PF08389	0.590
TRG_NLS_MonoExtC_3	80	85	PF00514	0.521
TRG_NLS_MonoExtN_4	151	156	PF00514	0.628
TRG_NLS_MonoExtN_4	78	85	PF00514	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCG4	Leptomonas seymouri	59%	100%
A0A1X0P2F5	Trypanosomatidae	29%	100%
A0A3R7P2X0	Trypanosoma rangeli	32%	100%
A0A3S7X6N5	Leishmania donovani	99%	100%
A4HLF8	Leishmania braziliensis	80%	100%
D0A4W4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	99%
E9B3T8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q486	Leishmania major	93%	100%
V5AZU2	Trypanosoma cruzi	32%	100%